Oral Bioavailability
DOWNLOAD
Download Oral Bioavailability PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Oral Bioavailability book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Oral Bioavailability
DOWNLOAD
Author : Xiaoling Li
language : en
Publisher: John Wiley & Sons
Release Date : 2011-08-04
Oral Bioavailability written by Xiaoling Li and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-08-04 with Medical categories.
Understand and assess the design, delivery, and efficacy of orally administered drugs A practical guide to understanding oral bioavailability, one of the major hurdles in drug development and delivery, Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications is designed to help chemists, biologists, life science researchers, pharmaceutical scientists, pharmacologists, clinicians, and graduate and students become familiar with the fundamentals and practices of the science of oral bioavailability. The difference in rate and extent between a drug taken orally and the actual amount of a drug reaching the circulatory system, oral bioavailability is an essential parameter for determining the efficacy and adverse effects of new and developing medications, as well as finding an optimal dosing regimen. This book provides a much-needed one-stop resource to help readers better understand and appreciate the many facets and complex problems of oral bioavailability, including the basic barriers to oral bioavailability, the methods used to determine relevant parameters, and the challenges of drug delivery. In addition, this comprehensive book discusses biological and physicochemical methods for improving bioavailability, integrates physicochemistry with physiology and molecular biology, and includes several state-of-the-art technologies and approaches Caco-2 cell culture model, MDCK, and other related cell culture models which are used to study the science of oral bioavailability.
Oral Bioavailability And Drug Delivery
DOWNLOAD
Author : Ming Hu
language : en
Publisher: John Wiley & Sons
Release Date : 2024-01-18
Oral Bioavailability And Drug Delivery written by Ming Hu and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-01-18 with Medical categories.
ORAL BIOAVAILABILITY AND DRUG DELIVERY Improve the performance and viability of newly-developed and approved drugs with this crucial guide Bioavailability is the parameter which measures the rate and extent to which a drug reaches a user’s circulatory system depending on the method of administration. For example, intravenous administration produces a bioavailability of 100%, since the drugs are injected directly into the circulatory system; in the case of oral administration, however, bioavailability can vary widely based on factors which, if not properly understood, can result in a failure in drug development, adverse effects, and other complications. The mechanics of oral bioavailability are therefore critical aspects of drug development. Oral Bioavailability and Drug Delivery provides a comprehensive coverage of this subject as well as its drug development applications. Beginning with basic terminology and fundamental concepts, it provides a thorough understanding of the challenges and barriers to oral bioavailability as well as the possibilities for improving this parameter. The resulting book is an indispensable tool for drug development research. Oral Bioavailability and Drug Delivery readers will also find: Discussion questions in many chapters to facilitate comprehension Detailed discussion of topics including dissolution, absorption, metabolism, and more Real-world examples of methods in actions throughout Oral Bioavailability and Drug Delivery is ideal for pharmaceutical and biotechnology scientists working in drug discovery and development; researchers in chemistry, biology, pharmacology, immunology, neuroscience, and other related fields; and graduate courses in drug development and delivery.
Oral Bioavailability Assessment
DOWNLOAD
Author : Ayman F. El-Kattan
language : en
Publisher: John Wiley & Sons
Release Date : 2017-06-06
Oral Bioavailability Assessment written by Ayman F. El-Kattan and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-06 with Medical categories.
Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability – one of the most significant hurdles in drug discovery and development. • Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability • Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development • Explains how preclinical animal models – used in preclinical testing – and in vitro tools translate to humans, which is an underappreciated and complicated area of drug development • Includes chapters about pharmacokinetic modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS) • Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/development
Oral Lipid Based Formulations
DOWNLOAD
Author : David J. Hauss
language : en
Publisher: CRC Press
Release Date : 2007-06-08
Oral Lipid Based Formulations written by David J. Hauss and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-06-08 with Medical categories.
Oral lipid-based formulations are attracting considerable attention due to their capacity to facilitate gastrointestinal absorption and reduce or eliminate the effect of food on the absorption of poorly water-soluble, lipophilic drugs. Despite the obvious and demonstrated utility of these formulations for addressing a persistent and growing problem
Oral Drug Absorption
DOWNLOAD
Author : Jennifer B. Dressman
language : en
Publisher: CRC Press
Release Date : 2016-04-19
Oral Drug Absorption written by Jennifer B. Dressman and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-19 with Medical categories.
Oral Drug Absorption, Second Edition thoroughly examines the special equipment and methods used to test whether drugs are released adequately when administered orally. The contributors discuss methods for accurately establishing and validating in vitro/in vivo correlations for both MR and IR formulations, as well as alternative approaches for MR an
Drug Bioavailability
DOWNLOAD
Author : Han van de Waterbeemd
language : de
Publisher: John Wiley & Sons
Release Date : 2006-03-06
Drug Bioavailability written by Han van de Waterbeemd and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-03-06 with Science categories.
The peroral application (swallowing) of a medicine means that the body must first resorb the active substance before it can begin to take effect. The efficacy of drug uptake depends on the one hand on the chemical characteristics of the active substance, above all on its solubility and membrane permeability. On the other hand, it is determined by the organism's ability to absorb pharmaceuticals by way of specific transport proteins or to excrete them. Since many pharmacologically active substances are poorly suited for oral intake, a decisive criterion for the efficacy of a medicine is its so-called bioavailability. Written by an international team from academia and the pharmaceutical industry, this book covers all aspects of the oral bioavailability of medicines. The focus is placed on methods for determining the parameters relevant to bioavailability. These range from modern physicochemical techniques via biological studies in vitro and in vivo right up to computer-aided predictions. The authors specifically address possibilities for optimizing bioavailability during the early screening stage for the active substance. Its clear structure and comprehensive coverage make this book equally suitable for researchers and lecturers in industry and teaching.
Absorption Of Orally Administered Enzymes
DOWNLOAD
Author : M. L. G. Gardner
language : en
Publisher:
Release Date : 1994
Absorption Of Orally Administered Enzymes written by M. L. G. Gardner and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with categories.
Revising Oral Pharmacokinetics Bioavailability And Bioequivalence Based On The Finite Absorption Time Concept
DOWNLOAD
Author : Panos Macheras
language : en
Publisher: Springer Nature
Release Date : 2023-01-01
Revising Oral Pharmacokinetics Bioavailability And Bioequivalence Based On The Finite Absorption Time Concept written by Panos Macheras and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-01 with Medical categories.
This book casts new light on the field of oral drug absorption. It outlines both the concept of the past and the novel concept of Finite Absorption Time (FAT). In addition, the authors explore the correlated need for re-definition of bioavailability, bioequivalence providing a plethora of experimental data. Accordingly, this book is intended for academics/students or scientists working in pharmaceutical industries, regulatory agencies, and contract research organizations. It can be used for teaching purposes in under- and post-graduate courses dealing with biopharmaceutics, pharmacokinetics and biomedical engineering.
Introduction To Basics Of Pharmacology And Toxicology
DOWNLOAD
Author : Gerard Marshall Raj
language : en
Publisher: Springer Nature
Release Date : 2019-11-16
Introduction To Basics Of Pharmacology And Toxicology written by Gerard Marshall Raj and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-16 with Medical categories.
This book illustrates, in a comprehensive manner, the most crucial principles involved in pharmacology and allied sciences. The title begins by discussing the historical aspects of drug discovery, with up to date knowledge on Nobel Laureates in pharmacology and their significant discoveries. It then examines the general pharmacological principles - pharmacokinetics and pharmacodynamics, with in-depth information on drug transporters and interactions. In the remaining chapters, the book covers a definitive collection of topics containing essential information on the basic principles of pharmacology and how they are employed for the treatment of diseases. Readers will learn about special topics in pharmacology that are hard to find elsewhere, including issues related to environmental toxicology and the latest information on drug poisoning and treatment, analytical toxicology, toxicovigilance, and the use of molecular biology techniques in pharmacology. The book offers a valuable resource for researchers in the fields of pharmacology and toxicology, as well as students pursuing a degree in or with an interest in pharmacology.
The Prediction Of Human Oral Bioavailability Of Drugs
DOWNLOAD
Author : Elizabeth Eileen Hills
language : en
Publisher:
Release Date : 2008
The Prediction Of Human Oral Bioavailability Of Drugs written by Elizabeth Eileen Hills and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with categories.