Oral Bioavailability Assessment
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Oral Bioavailability Assessment
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Author : Ayman F. El-Kattan
language : en
Publisher: John Wiley & Sons
Release Date : 2017-06-06
Oral Bioavailability Assessment written by Ayman F. El-Kattan and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-06 with Medical categories.
Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability – one of the most significant hurdles in drug discovery and development. • Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability • Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development • Explains how preclinical animal models – used in preclinical testing – and in vitro tools translate to humans, which is an underappreciated and complicated area of drug development • Includes chapters about pharmacokinetic modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS) • Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/development
Assessing Oral Bioavailability Of Metals In Soil
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Author : Mark E. Kelley
language : en
Publisher:
Release Date : 2002
Assessing Oral Bioavailability Of Metals In Soil written by Mark E. Kelley and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Medical categories.
The book also illustrates how bioavailability adjustments can be incorporated into risk assessments to generate risk-based cleanup values that are more site specific than those based on the default assumption of complete bioavailability. Although the book focuses on oral bioavailability of metals to human receptors, many of the basic principles described herein also can be applied to assessing bioavailability of organic compounds and for assessing bioavailability to ecological receptors."--BOOK JACKET.
Oral Drug Absorption
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Author : Jennifer B. Dressman
language : en
Publisher: CRC Press
Release Date : 2016-04-19
Oral Drug Absorption written by Jennifer B. Dressman and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-19 with Medical categories.
Oral Drug Absorption, Second Edition thoroughly examines the special equipment and methods used to test whether drugs are released adequately when administered orally. The contributors discuss methods for accurately establishing and validating in vitro/in vivo correlations for both MR and IR formulations, as well as alternative approaches for MR an
Oral Drug Absorption
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Author : Jennifer B. Dressman
language : en
Publisher: CRC Press
Release Date : 2000-06-06
Oral Drug Absorption written by Jennifer B. Dressman and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-06-06 with Medical categories.
A practical, hands-on guide for successfully developing oral drug products, this comprehensive reference runs the gamut from theoretical stages of computer-based calculations to practical guidelines for establishing in vitro/in vivo correlations. Coverage details the interrelationship between the physiology of the gastrointestinal tract and oral drug formulations and absorption, and progresses to the latest applications of pharmacokinetic analysis. Includes chapters by the innovators of the Biopharmaceutical Classification Scheme (BCS), human perfusions, and biorelevant dissolution testing! With over 600 literature references, equations, drawings, and photographs, Oral Drug Absorption offers multiple methods for predicting permeability, solubility, and dissolution for oral bioavailability and bioequivalence facilitates selection of appropriate drug candidates for development fully elaborates on the experimental and data analysis techniques of in vitro/in vivo correlations provides guidance to the Federal Drug Administration's BCS and its applications appends helpful case studies to the concepts discussed and much more! Contributions by more than 20 international specialists on the latest research make Oral Drug Absorption an invaluable tool and useful reference in the hands of pharmaceutical scientists, medicinal chemists, pharmacists, pharmacologists, toxicologists, biochemists, gastroenterologists, regulatory personnel, and graduate school students in these disciplines.
How Can Information On Oral Bioavailability Improve Human Health Risk Assessment For Lead Contaminated Soils
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Author : A. G. Oomen
language : en
Publisher:
Release Date : 2006
How Can Information On Oral Bioavailability Improve Human Health Risk Assessment For Lead Contaminated Soils written by A. G. Oomen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with categories.
Revising Oral Pharmacokinetics Bioavailability And Bioequivalence Based On The Finite Absorption Time Concept
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Author : Panos Macheras
language : en
Publisher: Springer Nature
Release Date : 2023-01-01
Revising Oral Pharmacokinetics Bioavailability And Bioequivalence Based On The Finite Absorption Time Concept written by Panos Macheras and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-01 with Medical categories.
This book casts new light on the field of oral drug absorption. It outlines both the concept of the past and the novel concept of Finite Absorption Time (FAT). In addition, the authors explore the correlated need for re-definition of bioavailability, bioequivalence providing a plethora of experimental data. Accordingly, this book is intended for academics/students or scientists working in pharmaceutical industries, regulatory agencies, and contract research organizations. It can be used for teaching purposes in under- and post-graduate courses dealing with biopharmaceutics, pharmacokinetics and biomedical engineering.
Oral Bioavailability And Drug Delivery
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Author : Ming Hu
language : en
Publisher: John Wiley & Sons
Release Date : 2024-01-09
Oral Bioavailability And Drug Delivery written by Ming Hu and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-01-09 with Medical categories.
ORAL BIOAVAILABILITY AND DRUG DELIVERY Improve the performance and viability of newly-developed and approved drugs with this crucial guide Bioavailability is the parameter which measures the rate and extent to which a drug reaches a user’s circulatory system depending on the method of administration. For example, intravenous administration produces a bioavailability of 100%, since the drugs are injected directly into the circulatory system; in the case of oral administration, however, bioavailability can vary widely based on factors which, if not properly understood, can result in a failure in drug development, adverse effects, and other complications. The mechanics of oral bioavailability are therefore critical aspects of drug development. Oral Bioavailability and Drug Delivery provides a comprehensive coverage of this subject as well as its drug development applications. Beginning with basic terminology and fundamental concepts, it provides a thorough understanding of the challenges and barriers to oral bioavailability as well as the possibilities for improving this parameter. The resulting book is an indispensable tool for drug development research. Oral Bioavailability and Drug Delivery readers will also find: Discussion questions in many chapters to facilitate comprehension Detailed discussion of topics including dissolution, absorption, metabolism, and more Real-world examples of methods in actions throughout Oral Bioavailability and Drug Delivery is ideal for pharmaceutical and biotechnology scientists working in drug discovery and development; researchers in chemistry, biology, pharmacology, immunology, neuroscience, and other related fields; and graduate courses in drug development and delivery.
Bioavailability In Environmental Risk Assessment
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Author : Weiping Chen
language : en
Publisher: CRC Press
Release Date : 1995-11-10
Bioavailability In Environmental Risk Assessment written by Weiping Chen and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-11-10 with Technology & Engineering categories.
Since bioavailability can alter health risk estimates by a factor of 10, 100 or more, its importance in risk assessment cannot be underestimated. Presenting the basic principles that govern bioavailability and how it is measured, this very unique and timely book fills a void in the existing literature on toxicology and toxicokinetics. It contains clear and concise discussions on the behavior of environmental contaminants and how they reach the bloodstream in living organisms. It also presents an exhaustive review of measured bioavailability factors for environmental contaminants most frequently encountered at contaminated sites.
The Comparative Bioavailability And In Vitro Assessment Of Solid Oral Dosage Forms Of Paracetamol
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Author : Karen Braae
language : en
Publisher:
Release Date : 1981
The Comparative Bioavailability And In Vitro Assessment Of Solid Oral Dosage Forms Of Paracetamol written by Karen Braae and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1981 with Acetaminophen categories.
Topical Drug Bioavailability Bioequivalence And Penetration
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Author : Vinod P. Shah
language : en
Publisher: Springer
Release Date : 2015-01-30
Topical Drug Bioavailability Bioequivalence And Penetration written by Vinod P. Shah and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-01-30 with Medical categories.
This authoritative volume explores advances in the techniques used to measure percutaneous penetration of drugs and chemicals to assess bioavailability and bioequivalence and discusses how they have been used in clinical and scientific investigations. Seven comprehensive sections examine topics including in vitro drug release, topical drugs products, clinical studies, and guidelines and workshop reports, among others. The book also describes how targeted transdermal drug delivery and more sophisticated mathematical modelling can aid in understanding the bioavailability of transdermal drugs. The first edition of this book was an important reference guide for researchers working to define the effectiveness and safety of drugs and chemicals that penetrated the skin. This second edition contains cutting-edge advances in the field and is a key resource to those seeking to define the bioavailability and bioequivalence of percutaneously active compounds to improve scientific and clinical investigation and regulation.