Organic Chemistry From Retrosynthesis To Asymmetric Synthesis
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Organic Chemistry From Retrosynthesis To Asymmetric Synthesis
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Author : Vitomir Šunjić
language : en
Publisher: Springer
Release Date : 2016-04-30
Organic Chemistry From Retrosynthesis To Asymmetric Synthesis written by Vitomir Šunjić and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-30 with Science categories.
This book connects a retrosynthetic or disconnection approach with synthetic methods in the preparation of target molecules from simple, achiral ones to complex, chiral structures in the optically pure form. Retrosynthetic considerations and asymmetric syntheses are presented as closely related topics, often in the same chapter, underlining the importance of retrosynthetic consideration of target molecules neglecting stereochemistry and equipping readers to overcome the difficulties they may encounter in the planning and experimental implementation of asymmetric syntheses. This approach prepares students in advanced organic chemistry courses, and in particular young scientists working at academic and industrial laboratories, for independently solving synthetic problems and creating proposals for the synthesis of complex structures.
Advances In Heterocyclic Chemistry
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Author :
language : en
Publisher: Academic Press
Release Date : 2018-05-21
Advances In Heterocyclic Chemistry written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-21 with Science categories.
Advances in Heterocyclic Chemistry, Volume 126, is the definitive series in the field, one that is of great importance to organic chemists, polymer chemists and many biological scientists. Because biology and organic chemistry increasingly intersect, the associated nomenclature is used more frequently in explanations. Updates to this release include sections on The Literature of Heterocyclic Chemistry, Part XVI, 2016, The preparation and properties of heteroarylazulenes and hetero-fused azulenes, Recent developments in pyrazole chemistry, Yne, Ene-Yne Synthetic Approaches to Heterocycles, Appel Salt and Heterocycles: A review of Thirty Years of 4,5-Dichloro-1,2,3-dithiazolium Chloride Chemistry, and more. Written by established authorities in the field, this comprehensive review combines descriptive synthetic chemistry and mechanistic insight to yield an understanding on how chemistry drives the preparation and useful properties of heterocyclic compounds. - Considered the definitive serial in the field of heterocyclic chemistry - Serves as the go-to reference for organic chemists, polymer chemists and many biological scientists - Provides timely, comprehensive reviews written by established authorities in the field - Combines descriptive synthetic chemistry and mechanistic insight to enhance understanding on how chemistry drives the preparation and useful properties of heterocyclic compounds
Biocatalysis In Asymmetric Synthesis
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Author : Gonzalo De Gonzalo
language : en
Publisher: Elsevier
Release Date : 2024-05-04
Biocatalysis In Asymmetric Synthesis written by Gonzalo De Gonzalo and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-04 with Science categories.
Biocatalysis in Asymmetric Synthesis, a new volume in the Foundations and Frontiers of Enzymology series, offers an applied discussion of synthesizing biological catalysts using asymmetric synthesis, for applications across research and industry. Here, global experts in the field analyze a wide variety of biocatalysts and their physical states, process conditions for their asymmetric synthesis, solvents required during synthesis, and even downstream procedures for the recovery of final products. The book adopts an interdisciplinary approach, merging fundamental biology and its synthetic applications across industries, with a wide range of practical examples, from directed evolution to biotransformation and production of novel enzymes and non-conventional catalysts. Throughout the book, the impact and application of biocatalysis in sustainable processing is considered in-depth. This book will also help non-experts in biocatalysis to apply this knowledge in their own research, providing a thorough overview of the ways asymmetric biocatalytic approaches may be adapted for different disciplines and downstream products. - Explores biocatalysts as exquisite catalysts for fine chiral compound synthesis in different reaction media - Features both foundational overviews and applied, practical examples across research and industry - Includes chapter contributions from international leaders in the field
Chemistry Of Natural Products
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Author : Mrs Sandhya Kota
language : en
Publisher: JEC PUBLICATION
Release Date :
Chemistry Of Natural Products written by Mrs Sandhya Kota and has been published by JEC PUBLICATION this book supported file pdf, txt, epub, kindle and other format this book has been release on with Juvenile Nonfiction categories.
Natural products have always captivated the imagination of scientists, researchers, and enthusiasts alike. They are the Earth's rich reservoir of chemical diversity, offering a vast array of compounds with fascinating structures and often remarkable biological activities. From the earliest discoveries of quinine and morphine to the modern isolation of complex molecules from the depths of the ocean, the field of natural product chemistry has been a journey of continuous exploration and revelation. This book, "Chemistry of Natural Products," is an exploration of that journey. It aims to provide a comprehensive overview of the chemistry, structure, and significance of natural products derived from a wide variety of sources, including plants, microorganisms, marine organisms, and more. While natural products have been used for millennia for their medicinal, nutritional, and even mystical properties, their relevance extends far beyond ancient traditions. In the following pages, we delve into the fascinating world of natural products, uncovering the intricacies of their chemical structures, the mechanisms behind their synthesis in nature, and their roles in ecological systems. The study of these compounds has provided insights into the evolution of life and has yielded invaluable leads for the development of pharmaceuticals, agrochemicals, and other useful products. We explore the isolation, characterization, and biosynthesis of natural products and delve into their diverse applications in the realms of medicine, agriculture, and industry.Throughout this book, we emphasize the interdisciplinary nature of natural product chemistry, as it bridges the fields of chemistry, biology, pharmacology, and ecology. It is our hope that this text will be a valuable resource for students, researchers, and anyone with an interest in the world of natural products. We have strived to present the information in a manner that is accessible, informative, and engaging, allowing readers to appreciate the wonders of these compounds and their significance in our lives. It is essential to acknowledge the countless researchers, scientists, and scholars who have dedicated their lives to the exploration of natural products, as their contributions have been instrumental in shaping our understanding of these compounds. We also extend our gratitude to the institutions, organizations, and funding agencies that have supported research in this field. As you embark on this journey through the "Chemistry of Natural Products," we invite you to delve into the intricacies and marvels of nature's chemical creations, each with its unique story waiting to be told.
Principles Of Asymmetric Synthesis
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Author : R.E. Gawley
language : en
Publisher: Elsevier
Release Date : 1996-11-21
Principles Of Asymmetric Synthesis written by R.E. Gawley and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-11-21 with Science categories.
The world is chiral. Most of the molecules in it are chiral, and asymmetric synthesis is an important means by which enantiopure chiral molecules may be obtained for study and sale. Using examples from the literature of asymmetric synthesis (more than 1300 references), the aim of this book is to present a detailed analysis of the factors that govern stereoselectivity in organic reactions. It is important to note that the references were each individually checked by the authors to verify relevance to the topics under discussion. The study of stereoselectivity has evolved from issues of diastereoselectivity, through auxiliary-based methods for the synthesis of enantiomerically pure compounds (diastereoselectivity followed by separation and auxiliary cleavage), to asymmetric catalysis. In the latter instance, enantiomers (not diastereomers) are the products, and highly selective reactions and modern purification techniques allow preparation - in a single step - of chiral substances in 99% ee for many reaction types. After an explanation of the basic physical-organic principles of stereoselectivity, the authors provide a detailed, annotated glossary of stereochemical terms. A chapter on "Analytical Methods" provides a critical overview of the most common methods for analysis of stereoisomers. The authors then follow the 'tried-and-true' format of grouping the material by reaction type. Thus, there are four chapters on carbon-carbon bond forming reactions (enolate alkylations, organometal additions to carbonyls, aldol and Michael reactions, and cycloadditions and rearrangements), one chapter on reductions and hydroborations (carbon-hydrogen bond forming reactions), and one on oxidations (carbon-oxygen and carbon-nitrogen bond forming reactions). Leading references are provided to natural product synthesis that have been accomplished using a given reaction as a key step. In addition to tables of examples that show high selectivity, a transition state analysis is presented to explain - to the current level of understanding - the stereoselectivity of each reaction. In one case (Cram's rule) the evolution of the current theory is detailed from its first tentative (1952) postulate to the current Felkin-Anh-Heathcock formalism. For other reactions, only the currently accepted rationale is presented. Examination of these rationales also exposes the weaknesses of current theories, in that they cannot always explain the experimental observations. These shortcomings provide a challenge for future mechanistic investigations.
The Logic Of Chemical Synthesis
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Author : E.J. Corey
language : en
Publisher: Рипол Классик
Release Date : 1991
The Logic Of Chemical Synthesis written by E.J. Corey and has been published by Рипол Классик this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Science categories.
Organic Chemistry
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Author : Mr. Rohit Manglik
language : en
Publisher: EduGorilla Publication
Release Date : 2024-05-07
Organic Chemistry written by Mr. Rohit Manglik and has been published by EduGorilla Publication this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-07 with Science categories.
Focuses on structure, synthesis, mechanisms, and reactions of organic compounds.
Introduction To Strategies For Organic Synthesis
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Author : Laurie S. Starkey
language : en
Publisher: John Wiley & Sons
Release Date : 2018-03-28
Introduction To Strategies For Organic Synthesis written by Laurie S. Starkey and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-03-28 with Science categories.
Bridging the Gap Between Organic Chemistry Fundamentals and Advanced Synthesis Problems Introduction to Strategies of Organic Synthesis bridges the knowledge gap between sophomore-level organic chemistry and senior-level or graduate-level synthesis to help students more easily adjust to a synthetic chemistry mindset. Beginning with a thorough review of reagents, functional groups, and their reactions, this book prepares students to progress into advanced synthetic strategies. Major reactions are presented from a mechanistic perspective and then again from a synthetic chemist’s point of view to help students shift their thought patterns and teach them how to imagine the series of reactions needed to reach a desired target molecule. Success in organic synthesis requires not only familiarity with common reagents and functional group interconversions, but also a deep understanding of functional group behavior and reactivity. This book provides clear explanations of such reactivities and explicitly teaches students how to make logical disconnections of a target molecule. This new Second Edition of Introduction to Strategies for Organic Synthesis: Reviews fundamental organic chemistry concepts including functional group transformations, reagents, stereochemistry, and mechanisms Explores advanced topics including protective groups, synthetic equivalents, and transition-metal mediated coupling reactions Helps students envision forward reactions and backwards disconnections as a matter of routine Gives students confidence in performing retrosynthetic analyses of target molecules Includes fully-worked examples, literature-based problems, and over 450 chapter problems with detailed solutions Provides clear explanations in easy-to-follow, student-friendly language Focuses on the strategies of organic synthesis rather than a catalogue of reactions and modern reagents The prospect of organic synthesis can be daunting at the outset, but this book serves as a useful stepping stone to refresh existing knowledge of organic chemistry while introducing the general strategies of synthesis. Useful as both a textbook and a bench reference, this text provides value to graduate and advanced undergraduate students alike.
Side Reactions In Organic Synthesis
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Author : Florencio Zaragoza Dörwald
language : en
Publisher: John Wiley & Sons
Release Date : 2006-03-06
Side Reactions In Organic Synthesis written by Florencio Zaragoza Dörwald and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-03-06 with Science categories.
Most syntheses in the chemical research laboratory fail and usually require several attempts before proceeding satisfactorily. Failed syntheses are not only discouraging and frustrating, but also cost a lot of time and money. Many failures may, however, be avoided by understanding the structure-reactivity relationship of organic compounds. This textbook highlights the competing processes and limitations of the most important reactions used in organic synthesis. By allowing chemists to quickly recognize potential problems this book will help to improve their efficiency and success-rate. A must for every graduate student but also for every chemist in industry and academia. Contents: 1 Organic Synthesis: General Remarks 2 Stereoelectronic Effects and Reactivity 3 The Stability of Organic Compounds 4 Aliphatic Nucleophilic Substitutions: Problematic Electrophiles 5 The Alkylation of Carbanions 6 The Alkylation of Heteroatoms 7 The Acylation of Heteroatoms 8 Palladium-Catalyzed C-C Bond Formation 9 Cyclizations 10 Monofunctionalization of Symmetric Difunctional Substrates
Classics In Total Synthesis
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Author : K. C. Nicolaou
language : en
Publisher: John Wiley & Sons
Release Date : 1996-04-11
Classics In Total Synthesis written by K. C. Nicolaou and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-04-11 with Science categories.
K.C. Nicolaou - Winner of the Nemitsas Prize 2014 in Chemistry This book is a must for every synthetic chemist. With didactic skill and clarity, K. C. Nicolaou and E. Sorensen present the most remarkable and ingenious total syntheses from outstanding synthetic organic chemists. To make the complex strategies more accessible, especially to the novice, each total synthesis is analyzed retrosynthetically. The authors then carefully explain each synthetic step and give hints on alternative methods and potential pitfalls. Numerous references to useful reviews and the original literature make this book an indispensable source of further information. Special emphasis is placed on the skillful use of graphics and schemes: Retrosynthetic analyses, reaction sequences, and stereochemically crucial steps are presented in boxed sections within the text. For easy reference, key intermediates are also shown in the margins. Graduate students and researchers alike will find this book a gold mine of useful information essential for their daily work. Every synthetic organic chemist will want to have a copy on his or her desk.