Organocatalytic Dynamic Kinetic Resolution
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Organocatalytic Dynamic Kinetic Resolution
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Author : Hélène Pellissier
language : en
Publisher: Royal Society of Chemistry
Release Date : 2022-05-06
Organocatalytic Dynamic Kinetic Resolution written by Hélène Pellissier and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-06 with Science categories.
In a classical kinetic resolution, two enantiomers of a racemate are transformed into chiral products at different rates with a maximum theoretical yield of 50%. However, the need to reduce costs and waste in synthesis have led to efforts to develop novel resolution procedures proceeding beyond this 50% limited yield. This has led to the evolution of classical kinetic resolution into dynamic kinetic resolution (DKR), allowing a quantitative yield of one of the enantiomers. DKR combines the resolution step of kinetic resolution with an in-situ racemization of the chirally-labile substrate. It is only in the last two decades that chiral green organocatalysts have been demonstrated to be capable of promoting DKRs considerably expanding the synthetic scope of the powerful concept of DKR. Collecting all the developments in the field of DKR, this book shows that a wide variety of organocatalysts allow excellent levels of stereocontrol and yields in many types of transformations. It is a great resource for academics and industrialists interested in green enantioselective catalytic reactions.
Dynamic Kinetic Resolution Dkr And Dynamic Kinetic Asymmetric Transformations Dykat
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Author : Jan-E. Bäckvall
language : en
Publisher: Georg Thieme Verlag
Release Date : 2022-12-07
Dynamic Kinetic Resolution Dkr And Dynamic Kinetic Asymmetric Transformations Dykat written by Jan-E. Bäckvall and has been published by Georg Thieme Verlag this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-07 with Science categories.
Principles and applications of DKR and DYKAT DKR and DYKAT are of ever increasing importance in the synthesis of enantiomerically enriched compounds. The preparation of enantiomerically pure compounds is of great importance in society today, in particular in pharmaceutical chemistry and in the agrochemical sector. Kinetic resolution is a popular method for differentiating two enantiomers in a racemic mixture that react at different rates with a chiral catalyst or reagent. The drawback of kinetic resolution is that the yield of one pure enantiomer is limited to a maximum of 50%. To overcome this limitation, an in situ racemization of the starting material can be combined with a kinetic resolution. This combination leads to a so called “dynamic kinetic resolution” (DKR), where the two enantiomers are in equilibrium with one another. The slow-reacting enantiomer will continuously be converted into the fast-reacting one, when the latter is transformed into the enantiomerically pure product. Thus, a racemic starting material can be transformed in catalytic processes into a single isomer of a chiral compound in up to 100% yield. DKR only applies to the resolution of racemic mixtures and the involvement of enantiomers leads to simple kinetics. When diastereomers, either as starting materials or as diastereomeric intermediates, are involved in the resolution process under dynamic conditions (via equilibria between diastereomers), the kinetics is different from DKR. These reactions are classified as “dynamic kinetic asymmetric transformations” (DYKAT). This volume covers the principles of DKR and DYKAT and presents examples of organocatalytic, chemoenzymatic, and transition-metal catalyzed approaches, including applications in the synthesis of complex, biologically active compounds.
Organocatalysis
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Author : Manfred Reetz
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-05-27
Organocatalysis written by Manfred Reetz and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-05-27 with Science categories.
This book provides an excellent overview on state-of-the-art of modern organocatalysis. It presents the contributions from leading experts, with backgrounds in academia and industry, to an Ernst Schering Research Foundation Symposium held in April 2007. It will be of interest to those who want a general overview of the topic, but also to those who want to learn more about the state-of-the-art, current trends and perspectives in this highly dynamic field of research.
Non Metal Catalyzed Synthesis
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Author : Yunfei Du
language : en
Publisher: Walter de Gruyter GmbH & Co KG
Release Date : 2023-12-04
Non Metal Catalyzed Synthesis written by Yunfei Du and has been published by Walter de Gruyter GmbH & Co KG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-12-04 with Science categories.
Kinetic Control In Synthesis And Self Assembly
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Author : Munenori Numata
language : en
Publisher: Academic Press
Release Date : 2018-11-23
Kinetic Control In Synthesis And Self Assembly written by Munenori Numata and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-23 with Science categories.
Kinetic Control in Synthesis and Self-Assembly provides a unique overview of the fundamental principles, novel methods and practical applications for researchers across organic synthesis, supramolecular chemistry and materials sciences. The book examines naturally occurring molecular systems in which kinetic processes are more ubiquitous than thermodynamic processes, also exploring the control of reactions and molecular self-assemblies, through kinetic processes, in artificial systems. These methods currently play a crucial role for tuning materials functions. From organic synthesis, to supramolecular assemblies, and from restricted spaces, to material synthesis for hierarchical structures, the book offers valuable coverage for researchers across disciplines. Interesting topics include how to regulate kinetic pathways more precisely, essential molecular design for kinetic traps, and how molecular environments surrounding molecules (i.e., solvent, temperature, and pressure effects) influence kinetic control in reactions and self-assemblies. Describes the nature and potential applications of kinetic processes compared to thermodynamic processes Presents information useful to researchers active in molecular synthesis and self-assembly toward materials Collates coverage of kinetic control for synthesis and self-assembly, treated separately in literature
Asymmetric Organocatalysis
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Author : Lukasz Albrecht
language : en
Publisher: John Wiley & Sons
Release Date : 2022-11-10
Asymmetric Organocatalysis written by Lukasz Albrecht and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-10 with Technology & Engineering categories.
Asymmetric Organocatalysis Comprehensive resource on the latest and most important developments in the highly vivid field of asymmetric organocatalysis The book provides a comprehensive overview of the most important advancements in the field of asymmetric organocatalysis that have occurred within the last decade. It presents valuable examples of newly developed synthetic methodologies based on various organocatalytic activation modes. Special emphasis is given to strategies where organocatalysis is expanding its potential by pushing the boundaries and founding new synergistic interactions with other fields of synthetic chemistry, such as metal catalysis, photocatalysis, and biocatalysis. The application of different concepts (such as vinylogy, dearomatization, or cascade reactivity), resulting in the development of new functionalization strategies, is also discussed. Sample topics covered within the book include: New developments in enantioselective Brønsted acid catalysis with strong hydrogen-bond donors Asymmetric phase-transfer catalysis, from classical applications to new concepts Halogen-bonding organocatalysis Asymmetric electrochemical organocatalysis and synergistic organo-organocatalysis Immobilized organocatalysts for enantioselective continuous flow processes Mechanochemistry and high-pressure techniques in asymmetric organocatalysis Useful tools in elucidation of organocatalytic reaction mechanisms With an overall focus on new reactions and catalysts, this two-volume work is an indispensable source for everyone working in the field of asymmetric organocatalysis.
Biocatalysis In Asymmetric Synthesis
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Author : Gonzalo De Gonzalo
language : en
Publisher: Elsevier
Release Date : 2024-05-04
Biocatalysis In Asymmetric Synthesis written by Gonzalo De Gonzalo and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-04 with Science categories.
Biocatalysis in Asymmetric Synthesis, a new volume in the Foundations and Frontiers of Enzymology series, offers an applied discussion of synthesizing biological catalysts using asymmetric synthesis, for applications across research and industry. Here, global experts in the field analyze a wide variety of biocatalysts and their physical states, process conditions for their asymmetric synthesis, solvents required during synthesis, and even downstream procedures for the recovery of final products. The book adopts an interdisciplinary approach, merging fundamental biology and its synthetic applications across industries, with a wide range of practical examples, from directed evolution to biotransformation and production of novel enzymes and non-conventional catalysts. Throughout the book, the impact and application of biocatalysis in sustainable processing is considered in-depth. This book will also help non-experts in biocatalysis to apply this knowledge in their own research, providing a thorough overview of the ways asymmetric biocatalytic approaches may be adapted for different disciplines and downstream products. Explores biocatalysts as exquisite catalysts for fine chiral compound synthesis in different reaction media Features both foundational overviews and applied, practical examples across research and industry Includes chapter contributions from international leaders in the field
Recent Developments In Asymmetric Organocatalysis
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Author : Helene Pellissier
language : en
Publisher: Royal Society of Chemistry
Release Date : 2010-03-23
Recent Developments In Asymmetric Organocatalysis written by Helene Pellissier and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-03-23 with Science categories.
The aim of this book is to cover the very recent developments in asymmetric organocatalysis, focussing on those published since the beginning of 2008. The last decade has witnessed an explosive growth in the field of asymmetric organocatalysis with an impressive amount of new catalysts, novel methodologies, and applications in numerous reaction types, such as nucleophilic substitutions, addition reactions, as well as cycloadditions, oxidations, reductions, kinetic resolutions, and miscellaneous reactions. This very diverse and intensely developing field is too wide to cover in a single review. The timeliness of the book together with the expected impact is excellent, since nowadays asymmetric organocatalysis is arguably the most intensively developed field in organic chemistry. The book is designed to meet the demands of a postgraduate textbook,containing case studies and Q&A sections, as well as a practical book filled with facts and data useful as a working tool for the practitioner. The book is divided into ten sections, dealing successively with nucleophilic additions to electron-deficient C=C double bonds, nucleophilic additions to C=O double bonds, nucleophilic additions to C=N double bonds, nucleophilic additions to unsaturated nitrogen, nucleophilic substitutions at aliphatic carbon, cycloaddition reactions, oxidations, reductions, kinetic resolutions and desymmetrisations, and miscellaneous reactions.
More Synthetic Approaches To Nonaromatic Nitrogen Heterocycles 2 Volume Set
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Author : Ana Maria Faisca Phillips
language : en
Publisher: John Wiley & Sons
Release Date : 2022-04-04
More Synthetic Approaches To Nonaromatic Nitrogen Heterocycles 2 Volume Set written by Ana Maria Faisca Phillips and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-04 with Science categories.
More Synthetic Approaches to Nonaromatic Nitrogen Heterocycles An authoritative collection of resources discussing the latest trends in the synthesis of nonaromatic nitrogen heterocycles Widely distributed in nature, nitrogen heterocycles are extremely common in synthetic substances found in pharmaceuticals, agrochemicals, and materials. The literature is evolving rapidly and explores newly emerging structures and medicines. More Synthetic Approaches to Nonaromatic Nitrogen Heterocycles offers R&D professionals the opportunity to easily access a collection of the latest relevant research in the area. In the second two-volume set of this practical reference distinguished researcher Dr. Ana Maria M. M. Faisca Phillips delivers a collection of resources focusing on the newest and most widely applicable trends emerging in synthetic strategies for nonaromatic nitrogen heterocycles. With coverage of topics including organocatalysis, cascade reactions, flow chemistry in synthesis, cycloaddition reactions, metathesis, cross-coupling reactions, and electrochemistry, the book provides quick access to critical new avenues of synthesis. More Synthetic Approaches to Nonaromatic Nitrogen Heterocycles: Volume 1 and 2 also offers readers: A thorough introduction to recent advances in the design and synthesis of cyclic peptidomimetics Comprehensive explorations of fused heterocycles and transition metal promoted synthesis of isoindoline derivatives Practical discussions of 1,4-diazepane ring-based systems and recent advances in the synthesis of azepane-based compounds In-depth examinations of strained aziridinium ions, asymmetric organocatalysis in alternative media, and the electrochemical synthesis of non-aromatic N-heterocycles Perfect for academic and industrial researchers in organic chemistry and synthesis, organometallic chemistry, pharmaceutical chemistry catalysis, and sustainable chemistry, More Synthetic Approaches to Nonaromatic Nitrogen Heterocycles: Volume 1 and 2 is an indispensable reference for anyone seeking an authoritative source of information on new and emerging trends in synthesis.
Organocatalysis
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Author : Maurizio Benaglia
language : en
Publisher: Walter de Gruyter GmbH & Co KG
Release Date : 2021-07-19
Organocatalysis written by Maurizio Benaglia and has been published by Walter de Gruyter GmbH & Co KG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-19 with Science categories.
Organocatalysis is considered today one of the three pillars in asymmetric catalysis, along with biocatalysis and organometallic catalysis. The current book gives an overview of the new reactions, the catalysts and their activation strategies reported in recent years. In addition, the applications of organocatalysis in total synthesis, radical reactions, flow chemistry and industrial practice are discussed.