Oxidative Stress And Diseases
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Glutathione System And Oxidative Stress In Health And Disease
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Author :
language : en
Publisher: BoD – Books on Demand
Release Date : 2020-08-26
Glutathione System And Oxidative Stress In Health And Disease written by and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-26 with Science categories.
The imbalance between the production of reactive oxygen species (ROS) and antioxidant defenses determines a state known as oxidative stress. Higher levels of pro-oxidants compared to antioxidant defenses may generate oxidative damage, which, in turn, may lead to modifications in cellular proteins, lipids, and DNA, reducing functional capacity and increasing the risk of diseases. Nevertheless, the clearance of harmful reactive chemical species is achieved by the antioxidant defense systems. These protection systems are referred to as the first and second lines of defense and comprise the classic antioxidants, enzymatic and nonenzymatic defenses, including glutathione. This book presents and discusses the advancement of research on health and diseases and their underlying mechanisms, exploring mainly aspects related to the glutathione antioxidant system.
Oxidative Stress And Diseases
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Author : Volodymyr Lushchak
language : en
Publisher: BoD – Books on Demand
Release Date : 2012-04-25
Oxidative Stress And Diseases written by Volodymyr Lushchak and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-04-25 with Medical categories.
The development of hypothesis of oxidative stress in the 1980s stimulated the interest of biological and biomedical sciences that extends to this day. The contributions in this book provide the reader with the knowledge accumulated to date on the involvement of reactive oxygen species in different pathologies in humans and animals. The chapters are organized into sections based on specific groups of pathologies such as cardiovascular diseases, diabetes, cancer, neuronal, hormonal, and systemic ones. A special section highlights potential of antioxidants to protect organisms against deleterious effects of reactive species. This book should appeal to many researchers, who should find its information useful for advancing their fields.
A Master Regulator Of Oxidative Stressthe Transcription Factor Nrf2
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Author : Jose Antonio Morales-Gonzalez
language : en
Publisher: BoD – Books on Demand
Release Date : 2016-12-21
A Master Regulator Of Oxidative Stressthe Transcription Factor Nrf2 written by Jose Antonio Morales-Gonzalez and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-21 with Science categories.
Due to that at present, the majority of diseases are associated with alterations in oxidative stress and inflammatory processes, and in that Nrf-2 is a modulator of these processes; knowing how this transcriptional factor functions and is regulated opens a therapeutic window to diverse diseases. Therefore, the efforts of various investigation groups are centered on finding activators and/or inhibitors of Nrf-2 to prevent or control diverse diseases, for example, cancer, where it would be important to regulate Nrf-2 in order for it to activate apoptosis pathways in cancerogenous cells, or in neurodegenerative diseases where cell death is predominant, it would be important for Nrf-2 to activate antiapoptotic pathways.
Oxidative Stress In Cancer Aids And Neurodegenerative Diseases
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Author : Luc Montagnier
language : en
Publisher: CRC Press
Release Date : 1997-10-06
Oxidative Stress In Cancer Aids And Neurodegenerative Diseases written by Luc Montagnier and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-10-06 with Medical categories.
Based on a conference on Oxidative Stress and Redox Regulation, held at the Pasteur Institute, Paris, this work examines fundamental, chemical, biological and medical studies of free radicals on different targets and the consequences of their reactivity. It covers the chemistry and biochemistry of free radicals, free radicals as second messengers that group the activation of transcription factors and enzymes, the importance of the antioxidant system in cell metabolism regulation, and the role of free radicals and antioxidants in disease management. The editors of this work are three of the most respected pioneers in the field. Dr. Montagnier is credited as the discoverer of HIV.
Oxidative Stress In Cancer Aids And Neurodegenerative Diseases
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Author : Luc Montagnier
language : en
Publisher: CRC Press
Release Date : 1997-10-06
Oxidative Stress In Cancer Aids And Neurodegenerative Diseases written by Luc Montagnier and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-10-06 with Medical categories.
Based on a conference on Oxidative Stress and Redox Regulation, held at the Pasteur Institute, Paris, this work examines fundamental, chemical, biological and medical studies of free radicals on different targets and the consequences of their reactivity. It covers the chemistry and biochemistry of free radicals, free radicals as second messengers that group the activation of transcription factors and enzymes, the importance of the antioxidant system in cell metabolism regulation, and the role of free radicals and antioxidants in disease management. The editors of this work are three of the most respected pioneers in the field. Dr. Montagnier is credited as the discoverer of HIV.
Role Of Oxidative Stress In Pathophysiology Of Diseases
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Author : Pawan K. Maurya
language : en
Publisher: Springer Nature
Release Date : 2020-06-15
Role Of Oxidative Stress In Pathophysiology Of Diseases written by Pawan K. Maurya and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-15 with Science categories.
This book illustrates the importance and significance of oxidative stress in the pathophysiology of various human diseases. The book initially introduces the phenomenon of oxidative stress, basic chemical characteristics of the species involved and summarizes the cellular oxidant and anti-oxidant system and the cellular effects and metabolism of the oxidative stress. In addition, it reviews the current understanding of the potential impact of oxidative stress on telomere shortening, aging, and age-related diseases. It also examines the role of oxidative stress in chronic diseases, including cancer, diabetes, cardiovascular diseases, and neurodegenerative disorders. Further, the book presents novel technologies for the detection of oxidative stress biomarkers using nanostructure biosensors, as well as in vitro and in vivo models to monitor oxidative stress. Lastly, the book addresses the drug delivery carriers that can help in combating oxidative stress.
Oxidative Stress
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Author : Canhua Huang
language : en
Publisher: Springer Nature
Release Date : 2021-05-27
Oxidative Stress written by Canhua Huang and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-27 with Science categories.
This book offers a systematic review of the cutting-edge knowledge in stress medicine. Cellular redox imbalance, resulting from overproduction of reactive oxide species (ROS), leads to oxidative stress and subsequent occurrence and development of many diseases, such as cancer, diabetes, pain, etc. In addition, ROS can induce post-translational modification of proteins and play roles through redox signaling pathways. In this book, the authors attempt to re-define the key concepts in oxidative stress, such as oxidative eustress and oxidative distress, revisit the pivotal signaling of oxidative stress in human diseases, and discuss the debate in current anti-oxidant strategies, such as natural products and drug repurposing. This book serves as a reference to graduate students and researchers in this growing field.
Oxidative Stress Disease And Cancer
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Author : Keshav K Singh
language : en
Publisher: World Scientific
Release Date : 2006-04-04
Oxidative Stress Disease And Cancer written by Keshav K Singh and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-04-04 with Medical categories.
This book aims to provide a comprehensive review of the most up-to-date knowledge of the sources and molecular mechanisms of oxidative stress, and its role in disease and cancer. It also focuses on the novel agents and methods that can be employed to prevent oxidative stress and associated diseases. The authors first review the most recent data on the basic mechanisms of oxidative stress. The second section discusses oxidative stress leading to several diseases and cancers, and in the third section, the strategies employed in the prevention and treatment of oxidative stress-related diseases are discussed. Contents:Yin and Yang of Mitochondrial ROS (A Starkov & K B Wallace)Intracellular Oxidative Stress Caused by Ionizing Radiation (H J Majima et al.)Oxidative Damage to Mitochondria (J C Tilak & T P A Devasagayam)Oxidative Stress and Antioxidant Defenses in Plants (O Blokhina & K Fagerstedt)Lipid- and Protein-Mediated Oxidative Damage to DNA (M D Evans & M S Cooke)Oxidative Damage to Nucleotide: Consequences and Preventive Mechanisms (Y Nakatsu & M Sekiguchi)Oxidative Damage to DNA and Its Repair (L J Rasmussen)Cellular Responses to Reactive Oxygen Species (I W Dawes)Oxidative Stress, Cell Proliferation, and Apoptosis (J S Carew et al.)Oxidative Damage to Carbohydrates and Amino Acids (M d'Ischia et al.)Superoxide Dismutase 2 Deficient Mice: The Role of Increased Reactive Oxygen Species in Genomic Instability (E Samper et al.)Oxidative Stress, Genetic Variation, and Disease (L Lyrenäs et al.)Oxidative Stress and Autoimmune Diseases (J Saegusa et al.)Does Oxidative Stress Determine Lifespan? (F L Muller & H Van Remmen)Oxidative Stress and Ataxia–Telangiectasia (E M Dunner & D J Watters)Oxidative Stress and Cardiovascular Disease (S Johar et al.)Oxidative Stress, Insulin Resistance, and Cardiovascular Disease (A Ceriello)Pathogenesis and Etiology of Down's Syndrome in Relation to Oxidative Stress (S Arbuzova & H Cuckle)Oxidative Stress and Ulcerative Colitis: Experimental Evidence and Implications for Treatment (D N Seril et al.)Oxidative Stress and Neurodegenerative Disease (K Schüssel et al.)Oxidative Stress and Mitochondrial Disease (C-Y Lu et al.)Oxidative Stress and Respiratory Disease (R Maselli & G Pelaia)Oxidative Stress and Human Reproduction (A Agarwal & S Allamaneni)Oxidative Stress and Multistage Carcinogenesis (P C Goswami & K K Singh)Oxidative Stress and Cancer Cachexia (G Mantovani & C Madeddu)Oxidative Stress in Cancer-Prone Diseases (G Pagano)Iron-Induced Carcinogenesis (S Toyokuni)Copper and Carcinogenesis (T Theophanides & J Anastassopoulou)Arsenic, Oxidative Stress, and Carcinogenesis (M F Hughes & K T Kitchin)Estrogen-Induced Carcinogenesis: Importance of Oxidative Stress (H K Bhat)Oxidative Stress in HIV Infection (W Dröge)Oxidative Stress and Breast Cancer (J Ahn & C B Ambrosone)Oxidative Stress and Photocarcinogenesis: Strategies for Prevention (S K Katiyar)Oxidative Stress and Coenzyme Q10 Therapy (F L Rosenfeldt et al.)Plant-Derived Antioxidants (F H Sarker & Y Li)Oxidative Stress and Cancer Therapy (K Pong)Nanoscale Antioxidant Therapeutics (T Dziubla et al.)Use of Biomarkers of Oxidative Stress in Human Studies (C-Y Chen & J B Blumberg) Readership: Academics, researchers, scientists, clinicians, physicians, members of the society for free radical biology and medicine and members of SFRR. Key Features:The first book that describes the roles of oxidative stress in diseasesOver 35 of the leading experts in the oxidative stress field have contributed to this book. Their expertise ranges from basic to translational to therapeutic aspects of oxidative stress-associated diseasesKeywords:Oxidative Stress;Disease;Cancer;Free Radical;Superoxide;Mitochondria;Aging;Antioxidant;Antioxidant Therapy
Oxidative Stress And Antioxidant Protection
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Author : Donald Armstrong
language : en
Publisher: John Wiley & Sons
Release Date : 2016-04-11
Oxidative Stress And Antioxidant Protection written by Donald Armstrong and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-11 with Science categories.
Oxidative Stress and Antioxidant Protection: The Science of Free Radical Biology and Disease Oxidative Stress and Antioxidant Protection begins with a historical perspective of pioneers in oxidative stress with an introductory section that explains the basic principles related to oxidative stress in biochemistry and molecular biology, demonstrating both pathways and biomarkers. This section also covers diagnostic imaging and differential diagnostics. The following section covers psychological, physiologic, pharmacologic and pathologic correlates. This section addresses inheritance, gender, nutrition, obesity, family history, behavior modification, natural herbal-botanical products, and supplementation in the treatment of disease. Clinical trials are also summarized for major medical disorders and efficacy of treatment, with particular focus on inflammation, immune response, recycling, disease progression, outcomes and interventions. Each of the chapters describes what biomarker(s) and physiological functions may be relevant to a concept of specific disease and potential alternative therapy. The chapters cover medical terminology, developmental change, effects of aging, senescence, lifespan, and wound healing, and also illustrates cross-over exposure to other fields. The final chapter covers how and when to interpret appropriate data used in entry level biostatistics and epidemiology. Authored and edited by leaders in the field, Oxidative Stress and Antioxidant Protection will be an invaluable resource for students and researchers studying cell biology, molecular biology, and biochemistry, as well professionals in various health science fields.
Oxidative Stress And Inflammation In Non Communicable Diseases Molecular Mechanisms And Perspectives In Therapeutics
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Author : Jordi Camps
language : en
Publisher: Springer
Release Date : 2014-07-19
Oxidative Stress And Inflammation In Non Communicable Diseases Molecular Mechanisms And Perspectives In Therapeutics written by Jordi Camps and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-07-19 with Medical categories.
Oxidative stress and inflammation underpin most diseases; their mechanisms are inextricably linked. For example, chronic inflammation is associated with oxidation, anti-inflammatory cascades are linked to decreased oxidation, increased oxidative stress triggers inflammation and redox balance inhibits the inflammatory cellular response. Whether or not oxidative stress and inflammation represent the causes or the consequences of cellular pathology, they contribute significantly to the pathogenesis of non-communicable diseases. The incidence of obesity and other related metabolic disturbances are rising, as are age-related diseases due to progressively aging populations. Interrelations between the mechanisms of oxidative stress and of inflammatory signaling and metabolism are, in the broad sense of energy transformation, being increasingly recognized as part of the problem in non-communicable diseases. The book Oxidative Stress and Inflammation in Non-communicable Diseases: Molecular Mechanisms and Perspectives in Therapeutics is an update on the latest research on the molecular basis of non-communicable diseases and the search for possible therapeutic alternatives. The authors of this monograph are experts in their field and the book as a whole, provides an overview of the biochemical alterations underlying diseases such as cardiovascular disease, cancer, obesity, renal disease, neurological diseases and diabetes, emphasizing those aspects that they share in common. We hope that this book will be useful for researchers in biomedicine and also for physicians interested in finding the root causes of the disease, as well as for post-graduate students in biochemistry, molecular biology, nutrition or medicine.