Paediatric Drug Optimization For Neglected Tropical Diseases

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Paediatric Drug Optimization For Neglected Tropical Diseases

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Author : World Health Organization
language : en
Publisher: World Health Organization
Release Date : 2023-11-21

Paediatric Drug Optimization For Neglected Tropical Diseases written by World Health Organization and has been published by World Health Organization this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-21 with Business & Economics categories.

Priority-setting is the first step to enable a targeted approach to research and development. Developing a prioritized drug portfolio of the most needed formulations for children is essential to streamline researchers’ and supplier’s efforts and resources around specific dosage forms and formulations that address most urgent needs for children. In general, due to limited financial incentives, few new drugs are being developed for Neglected Tropical Diseases (NTDs). Several NTDs disproportionately affect children compared to adults and, as is the case like for most diseases affecting adults and children, the burden to children is compounded by lack of inclusion of paediatric populations in clinical trials and/or lack of age-appropriate dosing regimens and formulations. The PADO-NTD exercise concluded with a final meeting organized in September 2023 with representatives from the four prioritized disease areas to reach consensus on a final PADO-NTD priority list, watch list and research questions and discuss transversal issues for the way forward. The meeting report will include summaries of the background, discussions and deliberations of all PADO exercises, and final conclusions and outputs of the overall PADO for NTD exercises.

First Meeting Of The Who Strategic And Technical Advisory Group Working Group On Access To Safe Efficacious And Quality Assured Health Products For Neglected Tropical Diseases

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Author : World Health Organization
language : en
Publisher: World Health Organization
Release Date : 2022-11-30

First Meeting Of The Who Strategic And Technical Advisory Group Working Group On Access To Safe Efficacious And Quality Assured Health Products For Neglected Tropical Diseases written by World Health Organization and has been published by World Health Organization this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-30 with Medical categories.

Paediatric Drug Optimization For Tuberculosis

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Author : World Health Organization
language : en
Publisher: World Health Organization
Release Date : 2024-05-30

Paediatric Drug Optimization For Tuberculosis written by World Health Organization and has been published by World Health Organization this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-30 with Medical categories.

Paediatric drug optimization (PADO) exercises have been convened by the World Health Organization (WHO) for various diseases, demonstrating their potential and impact to accelerate access to optimal formulations in the context of fragmented small markets for medicines for children. The WHO Global Tuberculosis Programme has convened PADO-TB meetings since February 2019 (PADO-TB1), followed by an interim review of the PADO-TB1 priorities in September 2020. Optimization of paediatric TB medicines forms part of the key actions in the Roadmap towards ending TB in children and adolescents, third edition and contributes to the achievement of the targets for ending TB in children and adolescents set out at the second United Nations High-level Meeting on the Fight Against TB in 2023. Considering the latest WHO recommendations on drug-susceptible TB, drug-resistant TB and TB preventive treatment, recent developments in new TB medicines and formulations made available, results of clinical trials and studies, and advancements of key medicines in the TB R&D pipeline, WHO convened the second PADO-TB meeting (PADO-TB2) on 3–5 October 2023. This meeting report summarizes the proceedings, discussions and the main consensus-based outputs of the PADO-TB2 meeting: - PADO-TB2 priority list (priority formulations to be investigated/developed in the short term and essential formulations to be developed in the longer term) - PADO-TB2 watch list (promising candidates for investigation/development for children within 5–10 years) - Priority research questions.

Global Report On Neglected Tropical Diseases 2024

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Author : World Health Organization
language : en
Publisher: World Health Organization
Release Date : 2024-05-04

Global Report On Neglected Tropical Diseases 2024 written by World Health Organization and has been published by World Health Organization this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-04 with Medical categories.

This document is the second in a series of global reports describing progress towards the 2030 targets set in Ending the neglect to attain the Sustainable Development Goals: a road map for neglected tropical diseases 2021–2030. It describes a wide range of activities, accomplishments and challenges across the portfolio of NTDs and across all six WHO regions. The report presents epidemiological and programmatic data for 2022, which were gathered, compiled and analysed in 2023. In some cases, 2023 data are available and presented; in other cases, less recent information is included, when 2022 data are not available. In addition, it presents the main facts or events that occurred in 2023. In line with the road map’s companion document Ending the neglect to attain the Sustainable Development Goals: a framework for monitoring and evaluating progress of the road map for neglected tropical diseases 2021−2030, the report includes quantitative information on the status of the overarching, cross-cutting and disease-specific indicators. This is followed by qualitative information on each of the three road map pillars and on regional and country progress. The conclusions of the report and way forward are further complemented by annexes on cross-cutting indicator 6, status of donated medicines for treatment of NTDs, articles on NTDs published in the Weekly Epidemiological Record, target product profiles published as of 31 December 2023 and the list of global NTD reports published by WHO so far.

Shaping The Global Innovation And Access Landscape For Better Paediatric Medicines

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Author : World Health Organization
language : en
Publisher: World Health Organization
Release Date : 2022-03-25

Shaping The Global Innovation And Access Landscape For Better Paediatric Medicines written by World Health Organization and has been published by World Health Organization this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-25 with Medical categories.

GAP-f’s three-year strategic plan (2022-2024) builds from the work undertaken to date by the network of leading partners, both individually and collectively, through GAP-f. With this strategy, GAP-f is excited to increase its footprint into a broader set of diseases to bring it closer to its vision of all children having equitable access to the medicines they need.

Second Meeting Of The Who Strategic And Technical Advisory Group Working Group On Access To Safe Efficacious And Quality Assured Health Products For Neglected Tropical Diseases

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Author : World Health Organization
language : en
Publisher: World Health Organization
Release Date : 2023-11-30

Second Meeting Of The Who Strategic And Technical Advisory Group Working Group On Access To Safe Efficacious And Quality Assured Health Products For Neglected Tropical Diseases written by World Health Organization and has been published by World Health Organization this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-30 with Medical categories.

The STAG Working Group on access to safe, efficacious and quality-assured health products for neglected tropical diseases was established in 2021 to facilitate alignment of stakeholders on strategies and best practices for improving access to medicines and other health products for NTDs. The Working Group held its second technical meeting virtually on 19 September 2023. The main outcomes of the meeting were to expand the scope of drug efficacy monitoring to include other neglected tropical diseases and to seek synergy in addressing common issues and challenges across diseases for procurement and supply chain management. In addition to the Working Group’s members, observers, invited guests and the WHO secretariat attended the meeting. This publication contains the report of the meeting and its recommendations to STAG, which will be helpful as a reference and of use to the wider NTD community.

Report Of The Paediatric Regulatory Network Meeting 12 13 May 2022

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Author : World Health Organization
language : en
Publisher: World Health Organization
Release Date : 2024-04-19

Report Of The Paediatric Regulatory Network Meeting 12 13 May 2022 written by World Health Organization and has been published by World Health Organization this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-04-19 with Business & Economics categories.

The Paediatric Regulatory Network was initially created as a global paediatric working group in February 2010 in response to a recommendation from the 2008 International Conference on Drug Regulatory Authorities and as part of the World Health Organization (WHO) Better Medicines for Children Project in collaboration with the Bill & Melinda Gates Foundation, to offer a platform for discussion on paediatric regulatory considerations for national regulatory authorities. The Network was reactivated in December 2019 as a global paediatric network supporting the availability of quality-assured medical products for children, by facilitating communication, collaboration, training and regulatory harmonization across the development, registration and pharmacovigilance of paediatric medical products. The Network’s activities contribute efficiently to the implementation of World Health Assembly resolutions WHA60.20 (2007) on better medicines for children, WHA69.20 (2016) on promoting innovation and access to quality, safe, efficacious and affordable medicines for children, WHA67.20 (2014) on regulatory system strengthening for medical products and WHA67.22 (2014) on access to essential medicines.

Report Of The Fifth Who Stakeholders Meeting On Gambiense And Rhodesiense Human African Trypanosomiasis Elimination Geneva Switzerland 7 9 June 2023

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Author : World Health Organization
language : en
Publisher: World Health Organization
Release Date : 2024-05-03

Report Of The Fifth Who Stakeholders Meeting On Gambiense And Rhodesiense Human African Trypanosomiasis Elimination Geneva Switzerland 7 9 June 2023 written by World Health Organization and has been published by World Health Organization this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-03 with Medical categories.

Concerted efforts by national programmes, supported by public–private partnerships, nongovernmental organizations, donors and academia under the auspices and coordination of the World Health Organization (WHO), have produced important achievements in the control of human African trypanosomiasis (HAT). As a consequence, the disease was targeted for elimination as a public health problem by 2020. The Sixty-sixth World Health Assembly endorsed this goal in resolution WHA66.12 on Neglected tropical diseases, adopted in 2013. National sleeping sickness control programmes (NSSCPs) are core to progressing in the control of the disease and in adapting to the different epidemiological situations. The involvement of different partners, as well as the support and trust of long-term donors, has been crucial for these achievements. More than 20 years of partnership among WHO, Sanofi and Bayer have enabled WHO to strengthen and sustain financial, technical and material support for the implementation of control activities in countries where HAT is endemic. The long-term support from the Government of Belgium, the Bill & Melinda Gates Foundation (BMGF) and other research institutions in the Democratic Republic of the Congo (DRC) has also been essential. WHO convened the fifth stakeholders meeting on the elimination of HAT due to infection with Trypanosoma brucei gambiense (g-HAT) and Trypanosoma brucei rhodesiense (r-HAT) in Geneva, Switzerland, on 7–9 June 2023. The meeting was held again in person after the coronavirus disease (COVID-19) pandemic and jointly for both forms of the disease. The previous meetings on g-HAT held in 2014, 2016 and 2018, as well as on r-HAT in 2015, 2017 and 2019, and jointly for g-HAT and r-HAT in 2021 (8) reinforced the partnership and commitment for HAT elimination and structured the mechanisms of collaboration within the WHO network for HAT elimination. The network includes NSSCPs, groups developing new tools, international and nongovernmental organizations involved in disease control, and donors. Fewer than 1000 cases of HAT annually have been reported over the past 5 years, which is a historic achievement. The area at risk has been substantially reduced. The elimination of HAT as a public health problem at the global level has been achieved. The new road map for neglected tropical diseases (NTDs) 2021−2030 (“the road map”) with the target to interrupt the transmission of g-HAT requires the strengthened and sustained efforts of all stakeholders, national authorities and partners, under WHO coordination. It will take disproportionally high efforts and innovative strategies to find the last cases of g-HAT and neutralize its transmission. Given the limited resources and other competing public health priorities, this is a challenge that requires our joint commitment.

Working For A Brighter Healthier Future

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Author :
language : en
Publisher: World Health Organization
Release Date : 2022-01-17

Working For A Brighter Healthier Future written by and has been published by World Health Organization this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-17 with Family & Relationships categories.

Tenth Meeting Of The Working Group On Monitoring Of Neglected Tropical Diseases Drug Efficacy Ghent 21 June 2023

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Author : World Health Organization
language : en
Publisher: World Health Organization
Release Date : 2024-02-19

Tenth Meeting Of The Working Group On Monitoring Of Neglected Tropical Diseases Drug Efficacy Ghent 21 June 2023 written by World Health Organization and has been published by World Health Organization this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-02-19 with Medical categories.

Helminth control programmes based on preventive chemotherapy against soil?transmitted helminthiases and schistosomiasis are continuing to scale up. In 2021, the global coverage of preventive chemotherapy reached 62.2% for soil-transmitted helminthiases and 40.3% for schistosomiasis; more than 650 million individuals were treated with albendazole and mebendazole for soil-transmitted helminthiases and with praziquantel for schistosomiasis. The expansion of preventive chemotherapy can potentially risk triggering anthelminthic drug resistance and put at stake the long-term public health benefits of the intervention. Antimicrobial resistance is not yet a public health problem in human helminthiases, as opposed to helminths of veterinary importance. The Working Group on Monitoring of Neglected Tropical Diseases Drug Efficacy (“the Working Group”) was established by the World Health Organization (WHO) in 2011 with the purpose of promoting: - the establishment of a standard system for monitoring drug efficacy; - the judicious use of anthelminthics in order to sustain their efficacy and delay antimicrobial resistance; and - the testing of alternative drugs and drug combinations, should antimicrobial resistance emerge for the front-line drugs presently used in preventive chemotherapy programmes. The tenth meeting of the Working Group was held at Ghent University (Ghent, Belgium) on 21 June 2023. The meeting was chaired by Professor Jozef Vercruysse (Ghent University). The rapporteurs were Dr Bruno Levecke (Ghent University) and Dr Denise Mupfasoni (WHO Global Neglected Tropical Diseases Programme). The objectives of the meeting were: - to review the data on monitoring the efficacy of anthelminthics currently used in large-scale deworming programmes for soil-transmitted helminthiases and schistosomiasis; - to review the need for, and recommend the revision of, the WHO guidance on monitoring drug efficacy in large-scale deworming programmes; and - to review ongoing research on anthelminthic drugs (combinations).