Paediatric Formulation
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Paediatric Formulation
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Author : Nunzio Denora
language : en
Publisher: MDPI
Release Date : 2021-09-02
Paediatric Formulation written by Nunzio Denora and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-02 with Science categories.
The development of paediatric medicines can be challenging since this is a different patient population with specific needs. A medicine designed for use in paediatric patients must consider the following aspects: patient population variability; the need for dose flexibility; route of administration; patient compliance; excipient tolerability. For example, the toxicity of excipients may differ in children compared to adults and children have different taste preferences. Globally, about 75% of drugs do not carry regulatory approval for use in children; worldwide, many medications prescribed for the treatment of paediatric diseases are used off-label, and less than 20% of package inserts have sufficient information for treating children. This book provides an update on both state-of-the-art methodology and operational challenges in paediatric formulation design and development. It aims at re-evaluating what is needed for more progress in the design and development of age-appropriate treatments for paediatric diseases, focusing on: formulation development; drug delivery design; efficacy, safety, and tolerability of drugs and excipients.
Pediatric Formulations
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Author : Daniel Bar-Shalom
language : en
Publisher: Springer Science & Business Media
Release Date : 2014-01-30
Pediatric Formulations written by Daniel Bar-Shalom and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-01-30 with Medical categories.
Until the 1990s, it was generally accepted that medicines were first developed for adults and their use in children was investigated later, if at all. One of the main tasks of hospital pharmacies was the manufacturing of child-appropriate formulations in a more or less makeshift way. The first change came in 1997 with U.S. legislation that rewarded manufacturers to do voluntary pediatric research. Ten years later, the European Union passed legislation that required manufacturers to discuss all pediatric aspects, including formulations, with the regulatory authorities as a condition of starting the registration procedure. In consequence, manufacturers must now cover all age groups, including the youngest ones. So far, pediatric formulations were more a focus for academic researchers. Through the changed regulatory environment, there is now a sudden high commercial demand for age-appropriate formulations. This book begins by highlighting the anatomical, physiological and developmental differences between adults and children of different ages. It goes on to review the existing technologies and attempts to draw a roadmap to better, innovative formulations, in particular for oral administration. The regulatory, clinical, ethical and pharmaceutical framework is also addressed.
Paediatric Formulation Design And Development
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Author : Nunzio Denora
language : en
Publisher:
Release Date : 2021
Paediatric Formulation Design And Development written by Nunzio Denora and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with categories.
The development of paediatric medicines can be challenging since this is a different patient population with specific needs. A medicine designed for use in paediatric patients must consider the following aspects: patient population variability; the need for dose flexibility; route of administration; patient compliance; excipient tolerability. For example, the toxicity of excipients may differ in children compared to adults and children have different taste preferences. Globally, about 75% of drugs do not carry regulatory approval for use in children; worldwide, many medications prescribed for the treatment of paediatric diseases are used off-label, and less than 20% of package inserts have sufficient information for treating children. This book provides an update on both state-of-the-art methodology and operational challenges in paediatric formulation design and development. It aims at re-evaluating what is needed for more progress in the design and development of age-appropriate treatments for paediatric diseases, focusing on: formulation development; drug delivery design; efficacy, safety, and tolerability of drugs and excipients.
Novel Paediatric Formulation For The Drug Sodium Benzoate
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Author : Julia Krause
language : en
Publisher: Cuvillier Verlag
Release Date : 2008-07-03
Novel Paediatric Formulation For The Drug Sodium Benzoate written by Julia Krause and has been published by Cuvillier Verlag this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-07-03 with Medical categories.
Pediatric Drug Formulations 7th Edition
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Author :
language : en
Publisher:
Release Date : 2018
Pediatric Drug Formulations 7th Edition written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.
Pediatric Drug Formulations
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Author : Milap C. Nahata
language : en
Publisher:
Release Date : 1990-01-01
Pediatric Drug Formulations written by Milap C. Nahata and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990-01-01 with Medicine categories.
Paediatric Drug Handling
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Author : Ian Costello
language : en
Publisher: Pharmaceutical Press
Release Date : 2007
Paediatric Drug Handling written by Ian Costello and has been published by Pharmaceutical Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Medical categories.
This book provides a comprehensive overview of all of the issues pharmacists serving pediatric patients must consider. Chapters relating to pharmacogenomics, medication error prevention, compounding, and government regulations are extremely informative.
Extemporaneous Formulations For Pediatric Geriatric And Special Needs Patients
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Author : Rita K. Jew
language : en
Publisher:
Release Date : 2016
Extemporaneous Formulations For Pediatric Geriatric And Special Needs Patients written by Rita K. Jew and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with Children categories.
Since its first publication, this book has been the go-to guide for treating patients who require any of the 80% of medications not commercially available in appropriate forms or dosages for paediatric, geriatric, or special needs populations. Now even more comprehensive, the third edition provides the same evidence-based formulation in easy-to-follow "recipes" for 197 nonsterile formulations, 39 of which are new, and two of which have been updated for this edition. Each "recipe" includes ingredients; preparation details and instructions; storage conditions; special instructions; alternatives; expiration dates; references; and documented stability data. An invaluable resource for practitioners and compiled by experts in the field, this book provides the best guidance you can get for the care you want to give.
Novel Paediatric Formulations For The Drug Sodium Benzoate
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Author : Julia Krause
language : en
Publisher: Cuvillier Verlag
Release Date : 2008
Novel Paediatric Formulations For The Drug Sodium Benzoate written by Julia Krause and has been published by Cuvillier Verlag this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with categories.
Paediatric Drug Optimization For Neglected Tropical Diseases
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Author : World Health Organization
language : en
Publisher: World Health Organization
Release Date : 2023-11-21
Paediatric Drug Optimization For Neglected Tropical Diseases written by World Health Organization and has been published by World Health Organization this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-21 with Business & Economics categories.
Priority-setting is the first step to enable a targeted approach to research and development. Developing a prioritized drug portfolio of the most needed formulations for children is essential to streamline researchers’ and supplier’s efforts and resources around specific dosage forms and formulations that address most urgent needs for children. In general, due to limited financial incentives, few new drugs are being developed for Neglected Tropical Diseases (NTDs). Several NTDs disproportionately affect children compared to adults and, as is the case like for most diseases affecting adults and children, the burden to children is compounded by lack of inclusion of paediatric populations in clinical trials and/or lack of age-appropriate dosing regimens and formulations. The PADO-NTD exercise concluded with a final meeting organized in September 2023 with representatives from the four prioritized disease areas to reach consensus on a final PADO-NTD priority list, watch list and research questions and discuss transversal issues for the way forward. The meeting report will include summaries of the background, discussions and deliberations of all PADO exercises, and final conclusions and outputs of the overall PADO for NTD exercises.