Pain And Neuroimmune Interactions
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Pain And Neuroimmune Interactions
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Author : Nayef E. Saadé
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Pain And Neuroimmune Interactions written by Nayef E. Saadé and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
For those of us involved in research on the neural mechanisms that relate tissue damage to pain. it is becoming more evident that the sensation of pain and suffering could be considered as part of a mechanism that involves not only sizeable areas in the brain but also simultaneous activations of the immune and the endocrine systems as well. A consensus is growing among specialists in the field that pain involves the sharing of molecular mechanisms between the nervous, immune and endocrine systems that can interact at peripheral and, ultimately, central levels. Furthermore, chronic pain could then be looked upon as a corollary of the imbalance in the cross talk between these systems, which could lead to new treatment strategies. The aim of this book is not to deal with acute pain that serves as an alarm signal, but to attempt to explain the molecular mechanisms of chronic pains considered as a multifactorial syndrome or disease.
Neuroimmune Interactions In Pain
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Author : Ru-Rong Ji
language : en
Publisher: Springer Nature
Release Date : 2023-05-05
Neuroimmune Interactions In Pain written by Ru-Rong Ji and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-05 with Medical categories.
As lifespans increase, more people around the world find themselves victims of chronic pain. In spite of this, treatment options continue to be severely limited. Anti-inflammatory drugs can only do so much, while painkillers like opioids have led to crippling addictions and fatal overdoses. The subject of the book is the role of immune cells, including glial cells, and neuroimmune interactions in chronic pain. The book begins by examining the preclinical and clinical evidence supporting the involvement of non-neuronal cells in chronic pain. It discusses the interactions between non-neuronal cells and neurons in the regulation of chronic pain. It then presents the implications of these findings, including promising and emerging treatments such as specialized pro-resolving mediators (SPMs, such as resolvins and protectins), immune cell therapy, and complementary and alternative medicine, as well as neuromodulation and regenerative medicine, which may prove to be the turning point for hundreds of millions of patients world-wide who struggle to escape from the shadow of chronic pain. The book presents ground-breaking research that will alter current perspectives on chronic pain.
Neuro Immune Interactions In Inflammation And Autoimmunity
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Author : Valentin A. Pavlov
language : en
Publisher: Frontiers Media SA
Release Date : 2018-07-24
Neuro Immune Interactions In Inflammation And Autoimmunity written by Valentin A. Pavlov and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-07-24 with categories.
The nervous system plays an important role in the regulation of immunity and inflammation. On the other hand unbalanced immune responses in inflammatory and autoimmune conditions may have a deleterious impact on neuronal integrity and brain function. Recent studies have characterized neural pathways communicating peripheral inflammatory signals to the CNS, and brain- and spinal cord-derived circuitries controlling various innate and adaptive immune responses and inflammation. A prototypical neural reflex circuit that regulates immunity and inflammation is the vagus nerve-based “inflammatory reflex”. Ongoing research has revealed cellular and molecular mechanisms underlying these neural circuits and indicated new therapeutic approaches in inflammatory and autoimmune disorders. Pharmacological and bioelectronic modulation of neural circuitry has been successfully explored in preclinical settings of sepsis, arthritis, inflammatory bowel disease, obesity-driven disorders, diabetes and other diseases. These studies paved the way to successful clinical trials with bioelectronic neuronal modulation in rheumatoid arthritis and inflammatory bowel disease. Dysregulated release of cytokines and other inflammatory molecules may have a severe impact on brain function. Brain inflammation (neuroinflammation), imbalances in brain neuronal integrity and neurotransmitter systems, and cognitive impairment are characteristic features of post-operative conditions, sepsis, liver diseases, diabetes and other disorders characterized by immune and metabolic dysregulation. Derangements in cytokine release also play a pivotal role in depression. Characteristic brain reactive antibodies in autoimmune conditions, including systemic lupus erythematosus and neuromyelitis optica, significantly contribute to brain pathology and cognitive impairment. These studies, and the simultaneous characterization of neuro-protective cytokines, identified new therapeutic approaches for treating neurological complications in inflammatory and autoimmune disorders. This Frontiers Research Topic is a forum for publishing research findings and methodological and conceptual advances at the intersection of immunology and neuroscience. We hope that presenting new insight into bi-directional neuro-immune communication in inflammation and autoimmunity will foster further collaborations and facilitate the development of new efficient therapeutic strategies.
Neuroimmune Interface In Health And Diseases
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Author : Ihssane Zouikr
language : en
Publisher: Frontiers Media SA
Release Date : 2017-12-06
Neuroimmune Interface In Health And Diseases written by Ihssane Zouikr and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-12-06 with categories.
It is now well appreciated that the immune system, in addition to its traditional role in defending the organism against pathogens, communicate in a well-organized fashion with the brain to maintain homeostasis and regulate a set of neural functions. Perturbation in this brain-immune interactions due to inflammatory responses may lead to psychiatric and neurological disorders. Microglia are one of the essential cells involved in the brain-immune interactions. Microglial cells are now not simply regarded as resident tissue macrophages in the brain. These cells are derived from myeloid progenitor cells in the yolk sac in early gestation, travel to the brain parenchyma and interact actively with neurons during the critical period of neurogenesis. Microglia provide a trophic support to developing neurons and take part in the neural wiring through the activity-dependent synapse elimination via direct neuron-microglia interactions. Altered microglial functions including changes in the gene expression due to early life inflammatory events or psychological and environmental stressors can be causally related to neurodevelopmental diseases and mental health disorders. This type of alterations in the neural functions can occur in the absence of infiltration of inflammatory cells in the brain parenchyma or leptomeninges. In this sense, the pathogenetic state underlying a significant part of psychiatric and neurological diseases may be similar to “para-inflammation”, an intermediate state between homeostatic and classical inflammatory states as defined by Ruslan Medzhitov (Nature 454:428-35, 2008). Therefore, it is important to study how systemic inflammation affects brain health and how local peripheral inflammation induces changes in the brain microenvironment. Chronic pain is also induced by disturbance in otherwise well-organized multisystem interplay comprising of reciprocal neural, endocrine and immune interactions. Especially, early-life insults including exposure to immune challenges can alter the neuroanatomical components of nociception, which induces altered pain response later in life. Recently the discrete roles of microglia and blood monocyte-derived macrophages are being defined. The distinction may be further highlighted by disorders in which the brain parenchymal tissue is damaged. Therefore, studies investigating the dynamics of immune cells in traumatic brain injury and neurotropic viral infections including human immunodeficiency virus, etc. as well as neurodegenerative diseases such as amyotrophic lateral sclerosis are promising to clarify the interplay between the central nervous and immune systems. The understanding of the histological architecture providing the infrastructure of such neuro-immune interplay is also essential. This Frontiers research topic brings together fourteen articles and aims to create a platform for researchers in the field of psychoneuroimmunology to share the recent theories, hypotheses and future perspectives regarding open questions on the mechanisms of cell-cell interactions with chemical mediators among the nervous, immune and endocrine systems. We hope that this platform would reveal the relevance of the studies on multisystem interactions to enhance the understanding of the mechanisms underlying a wide variety of neurological and psychiatric disorders.
Neuroimmune Interactions
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Author : Chester Robinson
language : en
Publisher:
Release Date : 2022-09-13
Neuroimmune Interactions written by Chester Robinson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-13 with categories.
The system of processes and structures which consists of interactions between the nervous system and the immune system is termed as the neuroimmune system. It involves electrophysiological and biochemical processes, and is integral in protecting the neurons from pathogens. Sensory neurons and immune cells are used by the neuroimmune system for the detection and management of harmful stimuli. The neuroimmune system is primarily comprised of glial cells. Neurons and glial cells work together to deal with attacking pathogens. Both glial cells and neurons express chemokine receptors, thus chemokines act as mediators in neuron-glial cell interaction. Different approaches, evaluations, methodologies and advanced studies on neuroimmune interactions and their clinical aspects have been included in this book. It presents this complex subject in the most comprehensible and easy to understand language. This book will serve as a valuable source of reference for graduate and post graduate students.
An Introduction To Pain And Its Relation To Nervous System Disorders
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Author : Anna A. Battaglia
language : en
Publisher: John Wiley & Sons
Release Date : 2016-05-02
An Introduction To Pain And Its Relation To Nervous System Disorders written by Anna A. Battaglia and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-05-02 with Science categories.
Introduction to Pain and its relation to Nervous System Disorders provides an accessible overview of the latest developments in the science underpinning pain research, including, but not limited to, the physiological, pathological and psychological aspects. This unique book fills a gap in current literature by focussing on the intricate relationship between pain and human nervous system disorders such as Autism, Alzheimer Disease, Parkinson’s Disease, Depression and Multiple Sclerosis. This fully illustrated, colour handbook will help non-experts, including advanced undergraduate and new postgraduate students, become familiar with the current, wide-ranging areas of research that cover every aspect of the field from chronic and inflammatory pain to neuropathic pain and biopsychosocial models of pain, functional imaging and genetics. Contributions from leading experts in neuroscience and psychiatry provide both factual information and critical points of view on their approach and the theoretical framework behind their choices. An appreciation of the strengths and weaknesses of brain imaging technology applied to pain research in humans provides the tools required to understand current cutting edge literature on the topic. Chapters covering placebo effects in analgesia and the psychology of pain give a thorough overview of cognitive, psychological and social influences on pain perception. Sections exploring pain in the lifecycle and in relation to nervous system disorders take particular relevance from a clinical point of view. Furthermore, an intellectually stimulating chapter analysing the co-morbidity of pain and depression provides a philosophical angle rarely presented in related handbooks. The references to external research databases and relevant websites aim to prompt readers to become critical and independent thinkers, and motivate them to carry out further reading on these topics. Introduction to Pain and its relation to Nervous System Disorders is essential reading for advanced undergraduate and postgraduate students in neuroscience, medical and biomedical sciences, as well as for clinical and medical healthcare professionals involved in pain management.
Neuroendocrine And Immune Crosstalk
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Author : George P. Chrousos
language : en
Publisher: Wiley-Blackwell
Release Date : 2006-12-04
Neuroendocrine And Immune Crosstalk written by George P. Chrousos and has been published by Wiley-Blackwell this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-12-04 with Medical categories.
Crosstalk between the neuroendocrine and immune systems plays an essential role in inflammatory, autoimmune, and allergic diseases. An international group of scientists from the fields of neurobiology, neuroendocrinology, immunology, and behavioral sciences reports here on recent advances in our understanding of the communication and modulation taking place between the neuroendocrine and immunological systems. In an effort to incorporate all recent knowledge in this field, broad aspects of endocrinology and neuropsychiatric and autoimmune disorders is included, with special attention given to recent progress in molecular biology and genetics. In particular, the volume focuses on diseases of the nervous system and their modulation by the immune and endocrine systems, as well as on the neuroimmunomodulation of inflammatory, autoimmune, and allergic diseases with an emphasis on the female gender. Special care has been taken by the editors to balance basic and clinical information. The volume is divided into sections: the cytokine and neuropeptide signal transduction systems and their immunomodulatory properties, the neuroendocrine immune basis of rheumatic disease, models of inflammation, the immunology of neuropsychiatric and allergic disorders, neuroendocrine and autoimmune adaptations in aging, neuroimmune interactions in chronic pain disorders and infectious diseases, and finally a structural and functional overview of the stress system. Clinical applications have been extrapolated from the basic knowledge and physiology of neuroimmune interactions, so this volume will provide a useful update for both researchers and clinicians. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member
Neuroimmune Interface In Health And Diseases
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Author :
language : en
Publisher:
Release Date : 2017
Neuroimmune Interface In Health And Diseases written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.
It is now well appreciated that the immune system, in addition to its traditional role in defending the organism against pathogens, communicate in a well-organized fashion with the brain to maintain homeostasis and regulate a set of neural functions. Perturbation in this brain-immune interactions due to inflammatory responses may lead to psychiatric and neurological disorders. Microglia are one of the essential cells involved in the brain-immune interactions. Microglial cells are now not simply regarded as resident tissue macrophages in the brain. These cells are derived from myeloid progenitor cells in the yolk sac in early gestation, travel to the brain parenchyma and interact actively with neurons during the critical period of neurogenesis. Microglia provide a trophic support to developing neurons and take part in the neural wiring through the activity-dependent synapse elimination via direct neuron-microglia interactions. Altered microglial functions including changes in the gene expression due to early life inflammatory events or psychological and environmental stressors can be causally related to neurodevelopmental diseases and mental health disorders. This type of alterations in the neural functions can occur in the absence of infiltration of inflammatory cells in the brain parenchyma or leptomeninges. In this sense, the pathogenetic state underlying a significant part of psychiatric and neurological diseases may be similar to "para-inflammation", an intermediate state between homeostatic and classical inflammatory states as defined by Ruslan Medzhitov (Nature 454:428-35, 2008). Therefore, it is important to study how systemic inflammation affects brain health and how local peripheral inflammation induces changes in the brain microenvironment. Chronic pain is also induced by disturbance in otherwise well-organized multisystem interplay comprising of reciprocal neural, endocrine and immune interactions. Especially, early-life insults including exposure to immune challenges can alter the neuroanatomical components of nociception, which induces altered pain response later in life. Recently the discrete roles of microglia and blood monocyte-derived macrophages are being defined. The distinction may be further highlighted by disorders in which the brain parenchymal tissue is damaged. Therefore, studies investigating the dynamics of immune cells in traumatic brain injury and neurotropic viral infections including human immunodeficiency virus, etc. as well as neurodegenerative diseases such as amyotrophic lateral sclerosis are promising to clarify the interplay between the central nervous and immune systems. The understanding of the histological architecture providing the infrastructure of such neuro-immune interplay is also essential. This Frontiers research topic brings together fourteen articles and aims to create a platform for researchers in the field of psychoneuroimmunology to share the recent theories, hypotheses and future perspectives regarding open questions on the mechanisms of cell-cell interactions with chemical mediators among the nervous, immune and endocrine systems. We hope that this platform would reveal the relevance of the studies on multisystem interactions to enhance the understanding of the mechanisms underlying a wide variety of neurological and psychiatric disorders.
Itch And Pain
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Author : Gil Yosipovitch
language : en
Publisher: IASP Press
Release Date : 2020-06
Itch And Pain written by Gil Yosipovitch and has been published by IASP Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06 with Chronic pain categories.
"The International Association for the Study of Pain (IASP) and the International Forum for the Study of Itch (IFSI) share a common mission of bringing clinicians and researchers to think and work together to understand pain and itch, respectively and help find better treatments for patients in both diseases. IASP has established a dedicated Special Interest Group (SIG) focusing specifically on the differences and commonalities between pain and itch pathways and mechanisms. Translating fundamental knowledge from pain to itch and vice versa can help targeting the development of new and better treatments. The purpose of this book entitled" Itch and Pain: Similarities, Interactions and Differences" follows these 2 societies' mission. It is edited by the past president and founder of IFSI (Gil Yosipovitch) and the present president of IASP (Lars Arendt-Nielsen) as well as by a researcher who trained in both itch and pain psychophysics (Hjalte Holm Andersen). For the first time the book provides a comprehensive overview of how these important sensations share common and different pathways/mechanisms and their interactions"--
Comorbidity Of Mental And Physical Disorders
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Author : N. Sartorius
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2014-11-26
Comorbidity Of Mental And Physical Disorders written by N. Sartorius and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-26 with Medical categories.
This publication presents evidence about the magnitude and severe consequences of comorbidity of mental and physical illnesses from a personal and societal perspective. Leading experts address the huge burden of co-morbidity to the affected individual as well as the public health aspects, the costs to society and interaction with factors stemming from the context of socioeconomic developments. The authors discuss the clinical challenge of managing cardiovascular illnesses, cancer, infectious diseases and other physical illness when they occur with a range of mental and behavioral disorders, including substance abuse, eating disorders and anxiety. Also covered are the organization of health services, the training of different categories of health personnel and the multidisciplinary engagement necessary to prevent and manage comorbidity effectively. The book is essential reading for general practitioners, internists, public health specialists, psychiatrists, cardiologists, oncologists, medical educationalists and other health care professionals.
