Palladium Catalyzed Modification Of Nucleosides Nucleotides And Oligonucleotides
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Palladium Catalyzed Modification Of Nucleosides Nucleotides And Oligonucleotides
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Author : Anant R. Kapdi
language : en
Publisher: Elsevier
Release Date : 2018-06-04
Palladium Catalyzed Modification Of Nucleosides Nucleotides And Oligonucleotides written by Anant R. Kapdi and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-04 with Science categories.
Palladium-Catalyzed Modification of Nucleosides, Nucleotides and Oligonucleotides describes the procedures and protocols related to the modification of nucleosides, nucleotides and oligonucleotides via Pd-mediated cross-coupling processes. The book highlights the growing area of nucleic acid modification and how Pd-mediated coupling reactions can assist this development. Users will find key synthetic protocols for these reactions in this latest volume in the Latest Trends in Palladium Chemistry series. As most of the research in the field of antiviral agents has centered on the use of modified nucleosides that have exhibited promising activity, this book provides an up-to-date reference for both professionals in industry and other interested parties. Provides synthetic routes for useful nucleoside molecules, information otherwise found only through time-consuming literature searches Covers metal-mediated and metal-catalyzed cross coupling processes of nucleosides and related compounds Includes Suzuki-Miyaura, Stille and Sonogashira reactions, as well as C-H bond functionalization Highlights the growing area of nucleic acid modification and how Pd-mediated coupling reactions can assist
Chemistry Of Nucleic Acids
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Author : Harri Lönnberg
language : en
Publisher: Walter de Gruyter GmbH & Co KG
Release Date : 2020-08-10
Chemistry Of Nucleic Acids written by Harri Lönnberg and has been published by Walter de Gruyter GmbH & Co KG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-10 with Science categories.
Life in all its forms is based on nucleic acids which store and transfer genetic information. The book addresses the main aspects of synthesis, hydrolytic stability, solution equilibria of nucleosides and nucleotides as well as base modifications of nucleic acids. The author further describes their structural analogues used as therapeutic drugs, such as antivirals and anticancer agents, and prodrug strategies of nucleotides.
Nucleic Acids Chemistry
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Author : Ramon Eritja
language : en
Publisher: Walter de Gruyter GmbH & Co KG
Release Date : 2021-01-18
Nucleic Acids Chemistry written by Ramon Eritja and has been published by Walter de Gruyter GmbH & Co KG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-18 with Science categories.
This book compiles recent research on the modification of nucleic acids. It covers backbone modifications and conjugation of lipids, peptides and proteins to oligonucleotides and their therapeutic use. Synthesis and application in biomedicine and nanotechnology of aptamers, fluorescent and xeno nucleic acids, DNA repair and artificial DNA are discussed as well.
Modified Nucleosides
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Author : Piet Herdewijn
language : de
Publisher: John Wiley & Sons
Release Date : 2008-09-08
Modified Nucleosides written by Piet Herdewijn and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-09-08 with Science categories.
Edited by one of the main driving forces behind the field's momentous rise in recent years, this one-stop reference is the first comprehensive resource to integrate recent advances. The first part addresses biochemical aspects and applications, the second and third parts are devoted to compounds with therapeutic potential, with the third part focusing on newly introduced anticancer nucleoside drugs. Essential reading for every scientist working in this area.
Advances In Heterocyclic Chemistry
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Author :
language : en
Publisher: Academic Press
Release Date : 2020-04-24
Advances In Heterocyclic Chemistry written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-24 with Science categories.
Advances in Heterocyclic Chemistry is the definitive series in the field - one of great importance to organic chemists, polymer chemists, and many biological scientists. Because biology and organic chemistry increasingly intersect, the associated nomenclature also is being used more frequently in explanations. Written by established authorities in the field from around the world, this comprehensive review combines descriptive synthetic chemistry and mechanistic insight to yield an understanding of how chemistry drives the preparation and useful properties of heterocyclic compounds. Considered the definitive serial in the field of heterocyclic chemistry Serves as the go-to reference for organic chemists, polymer chemists and many biological scientists Provides the latest comprehensive reviews written by established authorities in the field Combines descriptive synthetic chemistry and mechanistic insight to enhance understanding of how chemistry drives the preparation and useful properties of heterocyclic compounds
Synthesis Of Therapeutic Oligonucleotides
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Author : Satoshi Obika
language : en
Publisher: Springer
Release Date : 2018-12-08
Synthesis Of Therapeutic Oligonucleotides written by Satoshi Obika and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-12-08 with Medical categories.
This book presents the latest knowledge on a broad range of topics relating to the synthesis of natural and artificial oligonucleotides with therapeutic potential. Nucleic acid-based therapeutics are attracting much attention, and numerous therapeutic oligonucleotides, such as antisense oligonucleotides, siRNAs, splice-switching oligonucleotides, and nucleic acid aptamers, are being evaluated in clinical trials for the treatment of a variety of diseases. Synthesis of Therapeutic Oligonucleotides covers a broad range of topics in the field that are of high relevance to researchers, including the synthesis of natural and chemically modified oligonucleotides, the development of novel nucleic acid analogs, industrial scale synthesis and purification of oligonucleotides, and important aspects of chemistry, manufacturing, and controls (CMC). The aim is to provide new insights and inspire fresh ideas in nucleic acid chemistry that may ultimately lead to novel concepts and techniques and the discovery of more effective nucleic acid drugs. The book will be of high value for both established researchers in the field and students intending to specialize in nucleic acid chemistry research.
Modified Nucleic Acids
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Author : Kazuhiko Nakatani
language : en
Publisher: Springer
Release Date : 2016-04-04
Modified Nucleic Acids written by Kazuhiko Nakatani and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-04 with Science categories.
This book spans diverse aspects of modified nucleic acids, from chemical synthesis and spectroscopy to in vivo applications, and highlights studies on chemical modifications of the backbone and nucleobases. Topics discussed include fluorescent pyrimidine and purine analogs, enzymatic approaches to the preparation of modified nucleic acids, emission and electron paramagnetic resonance (EPR) spectroscopy for studying nucleic acid structure and dynamics, non-covalent binding of low- and high-MW ligands to nucleic acids and the design of unnatural base pairs. This unique book addresses new developments and is designed for graduate level and professional research purposes.
Palladacycles
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Author : Anant Kapdi
language : en
Publisher: Elsevier
Release Date : 2019-06-15
Palladacycles written by Anant Kapdi and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-15 with Science categories.
Palladacycles: Catalysis and Beyond provides an overview of recent research in palladacycles in catalysis for cross-coupling and similar reactions. In the quest for developing highly efficient and robust palladium-based catalysts for C-C bond formation via cross-coupling reactions, palladacycles have played a significant role. In recent years, they have found a wide variety of applications, ranging from catalysts for cross-coupling and related reactions, to their more recent application as anticancer agents. This book explores early examples of the use of palladacyclic complexes in catalysis employing azobenzene and hydrazobenzene as coordinating ligands. Its applications in processes such as selective reduction of alkenes, alkynes, or nitroalkanes are also covered. Palladacycles: Catalysis and Beyond reveals the tremendous advances that have taken place in the potential applications of palladacycles as versatile catalysts in academia and industry. It is a valuable resource for synthetic chemists, organometallic chemists, and chemical biologists.
A Handbook For Dna Encoded Chemistry
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Author : Robert A. Goodnow, Jr.
language : en
Publisher: John Wiley & Sons
Release Date : 2014-04-28
A Handbook For Dna Encoded Chemistry written by Robert A. Goodnow, Jr. and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-04-28 with Science categories.
This book comprehensively describes the development and practice of DNA-encoded library synthesis technology. Together, the chapters detail an approach to drug discovery that offers an attractive addition to the portfolio of existing hit generation technologies such as high-throughput screening, structure-based drug discovery and fragment-based screening. The book: Provides a valuable guide for understanding and applying DNA-encoded combinatorial chemistry Helps chemists generate and screen novel chemical libraries of large size and quality Bridges interdisciplinary areas of DNA-encoded combinatorial chemistry – synthetic and analytical chemistry, molecular biology, informatics, and biochemistry Shows medicinal and pharmaceutical chemists how to efficiently broaden available “chemical space” for drug discovery Provides expert and up-to-date summary of reported literature for DNA-encoded and DNA-directed chemistry technology and methods
C Furanosides
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Author : Peter Goekjian
language : en
Publisher: Academic Press
Release Date : 2017-11-30
C Furanosides written by Peter Goekjian and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-30 with Science categories.
Carbon analogs of carbohydrates, dubbed C-glycosides, have remained an important and interesting class of mimetics, be it in natural product synthesis, for pharmacological applications, as conformational probes, or for biological studies. C-Furanosides: Synthesis and Stereochemistry provides a much-needed overview of synthetic and stereochemical principles for C-furanosides: analogs of a 5-membered ring carbohydrate glycoside (furanoside), in which the anomeric oxygen has been replaced with a carbon. While our understanding of conformational behavior and of stereoselective synthesis in 6-membered ring compounds is quite good, our ability to predict the conformation of 5-membered ring compounds, or to predict the stereochemical outcome of a given reaction, remains anecdotal. Through a comprehensive review of literature approaches to the different C-furanoside stereoisomers, as well as an interpretation of the outcome in terms of a reasonable number of stereochemical models, C-Furanosides: Synthesis and Stereochemistry enables the reader to determine the best approach to a particular C-glycoside compound, and also hopes to provide a certain level of rationalization and predictability for the synthesis of new systems. Provides a comprehensive review of the growing literature in C-furanosides Enables readers to choose the most convenient approach to access a defined target in natural products synthesis or pharmacology and make reasonable predictions for the stereochemical outcome in unpublished cases Explores the various rational models for stereochemical analysis of furanoside reactivity, with a clear distinction made between physical chemical mechanisms and stereochemical models