Pathogenic Advances And Therapeutic Perspectives For Eosinophilic Inflammation
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Pathogenic Advances And Therapeutic Perspectives For Eosinophilic Inflammation
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Author : Florence E. Roufosse
language : en
Publisher: Frontiers Media SA
Release Date : 2018-12-06
Pathogenic Advances And Therapeutic Perspectives For Eosinophilic Inflammation written by Florence E. Roufosse and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-12-06 with categories.
With the recent approval of the first eosinophil-depleting therapeutic agents targeting the IL-5 pathway for treatment of severe eosinophilic asthma, eosinophils and eosinophilic disorders are in the limelight. Indeed, setbacks during clinical development of these compounds have revealed how much remains to be known about eosinophil biology in vivo, and have nurtured profuse research both on basic eosinophil biology and on pathogenic disease mechanisms, in order to better delineate the most meaningful targets for innovative therapeutic strategies. On one hand, variable degrees of eosinophil depletion observed in some compartments during IL-5-targeted treatment indicate that certain eosinophil subsets may not rely on this cytokine and/or that other important pro-eosinophilic mediators and signaling pathways are operative in vivo. On the other hand, it is increasingly clear that disorders involving eosinophils such as asthma are the final outcome of complex interactions between diverse cell types and mediators, beyond eosinophils and IL-5. These include type 2 helper T (Th2) cells and innate lymphoid cells, mast cells, and a variety of factors that either activate eosinophils or are released by them. Although a considerable amount of research has focused on asthma because it is a common condition and because management of severe asthma remains a major challenge, several rare eosinophilic disorders with more homogenous features have proven to be extremely useful models to reach a better understanding of the involvement of eosinophils in tissue damage and dysfunction, and of the micro-environmental interactions operating within the complex network of eosinophilic inflammation. Unraveling this interplay has resulted in advances in the development of molecular tools to detect disease subsets and to monitor therapeutic responses, and in identification of promising new therapeutic targets. This Research Topic dedicated to eosinophilic conditions covers aspects of the biology of eosinophils and closely related cells of particular relevance for drug development, reports on translational research investigating pathogenic mechanisms of specific eosinophilic disorders in humans that will likely result in significant changes in the way patients are managed, and presents an overview of the current advancement of targeted drug development for these conditions, with a special focus on asthma.
Pathogenic Advances And Therapeutic Perspectives For Eosinophilic Inflammation
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Author :
language : en
Publisher:
Release Date : 2018
Pathogenic Advances And Therapeutic Perspectives For Eosinophilic Inflammation written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.
With the recent approval of the first eosinophil-depleting therapeutic agents targeting the IL-5 pathway for treatment of severe eosinophilic asthma, eosinophils and eosinophilic disorders are in the limelight. Indeed, setbacks during clinical development of these compounds have revealed how much remains to be known about eosinophil biology in vivo, and have nurtured profuse research both on basic eosinophil biology and on pathogenic disease mechanisms, in order to better delineate the most meaningful targets for innovative therapeutic strategies. On one hand, variable degrees of eosinophil depletion observed in some compartments during IL-5-targeted treatment indicate that certain eosinophil subsets may not rely on this cytokine and/or that other important pro-eosinophilic mediators and signaling pathways are operative in vivo. On the other hand, it is increasingly clear that disorders involving eosinophils such as asthma are the final outcome of complex interactions between diverse cell types and mediators, beyond eosinophils and IL-5. These include type 2 helper T (Th2) cells and innate lymphoid cells, mast cells, and a variety of factors that either activate eosinophils or are released by them. Although a considerable amount of research has focused on asthma because it is a common condition and because management of severe asthma remains a major challenge, several rare eosinophilic disorders with more homogenous features have proven to be extremely useful models to reach a better understanding of the involvement of eosinophils in tissue damage and dysfunction, and of the micro-environmental interactions operating within the complex network of eosinophilic inflammation. Unraveling this interplay has resulted in advances in the development of molecular tools to detect disease subsets and to monitor therapeutic responses, and in identification of promising new therapeutic targets. This Research Topic dedicated to eosinophilic conditions covers aspects of the biology of eosinophils and closely related cells of particular relevance for drug development, reports on translational research investigating pathogenic mechanisms of specific eosinophilic disorders in humans that will likely result in significant changes in the way patients are managed, and presents an overview of the current advancement of targeted drug development for these conditions, with a special focus on asthma.
Asthma
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Author : Celso Pereira
language : en
Publisher: BoD – Books on Demand
Release Date : 2019-10-02
Asthma written by Celso Pereira and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-02 with Medical categories.
Asthma is a prevalent disease in all age groups that results from different pathogenic mechanisms, cells, and mediators engaged in innumerous clinical phenotypes and endotypes. This book exhaustively and didactically explores the biological expression of numerous cells and mediators involved in bronchial inflammation. The information provided aims at identifying the diversity and complexity of the interrelationships between the different players, drawing attention to critical mechanisms in asthma. It also highlights the requirement of new tools to identify strong biomarkers absolutely critical for managing asthma.
Middleton S Allergy E Book
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Author : A Wesley Burks
language : en
Publisher: Elsevier Health Sciences
Release Date : 2019-09-25
Middleton S Allergy E Book written by A Wesley Burks and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-25 with Medical categories.
Through eight outstanding editions, Middleton’s Allergy: Principles and Practice has been the reference of choice for both clinicians and researchers as both a practical reference and an effective self-assessment tool for board preparation. The 9th Edition continues the tradition of excellence with comprehensive coverage of all basic science and clinical applications regarding allergy practice and disease mechanisms. It brings you fully up to date with recent innovations in the diagnosis, prevention, and management of allergic disorders, including emerging global issues, the advent of precision medicine, and new immunologic therapies. Offers unparalleled depth and up-to-date guidance on the full spectrum of allergy across the lifespan, with significant updates throughout. Contains new chapters on Innate Lymphoid Cells, Systems Biology, and Treatment of Primary Immunodeficiency Diseases. Discusses emerging topics such as epidemic thunderstorm asthma and precision medicine in allergic disorders. Features more than 730 full-color illustrations, including many new cellular and molecular drawings of disease mechanisms. Includes new Summary of Important Concepts boxes, plus new multiple-choice questions online with explanations and answers. Features a new team of expert editors and more international contributors for a global perspective of this complex field.
Anti Neutrophil Cytoplasmic Antibody Anca Associated Vasculitis
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Author : Renato Alberto Sinico
language : en
Publisher: Springer Nature
Release Date : 2019-09-13
Anti Neutrophil Cytoplasmic Antibody Anca Associated Vasculitis written by Renato Alberto Sinico and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-13 with Medical categories.
This volume, written by well-known experts in the field, covers all aspects of Anti-Neutrophil Cytoplasmic Antibody (ANCA) Associated Vasculitis (AAV). The expression refers to a group of diseases, characterized by destruction and inflammation of small vessels. The clinical signs vary and affect several organs, such as the kidney, lung, skin, nervous system and others. The opening chapters give some historical hints, explain the genetic basis of the disease and provide insights into the pathogenesis derived from recent experimental studies and guides the reader through classification and nomenclature. A large part of the book is then devoted to a detailed description of the specific related diseases and their clinical presentations, the disease course, and potential complications. The advice regarding treatment is based on the best currently available evidence in this constantly evolving area. The book is part of Springer’s series Rare Diseases of the Immune System, which presents recently acquired knowledge on pathogenesis, diagnosis, and therapy with the aim of promoting a more holistic approach to these conditions. AAVs are systemic autoimmune diseases of unknown cause that affect small (to medium) sized blood vessels. They include granulomatosis with polyangiitis (formerly Wegener's granulomatosis), microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis (formerly Churg–Strauss syndrome). This volume will be an invaluable source of up-to-date information for all practitioners involved in the care of patients with these diseases.
Eosinophils In Health And Disease
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Author : James J. Lee
language : en
Publisher: Academic Press
Release Date : 2012-11-02
Eosinophils In Health And Disease written by James J. Lee and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-11-02 with Health & Fitness categories.
Eosinophils in Health and Disease provides immunology researchers and students with a comprehensive overview of current thought and cutting-edge eosinophil research, providing chapters on basic science, disease-specific issues, therapeutics, models for study and areas of emerging importance.
Eosinophilic Gastrointestinal Diseases
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Author : Glenn T. Furuta
language : en
Publisher: Clinics: Internal Medicine
Release Date : 2009
Eosinophilic Gastrointestinal Diseases written by Glenn T. Furuta and has been published by Clinics: Internal Medicine this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Medical categories.
Drs. Glen Furuta and Dan Atkins have assembled an in-depth look at Eosinophilic Gastrointestinal Diseases as related to allergy with topics such as "Basic pathogenetic mechanisms of Eosinophilic Esophagitis", "Nutritional management of patients with food allergies and EGIDs", "Chemotactic factors role in EGIDs", "Biomarkers associated with allergic diseases", "Association of other allergic diseases with EGIDs" and much more!
Eosinophilic Lung Diseases
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Author : Michael E. Wechsler
language : en
Publisher: European Respiratory Society
Release Date : 2022-01-01
Eosinophilic Lung Diseases written by Michael E. Wechsler and has been published by European Respiratory Society this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-01 with Medical categories.
A great deal of knowledge about eosinophilic lung diseases has been gained in the last few years, but unanswered questions concerning eosinophil biology still remain. It is in this context that this Monograph was developed. Broad in scope, the book bases its approach to the management of eosinophilic lung diseases on a fundamental understanding of eosinophil biology in health and disease. State-of-the-art reviews written by world-leading authorities and up-and-coming stars in the field take the reader on a journey through the different eosinophilic lung diseases. This Monograph will ensure the practicing clinician is better equipped to recognise and treat patients with eosinophilia, as well as appreciate the advances coming in the near future.
Molecular Biology Of The Cell
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Author : Bruce Alberts
language : en
Publisher:
Release Date : 2002
Molecular Biology Of The Cell written by Bruce Alberts and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Cytology categories.
Clinical Respiratory Medicine E Book
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Author : Stephen G. Spiro
language : en
Publisher: Elsevier Health Sciences
Release Date : 2012-07-30
Clinical Respiratory Medicine E Book written by Stephen G. Spiro and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-07-30 with Medical categories.
Clinical Respiratory Medicine provides practical guidance to help you more effectively diagnose and manage the full range of pulmonary disorders, including those seen in today’s most challenging patient populations. In print and online, this medical reference book delivers the answers you need to ensure the best outcomes. Better manage and treat patients with pulmonary disease with complete clinical coverage of the critical information relevant to your everyday practice, presented in a templated, user-friendly format. Find critical information quickly with the help of diagnostic algorithms. Thoroughly understand the needs and recognize co-morbidities of particular patient populations through entirely new chapters on lung structure, echocardiography, and obesity and its effects. Access the latest research and advancements in lung cancer, benign tumors, and the importance of pulmonary physiology in understanding lung function and the disease processes that occur. Watch and learn. Over 80 videos of practical procedures and interactive review questions are available online at www.expertconsult.com.