Pathophysiological Mechanisms Of Sarcopenia In Aging And In Muscular Dystrophy A Translational Approach
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Pathophysiological Mechanisms Of Sarcopenia In Aging And In Muscular Dystrophy A Translational Approach
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Author : Luciano Merlini
language : en
Publisher: Frontiers Media SA
Release Date : 2016-01-18
Pathophysiological Mechanisms Of Sarcopenia In Aging And In Muscular Dystrophy A Translational Approach written by Luciano Merlini and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-01-18 with Neurosciences. Biological psychiatry. Neuropsychiatry categories.
Loss of muscle mass and increased fibrosis characterize both sarcopenia of aging and muscular dystrophy. Research is increasingly showing that these two conditions also share several pathophysiological mechanisms, including mitochondrial dysfunction, increased apoptosis, abnormal modulation of autophagy, decline in satellite cells, increased generation of reactive oxygen species, and abnormal regulation of signaling and stress response pathways. This Research Topic will cover several mechanisms involved in aging and dystrophic sarcopenia and explore the therapeutic potential of various strategies for intervention.
Pathophysiological Mechanisms Of Sarcopenia In Aging And In Muscular Dystrophy A Translational Approach
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Author :
language : en
Publisher:
Release Date : 2015
Pathophysiological Mechanisms Of Sarcopenia In Aging And In Muscular Dystrophy A Translational Approach written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with categories.
Loss of muscle mass and increased fibrosis characterize both sarcopenia of aging and muscular dystrophy. Research is increasingly showing that these two conditions also share several pathophysiological mechanisms, including mitochondrial dysfunction, increased apoptosis, abnormal modulation of autophagy, decline in satellite cells, increased generation of reactive oxygen species, and abnormal regulation of signaling and stress response pathways. This Research Topic will cover several mechanisms involved in aging and dystrophic sarcopenia and explore the therapeutic potential of various strategies for intervention.
Haschek And Rousseaux S Handbook Of Toxicologic Pathology Volume 4 Toxicologic Pathology Of Organ Systems
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Author : Wanda M. Haschek
language : en
Publisher: Elsevier
Release Date : 2024-03-05
Haschek And Rousseaux S Handbook Of Toxicologic Pathology Volume 4 Toxicologic Pathology Of Organ Systems written by Wanda M. Haschek and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-05 with Medical categories.
Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume Four: Toxicologic Pathology of Organ Systems is a key reference on the integration of structure and functional changes in tissues associated with the response to pharmaceuticals, chemicals and biologics. Organ systems covered include cardiac, vascular and skeletal muscle systems and the endocrine, respiratory, reproductive, digestive and nervous systems. Completely revised with a new olfactory chapter, this new release is an essential part of the most authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists and regulators studying and making decisions on drugs, biologics, medical devices, and other chemicals, including agrochemicals and environmental contaminants. - Presents updated chapters on systems toxicologic pathology, including new chapter on olfactory - Offers high-quality and trusted content in a multi-contributed work written by leading international authorities in all areas of toxicologic pathology - Features hundreds of full-color images in both the print and electronic versions to highlight difficult concepts with clear illustrations
Skeletal Muscle Immunometabolism
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Author : Nicolas J. Pillon
language : en
Publisher: Frontiers Media SA
Release Date : 2021-06-29
Skeletal Muscle Immunometabolism written by Nicolas J. Pillon and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-29 with Science categories.
Translational Research In Breast Cancer
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Author : Erwei Song
language : en
Publisher: Springer
Release Date : 2017-12-28
Translational Research In Breast Cancer written by Erwei Song and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-12-28 with Medical categories.
This book offers a comprehensive introduction to translational efforts in breast cancer, addressing the latest approaches to precision medicine based on the current state of understanding of breast cancer. With the latest developments in breast cancer research, our understanding of the genomic changes and the oncogenic signaling cascade of breast cancer has made considerable strides. Further, the immuno-environment has been demonstrated as the barrier to clinical cancer. In addition, major advances in cancer biology, immunology, genomics and metabolism have broken new ground for designing therapeutic approaches and selecting appropriate treatments on the basis of more precise information on the individual patient. As a result of these two trends, a clearer picture of the molecular landscape of breast cancers has facilitated the development of diagnostic, prognostic and predictive biomarkers for clinical oncology. All these aspects are addressed in this volume, which offers a comprehensive resource for researchers, graduate students and oncologists in cancer research.
The Molecular Nutrition Of Amino Acids And Proteins
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Author : Dominique Dardevet
language : en
Publisher: Academic Press
Release Date : 2016-06-08
The Molecular Nutrition Of Amino Acids And Proteins written by Dominique Dardevet and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-06-08 with Technology & Engineering categories.
The Molecular Nutrition of Amino Acids and Proteins provides an in-depth look at the involvement and role of amino acids and proteins in molecular nutrition. Editor Dominique Dardevet has assembled a collection of chapters written by leading researchers and top professors that provide the reader with a comprehensive understanding of amino acids and proteins. The book provides an introduction to the fundamentals of amino acids and proteins as well as the composition of food. It then delves into the molecular biology of the cell and genetic machinery and its function. The Molecular Nutrition of Amino Acids and Proteins also features reference guides for terms and bullet-point summaries, making it readily accessible to novices while still providing the most up-to-date and detailed information that experienced researchers need. Provides a gentle introduction to the subject by first addressing nutritional information and then building in molecular aspects, clearly establishing fundamental information for the reader Facilitates reader comprehension by including succinct summary points in each chapter Contains a glossary of definitions that allows readers to easily reference terms Provides both a deep and broad understanding of the subject by containing overviews as well as detail-focused chapters
Muscle Atrophy
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Author : Junjie Xiao
language : en
Publisher: Springer
Release Date : 2018-11-02
Muscle Atrophy written by Junjie Xiao and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-02 with Science categories.
The book addresses the development of muscle atrophy, which can be caused by denervation, disuse, excessive fasting, aging, and a variety of diseases including heart failure, chronic kidney diseases and cancers. Muscle atrophy reduces quality of life and increases morbidity and mortality worldwide. The book is divided into five parts, the first of which describes the general aspects of muscle atrophy including its characteristics, related economic and health burdens, and the current clinical therapy. Secondly, basic aspects of muscle atrophy including the composition, structure and function of skeletal muscle, muscle changes in response to atrophy, and experimental models are summarized. Thirdly, the book reviews the molecular mechanisms of muscle atrophy, including protein degradation and synthesis pathways, noncoding RNAs, inflammatory signaling, oxidative stress, mitochondria signaling, etc. Fourthly, it highlights the pathophysiological mechanisms of muscle atrophy in aging and disease. The book’s fifth and final part covers the diagnosis, treatment strategies, promising agents and future prospects of muscle atrophy. The book will appeal to a broad readership including scientists, undergraduate and graduate students in medicine and cell biology.
Drug Discovery Toxicology
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Author : Yvonne Will
language : en
Publisher: John Wiley & Sons
Release Date : 2016-03-16
Drug Discovery Toxicology written by Yvonne Will and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-03-16 with Medical categories.
As a guide for pharmaceutical professionals to the issues and practices of drug discovery toxicology, this book integrates and reviews the strategy and application of tools and methods at each step of the drug discovery process. • Guides researchers as to what drug safety experiments are both practical and useful • Covers a variety of key topics – safety lead optimization, in vitro-in vivo translation, organ toxicology, ADME, animal models, biomarkers, and –omics tools • Describes what experiments are possible and useful and offers a view into the future, indicating key areas to watch for new predictive methods • Features contributions from firsthand industry experience, giving readers insight into the strategy and execution of predictive toxicology practices
Sarcopenia
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Author : Kunihiro Sakuma
language : en
Publisher: Elsevier
Release Date : 2021-07-23
Sarcopenia written by Kunihiro Sakuma and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-23 with Medical categories.
Sarcopenia: Molecular Mechanism and Treatment Strategies provides answers and guidance on a disease that has serious health consequences in terms of fractures, frailty, disability and diminished quality of life. Written by experts around the world, this book is for all those that care for aging populations. As the global population ages, sarcopenia remains a therapeutic challenge and major public health concern. Difficulties in defining sarcopenia as a clinical phenotype remain and have hindered treatment. Covers physical, dietary and pharmacological strategies to maintain adequate muscle mass to ensure healthy aging Provides a complete and up-to-date reference on molecular mechanisms of sarcopenia Presents a clear definition of sarcopenia, along with the latest research in one volume
Beyond Borders Myotonic Dystrophies A European Perception
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Author : Benedikt Schoser
language : en
Publisher: Frontiers Media SA
Release Date : 2019-01-21
Beyond Borders Myotonic Dystrophies A European Perception written by Benedikt Schoser and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-21 with categories.
Myotonic dystrophies (DMs) are pleotropic multisystemic diseases. These dominantly transmitted repeat disorders affect multiple organs of the human body at all ages – from the newborns to the elderly. The present Research Topic represents a timely addition to the expanding body of evidence which aims to provide novel perspectives in our understanding of myotonic dystrophies. This collection of original contributions and standpoint reviews from multiple leading DM centres in Europe describes the state of the art for the characterization of the DMs diseases, the development of molecular strategies to target its multisystemic nature, and provides evidence of screening and testing novel therapeutic avenues.