Pathophysiological Mechanisms Of Sarcopenia In Aging And In Muscular Dystrophy A Translational Approach
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Pathophysiological Mechanisms Of Sarcopenia In Aging And In Muscular Dystrophy A Translational Approach
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Author : Luciano Merlini
language : en
Publisher: Frontiers Media SA
Release Date : 2016-01-18
Pathophysiological Mechanisms Of Sarcopenia In Aging And In Muscular Dystrophy A Translational Approach written by Luciano Merlini and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-01-18 with Electronic book categories.
Loss of muscle mass and increased fibrosis characterize both sarcopenia of aging and muscular dystrophy. Research is increasingly showing that these two conditions also share several pathophysiological mechanisms, including mitochondrial dysfunction, increased apoptosis, abnormal modulation of autophagy, decline in satellite cells, increased generation of reactive oxygen species, and abnormal regulation of signaling and stress response pathways. This Research Topic will cover several mechanisms involved in aging and dystrophic sarcopenia and explore the therapeutic potential of various strategies for intervention.
Osteosarcopenia Bone Muscle And Fat Interactions
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Author : Gustavo Duque
language : en
Publisher: Springer Nature
Release Date : 2019-11-06
Osteosarcopenia Bone Muscle And Fat Interactions written by Gustavo Duque and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-06 with Science categories.
This edited work presents the most current evidence on osteosarcopenia from bench to bedside, which is expected to facilitate the understanding of this syndrome and to develop preventive and therapeutic strategies. With our aging population, chronic diseases such as osteoporosis and sarcopenia are becoming highly prevalent. Fortunately, our understanding of the bone and muscle interactions has increased in recent years. This has allowed to the coining of the term osteosarcopenia to describe a syndrome in which these two diseases overlap. This overlap between osteoporosis and sarcopenia has major negative effects not only on our older adults but also on health systems worldwide. Readers will find a highly translational approach that starts with a summary of recent discoveries on stem cells biology, muscle and bone interactions – including the role of local bone and muscle fat – followed by comprehensive reviews on myokines (i.e. myostatin), osteokines (i.e. osteocalcin) and adipokines (i.e. interleukins) as major players and determinants of bone and muscle loss with aging. In addition, the role of sex steroids (i.e. estrogens, androgens), and calciotropic hormones (i.e. parathyroid hormone, vitamin D) in the pathogenesis of this syndrome is also reviewed. Moreover, using practical diagnostic and therapeutic tips, this book summarizes the clinical characteristics of osteosarcopenic patients thus facilitating the diagnosis and treatment of this syndrome in clinical practice. Finally, the book presents the case for the Falls and Fractures Clinic as the optimal model of care for this syndrome, aimed to avoid fragmentation and optimize osteosarcopenia care, and simultaneously prevent falls and fractures in older persons. This book offers relevant information on the mechanisms of osteosarcopenia, and a practical guide on how to identify and treat this geriatric syndrome and its adverse outcomes, which are dramatically affecting our aging population. The work is written by leaders in the field and is especially suited not only to any researcher in the musculoskeletal arena but also to medical specialists and allied health professionals involved in the care of older persons.
Sarcopenia
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Author : Kunihiro Sakuma
language : en
Publisher: Elsevier
Release Date : 2021-07-22
Sarcopenia written by Kunihiro Sakuma and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-22 with Medical categories.
Sarcopenia: Molecular Mechanism and Treatment Strategies provides answers and guidance on a disease that has serious health consequences in terms of fractures, frailty, disability and diminished quality of life. Written by experts around the world, this book is for all those that care for aging populations. As the global population ages, sarcopenia remains a therapeutic challenge and major public health concern. Difficulties in defining sarcopenia as a clinical phenotype remain and have hindered treatment. Covers physical, dietary and pharmacological strategies to maintain adequate muscle mass to ensure healthy aging Provides a complete and up-to-date reference on molecular mechanisms of sarcopenia Presents a clear definition of sarcopenia, along with the latest research in one volume
Manfaat Buah Pala Sebagai Antisarcopenia
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Author : Yuni Susanti Pratiwi
language : id
Publisher: Deepublish
Release Date : 2019-09-01
Manfaat Buah Pala Sebagai Antisarcopenia written by Yuni Susanti Pratiwi and has been published by Deepublish this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-01 with Science categories.
Indonesia adalah Negara tropis yang kaya akan biodiversitas tanaman herbal yang mempunyai berbagai manfaat kesehatan. Salah satu bagian dari tanaman herbal yang dipercaya memiliki khasiat kesehatan adalah biji pala/nutmeg (Myristica fragnans). Secara tradisional, biji pala digunakan untuk memasak dan terbukti meningkatkan metabolism lemak yang pada akhirnya menurunkan kadar kolesterol dan triglister dalam darah. Menariknya, biji pala juga terbukti memiliki khasiat tersembunyi sebagai anti-sarcopenia melalui aktivasi signaling IGF1-Akt-mTOR pathway yang menghambat aktivitas penghancuran organel sel dan protein spesifik (autophagy) di dalam sel otot. Melalui buku ini, kami berharap pembaca dapat memahami secara mendetail tentang biji pala, mulai dari taksnomi, pemurniannya, isolasi potensial zak aktif dan sampai pada aktivitas biologisnya secara molecular. Pendekatan ilmiah inilah yang menjadi dasar untuk aplikasi klinik pada pasien di masa yang akan datang.
Muscle Homeostasis And Regeneration
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Author : Antonio Musarò
language : en
Publisher: MDPI
Release Date : 2020-11-20
Muscle Homeostasis And Regeneration written by Antonio Musarò and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-20 with Science categories.
The book is a collection of original research and review articles addressing the intriguing field of the cellular and molecular players involved in muscle homeostasis and regeneration. One of the most ambitious aspirations of modern medical science is the possibility of regenerating any damaged part of the body, including skeletal muscle. This desire has prompted clinicians and researchers to search for innovative technologies aimed at replacing organs and tissues that are compromised. In this context, the papers, collected in this book, addressing a specific aspects of muscle homeostasis and regeneration under physiopathologic conditions, will help us to better understand the underlying mechanisms of muscle healing and will help to design more appropriate therapeutic approaches to improve muscle regeneration and to counteract muscle diseases.
The Molecular Nutrition Of Amino Acids And Proteins
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Author : Dominique Dardevet
language : en
Publisher: Academic Press
Release Date : 2016-06-08
The Molecular Nutrition Of Amino Acids And Proteins written by Dominique Dardevet and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-06-08 with Health & Fitness categories.
The Molecular Nutrition of Amino Acids and Proteins provides an in-depth look at the involvement and role of amino acids and proteins in molecular nutrition. Editor Dominique Dardevet has assembled a collection of chapters written by leading researchers and top professors that provide the reader with a comprehensive understanding of amino acids and proteins. The book provides an introduction to the fundamentals of amino acids and proteins as well as the composition of food. It then delves into the molecular biology of the cell and genetic machinery and its function. The Molecular Nutrition of Amino Acids and Proteins also features reference guides for terms and bullet-point summaries, making it readily accessible to novices while still providing the most up-to-date and detailed information that experienced researchers need. Provides a gentle introduction to the subject by first addressing nutritional information and then building in molecular aspects, clearly establishing fundamental information for the reader Facilitates reader comprehension by including succinct summary points in each chapter Contains a glossary of definitions that allows readers to easily reference terms Provides both a deep and broad understanding of the subject by containing overviews as well as detail-focused chapters
Muscle Regeneration
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Author : Alexander Mauro
language : en
Publisher: Raven Press (ID)
Release Date : 1979
Muscle Regeneration written by Alexander Mauro and has been published by Raven Press (ID) this book supported file pdf, txt, epub, kindle and other format this book has been release on 1979 with Medical categories.
The Unfolded Protein Response
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Author : Roberto Pérez-Torrado
language : en
Publisher: Humana
Release Date : 2022-01-06
The Unfolded Protein Response written by Roberto Pérez-Torrado and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-06 with Science categories.
This volume is divided in six section covering the most experimental approaches involved in the study of the unfolded protein response (UPR) pathway. Chapters detail determination of unfolded protein levels, methods to study UPR signal transmission, analysing the outcomes of the UPR pathway activation, UPR studies in mammalian models, UPR in alternative models, and UPR and disease. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, The Unfolded Protein Response: Methods and Protocols aims to describe key methods and approaches used in the study of the UPR pathway and its complex cellular implications. Chapter 6 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Muscle Atrophy
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Author : Junjie Xiao
language : en
Publisher: Springer
Release Date : 2018-11-02
Muscle Atrophy written by Junjie Xiao and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-02 with Science categories.
The book addresses the development of muscle atrophy, which can be caused by denervation, disuse, excessive fasting, aging, and a variety of diseases including heart failure, chronic kidney diseases and cancers. Muscle atrophy reduces quality of life and increases morbidity and mortality worldwide. The book is divided into five parts, the first of which describes the general aspects of muscle atrophy including its characteristics, related economic and health burdens, and the current clinical therapy. Secondly, basic aspects of muscle atrophy including the composition, structure and function of skeletal muscle, muscle changes in response to atrophy, and experimental models are summarized. Thirdly, the book reviews the molecular mechanisms of muscle atrophy, including protein degradation and synthesis pathways, noncoding RNAs, inflammatory signaling, oxidative stress, mitochondria signaling, etc. Fourthly, it highlights the pathophysiological mechanisms of muscle atrophy in aging and disease. The book’s fifth and final part covers the diagnosis, treatment strategies, promising agents and future prospects of muscle atrophy. The book will appeal to a broad readership including scientists, undergraduate and graduate students in medicine and cell biology.
Haschek And Rousseaux S Handbook Of Toxicologic Pathology Volume 4 Toxicologic Pathology Of Organ Systems
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Author : Wanda M. Haschek
language : en
Publisher: Elsevier
Release Date : 2024-05-02
Haschek And Rousseaux S Handbook Of Toxicologic Pathology Volume 4 Toxicologic Pathology Of Organ Systems written by Wanda M. Haschek and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-02 with Medical categories.
Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume Four: Toxicologic Pathology of Organ Systems is a key reference on the integration of structure and functional changes in tissues associated with the response to pharmaceuticals, chemicals and biologics. Organ systems covered include cardiac, vascular and skeletal muscle systems and the endocrine, respiratory, reproductive, digestive and nervous systems. Completely revised with a new olfactory chapter, this new release is an essential part of the most authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists and regulators studying and making decisions on drugs, biologics, medical devices, and other chemicals, including agrochemicals and environmental contaminants. Presents updated chapters on systems toxicologic pathology, including new chapter on olfactory Offers high-quality and trusted content in a multi-contributed work written by leading international authorities in all areas of toxicologic pathology Features hundreds of full-color images in both the print and electronic versions to highlight difficult concepts with clear illustrations