Pdcd1and Male Infertility Pdf
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Co Signal Molecules In T Cell Activation
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Author : Miyuki Azuma
language : en
Publisher: Springer Nature
Release Date : 2019-11-22
Co Signal Molecules In T Cell Activation written by Miyuki Azuma and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-22 with Medical categories.
This book equips young immunologists and health professionals with a clear understanding of the fundamental concepts and roles of co-signal molecules and in addition presents the latest information on co-stimulation. The first part of the book is devoted to co-signal molecules and the regulation of T cells. Following an initial overview, subsequent chapters examine each co-signal molecule in turn and discuss the mechanisms by which co-signal molecules regulate the different types of T cell. The second part covers various clinical applications, including in autoimmune disease, neurological disorders, transplantation, graft-versus-host disease, and cancer immunotherapy. To date, co-stimulation blockade and co-inhibition blockade have shown beneficial effects and many additional clinical trials targeting co-signal molecules are ongoing. The mechanisms underlying these successful treatments are explained and the future therapeutic potential in the aforementioned diseases is evaluated. Co-signal Molecules in T Cell Activation will be a valuable reference guide to co-stimulation for basic and clinical researchers in the fields of both immunology and pharmaceutical science.
Nanobiomedicine
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Author : Shailendra K. Saxena
language : en
Publisher: Springer Nature
Release Date : 2020-02-03
Nanobiomedicine written by Shailendra K. Saxena and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-03 with Medical categories.
This book provides a comprehensive overview of the recent trends in various Nanotechnology-based therapeutics and challenges associated with its development. Nanobiotechnology is an interdisciplinary research that has wide applications in the various fields of biomedical research. The book discusses the various facets of the application of Nanotechnology in drug delivery, clinical diagnostics, Nanomedicine and treatment of infectious and chronic diseases. The book also highlights the recent advancements on important devices and applications that are based on Nanotechnology in medicine and brief the regulatory and ethical issues related to nanomedical devices. It also reviews the toxicological profile of various nanomaterials and emphasizes the need for safe nanomaterials for clinical use. Finally, the book discusses the recent developments of potential commercial applications of Nanotechnology.
Generation And Effector Functions Of Regulatory Lymphocytes
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Author : Gregory R. Bock
language : en
Publisher: John Wiley & Sons
Release Date : 2004-01-19
Generation And Effector Functions Of Regulatory Lymphocytes written by Gregory R. Bock and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-01-19 with Science categories.
Over the last several years, immunologists have re-discovered the importance of regulatory lymphocytes, formerly termed 'suppressor cells'. Many recent reports have documented their existence, effector functions and potential therapeutic benefits in autoimmunity and transplantation. However, even though modern techniques have allowed us to get a much more detailed picture of these cells, they are still highly controversial. Several unresolved issues responsible for this dilemma are discussed in this book: it is difficult to grow and clone such cells, their phenotypes and effector functions are diverse and can sometimes easily be lost, and it is not well understood how they interact with antigen-presenting cells. This book contains contributions from leading investigators from around the world, including lively discussion of the current state of the art in studies of regulatory lymphocytes. Topics featured are the physiological control of autoimmunity, the role of antigen-specific cells in various diseases and disease models and effector mechanisms. Therapeutic applications are considered, particularly for type 1 diabetes, tissue transplantation and the control of viral infection. This important and groundbreaking book should be of interest to all immunologists. Related Novartis Foundation symposia: 254 Immunoinformatics: bioinformatic strategies for better understanding of immune function Chair: Hans-Georg Rammensee 256 Cancer and inflammation Chair: Siamon Gordon
Molecular Infection Biology
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Author : Jörg Hinrich Hacker
language : en
Publisher: Wiley-Spektrum
Release Date : 2002-10-03
Molecular Infection Biology written by Jörg Hinrich Hacker and has been published by Wiley-Spektrum this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-10-03 with Medical categories.
This comprehensive volume focuses on molecular methods and principles of prokaryotic and eukaryotic pathogens. The authors present the molecular and cellular aspects by focusing on the interactions between pathogenic microorganisms and their hosts. The publication begins with an overview of the most important and dangerous causative agents of infectious diseases. Next are discussions of how microbial "weapons," pathogenicity factors, protein secretion machines, and surface variation systems work, presenting the molecular and genetic methods that are used by scientists for their discovery and analysis. Furthermore, infectious diseases are discussed in light of the newly formed research areas of evolutionary and cellular microbiology and genomics. Future aspects on diagnostic techniques, therapy, and vaccine development are also presented.
Targeted Therapies In Cancer
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Author : Manfred Dietel
language : en
Publisher: Springer
Release Date : 2014-11-23
Targeted Therapies In Cancer written by Manfred Dietel and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-23 with Medical categories.
From its introduction, oncological chemotherapy has been encumbered by poor selectivity because antiproliferative drugs are often toxic not only to tumor cells but also to important populations of the body’s non-neoplastic cells. Modern targeted therapies interact with defined molecules present on cancer cells, adding increased selectivity to their toxic effects. This book presents an integrated critical view on the theories, mechanisms, problems and pitfalls of the targeted therapy approach.
Guided Endodontics
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Author : Niraj Kinariwala
language : en
Publisher: Springer Nature
Release Date : 2020-11-21
Guided Endodontics written by Niraj Kinariwala and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-21 with Medical categories.
This superbly illustrated book provides a comprehensive overview of guided endodontics, a technology-driven, contemporary treatment approach that represents a paradigm shift in endodontics. Guided endodontics is now the proven, safe, predictable and, clinically, the most effective method for management of calcified root canals and root-end resection surgeries. This book covers detailed step-by-step digital treatment planning and the clinical application of static guides and dynamic navigation systems for, both, surgical and non-surgical endodontic treatment. In essence, this novel technology utilizes preoperative CBCT scans and intra-oral 3D scans as well as uniquely developed special software, for virtual planning of the endodontic treatment. This book delineates 3D printing, CBCT, digital impression systems, static guide designing with different software and clinical application of static and dynamic navigation in endodontics and much more. The concluding chapter addresses the future trends in 3D guidance in endodontics, in particular, and dentistry in general.
Vegetative Physiology And Biochemistry
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Author : Hugh Davson
language : en
Publisher: Elsevier
Release Date : 2014-05-12
Vegetative Physiology And Biochemistry written by Hugh Davson and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-12 with Medical categories.
The Eye: Volume 1, Vegetative Physiology and Biochemistry is a compendium of papers that describes the physiology of the eye, particularly its gross anatomy and embryology including its intra-ocular fluids, the intra-ocular pressure, the vitreous body, lens, cornea, and sciera. Several papers review the eyeball, the protective apparatus of the eye, the structure of the tissue in relation to the intra-ocular fluids, and the flow of aqueous humor. Several methods can be used to measure the intra-ocular pressure such as the manometric method and the tonometer. Giles (1959) reports that tonometer measurements in the newborn are within the normal adult range. One paper notes that in man, liquefaction of the vitreous body (the clear jelly-like structure which fills the space between retina and lens,) which is caused by dissolution of the fibrous network, is never repaired. This suggests that new fibers are either not formed or are formed in insufficient amounts. Another paper examines the relationship between pressure in the eye vessels and eye tension. Investigators and researches in the fields of physiology, psychology, ophthalmology, and in all branches of ocular physiology will find the compendium very rewarding.
Microbiome Host Interactions
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Author : D. Dhanasekaran
language : en
Publisher: CRC Press
Release Date : 2021-04-01
Microbiome Host Interactions written by D. Dhanasekaran and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-04-01 with Medical categories.
Microbiota are a promising and fascinating subject in biology because they integrate the microbial communities in humans, animals, plants, and the environment. In humans, microbiota are associated with the gut, skin, and genital, oral, and respiratory organs. The plant microbial community is referred to as "holobiont," and it is influential in the maintenance and health of plants, which themselves play a role in animal health and the environment. The contents of Microbiome-Host Interactions cover all areas as well as new research trends in the fields of plant, animal, human, and environmental microbiome interactions. The book covers microbiota in polar soil environments, in health and disease, in Caenorhabditis elegans, and in agroecosystems, as well as in rice root and actinorhizal root nodules, speleothems, and marine shallow-water hydrothermal vents. Moreover, this book provides comprehensive accounts of advanced next-generation DNA sequencing, metagenomic techniques, high-throughput 16S rRNA sequencing, and understanding nucleic acid sequence data from fungal, algal, viral, bacterial, cyanobacterial, actinobacterial, and archaeal communities using QIIME software (Quantitative Insights into Microbial Ecology). FEATURES Summarizes recent insight in microbiota and host interactions in distinct habitats, including Antarctic, hydrothermal vents, speleothems, oral, skin, gut, feces, reproductive tract, soil, root, root nodules, forests, and mangroves Illustrates the high-throughput amplicon sequencing, computational techniques involved in the microbiota analysis, downstream analysis and visualization, and multivariate analysis commonly used for microbiome analysis Describes probiotics and prebiotics in the composition of the gut microbiota, skin microbiome impact in dermatologic disease prevention, and microbial communities in the reproductive tract of humans and animals Presents information in a reachable way for students, teachers, researchers, microbiologists, computational biologists, and other professionals who are interested in strengthening or enlarging their knowledge about microbiome analysis with next-generation DNA sequencing in the different branches of the sciences
Auxin Signaling 2
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Author : ESTELLE ET AL
language : en
Publisher:
Release Date : 2021-03-31
Auxin Signaling 2 written by ESTELLE ET AL and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-31 with categories.
Leukemia And Lymphoma
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Author : Theodore F. Zipf
language : en
Publisher: Springer Science & Business Media
Release Date : 2003
Leukemia And Lymphoma written by Theodore F. Zipf and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Medical categories.
The techniques range from the use of patient-specific immunophenotypes to identify residual leukemia in patients who are in remission, to a variety of PCR techniques for detecting residual disease and measuring its level. Reverse transcription PCR (RT-PCR) is applied to acute myeloid leukemia (AML), chronic myelogenous leukemia (CML), and acute promyelocytic leukemia (APL). Other PCR methods are used for non-Hodgkin's lymphoma and for the monitoring of follicular lymphoma.