Peptide Antibodies
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Peptide Antibodies
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Author : Gunnar Houen
language : en
Publisher: Humana
Release Date : 2015-10-02
Peptide Antibodies written by Gunnar Houen and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-10-02 with Medical categories.
This extensive volume covers basic and advanced aspects of peptide antibody production, characterization and uses. Although peptide antibodies have been available for many years, they continue to be a field of active research and method development. For example, peptide antibodies which are dependent on specific posttranslational modifications are of great interest, such as phosphorylation, citrullination and others, while different forms of recombinant peptide antibodies are gaining interest, notably nanobodies, single chain antibodies, TCR-like antibodies, among others. Within this volume, those areas are covered, as well as several technical and scientific advances: solid phase peptide synthesis, peptide carrier conjugation and immunization, genomics, transcriptomics, proteomics and elucidation of the molecular basis of antigen presentation and recognition by dendritic cells, macrophages, B cells and T cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls. Comprehensive and authoritative, Peptide Antibodies: Methods and Protocols serves as an ideal reference for researchers exploring this vital and expansive area of study.
Design Production And Characterization Of Peptide Antibodies
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Author : Nicole Hartwig Trier
language : en
Publisher: Mdpi AG
Release Date : 2023-07-05
Design Production And Characterization Of Peptide Antibodies written by Nicole Hartwig Trier and has been published by Mdpi AG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-05 with Science categories.
Antibodies are key reagents in diagnostics and experimental biology, capable of detecting numerous antigenic targets. Proteins are often in focus and are usually effective targets for antibody production. Occasionally, however, the native protein is known but not available, or a very specific target is required. In these cases, synthetic peptides, copying essential sequences from the target, are good alternatives for antibody production. Peptide antibodies have been used in diagnostics and experimental biology with great success, especially because they can be produced to multiple targets, for example, native and denatured targets. Traditional peptide antibody proteins encompass animal-based immunization with a synthetic peptide, usually conjugated to a carrier protein to enhance immune presentation, as small peptides tend not to be immunogenic by themselves. There are several strategies for the conjugation of peptides to carriers applied for immunization. This is the most used approach for peptide antibody production. In addition to traditional peptide antibody production, peptide antibodies can be produced using libraries or sequencing. This Special Issue, "Design, Production and Characterization of Peptide Antibodies", aims to describe the current state-of-the-art techniques and characterization/applications within the field as well as new and emerging uses of peptide antibodies.
Peptide Antigens
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Author : G. Brian Wisdom
language : en
Publisher: IRL Press
Release Date : 1994
Peptide Antigens written by G. Brian Wisdom and has been published by IRL Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Medical categories.
Peptide antigens and their antibodies have been widely exploited for the measurement, location, and purification of oligopeptides such as peptide hormones. Recently, the use of peptides to mimic substructures of proteins has led to major expansion in the application of anti-peptide antibodies. These have been especially important in identifying the characterizing proteins which are only known by their primary structure derived from a DNA sequence. Another area of recent expansion is the use of defined peptided antigens to identify and map antibodies and T-cell receptors. This book provides information and detailed protocols for the main techniques for exploitation of peptide antigens and anti-peptide antibodies, and will interest research workers in many fields.
Synthetic Peptides As Antigens
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Author : Ruth Porter
language : en
Publisher: John Wiley & Sons
Release Date : 2008-04-30
Synthetic Peptides As Antigens written by Ruth Porter and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-30 with Medical categories.
The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.
Immunobiology Of Proteins And Peptides Vi
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Author : M. Zouhair Atassi
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Immunobiology Of Proteins And Peptides Vi written by M. Zouhair Atassi and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The articles in this volume represent papers delivered by invited speakers at the 6th International Symposium on the Immunobiology of Proteins and Peptides. In addition, a few of the abstracts submitted by participants were scheduled for minisymposia and some of the authors, whose presentations were judged by the Scientific Council to be of high quality, were invited to submit papers for publication in this volume. This symposium was established in 1976 for the purpose of bringing together, once every two or three years, active investigators in the forefront of contemporary immunology, to present their findings and discuss t heir significance in the light of current concepts and to identify important new directions of investigation. The founding of the symposium was stimulated by the achievement of major breakthroughs in the understanding of the immune recognition of proteins and peptides. We believed that these breakthroughs will lead to the creation of a new generation of peptide reagents which should have enormous potential in biological, therapeutic and basic applications. This anticipated explosion has in fact since occurred and many applications of these pep tides are now being realized.
Biochemistry Of Antibodies
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Author : R. Nezlin
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Biochemistry Of Antibodies written by R. Nezlin and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
When the history of immunology in the twentieth century is written, the decade of the 1960's will, in all probability, stand out as the period of greatest advance in the development of molecular immunology. It is appropriate and useful, therefore, that a schol arly and integrated presentation of this progress should be made available in English. The translation of Dr. Nezlin's "Biochem istry of Antibodies" from Russian admirably fulfills this need in the form of a scientific monograph directed to medical and biolog ical scientists. The appearance of this monograph also serves to emphasize the conceptual unification of diverse immunological phenomena which has emerged from progress in molecular immunology. This unity is a consequence of the key role played by the antibody mol ecule (either in solution or cell-bound) in every biological process properly described as immunological. Indeed, immunology as an independent natural science can be described as the study of the structure, interactions, and biosynthes is of the antibody molecule.
Antibodies Their Structure And Function
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Author : M.W. Steward
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Antibodies Their Structure And Function written by M.W. Steward and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
The student of biological science in his final years as an undergraduate and his first years as a graduate is expected to gain some familiarity with current research at the frontiers of his discipline. New research work is published in a perplexing diversity of publications and is inevitably con cerned with the minutiae of the subject. The sheer number of research journals and papers also causes confusion and difficulties of assimilation. Review articles usually presuppose a background knowledge of the field and are inevitably rather restricted in scope. There is thus a need for short but authoritative introductions to those areas of modern biological research which are either not dealt with in standard introductory textbooks or are not dealt with in sufficient detail to enable the student to go on from them to read scholarly reviews with profit. This series of books is designed to satisfy this need. The authors have been asked to produce a brief outline of their subject assuming that their readers will have read and remembered much of a standard introductory textbook of biology. This outline then sets out to provide by building on this basis, the conceptual framework within which modern research work is progressing and aims to give the reader an indication of the problems, both conceptual and practical, which must be overcome if progress is to be maintained.
Monoclonal Antibodies And Peptide Therapy In Autoimmune Diseases
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Author : Jean-François Bach
language : en
Publisher: Marcel Dekker
Release Date : 1993
Monoclonal Antibodies And Peptide Therapy In Autoimmune Diseases written by Jean-François Bach and has been published by Marcel Dekker this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Medical categories.
Combining principles of modern immunology with applications to immunopathology, this reference documents developments in the immunotherapy of autoimmune diseases - emphasizing monoclonal antibody and peptide approaches. receptor itself to intervening at the level of the major histocompatibility complex (MHC) antigens, Monoclonal Antibodies and Peptide Therapy in Autoimmune Diseases: provides an update on T-cell basic science; discusses most monoclonal antibodies used in autoimmune disease experiments; describes the concept of peptide therapy in its various forms; and presents fundamental pharmacological data that clarify the clinical usage of these new agents. Therapy in Autoimmune Diseases should be a useful resource for immunologists, rheumatologists, pharmacologists, pathologists, dermatologists, nephrologists, and graduate and medical school students in these disciplines.
Phage Display Of Peptides And Proteins
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Author : Brian K. Kay
language : en
Publisher: Elsevier
Release Date : 1996-10-23
Phage Display Of Peptides And Proteins written by Brian K. Kay and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-10-23 with Science categories.
Both novices and experts will benefit from this insightful step-by-step discussion of phage display protocols.Phage Display of Peptides and Proteins: A Laboratory Manual reviews the literature and outlines the strategies for maximizing the successful application of phage display technology to one's research. It contains the most up-to-date protocols for preparing peptide affinity reagents, monclonal antibodies, and evolved proteins. Prepared by experts in the field Provides proven laboratory protocols, troubleshooting, and tips Includes maps, sequences, and sample data Contains extensive and up-to-date references
Synthetic Polypeptides As Antigens
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Author : J.P. Briand
language : en
Publisher: Elsevier
Release Date : 1988-11-01
Synthetic Polypeptides As Antigens written by J.P. Briand and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988-11-01 with Medical categories.
Synthetic Polypeptides as Antigens is the first volume to give a comprehensive treatment under one cover of the various techniques used for synthesizing peptides by the solid phase approach, for coupling them to carrier molecules and analyzing their immunochemical activity by a variety of immunoassays. This book also describes methods for analyzing the antigenic structure of proteins and predicting the location of their antigenic sites. Recent advances in the detection of gene products with antipeptide antibodies, and the still controversial use of synthetic peptides as vaccines are also described. The book provides: - detailed descriptions of procedures - extensive bibliography - detailed analysis of the structural basis of antigenicity in proteins Synthetic Polypeptides as Antigens is intended for researchers and graduate students in molecular biology, protein structure, immunology, virology, and microbiology. Those using synthetic peptides as immunological probes will find this a most useful book, as will those wishing to overcome the difficulties of achieving antigenic mimicry by synthesis.