Peptide Nucleic Acids
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Peptide Nucleic Acids
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Author : Peter E. Nielsen
language : en
Publisher: Garland Science
Release Date : 2004
Peptide Nucleic Acids written by Peter E. Nielsen and has been published by Garland Science this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with DNA categories.
Peptide Nucleic Acids, Second Edition has been extensively revised, updated, and enlarged to contain many new chapters covering the most recent topics and applications in this fast-moving field. The book contains state-of-the-art protocols and applications on all aspects of peptide nucleic acids. Concepts are clearly explained with each chapter containing concise background information. Written by leading experts in the field, the book is an invaluable and complete reference work on this novel and exciting area.
Peptide Nucleic Acids
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Author : Peter E. Nielsen
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-04
Peptide Nucleic Acids written by Peter E. Nielsen and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-04 with Science categories.
Peptide nucleic acids (PNAs) have now existed for slightly more than ten years, with the interest in and applications of this pseudopeptide DNA mimic steadily increasing during the entire period. PNAs have rapidly attracted the attention of scientists from a diversity of fields ranging from (bio)organic and biophysical chemistry to prebiotic evolution, and from molecular biology to genetic diagnostics and drug development. Many of the applications take advantage of the unique properties of PNA—an uncharged pseudopeptide—that distinguish this DNA mimic from more traditional DNA analogs. Rather than trying to create a comprehensive collection of all published methods and protocols involving PNA—many of which have not yet been validated— I have decided to concentrate on select protocols that are either very well established by several groups around the world, such as PCR-clamping and in situ hybridization, or on new methods that may have broader future impact. Basic methods for PNA oligomer synthesis and analyses have also been included. I am very grateful to those friends and colleagues who have enthusiastically contributed their work, discussions, and writing, and thereby made this book possible. Peter E. Nielsen v Contents Preface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v Contributors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ix IINTRODUCTION 1 PNA Technology Peter E. Nielsen. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 II CHEMISTRY 2 Solid Phase Synthesis of PNA Oligomers Frederik Beck. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 29 3 Synthesis of PNA-Peptide Conjugates Satish Kumar Awasthi and Peter E. Nielsen. . . . . . . . . . . . . . . . . . 43 4 Parallel Synthesis of PNA-Peptide Conjugate Libraries Satish Kumar Awasthi and Peter E. Nielsen. . . . . . . . . . . . . . . . . .
Peptide Nucleic Acids Morpholinos And Related Antisense Biomolecules
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Author : Christopher Janson
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-03-06
Peptide Nucleic Acids Morpholinos And Related Antisense Biomolecules written by Christopher Janson and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-03-06 with Medical categories.
This volume is unique to the existing literature in the Peptide Nucleic Acid field, in that it focuses on comparing and contrasting PNA with other available oligonucleotide homologues and considers areas in which these biomolecules could be profitably applied to clinical and diagnostic applications. Part I of the book addresses comparative strengths and weaknesses of various nucleoside homologues. Part II of the book addresses specific translational or clinical applications for PNA and related antisense biomolecules. The editors have succeeded in presenting a balanced yet broad view of the methods available for gene targeting and modification.
Peptide Nucleic Acids
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Author : Eylon Yavin
language : en
Publisher:
Release Date : 2020-09-10
Peptide Nucleic Acids written by Eylon Yavin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-10 with categories.
This book compiles four review articles and four research papers that highlight recent developments in the field of peptide nucleic acid (PNA) chemistry and biomedicine. The review articles encompass a variety of fields related to PNA, emphasizing the versatility of this DNA mimic. Two excellent reviews detail the use of PNA for molecular diagnostics of miRNAs and genetic point mutations (SNPs). Another review provides a comprehensive analysis of the various approaches for gene editing using chemically modified PNA molecules. Lastly, PNA molecules are elegantly described as effective (antisense) antimicrobial agents in the final review. The high binding affinity of PNA to complementary DNA and RNA is highlighted in three research articles. Two articles show how PNA molecules act as splice modulating and RNA masking molecules, separately. In another contribution, the high affinity and achiral characteristics of PNAs are used to developed a stable L-DNA-based catalytic hairpin assembly. Lastly, chemically-modified PNA molecules are shown to be superior probes for SNP detection. Altogether, these studies illustrate how PNA molecules may be useful for a variety of biomedical applications as either therapeutic or diagnostic agents.
Peptide Nucleic Acids
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Author : Christopher Janson
language : en
Publisher:
Release Date : 2003-01-01
Peptide Nucleic Acids written by Christopher Janson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-01-01 with categories.
Peptide Nucleic Acids Morpholinos And Related Antisense Biomolecules
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Author : Christopher Janson
language : en
Publisher: Springer
Release Date : 2008-11-01
Peptide Nucleic Acids Morpholinos And Related Antisense Biomolecules written by Christopher Janson and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-11-01 with Medical categories.
This volume is unique to the existing literature in the Peptide Nucleic Acid field, in that it focuses on comparing and contrasting PNA with other available oligonucleotide homologues and considers areas in which these biomolecules could be profitably applied to clinical and diagnostic applications. Part I of the book addresses comparative strengths and weaknesses of various nucleoside homologues. Part II of the book addresses specific translational or clinical applications for PNA and related antisense biomolecules. The editors have succeeded in presenting a balanced yet broad view of the methods available for gene targeting and modification.
Pseudo Peptides In Drug Discovery
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Author : Peter E. Nielsen
language : en
Publisher: John Wiley & Sons
Release Date : 2006-03-06
Pseudo Peptides In Drug Discovery written by Peter E. Nielsen and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-03-06 with Science categories.
Peptides are among the most versatile bioactive molecules, yet the do not make good drugs, because they are quickly degraded or modified in the body. To overcome this problem, stable and at the same time biologically active pseudo-peptides have been developed. These novel compounds open up new perspectives in drug design by providing an entire range of highly specific and non-toxic pharmaceuticals. This is the first work devoted to the topic and draws together knowledge gained on different types of peptidomimetics and other pseudo-peptides with drug properties. As such, it includes peptoids, beta-peptides, polyamide DNA binders as well as peptide nucleic acids. The expert authors and editor discuss chemical properties and stability, biological activity and reactivity, as well as practical aspects of synthesis, making this a prime resource for drug developers and bioorganic chemists working with these compounds.
Dna Targeting Molecules As Therapeutic Agents
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Author : Michael J Waring
language : en
Publisher: Royal Society of Chemistry
Release Date : 2018-03-08
Dna Targeting Molecules As Therapeutic Agents written by Michael J Waring and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-03-08 with Science categories.
There have been remarkable advances towards discovering agents that exhibit selectivity and sequence-specificity for DNA, as well as understanding the interactions that underlie its propensity to bind molecules. This progress has important applications in many areas of biotechnology and medicine, notably in cancer treatment as well as in future gene targeting therapies. The editor and contributing authors are leaders in their fields and provide useful perspectives from diverse and interdisciplinary backgrounds on the current status of this broad area. The role played by chemistry is a unifying theme. Early chapters cover methodologies to evaluate DNA-interactive agents and then the book provides examples of DNA-interactive molecules and technologies in development as therapeutic agents. DNA-binding metal complexes, peptide and polyamide–DNA interactions, and gene targeting tools are some of the most compelling topics treated in depth. This book will be a valuable resource for postgraduate students and researchers in chemical biology, biochemistry, structural biology and medicinal fields. It will also be of interest to supramolecular chemists and biophysicists.
Synthetic Studies On Peptide Nucleic Acids Microform 1 Toward A Circular Bis Peptide Nucleic Acid 2 Sequence And Linker Effects In Bis Pna Hybridization To Dna
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Author : Joseph Tse
language : en
Publisher: Library and Archives Canada = Bibliothèque et Archives Canada
Release Date : 2004
Synthetic Studies On Peptide Nucleic Acids Microform 1 Toward A Circular Bis Peptide Nucleic Acid 2 Sequence And Linker Effects In Bis Pna Hybridization To Dna written by Joseph Tse and has been published by Library and Archives Canada = Bibliothèque et Archives Canada this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with categories.
Finally, progress towards the synthesis of a circular bis -PNA ligand using a templated chemical ligation reaction is reported.
The Interaction Of Peptide Nucleic Acid With Complementary Single Stranded Dna And Double Stranded Dna In The Development Of A Genetic Screening Protocol
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Author : Alexis Sauer
language : en
Publisher:
Release Date : 1997
The Interaction Of Peptide Nucleic Acid With Complementary Single Stranded Dna And Double Stranded Dna In The Development Of A Genetic Screening Protocol written by Alexis Sauer and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with categories.