Peptides In Energy Balance And Obesity
DOWNLOAD
Download Peptides In Energy Balance And Obesity PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Peptides In Energy Balance And Obesity book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Peptides In Energy Balance And Obesity
DOWNLOAD
Author : G. Ühbeck
language : en
Publisher: CABI
Release Date : 2009-01-01
Peptides In Energy Balance And Obesity written by G. Ühbeck and has been published by CABI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-01-01 with Energy metabolism categories.
Obesity is one of the relevant public health concerns and it is evident that body weight control is achieved through highly integrated physiological interactions like nutrient selection. Presenting an account of the roles of specific peptides in energy balance, this title provides an understanding of the patho-physiology of energy balance.
Energy Metabolism And Obesity
DOWNLOAD
Author : Patricia A. Donohoue
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-12-26
Energy Metabolism And Obesity written by Patricia A. Donohoue and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-12-26 with Medical categories.
This unique and authoritative book presents an up-to-date overview of the many aspects of energy balance and its relationships to disease processes resulting from excess energy consumption and storage. It provides a comprehensive treatment of important research and clinical aspects of energy metabolism and obesity. It will be a valuable resource for endocrinologists, diabetes specialists, internists and family practitioners.
Textbook Of Energy Balance Neuropeptide Hormones And Neuroendocrine Function
DOWNLOAD
Author : Eduardo A. Nillni
language : en
Publisher: Springer
Release Date : 2018-07-20
Textbook Of Energy Balance Neuropeptide Hormones And Neuroendocrine Function written by Eduardo A. Nillni and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-07-20 with Medical categories.
This textbook presents for the first time a comprehensive body of the latest knowledge in the field of neuropeptides and their action on energy balance. It contains a detailed and comprehensive account of the specific hypothalamic peptides in regards to their roles in energy balance, food intake control and co-morbidities, to better understand the patho-physiology of obesity. The textbook includes an examination the history of the evolution of human society from a thin to the obese phenotype and, within that context, how modern society habits and industrial food production did not respect the evolutionary trait resulting in changes in the energy balance set point. It provides a novel conceptualization of the problem of obesity when considering the biochemistry of peptide hormones and entertaining novel ideas on multiple approaches to the problems of energy balance, as well as demonstrates and explains why alterations in pro-hormone processing are paramount to understand metabolic disease. This text is excellent material for teaching graduate and medical school courses, as well as a valuable resource for researchers in biochemistry, cell, and molecular biology, neuroscientists, physician endocrinologists, and nutritionists.
Endocrinology Of The Gut
DOWNLOAD
Author : Frank P. Brooks
language : en
Publisher:
Release Date : 1974
Endocrinology Of The Gut written by Frank P. Brooks and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1974 with Endocrine glands categories.
Sensory And Metabolic Control Of Energy Balance
DOWNLOAD
Author : Wolfgang Meyerhof
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-09-24
Sensory And Metabolic Control Of Energy Balance written by Wolfgang Meyerhof and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-09-24 with Science categories.
During the last two decades, the prevalence of obesity has dramatically increased in western and westernized societies. Its devastating health consequences include hypertension, cardiovascular diseases, or diabetes and make obesity the second leading cause of unnecessary deaths in the USA. As a consequence, obesity has a strong negative impact on the public health care systems. Recently emerging scienti?c insight has helped understanding obesity as a complex chronic disease with multiple causes. A multileveled gene–environment interaction appears to involve a substantial number of susceptibility genes, as well as associations with low physical activity levels and intake of high-calorie, low-cost, foods. Unfor- nately, therapeutic options to prevent or cure this disease are extremely limited, posing an extraordinary challenge for today’s biomedical research community. Obesity results from imbalanced energy metabolism leading to lipid storage. Only detailed understanding of the multiple molecular underpinnings of energy metabolism can provide the basis for future therapeutic options. Numerous aspects of obesity are currently studied, including the essential role of neural and endocrine control circuits, adaptive responses of catabolic and anabolic pathways, metabolic fuel sensors, regulation of appetite and satiation, sensory information processing, transcriptional control of metabolic processes, and the endocrine role of adipose tissue. These studies are predominantly fuelled by basic research on mammalian models or clinical studies, but these ?ndings were paralleled by important insights, which have emerged from studying invertebrate models.
Metabolic Basis Of Obesity
DOWNLOAD
Author : Rexford S. Ahima
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-11-16
Metabolic Basis Of Obesity written by Rexford S. Ahima and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-16 with Medical categories.
The obesity epidemic has generated immense interest in recent years due to the wide-ranging and significant adverse health and economic consequences that surround the problem. Much attention has been focused on behaviors that lead to obesity, in particular to over consumption of energy-dense food and to sedentary lifestyle. However, obesity is an extremely complex condition with poorly defined pathogenesis. Thanks to greatly enhanced research in the area, the discovery of pathways in the brain and peripheral organs that mediate energy homeostasis has provided a framework for understanding the biological basis of obesity. Metabolic Basis of Obesity adds an important new dimension to the growing literature on obesity by offering a comprehensive review of specifically how metabolic imbalance culminates in obesity. Developed by a team of expert authors, this important title discusses the principles of energy balance, genetics of body weight regulation, hormones and adipokines, and metabolic pathways in the brain, liver, muscle and fat, to name just several of the areas covered. The book also examines the connection between obesity and diabetes, cardiovascular disease and other complications. Current and future diagnostic and treatment strategies are also reviewed. Comprehensive and timely, Metabolic Basis of Obesity is an essential reference for understanding the burgeoning problem of obesity.
Regulatory Peptides And Energy Balance
DOWNLOAD
Author : Samar Ghourab
language : en
Publisher:
Release Date : 2010
Regulatory Peptides And Energy Balance written by Samar Ghourab and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.
Pediatric Endocrinology
DOWNLOAD
Author : M. Sperling
language : en
Publisher:
Release Date : 2002
Pediatric Endocrinology written by M. Sperling and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Medical categories.
This New Edition is today's most comprehensive, definitive reference in the field, incorporating all of today's explosive discoveries in basic and clinical endocrinology. Its reliable, cutting-edge guidance for a full range of problems is combined with a wealth of information on the physiological, biochemical, and genetic basis at the molecular biological level. Dr. Mark A. Sperling and 33 contributing experts bring readers the benefits of discovery at the bench and its application at the bedside. New chapters, extensive revisions, and compelling updates will keep readers at the forefront of the diagnosis and management of endocrine disease in children. Incorporates the explosive growth in molecular biology as it relates to developmental and pediatric endocrinology. Extensively revised and updated chapters throughout reflect the latest information. Coverage of up-to-the-minute topics in the field, including molecular, biochemical, and clinical basis of hyperinsulinemic hypoglycemia of infancy and childhood diabetes mellitus energy balance/obesity growth hormone paradigms of mechanisms of hormone action, and others Contributions from new authors from distinguished institutions Numerous brand-new illustrations depict the most current information, particularly the basic science/genetic basis of certain entities
The Role Of Central Nervous System Glucagon Like Peptide 1 In The Regulation Of Energy Balance
DOWNLOAD
Author : Jason G. Barrera
language : en
Publisher:
Release Date : 2009
The Role Of Central Nervous System Glucagon Like Peptide 1 In The Regulation Of Energy Balance written by Jason G. Barrera and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with categories.
Glucagon-like peptide-1 (GLP-1), a product of the preproglucagon (PPG) gene, is synthesized in the intestine and the nucleus of the solitary tract (NTS) and regulates numerous physiological processes, including glucose homeostasis and food intake. Exendin-4 (Ex4), a highly potent, long-acting GLP-1 receptor (GLP-1r) agonist, is used clinically for the treatment of type 2 diabetes mellitus (T2DM). Interestingly, in patients Ex4 not only improves glycemic control, but it also produces weight loss. This finding raises the possibility that the GLP-1 system may be a viable therapeutic target for obesity. To this end, the purpose of this dissertation was to further characterize the role of the central nervous system (CNS) GLP-1 system in the regulation of energy balance. Central administration of Ex4, like GLP-1, robustly reduces food intake. However, several lines of evidence suggest that Ex4 acts via distinct mechanisms. Therefore, we tested the hypothesis that the central anorectic effects of GLP-1 and Ex4 are different. Specifically, these effects, and their sensitivity to GLP-1r antagonists, were compared. In addition, the GLP-1r-dependence of central Ex4 was assessed in GLP-1r knockout (GLP-1r-/- ) mice. Consistent with our hypothesis, central Ex4 reduced food intake at doses significantly lower than those required by GLP-1, and this effect was not blocked by GLP-1r antagonists. In contrast, GLP-1r antagonists completely blocked the anorectic effect of peripheral Ex4. Finally, central Ex4 failed to reduce food intake in GLP-1r-/- mice, indicating that this effect is in fact GLP-1r-dependent. Although these data underscore the fact that central GLP-1r agonism is sufficient to reduce food intake, the role of the endogenous CNS GLP-1 system in the regulation of energy balance remains unclear. Therefore, we tested the hypothesis that endogenous CNS GLP-1 system activity is required for normal energy balance. Specifically, RNA interference was used to knock down NTS PPG, and chronic intracerebroventricular (ICV) infusion of the GLP-1r antagonist exendin (9-39) (Ex9) was used to block CNS GLP-1r. Consistent with our hypothesis, both NTS PPG knockdown and chronic ICV Ex9 resulted in hyperphagia. However, whereas NTS PPG knockdown exacerbated high-fat diet-induced fat accumulation, chronic ICV Ex9 increased fat accumulation irrespective of diet. Finally, NTS PPG expression was found to correlate positively with fat mass, suggesting that CNS GLP-1 system activity may be altered in obesity. Taken together, the data presented in this dissertation reveal a novel role for the CNS GLP-1 system in the long-term regulation of energy balance. Moreover, they indicate that the GLP-1r agonist Ex4 interacts uniquely with this system to produce a powerful anorectic signal. As such, future studies are warranted to determine optimal strategies to target the CNS GLP-1 system for the treatment of obesity.
Regulation Of Body Weight
DOWNLOAD
Author : Claude Bouchard
language : en
Publisher:
Release Date : 1996-06-19
Regulation Of Body Weight written by Claude Bouchard and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-06-19 with Medical categories.
The fact that about 30-40% of the adults in the Western world are overweight or obese testifies to the frequency of the disturbances in body weight regulation. Scientists have established that caloric intake, macronutrient composition of the diet, basal and resting metabolic rate, thermic response to food, energy expenditure associated with movement and physical activity, and preferential storage of the surplus of calories as fat or lean tissues are critical determinants of energy balance and body weight. While much has been learned, the field is poised for major advances with the advent of a variety of imaging techniques, progress in quantitative and molecular genetics, use of transgenic rodent models and of breeding experiments with informative inbred strains, availability of stable isotopes for metabolic and behavioral studies, and a growing number of useful experimental animal and human models. This volume takes an integrative approach to obesity. It is structured around four major topics: (1) the animal and human models currently available for the study of body weight regulation with their strengths and limitations, (2) the molecular and genetic basis of the regulation of body weight, (3) the metabolic and physiological mechanisms involved, and (4) the behavioral and social determinants. The 13 background papers provide a critical overview of the present knowledge base while the group reports summarize the extensive deliberations of 38 international experts. Particular emphasis has been given to promising research areas and on the advances needed to ensure a better understanding of the biological and behavioral mechanisms of the regulation of body weight, with a particular emphasis on overweight and obesity.