Personalized Analysis Of Left Atrial Blood Flow Through Computational Modeling
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Personalized Analysis Of Left Atrial Blood Flow Through Computational Modeling
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Author : Sophia Bäck
language : en
Publisher: Linköping University Electronic Press
Release Date : 2025-04-02
Personalized Analysis Of Left Atrial Blood Flow Through Computational Modeling written by Sophia Bäck and has been published by Linköping University Electronic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-04-02 with categories.
In this thesis, the atrial blood flow was modeled using computational fluid dynamics (CFD) to better understand atrial hemodynamics and blood stasis. Atrial hemodynamics and especially stasis are of interest since thrombi can form in the left atrium, travel with the blood stream to the brain, and cause strokes. To model atrial blood flow in a personalized manner, several modeling assumptions and choices need to be made, for example how to model the motion of the atrial wall. There are different approaches to estimate stasis; however, there is no standard method. While it is known that in patients with atrial fibrillation (AF), the stroke risk is increased, the exact mechanisms for this are not fully understood, especially in patients that are in sinus rhythm most of the time. One approach to reduce the stroke risk is to occlude the left atrial appendage (LAA). However, this has not been evaluated for patients in an early phase of AF. The aim of this thesis was to enhance our understanding of left atrial hemodynamics. For this, the blood flow in the left atrium was simulated using CFD based on time-resolved CT images, including the patient-specific geometry and wall motion. In this thesis, different stasis markers are investigated and a new method to quantify atrial hemodynamics was developed, splitting the atrial blood flow into 6 components. Additionally, virtual LAA occlusion was investigated to see how it impacts atrial hemodynamics during sinus rhythm. In this thesis, the atrial blood flow and stasis in 21 paroxysmal AF patients during sinus rhythm were compared to 8 controls. The wall motion tracked from time-resolved CT that was used in the CFD simulations showed similar flow rates as measurements from 4D flow MRI. All stasis markers investigated showed higher stasis in AF patients during sinus rhythm compared to the controls. Atrial flow component analysis revealed how blood travels through the left atrium. In the control group, the blood flow was dominated by components characterizing a direct path through the LA. In the patients with AF, however, an increased amount of blood stays in the LA for more than two heart beats and more blood flows back to the lungs. Virtual LAAO showed a reduction of stasis, for some individuals to similar levels as the control group. For others, stasis was reduced but still high, and stasis was located close to the occlusion device. This could indicate an increased risk for device-related thrombi. In conclusion, this thesis contributes to our understanding of the atrial blood flow. Using CT-based CFD simulations, we could show that stasis is increased in AF patients during sinus rhythm. In the future, adding patient-specific stasis assessment could improve decision-making to prescribe anticoagulants and thus reduce the incidence of cardioembolic strokes.
Personalized Analysis Of Left Atrial Blood Flow Through Computational Modeling
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Author : Sophia Bäck
language : en
Publisher:
Release Date : 2025
Personalized Analysis Of Left Atrial Blood Flow Through Computational Modeling written by Sophia Bäck and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025 with categories.
Statistical Atlases And Computational Models Of The Heart Atrial Segmentation And Lv Quantification Challenges
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Author : Mihaela Pop
language : en
Publisher: Springer
Release Date : 2019-03-05
Statistical Atlases And Computational Models Of The Heart Atrial Segmentation And Lv Quantification Challenges written by Mihaela Pop and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-03-05 with Computers categories.
This book constitutes the thoroughly refereed post-workshop proceedings of the 9th International Workshop on Statistical Atlases and Computational Models of the Heart: Atrial Segmentation and LV Quantification Challenges, STACOM 2018, held in conjunction with MICCAI 2018, in Granada, Spain, in September 2018. The 52 revised full workshop papers were carefully reviewed and selected from 60 submissions. The topics of the workshop included: cardiac imaging and image processing, machine learning applied to cardiac imaging and image analysis, atlas construction, statistical modelling of cardiac function across different patient populations, cardiac computational physiology, model customization, atlas based functional analysis, ontological schemata for data and results, integrated functional and structural analyses, as well as the pre-clinical and clinical applicability of these methods.
Statistical Atlases And Computational Models Of The Heart Regular And Cmrxmotion Challenge Papers
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Author : Oscar Camara
language : en
Publisher: Springer Nature
Release Date : 2023-01-27
Statistical Atlases And Computational Models Of The Heart Regular And Cmrxmotion Challenge Papers written by Oscar Camara and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-27 with Computers categories.
This book constitutes the proceedings of the 13th International Workshop on Statistical Atlases and Computational Models of the Heart, STACOM 2022, held in conjunction with the 25th MICCAI conference. The 34 regular workshop papers included in this volume were carefully reviewed and selected after being revised and deal with topics such as: common cardiac segmentation and modelling problems to more advanced generative modelling for ageing hearts, learning cardiac motion using biomechanical networks, physics-informed neural networks for left atrial appendage occlusion, biventricular mechanics for Tetralogy of Fallot, ventricular arrhythmia prediction by using graph convolutional network, and deeper analysis of racial and sex biases from machine learning-based cardiac segmentation. In addition, 14 papers from the CMRxMotion challenge are included in the proceedings which aim to assess the effects of respiratory motion on cardiac MRI (CMR) imaging quality and examine the robustness of segmentation models in face of respiratory motion artefacts. A total of 48 submissions to the workshop was received.
Statistical Atlases And Computational Models Of The Heart M Ms And Emidec Challenges
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Author : Esther Puyol Anton
language : en
Publisher: Springer Nature
Release Date : 2021-01-28
Statistical Atlases And Computational Models Of The Heart M Ms And Emidec Challenges written by Esther Puyol Anton and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-28 with Computers categories.
This book constitutes the proceedings of the 11th International Workshop on Statistical Atlases and Computational Models of the Heart, STACOM 2020, as well as two challenges: M&Ms - The Multi-Centre, Multi-Vendor, Multi-Disease Segmentation Challenge, and EMIDEC - Automatic Evaluation of Myocardial Infarction from Delayed-Enhancement Cardiac MRI Challenge. The 43 full papers included in this volume were carefully reviewed and selected from 70 submissions. They deal with cardiac imaging and image processing, machine learning applied to cardiac imaging and image analysis, atlas construction, artificial intelligence, statistical modelling of cardiac function across different patient populations, cardiac computational physiology, model customization, atlas based functional analysis, ontological schemata for data and results, integrated functional and structural analyses, as well as the pre-clinical and clinical applicability of these methods.
Xv Mediterranean Conference On Medical And Biological Engineering And Computing Medicon 2019
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Author : Jorge Henriques
language : en
Publisher: Springer Nature
Release Date : 2019-09-24
Xv Mediterranean Conference On Medical And Biological Engineering And Computing Medicon 2019 written by Jorge Henriques and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-24 with Technology & Engineering categories.
This book gathers the proceedings of MEDICON 2019 – the XV Mediterranean Conference on Medical and Biological Engineering and Computing – which was held in September 26-28, 2019, in Coimbra, Portugal. A special emphasis has been given to practical findings, techniques and methods, aimed at fostering an effective patient empowerment, i.e. to position the patient at the heart of the health system and encourages them to be actively involved in managing their own healthcare needs. The book reports on research and development in electrical engineering, computing, data science and instrumentation, and on many topics at the interface between those disciplines. It provides academics and professionals with extensive knowledge on cutting-edge techniques and tools for detection, prevention, treatment and management of diseases. A special emphasis is given to effective advances, as well as new directions and challenges towards improving healthcare through holistic patient empowerment.
Functional Imaging And Modelling Of The Heart
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Author : Mihaela Pop
language : en
Publisher: Springer
Release Date : 2017-05-22
Functional Imaging And Modelling Of The Heart written by Mihaela Pop and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-22 with Computers categories.
This book constitutes the refereed proceedings of the 9th International Conference on Functional Imaging and Modeling of the Heart, held in Toronto, ON, Canada, in June 2017. The 48 revised full papers were carefully reviewed and selected from 63 submissions. The focus of the papers is on following topics: novel imaging and analysis methods for myocardial tissue characterization and remodeling; advanced cardiac image analysis tools for diagnostic and interventions; electrophysiology: mapping and biophysical modeling; biomechanics and flow: modeling and tissue property measurements.
Cardiac Modeling Aiming For Optimization Of Therapy
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Author : Javier Saiz
language : en
Publisher: Frontiers Media SA
Release Date : 2020-12-15
Cardiac Modeling Aiming For Optimization Of Therapy written by Javier Saiz and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-15 with Science categories.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Applied Complex Flow
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Author : Aydin Azizi
language : en
Publisher: Springer Nature
Release Date : 2023-02-01
Applied Complex Flow written by Aydin Azizi and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-02-01 with Technology & Engineering categories.
This book presents improved numerical techniques and applied computer-aided simulations as a part of emerging trends in mechatronics in all areas related to complex fluids, with particular focus on using a combination of modeling, theory, and simulation to study systems that are complex due to the rheology of fluids (i.e., ceramic pastes, polymer solutions and melts, colloidal suspensions, emulsions, foams, micro-/nanofluids, etc.) and multiphysics phenomena in which the interactions of various effects (thermal, chemical, electric, magnetic, or mechanical) lead to complex dynamics. The areas of applications span materials processing, manufacturing, and biology.
Diagnosis Monitoring And Treatment Of Heart Rhythm New Insights And Novel Computational Methods
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Author : Jieyun Bai
language : en
Publisher: Frontiers Media SA
Release Date : 2023-09-13
Diagnosis Monitoring And Treatment Of Heart Rhythm New Insights And Novel Computational Methods written by Jieyun Bai and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-13 with Science categories.