Personalized Immunotherapy For Tumor Diseases And Beyond
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Personalized Immunotherapy For Tumor Diseases And Beyond
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Author : Biaoru Li
language : en
Publisher: Bentham Science Publishers
Release Date : 2020-11-03
Personalized Immunotherapy For Tumor Diseases And Beyond written by Biaoru Li and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-03 with Medical categories.
This book introduces personalized immunotherapy with multi-dimensional models of analysis to determine the best plan for immunotherapy of patients. The book introduces readers to some basic concepts which lay the foundation for personalized immunotherapy: the development of a major histocompatibility complex (MHC), the genome profile of T cells and tumor cells, and genome-wide association studies. Chapters also cover special topics such as new immunoassay methods related to personalized immunotherapy and targeted immunotherapy which are geared towards familiarizing readers with current research practices. Focusing on the central theme of personalized immunotherapy, the authors provide a wealth of information about T-cell screening, tumor neoantigen cloning, primary tumor cell culture for T-cell cloning, bioinformatics strategies for understanding T-cell and primary tumor cell biology and function, and new developments in research on adoptive T-cell immunotherapy. These developments include T-cell gene therapy and T-cell gene editing, transgenic T-cells for increasing affinity to tumor cells such as CAR T-cells and TCR T-cells, and the systematic modeling of polyclonal specific T-cells and biobank technology. Key Features: - Introduces readers to basic concepts in personalized medicine and immunotherapy - Presents current information about immunological assays used in research - Presents an overview of T cell immunotherapy and cloning techniques - Presents an overview of tumor cell bioinformatics and its role in immunotherapy - Includes new developments and references for personalized immunotherapy techniques (T-cell gene therapy and T-cell gene editing, transgenic T-cells which target CAR T-cells and TCR T-cells, and polyclonal T-cell modeling) - Includes a section on biobanking - Presents information in an easy-to-read format for a wide range of readers - Brings contributions from experts with over 30 years of experience in personalized immunotherapy Personalized Immunotherapy for Tumor Diseases and Beyond is an ideal handbook for medical professionals and students involved in personalized medicine, immunology and oncology. General readers interested in the new developments in these fields will also benefit from the information provided.
Personalized Immunotherapy For Tumor Diseases And Beyond
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Author : Shen Li
language : en
Publisher:
Release Date : 2020-11-03
Personalized Immunotherapy For Tumor Diseases And Beyond written by Shen Li and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-03 with categories.
This book introduces personalized immunotherapy with multi-dimensional models of analysis to determine the best plan for immunotherapy of patients. The book introduces readers to some basic concepts which lay the foundation for personalized immunotherapy: the development of a major histocompatibility complex (MHC), the genome profile of T cells and tumor cells, and genome-wide association studies. Chapters also cover special topics such as new immunoassay methods related to personalized immunotherapy and targeted immunotherapy which are geared towards familiarizing readers with current research practices. Focusing on the central theme of personalized immunotherapy, the authors provide a wealth of information about T-cell screening, tumor neoantigen cloning, primary tumor cell culture for T-cell cloning, bioinformatics strategies for understanding T-cell and primary tumor cell biology and function, and new developments in research on adoptive T-cell immunotherapy. These developments include T-cell gene therapy and T-cell gene editing, transgenic T-cells for increasing affinity to tumor cells such as CAR T-cells and TCR T-cells, and the systematic modeling of polyclonal specific T-cells and biobank technology.Key Features: - Introduces readers to basic concepts in personalized medicine and immunotherapy- Presents current information about immunological assays used in research- Presents an overview of T cell immunotherapy and cloning techniques- Presents an overview of tumor cell bioinformatics and its role in immunotherapy- Includes new developments and references for personalized immunotherapy techniques (T-cell gene therapy and T-cell gene editing, transgenic T-cells which target CAR T-cells and TCR T-cells, and polyclonal T-cell modeling)- Includes a section on biobanking- Presents information in an easy-to-read format for a wide range of readers- Brings contributions from experts with over 30 years of experience in personalized immunotherapyPersonalized Immunotherapy for Tumor Diseases and Beyond is an ideal handbook for medical professionals and students involved in personalized medicine, immunology and oncology. General readers interested in the new developments in these fields will also benefit from the information provided
Novel Immunotherapeutic Approaches To The Treatment Of Cancer
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Author : Paul D. Rennert
language : en
Publisher: Springer
Release Date : 2016-05-30
Novel Immunotherapeutic Approaches To The Treatment Of Cancer written by Paul D. Rennert and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-05-30 with Medical categories.
Cancer care is undergoing a radical transformation as novel technologies are directed toward new treatments and personalized medicine. The most dramatic advances in the treatment of cancer have come from therapeutics that augment the immune response to tumors. The immune checkpoint inhibitors are the best-known and most highly advanced examples of Immune Therapeutics targeting tumor cells and include approved antibody drugs directed at the cell surface proteins CTLA4 and PD-1. These are now considered foundational treatments for several solid tumor indications, and that list of indications is growing quickly. More broadly, antibodies have become workhorse molecules across the entire immunotherapy landscape. Antibodies to novel targets modulate the activity of diverse immune cell regulatory proteins. Engineered antibodies can induce tumor cell death or expose tumor cells to poisonous toxins (ADCC and ADC, respectively). Bi-specific antibodies can engage multiple tumor targets simultaneously, or can redirect lymphocytes to attack tumor cells. The antigen-binding domains within antibodies can be spliced onto cell stimulatory domains and transduced into T cells or NK cells, creating remarkable tumor-specific cellular therapeutics (CAR-T, CAR-NK). Beyond antibody-based therapies there are highly diverse and differentiated technology tool kits being applied to immunotherapy. Small molecule drugs are being developed to attack the tumor microenvironment, novel tumor vaccine approaches are showing great promise, patient lymphocytes are being isolated, expanded and reintroduced to patients, gene-editing techniques are becoming widely deployed, and a vast number of new tumor targets, and mutated tumor proteins (neoantigens), are being discovered. The past decade has seen unprecedented success in the treatment of diverse cancers. The authors of this volume have been asked to not only review progress to date, but importantly, to look ahead, and anticipate the evolution of cancer treatment across diverse Immune Therapeutic approaches. Our hypothesis is that the advances we are seeing across the immunotherapy landscape will further evolve and synergize, leading us finally to outright cures for many cancers.
Personalized Immunotherapy Advancing Processes To Extend Patient Collectives
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Author : Patrick Schmidt
language : en
Publisher: Frontiers Media SA
Release Date : 2024-02-16
Personalized Immunotherapy Advancing Processes To Extend Patient Collectives written by Patrick Schmidt and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-02-16 with Medical categories.
Cancer Immunotherapy apart from checkpoint inhibitors is a highly personalized medicine that puts the patient's cells in the focus of drug manufacturing and promises outcomes that rarely have been seen in the history of cancer treatment. CAR-T cells can be mentioned here as the key example that has gained FDA and EMA approvals as the first living drugs for the treatment of leukemias and is now under clinical investigation for application in solid tumors as well. Improvements in cellular engineering in combination with advanced sequencing methods have made it possible to discover tumor-mutation-specific T-cell receptors that can be used to redirect effector cells toward the malignant cell pool with high specificity. This approach opens the opportunity to drug driver mutations that are occurring in a group of patients as well as to design unique patient individual treatment regimens.
Current Immunotherapeutic Strategies In Cancer
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Author : Matthias Theobald
language : en
Publisher: Springer
Release Date : 2020-09-20
Current Immunotherapeutic Strategies In Cancer written by Matthias Theobald and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-20 with Medical categories.
This book offers a comprehensive review of recent advances in cancer immunotherapy, and explores the value and limitations of the most effective current therapeutic strategies and emerging treatment modalities. It discusses in detail the successes achieved using monoclonal antibodies (mAbs), including developments with regard to conjugated mAbs and also bispecific mAbs as novel treatment options for leukemia and solid tumors. It also examines the advances toward personalized immunotherapy, focusing on the effectiveness of adoptive cell therapy using genetically engineered T cells with tumor-associated antigen-specific T-cell receptors and chimeric antigen receptors, as well as the role of tailored vaccines based on the patient’s cancer mutanome. Further, it describes the impressive therapeutic results recently achieved with checkpoint inhibitors, and analyzes novel strategies to modulate the immunosuppressive tumor microenvironment. Written by leading international experts and providing up-to-date information on emerging strategies, such as oncolytic virus-based therapy, epigenetic therapy, and combination therapy, the book appeals to all those with an interest in immunotherapy as it comes of age.
Personalized Medicine In Oncology
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Author : Ari VanderWalde
language : en
Publisher: Mdpi AG
Release Date : 2022-01-25
Personalized Medicine In Oncology written by Ari VanderWalde and has been published by Mdpi AG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-25 with categories.
Nowhere is the explosion in comprehensive genomic testing more evident than in oncology. Multiple consensus guidelines now recommend molecular testing as the standard of care for most metastatic tumors. To aid in the advancement of this rapidly changing field, we intend this Special Issue of JPM to focus on technical developments in the genomic profiling of cancer, detail promising somatic alterations that either are, or have a high likelihood of being, relevant in the near future, and to address issues related to the pricing and value of these tests. The last few years have seen the cost of molecular testing decrease by orders of magnitude. In 2018, we saw the first "site-agnostic" drug approvals in cancer (for microsatellite unstable cancer (PD-1 inhibitors) and NTRK-fusions (TRK inhibitors)). Research on targetable mutations, determination of genetic "signatures" that can use multiple individual genes/pathways, development of targeted therapy, and insight into the value of new technology remains at the cutting edge of research in this field. We are soliciting papers that present new technologies to assess predictive biomarkers in cancer, original research (pre-clinical or clinical) that demonstrates promise for particular targeted therapies in cancer, and articles that explore the clinical and financial impacts of this paradigmatic shift in cancer diagnostics and treatment.
Precision Medicine In Oncology
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Author : Bulent Aydogan
language : en
Publisher: John Wiley & Sons
Release Date : 2020-11-02
Precision Medicine In Oncology written by Bulent Aydogan and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-02 with Medical categories.
A FRESH EXAMINATION OF PRECISION MEDICINE'S INCREASINGLY PROMINENT ROLE IN THE FIELD OF ONCOLOGY Precision medicine takes into account each patient's specific characteristics and requirements to arrive at treatment plans that are optimized towards the best possible outcome. As the field of oncology continues to advance, this tailored approach is becoming more and more prevalent, channelling data on genomics, proteomics, metabolomics and other areas into new and innovative methods of practice. Precision Medicine in Oncology draws together the essential research driving the field forward, providing oncology clinicians and trainees alike with an illuminating overview of the technology and thinking behind the breakthroughs currently being made. Topics covered include: Biologically-guided radiation therapy Informatics for precision medicine Molecular imaging Biomarkers for treatment assessment Big data Nanoplatforms Casting a spotlight on this emerging knowledge base and its impact upon the management of tumors, Precision Medicine in Oncology opens up new possibilities and ways of working – not only for oncologists, but also for molecular biologists, radiologists, medical geneticists, and others.
Personalised Cancer Medicine
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Author : Anne Kerr
language : en
Publisher:
Release Date : 2021-02-23
Personalised Cancer Medicine written by Anne Kerr and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-23 with Medical categories.
Tissue Economies
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Author : Cathy Waldby
language : en
Publisher: Duke University Press
Release Date : 2006-03-20
Tissue Economies written by Cathy Waldby and has been published by Duke University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-03-20 with Medical categories.
DIVA cultural studies account of how the "bio-value" of blood, stem cells, organs, and cell lines moves back and forth between 'gift' and 'commodity'./div
Cancer Research And Textbook 2
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Author : Aliasghar Tabatabaei Mohammadi
language : en
Publisher: Nobel TM
Release Date : 2022-11-16
Cancer Research And Textbook 2 written by Aliasghar Tabatabaei Mohammadi and has been published by Nobel TM this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-16 with Medical categories.
What is Cancer? Cancer is a disease caused by the uncontrolled growth and spread of abnormal cells in the body. This abnormal growth of cells can form tumors or invade nearby tissues and organs, leading to serious health problems. Cancer can occur in any part of the body and can be life-threatening if not diagnosed and treated early. This essay aims to provide a comprehensive overview of cancer, including its causes, risk factors, symptoms, diagnosis, and treatment options. Causes of Cancer Cancer is caused by a complex interaction of genetic, environmental, and lifestyle factors that can damage the DNA within cells and trigger uncontrolled growth. Exposure to certain chemicals and radiation, viruses, and chronic inflammation are all potential causes of cancer. Additionally, genetic mutations and inherited gene mutations can increase the risk of developing certain types of cancer. Some lifestyle factors that may increase the risk of cancer include tobacco use, alcohol consumption, poor diet, and lack of physical activity.## Common Types of Cancer There are many different types of cancer that can affect various parts of the body, including but not limited to breast cancer, lung cancer, prostate cancer, colorectal cancer, skin cancer, and leukemia ## Diagnosis and Treatment of Cancer Diagnosis of cancer typically involves a combination of physical examination, medical history review, imaging tests, and laboratory tests. In some cases, a biopsy may be necessary to confirm the diagnosis. Treatment options for cancer may include surgery, radiation therapy, chemotherapy, immunotherapy, targeted therapy or a combination of these approaches The choice of treatment depends on the type and stage of cancer, as well as the patient's overall health and preferences It is important for individuals to have regular screenings and check-ups with their healthcare provider to detect cancer early, when it is most treatable. In conclusion, cancer is a serious disease that can have a significant impact on individuals and society as a whole Prevention and early detection efforts are key in reducing the impact of cancer on individuals and society.