Perspectives On Autoimmunity
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Perspectives On Autoimmunity
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Author : Irun R. Cohen
language : en
Publisher: CRC Press
Release Date : 2020-04-15
Perspectives On Autoimmunity written by Irun R. Cohen and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-15 with Health & Fitness categories.
First Published in 1988, this book offers a full, comprehensive guide to autoimmunity. Carefully compiled and filled with a vast repertoire of notes, diagrams, and references this book serves as a useful reference for students of medicine, and other practitioners in their respective fields.
Frontiers In Autoimmunity
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Author : Moncef Zouali
language : en
Publisher: IOS Press
Release Date : 2003
Frontiers In Autoimmunity written by Moncef Zouali and has been published by IOS Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Autoimmune diseases categories.
Langerhans Cells In Autoimmunity New Perspectives In Function And Homeostasis
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Author : Miguel-Angel Gutierrez
language : en
Publisher:
Release Date : 2018
Langerhans Cells In Autoimmunity New Perspectives In Function And Homeostasis written by Miguel-Angel Gutierrez and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.
Langerhans cells (LC) are the premier antigen presenting cells on epithelial surfaces. The key to LCs' functions is their residence in peripheral tissues as well as their capacity to migrate to local draining lymphoid organs. The present dissertation's goal is to elucidate the specific roles LCs play in the context of autoimmunity, by employing a mouse model genetically prone to develop multi-organ autoimmune disease, in which LCs can be traced and selectively depleted in vivo. Previous studies have elucidated LCs' ability to induce tolerance against skin-specific self-antigen and as well as to protect against the development of autoimmune skin inflammation. However, LCs' role in other, non-skin, organs where they are present, such as in cornea on eye surface and in gastric and genital mucosa, remains largely unknown. We found that LCs were altered in distribution and density in the cornea of autoimmune-prone mice. Importantly, aselective depletion of LCs led to acceleration of corneal inflammation, along with increased T cell activation and proliferation in eye-draining lymph nodes. These data allowed us to show for the first time that LCs play a protective role against corneal autoimmune disease, potentially through inhibition of T cell activation in a tissue-specific manner. Homeostatic migration of LCs from their tissue of residence to local draining lymph nodes is a hallmark of LC biology, however, the underlying mechanisms are largely unclear. We studied mechanism of LCs migration using models of autoimmune dermatitis, where LC migration was previously shown to be defective prior to the onset of clinical disease. We demonstrate that skin-resident dendritic epidermal T cells are reduced in the epidermis of these autoimmune-prone mice, and that a glycolipid that ameliorates skin inflammation restores DETCs and LC migration. This rescue of LC migration in autoimmune mice by skin-resident dendritic epidermal T cells is mediated, at least in part, via CD40-CD40L signaling. Such 'local' control of migratory behavior of tissue-resident dendritic cells can regulate systemic immune response in a tissue-specific manner, which has important implications for protection against inflammation, autoimmune diseases and graft rejection, and vaccination against cancers and infections.
Autoantibodies And Autoimmunity
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Author : Kenneth Michael Pollard
language : en
Publisher: John Wiley & Sons
Release Date : 2006-05-12
Autoantibodies And Autoimmunity written by Kenneth Michael Pollard and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-05-12 with Medical categories.
This is the first book to address all aspects of the biology of autoantibodies in a single volume, including a discussion of immunology, experimental models, clinical aspects, and the use of autoantibodies as probes in molecular and cellular biology. The editor, currently professor at the W.M. Keck Autoimmune Disease Center of The Scripps Research Institute, has assembled an all-star team of authors to report on the latest research, technologies, and applications. Following an introductory chapter, the book goes on to cover such topics as cellular mechanisms of autoantibody production, clinical and diagnostic usefulness in human disease, and animal models used to study the elicitation of autoantibodies. The whole is rounded off with a look at future perspectives. With its comprehensive coverage, this volume will appeal not only to immunologists and clinicians but also to cell and molecular biologists.
Probing Selected Autoimmune Diseases For Focused Perspectives
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Author : Mourad Aribi
language : en
Publisher: BoD – Books on Demand
Release Date : 2024-03-27
Probing Selected Autoimmune Diseases For Focused Perspectives written by Mourad Aribi and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-27 with Medical categories.
The book Probing Selected Autoimmune Diseases for Focused Perspectives provides an in-depth exploration of complex autoimmune disease landscapes, encompassing conditions such as myasthenia gravis, hepatosplenomegaly, autoimmune rheumatic diseases, Buerger's disease, and autoimmune thyroid diseases. Structured into six informative chapters, it initially delves into the delicate equilibrium between immune tolerance and defense, revealing the triggers of autoimmune reactions. Tailored for clinicians, researchers, scientists, and advanced students, particularly those involved in master's, Ph.D., or MD-Ph.D. programs in immunology and immunopathology, this work delivers valuable insights applicable to clinical practice and various medical disciplines.
Chronic Illness Vulnerability And Social Work
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Author : Liz Price
language : en
Publisher: Routledge
Release Date : 2015-05-01
Chronic Illness Vulnerability And Social Work written by Liz Price and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-05-01 with Medical categories.
Whilst the body has recently assumed greater sociological significance, there has been less engagement in social work and social care on the bodily experience of health, illness and disease. This innovative volume redresses the balance by exploring chronic illness and social work, through the specific lens of autoimmunity, engaging in wider debates around vulnerability, resistance and the lived experience of ongoing ill-health. Moving beyond existing conceptualisations of vulnerability as an issue of mental distress, ageing, child protection and poverty, Price and Walker demonstrate the role that society has to play in actively engaging the physical body, rather than working around and through it. The book focuses on auto-immune conditions such as lupus, multiple sclerosis, rheumatoid arthritis and scleroderma. Conditions like these allow for an exploration of the materiality of illness which exacerbates social and economic vulnerability and may precipitate personal and social crises, requiring a variety of interventions and support. The risks and challenges associated with chronic illness include disruptions to a sense of self and identity, altered relationships and the renegotiation of roles and responsibilities in a variety of relationships in addition to an economic impact, with the potential for disruption to employment status and financial insecurity. This text opens up a range of debates around some of the central concerns of the social work profession, including vulnerability, ill-health, and independence. It will be of interest to scholars and students of social work, nursing, disability studies, medicine and the social sciences.
Apoptosis And Autoimmunity
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Author : Joachim R. Kalden
language : en
Publisher: John Wiley & Sons
Release Date : 2006-03-06
Apoptosis And Autoimmunity written by Joachim R. Kalden and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-03-06 with Medical categories.
This is the first comprehensive book about the relationship between apoptosis and autoimmune diseases. It offers a unique up-to-date overview on research results on the defective execution of apoptosis and the incomplete clearance of apoptotic cells. The molecular and cellular mechanisms involved are described in detail. As a possible consequence of apoptotic dysfunction, the development of severe autoimmune diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus) is discussed. An outlook on future research topics includes the evaluation of novel therapeutic strategies.
Autoimmunity
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Author : W. Ollier
language : en
Publisher: Taylor & Francis
Release Date : 1992
Autoimmunity written by W. Ollier and has been published by Taylor & Francis this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Medical categories.
The need to understand the mechanisms whereby the immune system breaks down and turns against itself has drawn in scientists from many fields. As each area of the basic sciences advances so does our understanding of autoimmunity. This book is therefore written with the clear purpose of explaining autoimmunity to a non-specialist audience.
Physiologic Autoimmunity And Preventive Medicine
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Author : Alexander B. Poletaev
language : en
Publisher: Bentham Science Publishers
Release Date : 2013-06-03
Physiologic Autoimmunity And Preventive Medicine written by Alexander B. Poletaev and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-03 with Medical categories.
The immune system is a natural component, regulator and direct participant in the physiological activities in a healthy body. A considerable number of immune functions, including those related to antimicrobial defense, derive from autoclearance as well as construction and support of multicellularity. Various pathological processes in any organ are usually accompanied by different patterns of cell death and, thus, by increased exposure and presentation of self antigens. These events induce the secondary rise in production of autoantibodies with appropriate specificity (opsonins), which provides augmentation of clearance by facilitating the efficacy of macrophage-dependent consumption of debris in the affected organ. Secondary changes in production and serum content of autoantibodies can be considered the universal and earliest detectable marker of any chronic disease. Experimental and clinical production antibodies reveal antibodies against nuclear antigens, which penetrate into living cell nuclei and alter nuclear acid synthesis, cell proliferation and function. Autoantibodies can thus be regarded as hormone-like bioregulators of gene expression. The immune system is apparently able to reproduce complementary regulators for various cell receptors, including nuclear ones. The book focuses on physiological autoimmunity models and delves into the relation between autoimmunity and autoallergy in the context of disease prevention and prediction. The E-book is a unique and comprehensive monograph and includes a history and contemporary research on natural autoimmunity - a fundamental concept essential for many branches of medicine and pathology. The concepts described in this e-book also have broad practical implications for the healthcare sector, because it establishes effective method of early prediction for many different diseases and creates a basis for prophylaxis. The reference gives medical and clinical professionals a chance to revisit old dogmas and acquire fruitful perspectives for theoretical reasoning and research planning.
Precision Medicine And Artificial Intelligence
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Author : Michael Mahler
language : en
Publisher: Academic Press
Release Date : 2021-03-12
Precision Medicine And Artificial Intelligence written by Michael Mahler and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-12 with Science categories.
Precision Medicine and Artificial Intelligence: The Perfect Fit for Autoimmunity covers background on artificial intelligence (AI), its link to precision medicine (PM), and examples of AI in healthcare, especially autoimmunity. The book highlights future perspectives and potential directions as AI has gained significant attention during the past decade. Autoimmune diseases are complex and heterogeneous conditions, but exciting new developments and implementation tactics surrounding automated systems have enabled the generation of large datasets, making autoimmunity an ideal target for AI and precision medicine. More and more diagnostic products utilize AI, which is also starting to be supported by regulatory agencies such as the Food and Drug Administration (FDA). Knowledge generation by leveraging large datasets including demographic, environmental, clinical and biomarker data has the potential to not only impact the diagnosis of patients, but also disease prediction, prognosis and treatment options. Allows the readers to gain an overview on precision medicine for autoimmune diseases leveraging AI solutions Provides background, milestone and examples of precision medicine Outlines the paradigm shift towards precision medicine driven by value-based systems Discusses future applications of precision medicine research using AI Other aspects covered in the book include regulatory insights, data analytics and visualization, types of biomarkers as well as the role of the patient in precision medicine