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Phagocytosis


Phagocytosis
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Phagocytosis And Phagosomes


Phagocytosis And Phagosomes
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Author : Roberto J. Botelho
language : en
Publisher: Springer Nature
Release Date : 2023-06-26

Phagocytosis And Phagosomes written by Roberto J. Botelho and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-26 with Science categories.


This volume explores updated and entirely new experimental approaches used to investigate phagocytosis and phagosome maturation. In order to aid in the study of engulfment, maturation, resolution, and pathogen manipulation of phagocytes, the book features methodology to quantify uptake and maturation specific to certain phagocytes, particles, or pathogens, while other chapters offer methods that can be applied generically across the field. Methods are presented to study phagocytosis and phagosome maturation in vivo, in cellulo, and through in vitro analyses. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Phagocytosis and Phagosomes: Methods and Protocols, Second Edition serves as a vital resource for both experts in the field as well as for investigators delving into phagocytosis and phagosome maturation for the first time.



Phagocytosis Molecular Mechanisms And Physiological Implications


Phagocytosis Molecular Mechanisms And Physiological Implications
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Author : Esther M. Lafuente
language : en
Publisher: Frontiers Media SA
Release Date : 2020-12-03

Phagocytosis Molecular Mechanisms And Physiological Implications written by Esther M. Lafuente and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-03 with Medical categories.


This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.



Phagocytosis


Phagocytosis
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Author : Urja Naik
language : en
Publisher: Biota Publishing
Release Date : 2013-04-01

Phagocytosis written by Urja Naik and has been published by Biota Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-01 with Science categories.


Phagocytosis is an evolutionarily conserved mechanism that serves as the first line of host defense in multicellular organisms. The traditional definition of phagocytosis involves the engulfment and degradation of large solid particles (>0.5 μm), initiated by receptor activation on phagocytes. It forms an essential aspect of innate immunity through the uptake and destruction of infectious pathogens, while also participating in the removal of apoptotic cells during tissue remodeling and development. Professional phagocytes, such as macrophages, neutrophils, and dendritic cells, are well equipped with a wide range of phagocytic receptors. In addition, these specialized leukocytes can signal to lymphocytes within the adaptive arm of host immunity. This review emphasizes the role of two well-characterized opsonic receptors, the Fcγ receptor and the complement receptor, CR3 in macrophages. In particular, it focuses on the different mechanisms employed by these receptors during particle recognition and phagocytic uptake. Bacterial species often manipulate phagocyte signaling in order to evade their engulfment and degradation and consequently provide further insight into key regulators of the phagocytic process. Finally, we draw attention to the physiological relevance of studying the simultaneous engagement of multiple phagocytic receptors, in order to better understand receptor crosstalk and the underlying coordination of downstream signaling for efficient phagocytosis.



Phagocytosis Of Dying Cells


Phagocytosis Of Dying Cells
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Author : Dmitri V. Krysko
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-03-10

Phagocytosis Of Dying Cells written by Dmitri V. Krysko and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-03-10 with Medical categories.


Phagocytosis has been at the forefront of cell biology for more than a century. Initially, phagocytosis, which comes from Greek words meaning “devouring cells,” was discovered in the late 19th century by Ilya Metchnikoff, who was awarded, together with Paul Ehrlich, the Nobel Prize in Physiology and Medicine in 1908 “in recognition of their work on immunity.” At that time Metchnikoff had already identified a function for phagocytes not only in host defense but also as scavengers of degenerating host cells during metamorphosis of tadpoles, thus providing one of the first descriptions of apoptotic cell clearance by macrophages (Kaufmann 2008). Since then, much has been learned about phagocytosis, and the previous several decades have witnessed outstanding progress in understanding the functions and the molecular mechanisms of phagocytosis. Two main types of targets are cleared by phagocytosis: microbial pathogens and dying cells. Rapid recognition and clearance of dying cells by phagocytes plays a pivotal role in development, maintenance of tissue homeostasis, control of immune responses, and resolution of inflammation. Clearance of dying cells can be divided into several stages, including sensing, r- ognition, binding and signaling, internalization, and immunological responses. In this book, our contributors address these different stages of dead cell cle- ance and examine how impaired clearance of dying cells may lead to human d- eases. We have attempted to provide sufficient cross-referencing and indexing to enable the reader to easily locate the ideas elaborated in the different chapters.



Phagocytosis Past And Future


Phagocytosis Past And Future
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Author : Liana Bolis
language : en
Publisher: Elsevier
Release Date : 2012-12-02

Phagocytosis Past And Future written by Liana Bolis and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Nature categories.


Phagocytosis—Past and Future is a collection of contributions by investigators who met in the Province of Messina, Sicily, in October 1980 to discuss the functions of phagocytic leukocytes in the host-parasite relationship. The topics discussed are largely in the areas of cell biology, cellular immunology, and biochemistry. They ranged from aspects of cellular movement and the ingestion process per se, to definition of substances that affect the function of phagocytic leukocytes and the nature of cidal mechanisms at the molecular level. This volume is organized into six sections encompassing 33 chapters and begins with an overview of Ilya Ilich Metchnikoff's life as well as his scientific contributions, particularly in the area of bacteriology and his research on mesodermal amoeboid cells. The next chapters focus on the mechanism of phagocytosis, with reference to aspects of cell membrane, cell movement, and ingestion. The reader is methodically introduced to the biochemical aspects of phagocytosis, from molecular modulations to energetics, oxygen radicals, and enzymes. The discussion then shifts to macrophages, their function in antigen recognition, receptor-mediated endocytosis in macrophage cell hybrids, and the role of phagocytosis in macrophage activation. The remaining chapters examine the cidal mechanisms of phagocytic leukocytes and aspects of inflammation. This book will be of interest to scientists and researchers in fields such as biology, biochemistry, immunology, pathology, pharmacology, and physiology.



Molecular And Cellular Biology Of Phagocytosis


Molecular And Cellular Biology Of Phagocytosis
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Author : Maurice B. Hallett
language : en
Publisher: Springer Nature
Release Date : 2020-05-12

Molecular And Cellular Biology Of Phagocytosis written by Maurice B. Hallett and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-12 with Medical categories.


Phagocytosis is the engulfment of particulate matter by cells. It is a fundamental (and probably “primitive”) cell biological process which is important in single celled organisms such as amoeba; multicellular animals including coelenterates; and in higher animals. In humans and other mammals, specialised immune cells (phagocytes) utilise phagocytosis in their crucial role of engulfing and destroying infecting microbes. Yet, surprisingly, the biophysics and biochemistry underlying the process has only become clear recently with the advent of genetic manipulation and advances in single cell imaging. In this volume, the aim is to bring together recent fundamental advances that give a clear picture of the underlying mechanism involved in phagocytosis. Not only is this an important topic in its own right, but a full understanding of the process will have a potential impact on human medicine, since as antibiotics become less effective in fight infection, researchers are looking at alternative approaches, including enhancing the “natural” immunity brought about by immune phagocytes. The aim is to provide a comprehensive volume on the topic, with separate chapters on identified recent advances, each written by the major contributors in each area. In addition, the volume will attempt to give a wider overview than is often the case in single author reviews, with an emphasis here on the cell biological understanding of phagocytosis using biophysical approaches alongside the biochemical and imaging approaches.



Phagocytosis New Insights For The Healthcare Professional 2011 Edition


Phagocytosis New Insights For The Healthcare Professional 2011 Edition
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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2012-01-09

Phagocytosis New Insights For The Healthcare Professional 2011 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-09 with Science categories.


Phagocytosis: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Phagocytosis in a concise format. The editors have built Phagocytosis: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Phagocytosis in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Phagocytosis: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.



Phagocytosis Of Bacteria And Bacterial Pathogenicity


Phagocytosis Of Bacteria And Bacterial Pathogenicity
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Author : Joel D. Ernst
language : en
Publisher: Cambridge University Press
Release Date : 2006-09-07

Phagocytosis Of Bacteria And Bacterial Pathogenicity written by Joel D. Ernst and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-09-07 with Science categories.


This book provides up-to-date information on the crucial interaction of pathogenic bacteria and professional phagocytes, the host cells whose purpose is to ingest, kill, and digest bacteria in defense against infection. The introductory chapters focus on the receptors used by professional phagocytes to recognize and phagocytose bacteria, and the signal transduction events that are essential for phagocytosis of bacteria. Subsequent chapters discuss specific bacterial pathogens and the strategies they use in confronting professional phagocytes. Examples include Helicobacter pylori, Streptococcus pneumoniae, and Yersinae, each of which uses distinct mechanisms to avoid being phagocytosed and killed. Contrasting examples include Listeria monocytogenes and Mycobacterium tuberculosis, which survive and replicate intracellularly, and actually cooperate with phagocytes to promote their entry into these cells. Together, the contributions in this book provide an outstanding review of current knowledge regarding the mechanisms of phagocytosis and how specific pathogenic bacteria avoid or exploit these mechanisms.



Phagocytosis The Host


Phagocytosis The Host
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Author : S. Gordon
language : en
Publisher: Elsevier
Release Date : 1999-11-22

Phagocytosis The Host written by S. Gordon and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-11-22 with Science categories.


An accompanying volume (Volume 6) in this series presents strategies of cellular invasion from the viewpoint of the microbe. This filed of study is growing rapidly after a somewhat slow start over recent decades. This collection of invited chapters attempts to reflect current research, and brings together cell biologists, microbiologists and immunologists with disparate interests. However, there is a certain unity, even repetition of key themes, hopefully like a symphony rather than a boring catalogue. It will be evident that editorial bias favors intracellular paratism and medically important organisms. The neutrophil is far more than a supporting player to the macrophage, and some attempt is made to remind the reader of some of its unique skills. To retain a manageable size, the emphasis is on relatively early events such as mutual recognition, cell entry, and response, rather than on longterm changes in gene expression by either host cell or pathogen. Viruses are excluded not because of lack of importance but because of somewhat different research approaches, although it is cytogenes, share common strategies in invasion and intercellular spread.



Phagocytosis


Phagocytosis
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Author : Carlos Rosales, Ph.d.
language : en
Publisher:
Release Date : 2018

Phagocytosis written by Carlos Rosales, Ph.d. and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with Phagocytosis categories.