Pharmaceutical Suspensions
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Pharmaceutical Suspensions
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Author : Alok K. Kulshreshtha
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-11-05
Pharmaceutical Suspensions written by Alok K. Kulshreshtha and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-11-05 with Medical categories.
The suspension dosage form has long been used for poorly soluble active ingre- ents for various therapeutic indications. Development of stable suspensions over the shelf life of the drug product continues to be a challenge on many fronts. A good understanding of the fundamentals of disperse systems is essential in the development of a suitable pharmaceutical suspension. The development of a s- pension dosage form follows a very complicated path. The selection of the proper excipients (surfactants, viscosity imparting agents etc.) is important. The particle size distribution in the finished drug product dosage form is a critical parameter that significantly impacts the bioavailability and pharmacokinetics of the product. Appropriate analytical methodologies and instruments (chromatographs, visco- ters, particle size analyzers, etc.) must be utilized to properly characterize the s- pension formulation. The development process continues with a successful scale-up of the manufacturing process. Regulatory agencies around the world require cli- cal trials to establish the safety and efficacy of the drug product. All of this devel- ment work should culminate into a regulatory filing in accordance with the regulatory guidelines. Pharmaceutical Suspensions, From Formulation Development to Manufacturing, in its organization, follows the development approach used widely in the pharmaceutical industry. The primary focus of this book is on the classical disperse system – poorly soluble active pharmaceutical ingredients s- pended in a suitable vehicle.
Pharmaceutical Suspensions
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Author : Alok K. Kulshreshtha
language : en
Publisher: Springer
Release Date : 2010
Pharmaceutical Suspensions written by Alok K. Kulshreshtha and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Electronic books categories.
Rheology Of Pharmaceutical Suspensions
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Author : WAYNE MARTIN GRIM
language : en
Publisher:
Release Date : 1960
Rheology Of Pharmaceutical Suspensions written by WAYNE MARTIN GRIM and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1960 with Rheology categories.
Pharmaceutical Emulsions And Suspensions
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Author : Françoise Nielloud
language : en
Publisher: CRC Press
Release Date : 2000-02-25
Pharmaceutical Emulsions And Suspensions written by Françoise Nielloud and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-02-25 with Medical categories.
Analyzes construction of experiments, focusing on variables, models, matrices, and reproducibility. This timely reference systematically examines the basic concepts and theoretical issues, methodologies for experiment and measurement, and practical health applications of emulsions and dispersions-describing formulation problems and identifying potential carriers for the delivery or targeting of new drugs. Evaluates anionic, cationic, and nonionic surfactants as dispersing, emulsifying, foaming, penetrating, and wetting agents. Written by more than 20 international researchers, Pharmaceutical Emulsions and Suspensions discusses uses of macroemulsions and (submicron) microemulsions illuminates delivery devices such as microparticles, nanospheres, liposomes, and mixed micelles investigates the application of self-emulsifying drug delivery systems (SEDDS) introduces techniques for increasing drug solubility with nanosuspensions addresses stabilization, flocculation, and coagulation problems in pharmaceutical and cosmetic suspensions surveys drug delivery by way of dermatological, follicular, and ocular routes explains the pharmacodynamics, bioavailability, and pharmacokinetics in the drug formulation development process compares and contrasts monomeric and micellar adsorption at oil-water interfaces and more! Containing over 1800 references, tables, equations, drawings, and micrographs, Pharmaceutical Emulsions and Suspensions is an ideal resource for pharmacists; physical, surface, colloid, cosmetic, food, and agricultural chemists; and upper-level undergraduate and graduate students in these disciplines.
Suspension Concentrates
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Author : Tharwat F. Tadros
language : en
Publisher: Walter de Gruyter GmbH & Co KG
Release Date : 2017-02-20
Suspension Concentrates written by Tharwat F. Tadros and has been published by Walter de Gruyter GmbH & Co KG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-02-20 with Science categories.
Suspension Concentrates is a survey into the theory of the formulation and stabilization of suspensions, elaborating on the breaking of aggregates and agglomerates and the role of dispersing agents on flocculation and electrostatic and steric stabilization. Practical analysis by rheology is discussed. Suspension Concentrates is ideal for research scientists and Ph.D. students investigating chemistry, chemical engineering and colloidal science.
Pharmaceutical Dosage Forms
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Author : Herbert Lieberman
language : en
Publisher: CRC Press
Release Date : 2020-08-26
Pharmaceutical Dosage Forms written by Herbert Lieberman and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-26 with Medical categories.
Stressing the theory involved in formulating suspensions, emulsions, and colloidal drug products, this Second Edition of a well-received reference test highlights typical formulations, the avoidance of formulation pitfalls, and compliance with established regulatory principles.
Dispersion Of Powders
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Author : Tharwat F. Tadros
language : en
Publisher: John Wiley & Sons
Release Date : 2012-04-24
Dispersion Of Powders written by Tharwat F. Tadros and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-04-24 with Science categories.
Teaching the fundamental knowledge required for successful dispersion of powders in a liquid, this book covers a host of topics -- from recent advances to industrial applications. In 15 chapters it supports formulation chemists in preparing a suspension in a more rational way, by applying the principles of colloid and interface science, while at the same time enabling the research scientist to discover new methods for preparing stable suspensions. Essential reading for those working in the pharmaceutical, cosmetic, food, paint, ceramic and agricultural industries.
Downstream Processing Of Pharmaceutical Crystal Suspensions Via Membrane Technology
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Author : Fatima Anjum
language : en
Publisher:
Release Date : 2024
Downstream Processing Of Pharmaceutical Crystal Suspensions Via Membrane Technology written by Fatima Anjum and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024 with categories.
Poorly Soluble Drugs
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Author : Gregory K. Webster
language : en
Publisher: CRC Press
Release Date : 2017-01-06
Poorly Soluble Drugs written by Gregory K. Webster and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-06 with Medical categories.
This book is the first text to provide a comprehensive assessment of the application of fundamental principles of dissolution and drug release testing to poorly soluble compounds and formulations. Such drug products are, vis-à-vis their physical and chemical properties, inherently incompatible with aqueous dissolution. However, dissolution methods are required for product development and selection, as well as for the fulfillment of regulatory obligations with respect to biopharmaceutical assessment and product quality understanding. The percentage of poorly soluble drugs, defined in classes 2 and 4 of the Biopharmaceutics Classification System (BCS), has significantly increased in the modern pharmaceutical development pipeline. This book provides a thorough exposition of general method development strategies for such drugs, including instrumentation and media selection, the use of compendial and non-compendial techniques in product development, and phase-appropriate approaches to dissolution development. Emerging topics in the field of dissolution are also discussed, including biorelevant and biphasic dissolution, the use on enzymes in dissolution testing, dissolution of suspensions, and drug release of non-oral products. Of particular interest to the industrial pharmaceutical professional, a brief overview of the formulation and solubilization techniques employed in the development of BCS class 2 and 4 drugs to overcome solubility challenges is provided and is complemented by a collection of chapters that survey the approaches and considerations in developing dissolution methodologies for enabling drug delivery technologies, including nanosuspensions, lipid-based formulations, and stabilized amorphous drug formulations.
Colloid Stability And Application In Pharmacy
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Author : Tharwat F. Tadros
language : en
Publisher: Wiley-VCH
Release Date : 2007-09-04
Colloid Stability And Application In Pharmacy written by Tharwat F. Tadros and has been published by Wiley-VCH this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-09-04 with Science categories.
This volume examines the role of colloid and interface science in pharmacy, as well as pharmaceutical formulations and drug delivery. It then goes on to treat pharmaceutical suspensions and emulsions, including multiple emulsions, as well as liposomes and the role of nanotechnology in drug delivery. A final section is devoted to the hot topic of stem cell research.