Pharmaco Complexity
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Pharmaco Complexity
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Author : Anthony J. Hickey
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-12-15
Pharmaco Complexity written by Anthony J. Hickey and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-12-15 with Medical categories.
The historical approach to the interpretation of physical, chemical and biological phenomena has been to consider relationships with causative factors that can be reduced to linearity allowing simple and direct interpretation. However, it is increasingly evident that there is often more information in the data than linear interpretations allow. The current capacity for computers to assist in identifying non-linear relationships allows greater interpretation of data which illuminates the phenomena allowing the information to be translated into knowledge that can be used wisely to promote various desirable pharmaceutical outcomes. This short volume is intended to stimulate the reader to contemplate research and development areas in which the data might be more accurately interpreted to allow greater understanding and ultimately control of the pharmaceutically complex phenomena.
Pharmaco Complexity
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Author : Anthony J. Hickey
language : en
Publisher: Springer Nature
Release Date : 2020-06-24
Pharmaco Complexity written by Anthony J. Hickey and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-24 with Medical categories.
Non-linear phenomena pervade the pharmaceutical sciences. Understanding the interface between each of these phenomena and the way in which they contribute to overarching processes such as pharmaceutical product development may ultimately result in more efficient, less costly and rapid implementation. The benefit to Society is self-evident in that affordable treatments would be rapidly forthcoming. We have aggregated these phenomena into one topic “Pharmaco-complexity: Non-linear Phenomena and Drug Product Development”.
Approaching Complex Diseases
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Author : Mariano Bizzarri
language : en
Publisher: Springer Nature
Release Date : 2020-04-17
Approaching Complex Diseases written by Mariano Bizzarri and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-17 with Medical categories.
This volume – for pharmacologists, systems biologists, philosophers and historians of medicine – points to investigate new avenues in pharmacology research, by providing a full assessment of the premises underlying a radical shift in the pharmacology paradigm. The pharmaceutical industry is currently facing unparalleled challenges in developing innovative drugs. While drug-developing scientists in the 1990s mostly welcomed the transformation into a target-based approach, two decades of experience shows that this model is failing to boost both drug discovery and efficiency. Selected targets were often not druggable and with poor disease linkage, leading to either high toxicity or poor efficacy. Therefore, a profound rethinking of the current paradigm is needed. Advances in systems biology are revealing a phenotypic robustness and a network structure that strongly suggest that exquisitely selective compounds, compared with multitarget drugs, may exhibit lower than desired clinical efficacy. This appreciation of the role of polypharmacology has significant implications for tackling the two major sources of attrition in drug development, efficacy and toxicity. Integrating network biology and polypharmacology holds the promise of expanding the current opportunity space for druggable targets.
Uncertainty In Pharmacology
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Author : Adam LaCaze
language : en
Publisher: Springer Nature
Release Date : 2020-02-20
Uncertainty In Pharmacology written by Adam LaCaze and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-20 with Medical categories.
This volume covers a wide range of topics concerning methodological, epistemological, and regulatory-ethical issues around pharmacology. The book focuses in particular on the diverse sources of uncertainty, the different kinds of uncertainty that there are, and the diverse ways in which these uncertainties are (or could be) addressed. Compared with the more basic sciences, such as chemistry or biology, pharmacology works across diverse observable levels of reality: although the first step in the causal chain leading to the therapeutic outcome takes place at the biochemical level, the end-effect is a clinically observable result—which is influenced not only by biological actions, but also psychological and social phenomena. Issues of causality and evidence must be treated with these specific aspects in mind. In covering these issues, the book opens up a common domain of investigation which intersects the deeply intertwined dimensions of pharmacological research, pharmaceutical regulation and the related economic environment. The book is a collective endeavour with in-depth contributions from experts in pharmacology, philosophy of medicine, statistics, scientific methodology, formal and social epistemology, working in constant dialogue across disciplinary boundaries.
Interculturologies Moving Forward With Interculturality In Research And Education
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Author : Fred Dervin
language : en
Publisher: Springer Nature
Release Date : 2024-08-23
Interculturologies Moving Forward With Interculturality In Research And Education written by Fred Dervin and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-08-23 with Education categories.
This book showcases 100 terms related to the scientific, educational and political notion of interculturality. Each term is presented with its specific multilingual discussions, scientific origins, multifaceted content, and short reviews of the global literature in English. Some myths, imaginaries and ideologies (‘interculturologies’ in the book) that they have led to construct are also introduced. Questions at the end of each entry encourage readers to think further regarding the notion of interculturality in research and education. Based on the author's decades-long experience in researching and teaching in the interdisciplinary field of intercultural communication education in different parts of the world, his constant reflexive and critical engagement with the notion of interculturality, and in-depth reviews of current research, the author has carefully selected (recurrent) concepts, notions, and ideas to be deconstructed in order to challenge readers to think further with him, especially beyond ‘Western’ and certain static and resistant ideological positions. These represent a complex body of concepts and notions, but also involve myths and imaginaries that can prevent us from moving forward in our thinking and in acting interculturally in research and education. This book serves as a reading guide for further interculturologies that the reader might identify in the future or as they engage with the book.
Vascular Pharmacology
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Author :
language : en
Publisher: Academic Press
Release Date : 2017-02-14
Vascular Pharmacology written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-02-14 with Medical categories.
Vascular Pharmacology: Smooth Muscle provides up-to-date information on the structure, function, signaling, and development of vascular smooth muscle. Contributors include prominent scientists and highly-recognized experts with major accomplishments in the field of vascular smooth muscle research. - Presents a must read reference on vascular smooth muscle physiology and pharmacology - Contains up-to-date information on the structure, function, signaling, and development of vascular smooth muscle - Includes contributors from prominent scientists and highly-recognized experts with major accomplishments in the field of vascular smooth muscle research
A Pharmacology Primer
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Author : Terry P. Kenakin
language : en
Publisher: Academic Press
Release Date : 2009-02-07
A Pharmacology Primer written by Terry P. Kenakin and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-02-07 with Medical categories.
This successful guide assists scientists trained in molecular biology and related fields who now need to know the basic theories, principles and practical applications of pharmacology. This latest edition continues the tradition of better preparing researchers in the basics of pharmacology. With expanded hands-on exercises and the addition of Pharmacokinetics coverage, new human interest material including historical facts in pharmacology and a new section on therapeutics that will help readers identify with diseases and drug treatments.The ideal book for researchers in drug discovery who have seen their role shift from "individual" to "team player" where that team includes chemists, biologists, and others with strong, but varied, science backgrounds who must now work together toward their common pharmacology goal. At GlaxoSmithKline, a pharmaceuticals world-leader, Terry Kenakin regularly teaches a course for their research scientists and has drawn on his experience to create a pharmacology primer.*New - Latest coverage of the chemistry of drugs including expanded coverage of the pharmacokinetic discussion of druglike properties -- Increases reader understanding of necessary ADME (Absorption, Distribution, Metabolism, and Excretion) properties and increases the rate of drug approval and acceptance. *Context - Unique discussions on various drug discovery teams and the role of the chemist on those teams -- Promotes the understanding of these expanding roles and responsibilities and how to maximize the effective contributions of each matrix team member. *Real-world learning - There are hands-on exercises, with extensive answers, utilizing real data on structure activity relationships; utilization of pharmacological principles to make general statements about how changes in structure lead to changes in drug activity. + hands on exercises with extensive answers on Pharmacokinetics -- Stengthens practical application and understanding of core concepts and principles.*Study sections are organized with ASPET (American Society for Pharmacology and Experimental Therapeutics)and other international organizations -- Ensures that learning follows professional industry standards.
Issues In Pharmacology Pharmacy Drug Research And Drug Innovation 2012 Edition
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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2013-01-10
Issues In Pharmacology Pharmacy Drug Research And Drug Innovation 2012 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-01-10 with Medical categories.
Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Molecular Pharmacology. The editors have built Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Molecular Pharmacology in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Reviews Of Physiology Biochemistry And Pharmacology Vol 174
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Author : Bernd Nilius
language : en
Publisher: Springer
Release Date : 2018-05-10
Reviews Of Physiology Biochemistry And Pharmacology Vol 174 written by Bernd Nilius and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-10 with Medical categories.
Leading researchers are specially invited to provide a complete understanding of a key topic within the multidisciplinary fields of physiology, biochemistry and pharmacology. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.
Contemporary Research Methods In Pharmacy And Health Services
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Author : Shane P. Desselle
language : en
Publisher: Academic Press
Release Date : 2022-05-10
Contemporary Research Methods In Pharmacy And Health Services written by Shane P. Desselle and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-10 with Medical categories.
Emerging methods, as well as best practices in well-used methods, in pharmacy are of great benefit to researchers, graduate students, graduate programs, residents and fellows also in other health science areas. Researchers require a text to assist in the design of experiments to address seemingly age-old problems. New interventions are needed to improve medication adherence, patients' lived experiences in health care, provider-patient relationships, and even various facets of pharmacogenomics. Advances in systems re-engineering can optimize health care practitioners' roles. Contemporary Research Methods in Pharmacy and Health Services includes multi-authored chapters by renowned experts in their field. Chapters cover examples in pharmacy, health services and others transcendent of medical care, following a standardized format, including key research points; valid and invalid assumptions; pitfalls to avoid; applications; and further inquiry. This is a valuable resource for researchers both in academia and corporate R&D, primarily in pharmacy but also in health services, and other health disciplines. Social science researchers and government scientists can also benefit from the reading. - Provides multi-authored chapters by renowned experts in their field - Includes examples for pharmacy and health services and others that are transcendent of medical care - Covers key research points, valid and invalid assumptions, pitfalls to avoid, applications, and further inquiry