Pharmacogenomic Insights Into Cancer Prevention
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Pharmacogenomic Insights Into Cancer Prevention
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Author : Sujit Nair
language : en
Publisher: LAP Lambert Academic Publishing
Release Date : 2012
Pharmacogenomic Insights Into Cancer Prevention written by Sujit Nair and has been published by LAP Lambert Academic Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with categories.
Pharmacogenomic profiling of cancer has recently seen much activity with the accessibility of the newest generation of high-throughput platforms & technologies. Myriad mechanistic studies have been devoted to identifying dietary phytochemicals from fruit or vegetables that can help prevent cancer, with evidence suggesting an inverse correlation between intake & risk of certain cancers. To develop a comprehensive understanding of cancer pathogenesis, & potential for chemopreventive intervention with dietary factors, an integrated approach that encompasses both pharmacogenomic & mechanistic aspects is desirable. This work discusses the identification of germane molecular targets by expression profiling using dietary factors, synergistic effects in combinatorial use of dietary factors in colon cancer, regulatory studies in prostate cancer, concerted modulation of key players in inflammation & carcinogenesis, & delineation of prostate cancer biological networks. This will greatly enhance our understanding of the transcriptional circuitry in cancer & important master regulators in the cell that may potentially be exploited for preventive intervention using dietary phytomedicines.
Translational Research And Onco Omics Applications In The Era Of Cancer Personal Genomics
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Author : Erika Ruiz-Garcia
language : en
Publisher: Springer Nature
Release Date : 2019-11-11
Translational Research And Onco Omics Applications In The Era Of Cancer Personal Genomics written by Erika Ruiz-Garcia and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-11 with Science categories.
Being a complex disease that affects millions of people world over, cancer research has assumed great significance. Translational cancer research transforms scientific discoveries in the laboratory into clinical application to reduce incidence of cancer, morbidity and mortality. On the other hand, personalized medicine in cancer is the concept that selection of a treatment should be tailored according to the individual patient’s specific genomic characteristics, including mutations, chromosomal aberrations, protein interactions, and SNPs, and even more, taking into account the inmume system, the metabolism and maybe in the next future also the microbiome.
Essentials Of Cancer Genomic Computational Approaches And Precision Medicine
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Author : Nosheen Masood
language : en
Publisher: Springer Nature
Release Date : 2020-03-20
Essentials Of Cancer Genomic Computational Approaches And Precision Medicine written by Nosheen Masood and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-20 with Medical categories.
This book concisely describes the role of omics in precision medicine for cancer therapies. It outlines our current understanding of cancer genomics, shares insights into the process of oncogenesis, and discusses emerging technologies and clinical applications of cancer genomics in prognosis and precision-medicine treatment strategies. It then elaborates on recent advances concerning transcriptomics and translational genomics in cancer diagnosis, clinical applications, and personalized medicine in oncology. Importantly, it also explains the importance of high-performance analytics, predictive modeling, and system biology in cancer research. Lastly, the book discusses current and potential future applications of pharmacogenomics in clinical cancer therapy and cancer drug development.
Progress And Challenges In Precision Medicine
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Author : Mukesh Verma
language : en
Publisher: Academic Press
Release Date : 2016-12-22
Progress And Challenges In Precision Medicine written by Mukesh Verma and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-22 with Science categories.
Progress and Challenges in Precision Medicine presents an insightful overview to the myriad factors of personalized and precision medicine. The availability of the human genome, large amounts of data on individual genetic variations, environmental interactions, influence of lifestyle, and cutting-edge tools and technologies for big-data analysis have led to the age of personalized and precision medicine. Bringing together a global range of experts on precision medicine, this book collects previously scattered information into one concise volume which covers the most important developments so far in precision medicine and also suggests the most likely avenues for future development. The book includes clinical information, informatics, public policy implications, and information on case studies. It is a useful reference and background work for students, researchers, and clinicians working in the biomedical and medical fields, as well as policymakers in the health sciences. Provides an overview of the growing field of precision medicine Contains chapters from geographically diverse experts in their field Explores important aspects of precision medicine, including applications, ethics, and development
Precision Medicine And Artificial Intelligence
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Author : Michael Mahler
language : en
Publisher: Academic Press
Release Date : 2021-03-12
Precision Medicine And Artificial Intelligence written by Michael Mahler and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-12 with Science categories.
Precision Medicine and Artificial Intelligence: The Perfect Fit for Autoimmunity covers background on artificial intelligence (AI), its link to precision medicine (PM), and examples of AI in healthcare, especially autoimmunity. The book highlights future perspectives and potential directions as AI has gained significant attention during the past decade. Autoimmune diseases are complex and heterogeneous conditions, but exciting new developments and implementation tactics surrounding automated systems have enabled the generation of large datasets, making autoimmunity an ideal target for AI and precision medicine. More and more diagnostic products utilize AI, which is also starting to be supported by regulatory agencies such as the Food and Drug Administration (FDA). Knowledge generation by leveraging large datasets including demographic, environmental, clinical and biomarker data has the potential to not only impact the diagnosis of patients, but also disease prediction, prognosis and treatment options. Allows the readers to gain an overview on precision medicine for autoimmune diseases leveraging AI solutions Provides background, milestone and examples of precision medicine Outlines the paradigm shift towards precision medicine driven by value-based systems Discusses future applications of precision medicine research using AI Other aspects covered in the book include regulatory insights, data analytics and visualization, types of biomarkers as well as the role of the patient in precision medicine
Economic Dimensions Of Personalized And Precision Medicine
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Author : Ernst R. Berndt
language : en
Publisher: University of Chicago Press
Release Date : 2019-04-22
Economic Dimensions Of Personalized And Precision Medicine written by Ernst R. Berndt and has been published by University of Chicago Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-04-22 with Business & Economics categories.
Personalized and precision medicine (PPM)—the targeting of therapies according to an individual’s genetic, environmental, or lifestyle characteristics—is becoming an increasingly important approach in health care treatment and prevention. The advancement of PPM is a challenge in traditional clinical, reimbursement, and regulatory landscapes because it is costly to develop and introduces a wide range of scientific, clinical, ethical, and socioeconomic issues. PPM raises a multitude of economic issues, including how information on accurate diagnosis and treatment success will be disseminated and who will bear the cost; changes to physician training to incorporate genetics, probability and statistics, and economic considerations; questions about whether the benefits of PPM will be confined to developed countries or will diffuse to emerging economies with less developed health care systems; the effects of patient heterogeneity on cost-effectiveness analysis; and opportunities for PPM’s growth beyond treatment of acute illness, such as prevention and reversal of chronic conditions. This volume explores the intersection of the scientific, clinical, and economic factors affecting the development of PPM, including its effects on the drug pipeline, on reimbursement of PPM diagnostics and treatments, and on funding of the requisite underlying research; and it examines recent empirical applications of PPM.
Cancer Prevention
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Author : H.-J. Senn
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-05-26
Cancer Prevention written by H.-J. Senn and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-05-26 with Medical categories.
This volume contains the main proceedings of the fourth international conference on "Cancer Prevention 2006," which was held during February 16–18, 2006, in St. Gallen, Switzerland. Written by international experts in the field, the book comprises a comprehensive update on the most recent developments in the upsurging fields of molecular biology and cancer genetics and their interactions with clinical epidemiology and cancer prevention at various levels.
Textbook Of Personalized Medicine
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Author : Kewal K. Jain
language : en
Publisher: Humana Press
Release Date : 2015-03-17
Textbook Of Personalized Medicine written by Kewal K. Jain and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-03-17 with Medical categories.
Advances in the technology used in personalized medicine and increased applications for clinical use have created a need for this expansion and revision of Kewal K. Jain’s Textbook of Personalized Medicine. As the first definitive work on this topic, this book reviews the fundamentals and development of personalized medicine and subsequent adoptions of the concepts by the biopharmaceutical industry and the medical profession. It also discusses examples of applications in key therapeutic areas, as well as ethical and regulatory issues, providing a concise and comprehensive source of reference for those involved in healthcare management, planning and politics. Algorithms are included as a guide to those involved in the management of important diseases where decision-making is involved due to the multiple choices available. Textbook of Personalized Medicine, Second Edition will serve as a convenient source of information for physicians, scientists, decision makers in the biopharmaceutical and healthcare industries and interested members of the public.
How Tobacco Smoke Causes Disease
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Author : United States. Public Health Service. Office of the Surgeon General
language : en
Publisher:
Release Date : 2010
How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Government publications categories.
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Genomic And Precision Medicine
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Author : Geoffrey S. Ginsburg
language : en
Publisher: Academic Press
Release Date : 2017-03-30
Genomic And Precision Medicine written by Geoffrey S. Ginsburg and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-30 with Science categories.
Genomic and Precision Medicine: Primary Care, Third Edition is an invaluable resource on the state-of-the-art tools, technologies and policy issues that are required to fully realize personalized health care in the area of primary care. One of the major areas where genomic and personalized medicine is most active is the realm of the primary care practitioner. Risk, family history, personal genomics and pharmacogenomics are becoming increasingly important to the PCP and their patients, and this book discusses the implications as they relate to primary care practitioners. Presents a comprehensive volume for primary care providers Provides succinct commentary and key learning points that will assist providers with their local needs for the implementation of genomic and personalized medicine Includes a current overview on major opportunities for genomic and personalized medicine in practice Highlights case studies that illustrate the practical use of genomics in the management in patients