Pharmacogenomics And Proteomics
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Pharmacogenomics And Proteomics
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Author : Steven How-Yan Wong
language : en
Publisher: AACC Press
Release Date : 2006
Pharmacogenomics And Proteomics written by Steven How-Yan Wong and has been published by AACC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Medical categories.
Reviews the fundamentals of molecular biology and general clinical implications important in understanding fundamental concepts, a general review of ethical considerations, methods of predicting response using artificial networks, regulatory issues, reimbursement, quality assurance considerations, and future market analysis; methodologies that merge the disciplines of pharmacogenetics with those of proteomics, metabolomics, and metabonomics; specific clinical applications of pharmacogenetics of major drug groups, specialties, and diseases, and how they are linked to potential clinical management; and selected biotechnologies relevant to the application of clinical pharmacogenomics and proteomics to clinical practice.
Handbook Of Pharmacogenomics And Stratified Medicine
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Author : Sandosh Padmanabhan
language : en
Publisher: Academic Press
Release Date : 2014-04-28
Handbook Of Pharmacogenomics And Stratified Medicine written by Sandosh Padmanabhan and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-04-28 with Science categories.
Handbook of Pharmacogenomics and Stratified Medicine is a comprehensive resource to understand this rapidly advancing field aiming to deliver the right drug at the right dose to the right patient at the right time. It is designed to provide a detailed, but accessible review of the entire field from basic principles to applications in various diseases. The chapters are written by international experts to allow readers from a wide variety of backgrounds, clinical and non-clinical (basic geneticists, pharmacologists, clinicians, trialists, industry personnel, ethicists) to understand the principles underpinning the progress in this area, the successes, failures and the challenges ahead. To be accessible to the widest range of readers, the clinical application section introduces the disease process, existing therapies, followed by pharmacogenomics and stratified medicine details.Medicine is the cornerstone of modern therapeutics prescribed on the basis that its benefit should outweigh its risk. It is well known that people respond differently to medications and in many cases the risk-benefit ratio for a particular drug may be a gray area. The last decade has seen a revolution in genomics both in terms of technological innovation and discovering genetic markers associated with disease. In parallel there has been steady progress in trying to make medicines safer and tailored to the individual. This has occurred across the whole spectrum of medicine, some more than others. In addition there is burgeoning interest from the pharmaceutical industry to leverage pharmacogenomics for more effective and efficient clinical drug development. - Provides clinical and non-clinical researchers with practical information normally beyond their usual areas of research or expertise - Includes an basic principles section explaining concepts of basic genetics, genetic epidemiology, bioinformatics, pharmacokinetics and pharmacodynamics - Covers newer technologies– next generation sequencing, proteomics, metabolomics - Provides information on animal models, lymphoblastoid cell lines, stem cells - Provides detailed chapters on a wide range of disease conditions, implementation and regulatory issues - Includes chapters on the global implications of pharmacogenomics
The Dictionary Of Genomics Transcriptomics And Proteomics
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Author : Guenter Kahl
language : en
Publisher: John Wiley & Sons
Release Date : 2015-06-17
The Dictionary Of Genomics Transcriptomics And Proteomics written by Guenter Kahl and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-06-17 with Science categories.
Now in its fifth edition and for the first time available as an electronic product with all entries cross-linked. This very successful long-seller has once again been thoroughly updated and greatly expanded. It now contains over 13,000 entries, and comprehensively covering genomics, transcriptomics, and proteomics. Each entry contains an extensive explanation, including a comprehensive listing of synonyms and acronyms, and all formulas have been redrawn to create a uniform style, while most of the figures are custom designed for this dictionary. The ultimate reference for all terms in the -omics fields.
Genomics And Pharmacogenomics In Anticancer Drug Development And Clinical Response
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Author : Federico Innocenti
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-10-30
Genomics And Pharmacogenomics In Anticancer Drug Development And Clinical Response written by Federico Innocenti and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-10-30 with Medical categories.
Genomics and Pharmacogenomics in Anticancer Drug Development and Clinical Response provides the most comprehensive body of knowledge available on the role of genetic and genomic variation in the individualization of drug therapies in cancer patients. As a consequence of the intrinsic chromosomal and genetic instability of the tumor genome, it is generally believed that tailoring of chemotherapy in cancer - tients might be achieved by molecular analysis of patient tumor DNA. In addition, to reduce the toxicity risk of patients, the tumor DNA information should be in- grated with the available data on polymorphic drug-metabolizing enzyme and tra- porter genes mediating the exposure of patients to active drugs and/or their active metabolites. The chapters of this book clearly show how DNA information from both the host (germline) and the tumor should be taken into account for rational selection of drug therapies in cancer patients, an aspect that received little attention, despite its importance. The availability of new molecular approaches to the selection of drug therapy is an emerging need, because the traditional approach based on the evaluation of patient and tumor characteristics is clearly far from optimal. Many treated patients do not experience signi?cant bene?ts from the treatment, while they often experience moderate to severe toxicities. In addition, the development and clinical use of novel molecularly targeted agents (alone or in combination with classical cytotoxic therapy) requires the und- standing of the molecular features of the tumors and the identi?cation of tumor markers of response.
Omics In Clinical Practice
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Author : Yu Liu
language : en
Publisher: CRC Press
Release Date : 2014-06-20
Omics In Clinical Practice written by Yu Liu and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-06-20 with Science categories.
This book serves as an introduction to genomics, proteomics, and transcriptomics, putting these fields in relation to human disease and ailments. The various chapters consider the role of translation and personalized medicine, as well as pathogen detection, evolution, and infection, in relation to genomics, proteomics, and transcriptomics. The topic of companion diagnostics is also covered. The book is broken into five sections. Part I examines the connection between omics and human disease. Part II looks at the applications for the fields of translational and personalized medicine. Part III focuses on molecular and genetic markers. Part IV describes the use of omics while studying pathogens, and Part V examines the applications for companion diagnostics. The book: • Introduces genomics, proteomics, and transcriptomics in relation to human disease and ailments • Considers the role of translation and personalized medicine in relation to genomics, proteomics, and transcriptomics • Covers molecular and genetic markers • Considers the role of genomics, proteomics, and transcriptomics in relation to pathogen detection, evolution, and infection • Covers companion diagnostics in relation to genomics, proteomics, and transcriptomics clinical applications and research
Integrative Proteomics
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Author : Hon-Chiu Leung
language : en
Publisher: BoD – Books on Demand
Release Date : 2012-02-24
Integrative Proteomics written by Hon-Chiu Leung and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-02-24 with Science categories.
Proteomics was thought to be a natural extension after the field of genomics has deposited significant amount of data. However, simply taking a straight verbatim approach to catalog all proteins in all tissues of different organisms is not viable. Researchers may need to focus on the perspectives of proteomics that are essential to the functional outcome of the cells. In Integrative Proteomics, expert researchers contribute both historical perspectives, new developments in sample preparation, gel-based and non-gel-based protein separation and identification using mass spectrometry. Substantial chapters are describing studies of the sub-proteomes such as phosphoproteome or glycoproteomes which are directly related to functional outcomes of the cells. Structural proteomics related to pharmaceutics development is also a perspective of the essence. Bioinformatics tools that can mine proteomics data and lead to pathway analyses become an integral part of proteomics. Integrative proteomics covers both look-backs and look-outs of proteomics. It is an ideal reference for students, new researchers, and experienced scientists who want to get an overview or insights into new development of the proteomics field.
Pharmacoproteomics
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Author : Seth K. Amponsah
language : en
Publisher: Springer Nature
Release Date : 2024-09-01
Pharmacoproteomics written by Seth K. Amponsah and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-09-01 with Science categories.
This book gives an overview of pharmacoproteomics and its clinical applications, as well as the latest information on drug mechanisms at the proteome level, the relationship between proteomics and toxicity or resistance, and how proteomics aid in discovery of new drug targets. The book also highlights recent advances in analytical methods, analysis, and interpretation of pharmacoproteomic data. Pharmacoproteomics: Recent Trends and Applications is an ideal book for those working in pharmaceutical industries, as well as scientists, health care professionals, and researchers who work in the field of genomics, pharmacology, pharmacokinetics, toxicology, and pharmaceutical chemistry.
Pharmacogenomics
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Author : Werner Kalow
language : en
Publisher: CRC Press
Release Date : 2001-05-08
Pharmacogenomics written by Werner Kalow and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-05-08 with Medical categories.
"Summarizes the history of, and available applications, techniques, and approaches to, pharmacogenomics--improving efficacy and tolerance to pharmaceutical compounds, evaluating pharmacogenomics on clinical trial design, and increasing the chances of successful clinical trials and patient outcomes. Compares pharmacogenomics to pharmacogenetics, focusing on the essential components that incorporate individual genetic variations to drug regimens resulting in different responses to therapeutics."
Omics For Personalized Medicine
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Author : Debmalya Barh
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-10-14
Omics For Personalized Medicine written by Debmalya Barh and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-14 with Medical categories.
“Omics for Personalized Medicine” will give to its prospective readers the insight of both the current developments and the future potential of personalized medicine. The book brings into light how the pharmacogenomics and omics technologies are bringing a revolution in transforming the medicine and the health care sector for the better. Students of biomedical research and medicine along with medical professionals will benefit tremendously from the book by gaining from the diverse fields of knowledge of new age personalized medicine presented in the highly detailed chapters of the book. The book chapters are divided into two sections for convenient reading with the first section covering the general aspects of pharmaocogenomic technology that includes latest research and development in omics technologies. The first section also highlights the role of omics in modern clinical trials and even discusses the ethical consideration in pharmocogenomics. The second section is focusing on the development of personalized medicine in several areas of human health. The topics covered range from metabolic and neurological disorders to non-communicable as well as infectious diseases, and even explores the role of pharmacogenomics in cell therapy and transplantation technology. Thirty-four chapters of the book cover several aspects of pharmacogenomics and personalized medicine and have taken into consideration the varied interest of the readers from different fields of biomedical research and medicine. Advent of pharmacogenomics is the future of modern medicine, which has resulted from culmination of decades of research and now is showing the way forward. The book is an honest endeavour of researchers from all over the world to disseminate the latest knowledge and knowhow in personalized medicine to the community health researchers in particular and the educated public in general.
Integrative Omics
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Author : Manish Kumar Gupta
language : en
Publisher: Elsevier
Release Date : 2024-05-03
Integrative Omics written by Manish Kumar Gupta and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-03 with Science categories.
Integrative Omics: Concepts, Methodology and Applications provides a holistic and integrated view of defining and applying network approaches, integrative tools, and methods to solve problems for the rationalization of genotype to phenotype relationships. The reference includes a range of chapters in a systemic 'step by step' manner, which begins with the basic concepts from Omic to Multi Integrative Omics approaches, followed by their full range of approaches, applications, emerging trends, and future trends. All key areas of Omics are covered including biological databases, sequence alignment, pharmacogenomics, nutrigenomics and microbial omics, integrated omics for Food Science and Identification of genes associated with disease, clinical data integration and data warehousing, translational omics as well as omics technology policy and society research. Integrative Omics: Concepts, Methodology and Applications highlights the recent concepts, methodologies, advancements in technologies and is also well-suited for researchers from both academic and industry background, undergraduate and graduate students who are mainly working in the area of computational systems biology, integrative omics and translational science. The book bridges the gap between biological sciences, physical sciences, computer science, statistics, data science, information technology and mathematics by presenting content specifically dedicated to mathematical models of biological systems. - Provides a holistic, integrated view of a defining and applying network approach, integrative tools, and methods to solve problems for rationalization of genotype to phenotype relationships - Offers an interdisciplinary approach to Databases, data analytics techniques, biological tools, network construction, analysis, modeling, prediction and simulation of biological systems leading to 'translational research', i.e., drug discovery, drug target prediction, and precision medicine - Covers worldwide methods, concepts, databases, and tools used in the construction of integrated pathways