Pharmacological Approaches Targeting Neutrophilic Inflammation Volume Ii

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Pharmacological Approaches Targeting Neutrophilic Inflammation Volume Ii

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Author : Galina Sud’ina
language : en
Publisher: Frontiers Media SA
Release Date : 2022-12-22

Pharmacological Approaches Targeting Neutrophilic Inflammation Volume Ii written by Galina Sud’ina and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-22 with Science categories.

Pharmacology Volume Ii

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Author : Harry Majewski
language : en
Publisher: EOLSS Publications
Release Date : 2009-10-29

Pharmacology Volume Ii written by Harry Majewski and has been published by EOLSS Publications this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-10-29 with Pharmacology categories.

Pharmacology is a component of Encyclopedia of Biological, Physiological and Health Sciences in the global Encyclopedia of Life Support Systems (EOLSS), which is an integrated compendium of twenty one Encyclopedias. Pharmacology is the study of the actions of chemicals on the body and most usually it is defined as chemicals that can have a therapeutic action to treat disease. Since it looks at the interaction between chemicals and body systems pharmacology utilizes the basic disciplines of chemistry, biochemistry, physiology, pathology and microbiology in its practice. Pharmacology is a foundation science for pharmacy which is the rational prescribing of drugs to treat disease and the foundation science for toxicology which is the study of the toxic actions of chemicals on the body. The two volumes are organized in groups of chapters as follows: The first group of chapters discuss pharmacological principles and these include chapters on Pharmacodynamics; Pharmacokinetics, Neuropharmacology, Autonomic Pharmacology and Clinical Pharmacology. The second group of chapters discusses the processes of Drug discovery and the Safety requirements for drugs to be used therapeutically and include Drug Discovery and Safety Pharmacology assessment. The largest group of chapters discuss different therapeutic areas and include Cardiovascular and renal pharmacology; Endocrine pharmacology; Neuropsychopharmacology; Pulmonary Pharmacology; Gastrointestinal pharmacology; Poisons venoms and toxins; Drugs on skeletal muscle; the Pharmacotherapy of inflammation; Reproductive pharmacology; Pain pharmacology and analgesia. The final group of chapters discuss new approaches and include Pharmacogenetics and pharmacogenomics; Immunopharmacology and Gene therapy. These two volumes are aimed at the following a wide spectrum of audiences from the merely curious to those seeking in-depth knowledge: University and College students Educators, Professional practitioners, Research personnel and Policy analysts, managers, and decision makers and NGOs.

Resolution Pharmacology Innovative Therapeutic Approaches Based On The Biology Of Resolution To Control Chronic Diseases Of Western Societies

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Author : Mauro Perretti
language : en
Publisher: Frontiers Media SA
Release Date : 2019-11-04

Resolution Pharmacology Innovative Therapeutic Approaches Based On The Biology Of Resolution To Control Chronic Diseases Of Western Societies written by Mauro Perretti and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-04 with categories.

In this eBook, we have grouped together 16 original contributions which have addressed the translational potential for therapeutics developed on the conceptual framework of the resolution of inflammation. The take home message of our effort, and the efforts of our colleagues who wrote these pieces, is that completely different drugs can be designed and modelled on the mediators and targets of resolution. By implementing this 180° shift in the way we plan the drug development programme (that is by focusing on agonists and/or promoting the actions of pro-resolution agonists) we can offer a fresh approach to the clinical management of chronic diseases that affect the modern society. With this series of articles we foresee the birth of Resolution Pharmacology. The 16 contributions presented herein confirm the broad relevance of pro-resolving physio-pharmacology with the description of pro-resolving mechanisms in distinct diseases, from atherosclerosis and heart infarct, to cystic fibrosis and diabetes. This testifies on one hand the fundamental role that inflammatory mechanisms play in virtually all pathological settings and, on the other hand, the great potential that a novel approach to anti-inflammatory therapy by exploiting resolution mediators and targets may have. Thus, while there is broad recognition that evidence-based interventions have transformed cardiovascular, inflammation and endocrine care, new therapies are still needed for growing numbers of patients with unmet needs. As an example, an estimated 17 million people world-wide die annually of cardiovascular diseases, particularly heart attacks and strokes. Cardiovascular diseases occur almost equally in men and women and are the leading cause of death and morbidity worldwide. It is estimated that only 1/1,000 compounds entering preclinical testing are then trialled in man and the actual cost of developing a new therapeutic into clinical practice has grown exponentially over the past two decades (estimated $1.2B). Over the last 20 years or more, scientists have appreciated the biology of the resolution of inflammation, which provides a new paradigm in our understanding of the inflammatory process with the appreciation of genetic, molecular and cellular mechanisms that are engaged to actively resolve inflammation. The ‘resolution of acute inflammation’ is enabled by counter-regulatory checkpoints to terminate the host reaction while at the same time promoting healing and repair. The potential of lipid mediators to enact pro-resolving effects in the context of cystic fibrosis is presented by Recchiuti et al., while Fredman reasons on the potential for these molecules in atherosclerosis. This resonates well with the contributions from Bäck and colleagues who have focused on pro-resolving receptors to offer vasculo-protection in intimal hyperplasia and more generally in cardiovascular disease. On the same vein is the scholar contribution of Leoni and Soehnlein who focus on heart disease, with Qin et al. presenting the latest findings on the effect of an Annexin A1-derived peptide in myocardial infarction. Hansen et al. and de Gaetano et al. bring in the complexity of diabetes and associated morbidity with a focus on specialised pro-resolving lipid mediators but also introducing the potential of dietary approaches. As the western diet favours disease, an omega-3 rich diet can lead to higher availability of lipid mediators to afford tissue protection if not reverting its pathological status. Docosahexaenoic acid and its bioactive derivatives are endowed with potent anti-nociceptive properties following bone fracture, as shown by Zhang et al. The broad relevance of the pharmacological approach reaches the skin with Resolvin D1 protecting against UV irradiation (Saito et al.). Reduced skin inflammation is also achieved with an Annexin A1 peptide that impacts on the outcome of heterologous transplantation (Lacerda et al.). Indeed, modulating the phenotype of immune cells can provide long lasting beneficial outcomes, as attained with CDK inhibitors (Cartwright et al.) and PI3K inhibitors in experimental gout (Galvao et al.). Such an effect is also achieved with a third group of pro-resolving therapeutics, the melanocortin receptor agonists, with important modulation of macrophage reactivity (Patruno et al.) with Spana et al., providing new pharmacology following selective activation of the MC1 receptor. Finally, Hopkin et al. discuss the potential for targeting immune cell trafficking as a way to control immune mediated diseases, bringing in not only pro-resolving mediator agonists, but also approaches to reduce chemo/cytokine gradients or modulating S1P and 11-beta hydroxysteroid dehydrogenase. Finally, we wish to highlight that this wealth of science has also bought to the forefront specific pro-resolving receptors (including FPR2/ALX, GPR32, ChemR23 and MC1), all G protein coupled receptors that are therefore amenable to pharmacological exploitation for drug discovery programmes. We see that not only agonists to the receptors can be developed, some of them modelled on the natural ligands (e.g. resolvins, lipoxins, Annexin A1-derived peptides or melanocortin peptides), but also that the creativity of this pharmacology can be attained through biased ligands and positive allosteric modulators. Deep knowledge of pro-resolving receptor biology and their cell-specific signalling can accelerate the generation of novel anti-inflammatory depicted on the resolution of inflammation. In conclusion, with this eBook, we propose time is ready to exploit the concepts of resolution and use its targets and mediators for the identification of better drugs to establish ‘Resolution Pharmacology’. We predict Resolution Pharmacology will represent an important innovation in the way common diseases will be treated in the next decades of this millennium.

Novel Anti Inflammatory Approaches For Cystic Fibrosis Lung Disease Identification Of Molecular Targets And Design Of Innovative Therapies

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Author : Carla Maria Pedrosa Ribeiro
language : en
Publisher: Frontiers Media SA
Release Date : 2022-01-04

Novel Anti Inflammatory Approaches For Cystic Fibrosis Lung Disease Identification Of Molecular Targets And Design Of Innovative Therapies written by Carla Maria Pedrosa Ribeiro and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-04 with Science categories.

Role Of Neutrophils In Disease Pathogenesis

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Author : Maitham Khajah
language : en
Publisher: BoD – Books on Demand
Release Date : 2017-06-07

Role Of Neutrophils In Disease Pathogenesis written by Maitham Khajah and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-07 with Medical categories.

This book highlights the important role of neutrophils in health as well as in the pathogenesis of various diseases. Section 1 provides a general background information regarding the mechanisms and various triggers of neutrophil extracellular traps (NETs) formation and their role in various infectious and noninfectious diseases (such as postinjury inflammation). Section 2 provides recent evidence regarding the role of neutrophils in the pathogenesis as well as a therapeutic target for selected disease conditions such as periodontal diseases, rheumatoid arthritis, and cystic fibrosis. Section 3 describes the anti-inflammatory properties of neutrophils with focus regarding their role in graft versus host disease. This book provides a wider picture with regard to the importance of this immune cell type in various diseases with focus on one of its recently discovered properties, NETs. Therapeutic targets aimed to modulate neutrophil functions might provide novel approaches in the treatment of various diseases of infectious and noninfectious origin.

Chemoinformatics Approaches To Structure And Ligand Based Drug Design Volume Ii

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Author : Adriano D. Andricopulo
language : en
Publisher: Frontiers Media SA
Release Date : 2022-07-27

Chemoinformatics Approaches To Structure And Ligand Based Drug Design Volume Ii written by Adriano D. Andricopulo and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-27 with Science categories.

Molecular Pharmacological Approaches Against Lung Diseases Targeted Drug Discovery

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Author : Poonam Arora
language : en
Publisher: Frontiers Media SA
Release Date : 2024-07-12

Molecular Pharmacological Approaches Against Lung Diseases Targeted Drug Discovery written by Poonam Arora and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-12 with Science categories.

Molecular Pharmacological approaches against lung diseases: targeted drug discovery The global burden of lung diseases is rising continuously and is a constant concern. Lung diseases of concern, including asthma, infection (pneumonia), lung cancer, abnormal build-up of fluid, swelling, and inflammation, both neoplastic and non-neoplastic diseases, are listed as the third leading cause of death by the World Health Organization. The most common disease in the lungs includes asthma, cystic fibrosis, chronic obstructive pulmonary disease etc. The respiratory issues listed here, among others, are exacerbated by environmental toxicants which directly come in contact with the lung architecture thereby causing lung pathologies resulting in the exacerbated immune response in affected patients. Biologically active molecules including small or large molecular weight compounds from natural or synthetic sources exhibit prominent pharmacological properties that impact health by modulating disease pathophysiology, and influence the ligand-receptor interactions, depending upon the pathway and their bioavailability.

Inflammatory Immune Disease Molecular Mechanisms Translational Approaches And Therapeutics Volume Ii

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Author : Tao Xu
language : en
Publisher: Frontiers Media SA
Release Date : 2023-03-17

Inflammatory Immune Disease Molecular Mechanisms Translational Approaches And Therapeutics Volume Ii written by Tao Xu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-17 with Science categories.

Inflammatory Bowel Disease

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Author : Sami Karoui
language : en
Publisher: BoD – Books on Demand
Release Date : 2012-01-27

Inflammatory Bowel Disease written by Sami Karoui and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-27 with Medical categories.

This book is dedicated to inflammatory bowel disease, and the authors discuss the advances in the pathogenesis of inflammatory bowel disease, as well as several new parameters involved in the etiopathogeny of Crohn's disease and ulcerative colitis, such as intestinal barrier dysfunction and the roles of TH 17 cells and IL 17 in the immune response in inflammatory bowel disease. The book also focuses on several relevant clinical points, such as pregnancy during inflammatory bowel disease and the health-related quality of life as an end point of the different treatments of the diseases. Finally, advances in management of patients with inflammatory bowel disease are discussed, especially in a complete review of the recent literature.

Drug Repurposing And Polypharmacology A Synergistic Approach In Multi Target Based Drug Discovery

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Author : Mithun Rudrapal
language : en
Publisher: Frontiers Media SA
Release Date : 2023-01-30

Drug Repurposing And Polypharmacology A Synergistic Approach In Multi Target Based Drug Discovery written by Mithun Rudrapal and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-30 with Science categories.