Pharmacology Of Endogenous Neurotoxins
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Pharmacology Of Endogenous Neurotoxins
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Author : Andreas Moser
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Pharmacology Of Endogenous Neurotoxins written by Andreas Moser and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
It is a great pleasure to write the foreword to this important volume for several reasons. First: As far as we know, already primitive societies had to cope with environmental toxins of many kinds and set up regulations to limit their effects on food and drug use. Modem science, synthesizing tens of millions of new compounds has incredibly magnified this challenge. Today, xenobiotic metabolism has become a crucial task for humans and many other species alike. Second: When reading this book, one is impressed by the extraordinary speed at which neurotoxicology has advanced. Obviously, processing (and endogenous formation) oftox ins has become an extremely relevant topic. When I had the chance, almost three decades ago, to work in chemical pharmacology with Bernard B. Brodie at NIH, the drug metabo lizing system of the liver had just been recognized and characterized. We had just started to work on the biogenic amines, newly discovered cyclic nucleotides in rat brain, human cere brospinal fluid, and on the effects of toxic drugs like amphetamines. Today, biochemical neuropharmacology is a mature field of neuroscience.
Pharmacology Of Endogenous Neurotoxins
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Author : Andreas Moser
language : en
Publisher:
Release Date : 1997-12-18
Pharmacology Of Endogenous Neurotoxins written by Andreas Moser and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-12-18 with categories.
Neurotoxins And Neurodegenerative Disease
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Author : James William Langston
language : en
Publisher:
Release Date : 1992
Neurotoxins And Neurodegenerative Disease written by James William Langston and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Nervous system categories.
The use of neurotoxins as tools to study neurodegenerative disorders is explored by both basic and clinical scientists in this text. The emphasis is on whether or not exogenous or endogenous neurotoxins may be part of the natural etiology of neurodegenerative disorders. An in-depth analysis of the potential mechanism of action of various neurotoxins, including MPTP, methamphetamine, kainic acid and several other excitotoxins, and the cholinergic neurotoxin AF-64A, is featured.
Characterization Of The Formation Of Endogenous Neurotoxins In The Rat Brain Following Administration Of Neurotoxic Amphetamines
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Author : Karen Jean Axt
language : en
Publisher:
Release Date : 1988
Characterization Of The Formation Of Endogenous Neurotoxins In The Rat Brain Following Administration Of Neurotoxic Amphetamines written by Karen Jean Axt and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988 with Amphetamines categories.
In Vitro Neurotoxicology
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Author : Evelyn Tiffany-Castiglioni
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-06
In Vitro Neurotoxicology written by Evelyn Tiffany-Castiglioni and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-06 with Medical categories.
Well-respected leaders in the field of in vitro neurotoxicology take a fresh look at their own and other's work, critically and comparatively analyzing it across experimental systems and toxicants, and synthesizing essential principles for in vitro neurotoxicity testing. Neurotoxicants of significance to human health are emphasized, especially those for which metabolism and dose-responses are well well studied both in vivo and in vitro: lead, mercury, organophosphorous insecticides, polychlorinated biphenyls and dioxin, ethanol, and endogenous proteins. The goal is to set out new concepts and research directions that will hasten significant improvement in the methods and systems for in vitro neurotoxicity testing.
Neurotoxic Factors In Parkinson S Disease And Related Disorders
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Author : Michael Storch
language : en
Publisher: Springer Science & Business Media
Release Date : 2000
Neurotoxic Factors In Parkinson S Disease And Related Disorders written by Michael Storch and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Medical categories.
nd This book stems from the 2 Parkinson's Disease Symposium on "Neurotoxic Factors in Parkinsons disease and related disorders", held on August 6-7,1999 at the University ofUlm Medical School in Ulm at the Danube, Germany. The symposium wasalso asatellite ofthejointmeetingofthe InternationalSocietyfor Neurochemistry (ISN) and the European Society for Neurochemistry (ESN) that followed immediately afterwards in Berlin. The specific topic, neurotoxic factors in Parkinson's disease (PD), was chosen in light of accumulating neurobiological and epidemiological evidence indicating that the causes of this second most common neurodegenerative disorder, and possibly of related conditions such as multiple systems atrophy, in some manner involve environ mental (xenobiotic) and even endogenous toxic agents. This volume brings together much of that neurobiological evidence; and in epidemiology, several recent major studies ofPD - for example, a study of20,000 twins published in the Journal of the American Medical Association in 1999 - conclude that environmental and life style than genetics, appear to be critical in the idiopathic disease. However, factors, rather the precise roles of neurotoxic factors in the pathogenesis of PD and related basal ganglia disorders remain uncertain, despite the cascade of research resulting from the discovery of the prototype MPTP in the early 1980's, and frankly, we have been surprised by the paucity of concentrated attention on specific environmental agents other than MPTP.
Metabolism Of Endogenous Neurotoxins In Neurodegenerative Disease
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Author : Kathrin R. Sidell
language : en
Publisher:
Release Date : 2001
Metabolism Of Endogenous Neurotoxins In Neurodegenerative Disease written by Kathrin R. Sidell and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with Alzheimer's disease categories.
Neuropsychopharmacotherapy
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Author : Peter Riederer
language : en
Publisher: Springer Nature
Release Date : 2022-11-04
Neuropsychopharmacotherapy written by Peter Riederer and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-04 with Medical categories.
This book provides a reference guide describing the current status of medication in all major psychiatric and neurological indications, together with comparisons of pharmacological treatment strategies in clinical settings in Europe, USA, Japan and China. In addition, it highlights herbal medicine as used in China and Japan, as well as complementary medicine and nutritional aspects. This novel approach offers international readers a global approach in a single dedicated publication and is also a valuable resource for anyone interested in comparing treatments for psychiatric disorders in three different cultural areas. There are three volumes devoted to Basic Principles and General Aspects, offering a general overview of psychopharmacotherapy (Vol. 1); Classes, Drugs and Special Aspects covering the role of psychotropic drugs in the field of psychiatry and neurology (Vol. 2) and Applied Psychopharmacotherapy focusing on applied psychopharmacotherapy (Vol. 3). These books are invaluable to psychiatrists, neurologists, neuroscientists, medical practitioners and clinical psychologists.
Clinical Studies And Therapies In Parkinson S Disease
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Author : Juan Segura-Aguilar
language : en
Publisher: Academic Press
Release Date : 2021-06-12
Clinical Studies And Therapies In Parkinson S Disease written by Juan Segura-Aguilar and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-12 with Medical categories.
More than 50 years have passed since the use of L-dopa in the palliative treatment of Parkinson’s disease, but it remains the most common treatment despite inducing severe side effects such as dyskinesia after 4–6 years of use. Numerous preclinical investigations based on endogenous neurotoxin models have promised various therapies for Parkinson’s disease, but these efforts have failed when attempting to transfer these successful results to preclinical studies. Although several publications have warned of these failures, the scientific community remains mostly unaware, and there is a need to focus their efforts on potential therapeutics that can slow or halt development of the disease. Clinical Studies and Therapies in Parkinson’s Disease: Translations from Preclinical Models analyzes preclinical models based on exogenous neurotoxins and why they have failed. Neuroscientists, neurologists, and neuropharmacologists will benefit greatly from the book’s discussion of these newer models, their benefits, and the need for their implementation. This book also provides the basic concepts of dopamine metabolism for students taking courses in neurochemistry, neuroscience, neuropharmacology, biochemistry, and medicine. Reviews Parkinson's disease classification, pharmacological therapies, and nonmotor and motor symptoms Analyzes preclinical models of Parkinson’s disease therapies based on exogenous neurotoxins and why they have failed Reviews genetic preclinical models based on genetic mutations and endogenous neurotoxins Proposes a more physiological model directly related to the metabolism of dopaminergic neurons Provides the basic concepts and mechanisms of dopamine metabolism
Pharmacology Of Neurotransmitter Release
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Author : Thomas C. Südhof
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-12-07
Pharmacology Of Neurotransmitter Release written by Thomas C. Südhof and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-12-07 with Medical categories.
It has been known for half a century that neurotransmitters are released in preformed quanta, that the quanta represent transmitter-storing vesicles, and that release occurs by exocytosis. The focus of this book is twofold. In the first part, the molecular events of exocytosis are analysed. In the second part of the book, the presynaptic receptors for endogenous chemical signals are presented that make neurotransmitter release a highly regulated process.