Phosphoinositides I Enzymes Of Synthesis And Degradation

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Phosphoinositides I Enzymes Of Synthesis And Degradation

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Author : Tamas Balla
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-03-08

Phosphoinositides I Enzymes Of Synthesis And Degradation written by Tamas Balla and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-03-08 with Medical categories.

Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases – and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume I untangles the web of these enzymes and their products, and relates them to function in health and disease. Phosphoinositide 3-kinases and 3-phosphatases have received a special focus in volume I, and recent therapeutic developments in human disease are presented along with a historical perspective illustrating the impressive progress in the field.

Phosphoinositides I Enzymes Of Synthesis And Degradation

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Author : Tamas Balla
language : en
Publisher: Springer
Release Date : 2012-03-14

Phosphoinositides I Enzymes Of Synthesis And Degradation written by Tamas Balla and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-03-14 with Medical categories.

Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases – and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume I untangles the web of these enzymes and their products, and relates them to function in health and disease. Phosphoinositide 3-kinases and 3-phosphatases have received a special focus in volume I, and recent therapeutic developments in human disease are presented along with a historical perspective illustrating the impressive progress in the field.

Phosphoinositides

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Author : Dr. Tamas Balla
language : en
Publisher:
Release Date : 2012

Phosphoinositides written by Dr. Tamas Balla and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Inositol phosphates categories.

Biology Of Phosphoinositides

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Author : Shamshad Cockcroft
language : en
Publisher: Oxford University Press, USA
Release Date : 2000

Biology Of Phosphoinositides written by Shamshad Cockcroft and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Language Arts & Disciplines categories.

This is a review of the current opinions on lipid signalling research with an emphasis on the integration of the use of lipid signals in signal transduction and membrane trafficking. These two areas have traditionally been seen as separate, but in the light of recent research it has become apparent that any work in this area must include the two, as this book does. In the text, control of synthesis, translocation, and degradation of phosphoinositides is given extensive coverage; there is specific discussion of the PH and FYVE lipid binding domains that allow lipids to control the movement, location, and activation-state of membrane proteins; the regulation of phospholipase C, phospholipase D, the phosphoinositide-3-kinases, chloride channel conductance by inositol (3,4,5,6) tetraphosphate, and of cytoskeletal protein activity by inositol lipids are all covered in depth.

Phosphoinositides And Disease

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Author : Marco Falasca
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-10-20

Phosphoinositides And Disease written by Marco Falasca and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-10-20 with Medical categories.

Phosphoinositides (PIs) are minor components of cellular membranes that play critical regulatory roles in several intracellular functions. This book describes the main enzymes regulating the turnover of each of the seven PIs in mammalian cells, some of their intracellular functions and some evidence of their involvement in human diseases. Due to the complex inter-relation between the distinct PIs and the plethora of functions that they can regulate inside a cell, this book is not meant to be a comprehensive coverage of all aspects of PIs signalling but rather an overview on the current state of the field and where it could go from here. Phosphoinositide and inositol phosphates interact with and modulate the recruitment and activation of key regulatory proteins and in doing so control diverse functions including cell growth and proliferation, apoptosis, cytoskeletal dynamics, insulin action, vesicle trafficking and nuclear function. Initially, inositide signaling was limited to the PLC pathway; however, it is now clear that all the seven phosphoinositides and more than 30 different inositol phosphates likely have specific signaling functions. Moreover there is a growing list of proteins that are regulated by inositol signaling. This has raised the question as to how inositol signaling can control diverse processes and yet maintain signaling specificity. Controlling the levels of inositol signaling molecules and their subcellular compartmentalisation is likely to be critical. This meeting will bring together scientists from different backgrounds to discuss how understanding inositol signaling may be used to target complex human diseases that manifest themselves when inositol signaling is deregulated.

Encyclopedia Of Signaling Molecules

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Author :
language : en
Publisher:
Release Date : 19??

Encyclopedia Of Signaling Molecules written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 19?? with categories.

Plant Lipid Metabolism

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Author : J.C. Kader
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-04-18

Plant Lipid Metabolism written by J.C. Kader and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-18 with Science categories.

A collection of papers that comprehensively describe the major areas of research on lipid metabolism of plants. State-of-the-art knowledge about research on fatty acid and glycerolipid biosynthesis, isoprenoid metabolism, membrane structure and organization, lipid oxidation and degradation, lipids as intracellular and extracellular messengers, lipids and environment, oil seeds and gene technology is reviewed. The different topics covered show that modern tools of plant cellular and molecular biology, as well as molecular genetics, have been recently used to characterize several key enzymes of plant lipid metabolism (in particular, desaturases, thioesterases, fatty acid synthetase) and to isolate corresponding cDNAs and genomic clones, allowing the use of genetic engineering methods to modify the composition of membranes or storage lipids. These findings open fascinating perspectives, both for establishing the roles of lipids in membrane function and intracellular signalling and for adapting the composition of seed oil to the industrial needs. This book will be a good reference source for research scientists, advanced students and industrialists wishing to follow the considerable progress made in recent years on plant lipid metabolism and to envision the new opportunities offered by genetic engineering for the development of novel oil seeds.

Biochemistry Of Lipids Lipoproteins And Membranes

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Author : Neale Ridgway
language : en
Publisher: Elsevier
Release Date : 2015-07-24

Biochemistry Of Lipids Lipoproteins And Membranes written by Neale Ridgway and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-07-24 with Science categories.

Biochemistry of Lipids: Lipoproteins and Membranes, Volume Six, contains concise chapters that cover a wide spectrum of topics in the field of lipid biochemistry and cell biology. It provides an important bridge between broad-based biochemistry textbooks and more technical research publications, offering cohesive, foundational information. It is a valuable tool for advanced graduate students and researchers who are interested in exploring lipid biology in more detail, and includes overviews of lipid biology in both prokaryotes and eukaryotes, while also providing fundamental background on the subsequent descriptions of fatty acid synthesis, desaturation and elongation, and the pathways that lead the synthesis of complex phospholipids, sphingolipids, and their structural variants. Also covered are sections on how bioactive lipids are involved in cell signaling with an emphasis on disease implications and pathological consequences. Serves as a general reference book for scientists studying lipids, lipoproteins and membranes and as an advanced and up-to-date textbook for teachers and students who are familiar with the basic concepts of lipid biochemistry References from current literature will be included in each chapter to facilitate more in-depth study Key concepts are supported by figures and models to improve reader understanding Chapters provide historical perspective and current analysis of each topic

Molecular Biology Of The Male Reproductive System

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Author : David de Kretser
language : en
Publisher: Elsevier
Release Date : 2012-12-02

Molecular Biology Of The Male Reproductive System written by David de Kretser and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Science categories.

Written by experts in their respective fields, this book reviews the expanding knowledge concerning the mechanisms regulating male reproduction at the molecular and cellular levels. It covers the development of the testes and regulatory controls for spermatogenesis and steroidogenesis, and it considers aspects of Sertoli cell function. Areas of emphasis include communication between the various cell types involved in reproduction by hormone and growth factors and the mechanisms by which these factors regulate gene expression. A number of mammalian systems, including humans, are covered. The carefully selected authors provide a clear synopsis of the concepts in each area as well as the latest references, enabling the reader to investigate the topic further. This book is of interest to those seeking an understanding of the regulatory mechanisms in male reproduction and is written for the graduate and postgraduate levels. Key Features * Provides up-to-date reviews of the molecular and cellular biology of male reproduction * Includes chapters on the developmental biology of the testes * Links conventional hormonal control of testicular function with the evolving role of growth factors and proto-oncogenes

Cellular And Molecular Biology Of Bone

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Author : Masaki Noda
language : en
Publisher: Academic Press
Release Date : 1993-09-13

Cellular And Molecular Biology Of Bone written by Masaki Noda and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-09-13 with Medical categories.

Cellular and Molecular Biology of Bone covers the differentiation of these cells, the regulation of their growth and metabolism, and their death and resorption.