Phosphoinositides And Disease
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Phosphoinositides And Disease
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Author : Marco Falasca
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-10-21
Phosphoinositides And Disease written by Marco Falasca and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-10-21 with Medical categories.
Phosphoinositides (PIs) are minor components of cellular membranes that play critical regulatory roles in several intracellular functions. This book describes the main enzymes regulating the turnover of each of the seven PIs in mammalian cells, some of their intracellular functions and some evidence of their involvement in human diseases. Due to the complex inter-relation between the distinct PIs and the plethora of functions that they can regulate inside a cell, this book is not meant to be a comprehensive coverage of all aspects of PIs signalling but rather an overview on the current state of the field and where it could go from here. Phosphoinositide and inositol phosphates interact with and modulate the recruitment and activation of key regulatory proteins and in doing so control diverse functions including cell growth and proliferation, apoptosis, cytoskeletal dynamics, insulin action, vesicle trafficking and nuclear function. Initially, inositide signaling was limited to the PLC pathway; however, it is now clear that all the seven phosphoinositides and more than 30 different inositol phosphates likely have specific signaling functions. Moreover there is a growing list of proteins that are regulated by inositol signaling. This has raised the question as to how inositol signaling can control diverse processes and yet maintain signaling specificity. Controlling the levels of inositol signaling molecules and their subcellular compartmentalisation is likely to be critical. This meeting will bring together scientists from different backgrounds to discuss how understanding inositol signaling may be used to target complex human diseases that manifest themselves when inositol signaling is deregulated.
Phosphoinositides I Enzymes Of Synthesis And Degradation
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Author : Tamas Balla
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-03-14
Phosphoinositides I Enzymes Of Synthesis And Degradation written by Tamas Balla and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-03-14 with Medical categories.
Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases – and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume I untangles the web of these enzymes and their products, and relates them to function in health and disease. Phosphoinositide 3-kinases and 3-phosphatases have received a special focus in volume I, and recent therapeutic developments in human disease are presented along with a historical perspective illustrating the impressive progress in the field.
Phosphoinositides Ii The Diverse Biological Functions
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Author : Tamas Balla
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-02-28
Phosphoinositides Ii The Diverse Biological Functions written by Tamas Balla and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-02-28 with Medical categories.
Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases – and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume II extends into the role of phosphoinositides in membrane organization and vesicular traffic. Endocytosis and exocytosis are modulated by phosphoinositides, which determine the fate and activity of integral membrane proteins. Phosphatidylinositol(4,5)-bisphosphate is a prominent flag in the plasma membrane, while phosphatidylinositol-3-phosphate decorates early endosomes. The Golgi apparatus is rich in phosphatidylinositol-4-phosphate, stressed cells increase phosphatidylinositol(3,5)-bisphosphate, and the nucleus has a phosphoinositide metabolism of its own. Phosphoinositide-dependent signaling cascades and the spatial organization of distinct phosphoinositide species are required in organelle function, fission and fusion, membrane channel regulation, cytoskeletal rearrangements, adhesion processes, and thus orchestrate complex cellular responses including growth, proliferation, differentiation, cell motility, and cell polarization.
Phosphoinositides I Enzymes Of Synthesis And Degradation
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Author : Tamas Balla
language : en
Publisher: Springer
Release Date : 2012-03-14
Phosphoinositides I Enzymes Of Synthesis And Degradation written by Tamas Balla and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-03-14 with Medical categories.
Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases – and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume I untangles the web of these enzymes and their products, and relates them to function in health and disease. Phosphoinositide 3-kinases and 3-phosphatases have received a special focus in volume I, and recent therapeutic developments in human disease are presented along with a historical perspective illustrating the impressive progress in the field.
Phosphoinositide 3 Kinase In Health And Disease
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Author : Christian Rommel
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-10-17
Phosphoinositide 3 Kinase In Health And Disease written by Christian Rommel and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-10-17 with Medical categories.
PI3K has become a very intense area of research, with over 2000 publications on PI3K in PubMed for 2009 alone. The expectations for a therapeutic impact of intervention with PI3K activity are high, and progress in the clinical arena is being monitored by many. However, targeted therapies almost invariably encounter roadblocks, often exposing unresolved questions in the basic understanding of the target
Phosphoinositide 3 Kinase In Health And Disease
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Author :
language : en
Publisher:
Release Date : 2010
Phosphoinositide 3 Kinase In Health And Disease written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Protein kinases categories.
Phosphoinositides In Subcellular Targeting And Enzyme Activation
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Author : Harald Stenmark
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Phosphoinositides In Subcellular Targeting And Enzyme Activation written by Harald Stenmark and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Cells of the immune system are activated by a variety of stimuli that are derived from other cells, ingested material or from invading microorganisms. This issue of CTMI focuses on the mechanisms of phosphoinositide-mediated protein recruitment to intracellular membranes.
Phosphoinositide 3 Kinase In Health And Disease
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Author : Christian Rommel
language : en
Publisher: Springer
Release Date : 2010-10-01
Phosphoinositide 3 Kinase In Health And Disease written by Christian Rommel and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-10-01 with Medical categories.
PI3K has become a very intense area of research, with over 2000 publications on PI3K in PubMed for 2009 alone. The expectations for a therapeutic impact of intervention with PI3K activity are high, and progress in the clinical arena is being monitored by many. However, targeted therapies almost invariably encounter roadblocks, often exposing unresolved questions in the basic understanding of the target
Phosphoinositide 3 Kinase In Health And Disease
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Author : Christian Rommel
language : en
Publisher: Springer
Release Date : 2010-10-01
Phosphoinositide 3 Kinase In Health And Disease written by Christian Rommel and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-10-01 with Medical categories.
From humble beginnings over 25 years ago as a lipid kinase activity associated with certain oncoproteins, PI3K (phosphoinositide 3-kinase) has been catapulted to the forefront of drug development in cancer, immunity and thrombosis, with the first clinical trials of PI3K pathway inhibitors now in progress. Here we give a brief overview of some key discoveries in the PI3K area and their impact, and include thoughts on the current state of the field, and where it could go from here
Phosphoinositides
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Author : Dr. Tamas Balla
language : en
Publisher:
Release Date : 2012
Phosphoinositides written by Dr. Tamas Balla and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Inositol phosphates categories.