Phosphoinositides In Subcellular Targeting And Enzyme Activation

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Phosphoinositides In Subcellular Targeting And Enzyme Activation

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Author : Harald Stenmark
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Phosphoinositides In Subcellular Targeting And Enzyme Activation written by Harald Stenmark and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.

Cells of the immune system are activated by a variety of stimuli that are derived from other cells, ingested material or from invading microorganisms. This issue of CTMI focuses on the mechanisms of phosphoinositide-mediated protein recruitment to intracellular membranes.

Coronavirus Replication And Reverse Genetics

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Author : Luis Enjuanes
language : en
Publisher: Springer
Release Date : 2004-10-05

Coronavirus Replication And Reverse Genetics written by Luis Enjuanes and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-10-05 with Medical categories.

Human coronaviruses caused the SARS epidemic that infected more than 8000 people, killing about ten percent of them in 32 countries. This book provides essential information on these viruses and the development of vaccines to control coronavirus infections.

Phosphoinositides In Subcellular Targeting And Enzyme Activation

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Author : Harald Stenmark
language : en
Publisher: Springer
Release Date : 2011-09-03

Phosphoinositides In Subcellular Targeting And Enzyme Activation written by Harald Stenmark and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-03 with Medical categories.

Cells of the immune system are activated by a variety of stimuli that are derived from other cells, ingested material or from invading microorganisms. This issue of CTMI focuses on the mechanisms of phosphoinositide-mediated protein recruitment to intracellular membranes.

Molecular Analysis Of B Lymphocyte Development And Activation

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Author : Harinder Singh
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-03-30

Molecular Analysis Of B Lymphocyte Development And Activation written by Harinder Singh and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-03-30 with Medical categories.

The B lymphocyte lineage represents an important paradigm for exploring the molecular mechanisms underlying cell fate specification, differentiation and cellular activation. In the past five years, major advances have been achieved in our understanding of the transcriptional control of early B cell development and terminal plasma cell differentiation. In addition new insights became available for the processes of B cell activation, class switch recombination and somatic hypermutation. Many of the new findings and their implications for a molecular understanding of B cell biology in particular and cell differentiation in general are covered in this volume.

Hot Topics In Neural Membrane Lipidology

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Author : Akhlaq A. Farooqui
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-04-05

Hot Topics In Neural Membrane Lipidology written by Akhlaq A. Farooqui and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-04-05 with Medical categories.

Glycerophospholipid and sphingolipid-derived lipid mediators facilitate the transfer of messages not only from one cell to another but also from one subcellular organelle to another. These molecules are not only components of neural membranes but also storage depots for lipid mediators. Information on the generation and involvement of lipid mediators in neurological disorders is scattered throughout the literature in the form of original papers and reviews. This book will provide readers with a comprehensive description of glycerophospholipid, sphingolipid and cholesterol-derived lipid mediators and their involvement in neurological disorders.

Glycerophospholipids In The Brain

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Author : Akhlaq A. Farooqui
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-10-28

Glycerophospholipids In The Brain written by Akhlaq A. Farooqui and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-10-28 with Science categories.

This volume provides a comprehensive description of phospholipid metabolism in brain, activities of phospholipases A2, and their involvement in neurological disorders. The purpose of this book is to present readers with cutting edge information in a lively manner that is useful not only to student and teachers but also to researchers and physicians.

Overcoming Steroid Insensitivity In Respiratory Disease

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Author : Ian Adcock
language : en
Publisher: John Wiley & Sons
Release Date : 2008-09-15

Overcoming Steroid Insensitivity In Respiratory Disease written by Ian Adcock and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-09-15 with Medical categories.

Written by well-known experts in field, this is the first book dedicated to dealing with the single most challenging management issue in long-term steroid therapy. Overcoming Steroid Insensitivity in Respiratory Disease reviews important new advances in therapeutics and provides the clinician with the most up to date information on one of the most significant therapeutic challenges to effective management of these diseases. This unique book is an invaluable resource for all postgraduate students and specialist physicians in pulmonology allergy and asthma. It is also of interest for workers in biomedical and pharmaceutical research.

Membrane Trafficking In Viral Replication

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Author : Mark Marsh
language : en
Publisher: Springer Science & Business Media
Release Date : 2005-10-25

Membrane Trafficking In Viral Replication written by Mark Marsh and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-10-25 with Medical categories.

Viruses are major pathogens in humans, and in the organisms with which we share this planet. The massive health and economic burden these agents impose has spurred a huge research effort to understand their most intimate details. One outcome of this effort has been the production, in many but certainly not all cases, of effective vaccines and therapies. - other consequence has been the realization that we can exploit viruses and put them to work on our behalf. Viruses are still seen to have the most - tential as vehicles for gene delivery and other therapeutic applications. However, their ability to exploit cellular functions to their own ends makes viruses not only highly effective pathogens but also exquisite experimental tools. Work with viruses underpins much of our current understanding of molecular cell biology and related fields. For membrane traffic in parti- lar, viruses have been crucial in providing insights into key cellular fu- tions and the molecular mechanisms underlying these events.

Specialization And Complementation Of Humoral Immune Responses To Infection

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Author : Tim Manser
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-12-31

Specialization And Complementation Of Humoral Immune Responses To Infection written by Tim Manser and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-12-31 with Medical categories.

The importance of specific antibodies for the clearance of and long-term resistance to many infectious pathogens has long been appreciated. Moreover, the role in these processes of the different antibody heavy chain isotypes, each tailored to induce diverse effector pathways such as those mediated by complement and Fc receptors and to promote antibody localization in distinct regions of the body, is well established. Insights into the molecular mechanism of isotype class switching showed that during an immune response B cells could change the heavy chain of the antibody they produced, without influencing the structure and specificity of the antigen-binding variable regions of this antibody (Honjo 1983). More recently, the germinal center pathway of B cell development was elucidated, in which antibody variable regions undergo extensive structural alteration via hypermutation followed by stringent phenotypic selection (Berek 1992; Kelsoe 1995). Emerging from this pathway are memory B cells and long-lived antibody-forming cells that express antigen receptors and secrete antibodies, respectively, with increased affinity and specificity for the foreign antigen. Taken together, these findings led to a view of the acquisition of antibody-mediated resistance to infectious pathogens in mammals that involved extensive somatic matu- tion of antibody heavy and variable region structure and function during the immune response. This was in keeping with the concept that the B cell compartment comprises a major arm of the adaptive immune system. Such a view was reinforced by molecular analyses of antiviral antibody responses (Zinkernagel 1996).

Signalling From Internalised Growth Factor Receptors

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Author : Inger Helene Madshus
language : en
Publisher: Springer Science & Business Media
Release Date : 2004-07-09

Signalling From Internalised Growth Factor Receptors written by Inger Helene Madshus and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-07-09 with Medical categories.

The book will concentrate on how growth factor receptors are down-regulated by endocytosis and intracellular trafficking. The authors will further discuss what is currently understood about the effect of cellular microenvironments on signal transduction.