Signalling From Internalised Growth Factor Receptors
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Signalling From Internalised Growth Factor Receptors
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Author : Inger Helene Madshus
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-05
Signalling From Internalised Growth Factor Receptors written by Inger Helene Madshus and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-05 with Medical categories.
This book reviews knowledge on the interconnection of signal transduction and endocytosis/intracellular trafficking. The chapters cover knowledge obtained by using different model systems. The first chapter deals with Receptor Tyrosin Kinases (RTKs) with emphasis on the Epidermal Growth Factor Receptor (EGF receptor) and the Platelet Derived Growth Factor Receptor (PDGF receptor). The second chapter deals with the RTK c-Met and with how this RTK becomes carcinogenic. The third chapter reviews recent understanding on the mechanisms of action of the numerous fibroblast growth factors and their receptors. In the fourth chapter we learn about the trafficking of and signalling from the Growth Hormone Receptor and how this receptor is controlled by ubiquitination. The fifth chapter is devoted to the Interleukin II receptor, essential for activation of T cells. Links between ubiquitination, signalling, endocytosis, and sorting are reviewed. The last chapter discusses current views on how monoubiquitination controls both signalling and trafficking and thereby the final outcome of receptor activation.
Signalling From Internalised Growth Factor Receptors
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Author : Inger Helene Madshus
language : en
Publisher:
Release Date : 2014-01-15
Signalling From Internalised Growth Factor Receptors written by Inger Helene Madshus and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-01-15 with categories.
Endocytosis And Signaling
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Author : Christophe Lamaze
language : en
Publisher: Springer
Release Date : 2018-08-10
Endocytosis And Signaling written by Christophe Lamaze and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-08-10 with Science categories.
This book focuses on the context dependency of cell signaling by showing how the endosomal system helps to structure and regulate signaling pathways. The location and concentration of signaling nodes regulate their activation cycles and engagement with distinct effector pathways. Whilst many cell signaling pathways are initiated from the cell surface, endocytosis provides an opportunity for modulating signaling networks’ output. In this book, first a series of reviews describe the endocytic and endosomal system and show how these subcellular platforms sort and regulate a wide range of signaling pathway components and phenotypic outputs. The book then reviews the latest scientific insights into how endocytic trafficking and subcellular location modulate a set of major pathways that are essential to normal cellular function and organisms’ development.
Handbook Of Cell Signaling
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Author : Ralph A. Bradshaw
language : en
Publisher: Academic Press
Release Date : 2009-11-03
Handbook Of Cell Signaling written by Ralph A. Bradshaw and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-11-03 with Science categories.
Handbook of Cell Signaling, Three-Volume Set, 2e, is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The second edition is an up-to-date, expanded reference with each section edited by a recognized expert in the field. Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field. Handbook of Cell Signaling, 2/e will appeal to a broad, cross-disciplinary audience interested in the structure, biochemistry, molecular biology and pathology of cellular effectors. - Contains over 350 chapters of comprehensive coverage on cell signaling - Includes discussion on topics from ligand/receptor interactions to organ/organism responses - Provides user-friendly, well-illustrated, reputable content by experts in the field
Peptide Receptors Advances In Research And Application 2012 Edition
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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2012-12-26
Peptide Receptors Advances In Research And Application 2012 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-26 with Science categories.
Peptide Receptors—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Peptide Receptors. The editors have built Peptide Receptors—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Peptide Receptors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Peptide Receptors—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Cumulated Index Medicus
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Author :
language : en
Publisher:
Release Date : 1996
Cumulated Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Medicine categories.
Receptor Desensitization And Ca2 Signaling
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Author : M. K. Uchida
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 1996-04-25
Receptor Desensitization And Ca2 Signaling written by M. K. Uchida and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-04-25 with Medical categories.
The last decade has witnessed a wealth of new information on the mechanisms underlying cell signaling. Molecular approaches have revealed the identity and structure of many of the receptor proteins which permit cells to respond to different chemical signals. An important mechanism regulating receptor function is desensitization, i.e. the suppression of a cellular response induced by the continuous presence of a constant agonist stimulus. This book features selected studies on receptor-mediated desensitization in various cells and tissues triggered by Ca2+. Post-receptor mechanisms are also considered. The contributions focus on muscarinic, histamine and adrenergic receptor systems as well as the phosphoinositidase C signaling pathway. The authoritative information compiled in this book will not only prove of great value to researchers interested in signal transduction but is also crucial for the development of new drugs.
Iee Proceedings
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Author :
language : en
Publisher:
Release Date : 2006
Iee Proceedings written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Bioinformatics categories.
Egfr Signaling Networks In Cancer Therapy
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Author : John D. Haley
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-03-01
Egfr Signaling Networks In Cancer Therapy written by John D. Haley and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-03-01 with Medical categories.
The epidermal gro wth factor (EGF ) receptor and its downstream signal transduction networks have been implicated in the ontology and maintenance of tumor tissues, which has motivated the discovery and development of molecularly targeted anti-EGF receptor therapies. Over decades of study, the EGF receptor structure, its ligand binding domains, the physical biochemistry underlying its intrinsic tyrosine kinase catalytic function and the modular interactions with SH2, PTB, and SH3 domain containing signaling adaptor p- teins required for signal transduction, have been extensively dissected. Not only is the EGF receptor the nexus of many streams of information, but it also forms one part of a calcul- ing device by forming dimers and oligomers with the other three receptors in its family in response to at least eleven ligands (some of which are expressed in multiple forms with overlapping or quite distinct functions). This phenomenon, while recruiting to the inner surface of the cell membrane and activating multiple second messenger proteins, also allows the possibility of cross talk between these systems, permitting a further layer of information to be exchanged. Less well described are the cross re gulation of the EGF receptor and other anti-apoptotic, mitogenic and metabolic signaling systems. The study of these systems has yielded new surprises. One hurdle in these efforts has been that signal transduction pathways have frequently been defined in the generic absence of their tissue-specific or cell-interaction specific context.
Cell Signalling
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Author : John Hancock
language : en
Publisher: Oxford University Press
Release Date : 2021
Cell Signalling written by John Hancock and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with Science categories.
There has never been a more exciting time to be a biologist. Not only ado we understand more about the biological world than ever before, but we're using that understanding in ever-more creative and valuable ways. Our understanding of the way our genes work is being used to explore new ways to treat disease; our understanding of ecosystems is being used to explore more effective ways to protect the diversity of life on Earth: our understanding of plant science is being used to explore more sustainable ways to feed a growing human population. Use the Oxford Biology Primers to explore biology for yourself-to find out more about what scientists at the cutting edge of the subject are researching and the biological problems they're trying to solve. Cell signalling is instrumental to understanding the workings of all organisms, including humans; this concise introduction to the main aspects of cell signalling in biological systems is a valuable accompaniment to the study of biological science, as well as medicine, biomedical science, and environmental science. Book jacket.