Physiology Of The Csf And Blood Brain Barriers
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Physiology Of The Csf And Blood Brain Barriers
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Author : Hugh Davson
language : en
Publisher: CRC Press
Release Date : 1995-11-27
Physiology Of The Csf And Blood Brain Barriers written by Hugh Davson and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-11-27 with Science categories.
This text/reference uses 574 figures and illustrations to help explain the relationships between blood and the cerebrospinal fluid (CSF) and central nervous system (CNS). The authors focus on the interaction of these fluids and the relative importance of the transport mechanisms of hormones from blood to nervous tissue. Carrier-mediated transport of many neuroactive peptides is discussed. Special aspects of the blood-brain barrier are covered in detail. An entire chapter is devoted to the comparative physiology of the CSF and the brain barriers. Physiologists in all fields will have an interest in the updated theories covered in this book.
Physiology Of The Csf And Blood Brain Barriers
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Author : Katherine Stokes
language : en
Publisher:
Release Date : 2019-06-20
Physiology Of The Csf And Blood Brain Barriers written by Katherine Stokes and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-20 with categories.
The cerebrospinal fluid (CSF) is a clear colorless fluid found in the brain and the spinal cord. It acts as a cushion for the brain, providing basic immunological and mechanical protection to the brain inside the skull. It serves an important role in cerebral autoregulation of cerebral blood flow. The brain produces approximately 500 ml of cerebrospinal fluid everyday. The blood brain barrier (BBB) is a selective semipermeable boundary separating the circulating blood from the brain and the extracellular fluid of the central nervous system. It restricts the diffusion of solutes in the blood and hydrophilic molecules into the CSF but allows the diffusion of hormones, oxygen, carbon dioxide and other polar molecules. The blood brain barrier acts to protect the brain from circulating pathogens. In cases where an infection occurs, a drug has to be administered directly into the CSF such that it can cross over into the blood-cerebrospinal fluid barrier. This book contains some path-breaking studies in the physiology of the cerebrospinal fluid and blood brain barriers. It will also provide interesting topics for research, which interested readers can take up. Coherent flow of topics, student-friendly language and extensive use of examples make this book an invaluable source of knowledge.
The Blood Cerebrospinal Fluid Barrier
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Author : Wei Zheng
language : en
Publisher: CRC Press
Release Date : 2005-03-30
The Blood Cerebrospinal Fluid Barrier written by Wei Zheng and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-03-30 with Medical categories.
Despite the existence of two barrier systems in the brain, research over the last century has mostly focused on the blood-brain barrier rather than on the blood-CSF barrier. Today, there is a greater understanding of the function of the blood-CSF barrier and of the choroid plexus, a tissue that is the primary site of this barrier. With the growing number of studies that focus on the role of the blood-CSF barrier in CNS homeostasis and neurological disorders, a modern overview of the blood-CSF barrier is long overdue. The Blood-Cerebrospinal Fluid Barrier is exclusively devoted to the blood-CSF barrier. Internationally renowned experts discuss the most recent progress in the field of choroid plexus physiology and update our knowledge of the function of the blood-CSF barrier. The book begins with an overview of the development and morphology of the choroid plexus, and then covers various aspects of its function, such as the regulation of choroidal blood flow, ion transport, and the production and transport of polypeptides. Following an extensive section on the role of the choroid plexus in CNS disorders, the final section discusses in vitro, in vivo, and in situ models of the blood-CSF barrier. This unique book analyzes a wealth of new research on the proven and potential roles of the choroid plexus/blood-CSF barrier in the brain. It is a valuable resource that will foster future studies in neuroscience, pharmacology, and toxicology.
Barriers And Fluids Of The Eye And Brain
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Author : Malcolm Beverley Segal
language : en
Publisher: CRC Press
Release Date : 1992
Barriers And Fluids Of The Eye And Brain written by Malcolm Beverley Segal and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Aqueous humor categories.
This volume presents the latest findings regarding the control of the fluid environments of the eye and brain. The book is comprised of papers presented at a symposium honoring the 80th birthday of Professor Hugh Davson. The contributors are previous students of Hugh Davson who are now leading authorities in the fields of the eye and brain. The eye is considered from its many interfaces, including the role of prostaglandins, blood flow in diabetes, and the vitreous body. Other topics discussed include the role of carbonic anhydrase, cerebrospinal fluid and its drainage, and the development of the blood/brain barrier to macromolecules. The book also shows how recent findings about homologous molecules refute earlier studies with foreign tracers, and offers a fascinating glimpse into the future with a description of the latest imaging techniques used in neurological diagnosis.
Biology And Physiology Of The Blood Brain Barrier
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Author : Pierre-Olivier Couraud
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Biology And Physiology Of The Blood Brain Barrier written by Pierre-Olivier Couraud and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Medical categories.
The endothelial cells of the cerebral vasculature constitute, together with perivascular elements (astrocytes, pcricytes, basement membrane), the blood-brain barrier (BBB), which strictly limits and specifically controls the exchanges between the blood and the cerebral extracellular spacc.The existence of such a physical, enzymatic, and active barrier isolating the central nervous system has broad physiological, biological, pharmacological, and patho logical consequences, most of which are not yet fully elucidated. The Cerebral Vascular Biology conference (CVB '95) was organized and held at the "Carre des Sciences" in Paris on July I 0-12, 1995. Like the CVB '92 conference held in Duluth, Minnesota, three years ago, the objectives were to provide a forum for presentation of the most recent progresses and to stimulate discussions in the ticld of the biology, physiology. and pathology of the blood-brain barrier. The Paris conference gathered more than !50 participants. including investigators in basic neuroscience, physicians. and stu dents, who actively contributed to the scientific program by their oral or poster presentations. This volume contains a collection of short articles that summarize most of the new data that were presented at the conference. Six thematic parts focus on physiological transports. drug delivery, multidrug resistance P-glycoprotein, signal transduction at the BBB. interactions between the immune system and the cerebral endothelial cells, and the blood-brain barrier-related pathologies in the central nervous system. In addition, two introductory articles present new insights in the rapidly evolving topics of cerebral angiogenesis and gene transfer to the brain.
Physiology Of The Cerebrospinal Fluid
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Author : Hugh Davson
language : en
Publisher:
Release Date : 1967
Physiology Of The Cerebrospinal Fluid written by Hugh Davson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1967 with Acid-base equilibrium categories.
Blood Brain Barrier In Physiology And Medicine
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Author : Stanley I. Rapoport
language : en
Publisher:
Release Date : 1976
Blood Brain Barrier In Physiology And Medicine written by Stanley I. Rapoport and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1976 with Aqueous humor categories.
The Blood Cerebrospinal Fluid Barrier
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Author : Wei Zheng
language : en
Publisher:
Release Date : 2005
The Blood Cerebrospinal Fluid Barrier written by Wei Zheng and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with MEDICAL categories.
Despite the existence of two barrier systems in the brain, research over the last century has mostly focused on the blood-brain barrier rather than on the blood-CSF barrier. Today, there is a greater understanding of the function of the blood-CSF barrier and of the choroid plexus, a tissue that is the primary site of this barrier. With the growing number of studies that focus on the role of the blood-CSF barrier in CNS homeostasis and neurological disorders, a modern overview of the blood-CSF barrier is long overdue. The Blood-Cerebrospinal Fluid Barrier is exclusively devoted to the blood-CSF.
The Cerebral Circulation
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Author : Marilyn J. Cipolla
language : en
Publisher: Biota Publishing
Release Date : 2016-07-28
The Cerebral Circulation written by Marilyn J. Cipolla and has been published by Biota Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-28 with Medical categories.
This e-book will review special features of the cerebral circulation and how they contribute to the physiology of the brain. It describes structural and functional properties of the cerebral circulation that are unique to the brain, an organ with high metabolic demands and the need for tight water and ion homeostasis. Autoregulation is pronounced in the brain, with myogenic, metabolic and neurogenic mechanisms contributing to maintain relatively constant blood flow during both increases and decreases in pressure. In addition, unlike peripheral organs where the majority of vascular resistance resides in small arteries and arterioles, large extracranial and intracranial arteries contribute significantly to vascular resistance in the brain. The prominent role of large arteries in cerebrovascular resistance helps maintain blood flow and protect downstream vessels during changes in perfusion pressure. The cerebral endothelium is also unique in that its barrier properties are in some way more like epithelium than endothelium in the periphery. The cerebral endothelium, known as the blood-brain barrier, has specialized tight junctions that do not allow ions to pass freely and has very low hydraulic conductivity and transcellular transport. This special configuration modifies Starling's forces in the brain microcirculation such that ions retained in the vascular lumen oppose water movement due to hydrostatic pressure. Tight water regulation is necessary in the brain because it has limited capacity for expansion within the skull. Increased intracranial pressure due to vasogenic edema can cause severe neurologic complications and death.
An Introduction To The Blood Brain Barrier
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Author : Davson
language : en
Publisher: CRC Press
Release Date : 1993
An Introduction To The Blood Brain Barrier written by Davson and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Medical categories.
This book is devoted to exploring the complexities of the blood-brain barrier. The book begins by reviewing the historical experiments that led to the concept of a barrier protecting the brain from variations in the blood. Transport kinetics and carrier-mediated processes are described, and the mechanism by which molecules can cross the barrier is discussed. Ways in which the barrier can be disrupted and opened are covered as well. Subsequent chapters in the book describe the transport of glucose and amino acids into the central nervous systems, cover recent findings by which peptides and proteins are able to gain entry or are excluded from the brain, and analyze models that can be used for investigating how the blood-brain barrier can be disordered in neurological disease processes.