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Phytochemical Drug Discovery For Central Nervous System Disorders

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Phytochemical Drug Discovery For Central Nervous System Disorders

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Author : Chukwuebuka Egbuna
language : en
Publisher: John Wiley & Sons
Release Date : 2023-06-23

Phytochemical Drug Discovery For Central Nervous System Disorders written by Chukwuebuka Egbuna and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-23 with Medical categories.

PHYTOCHEMICAL DRUG DISCOVERY FOR CENTRAL NERVOUS SYSTEM DISORDERS Understand herbal and plant-based treatments for chronic disorders with this groundbreaking work Due in part to the aging of the global population, disorders of the central nervous system have become an increasingly grave public health concern in recent years. Demand for pharmaceutical treatments has been correspondingly high, but there are many barriers to the successful development of effective synthetic drugs. Phytomedicines, or plant-based and herbal medicines, have proven to be an effective alternative, boasting lower toxicity and cost and higher efficacy, and one that demands greater research and broader-based practitioner knowledge. Phytochemical Drug Discovery for Central Nervous System Disorders meets this demand with a timely, clearly-structured guide. It thorough coverage presents a wide range of phytochemicals with potential as candidates for drug discovery, describing their sources, properties, and therapeutic efficacy. The result is a vital contribution to the ongoing fight against central nervous system (CNS) disorders. Phytochemical Drug Discovery for Central Nervous System Disorders readers will also find: Detailed treatment of CNS-active plant products, neuroprotective chemicals, plant-based nutraceutical products, and more Up-to-date information on FDA-approved drugs and existing plant-based products used to treat CNS disorders An authorial team featuring experts from across the globe Phytochemical Drug Discovery for Central Nervous System Disorders is essential for drug discovery scientists, drug developers, medicinal chemists, biochemists, and any researchers and professionals in the health care or pharmaceutical industries.

Phytochemical Drug Discovery For Central Nervous System Disorders

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Author : Chukwuebuka Egbuna
language : en
Publisher: John Wiley & Sons
Release Date : 2023-07-13

Dendrobium Nobile

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Author : Jingshan Shi
language : en
Publisher: CABI
Release Date : 2025-03-24

Dendrobium Nobile written by Jingshan Shi and has been published by CABI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-03-24 with Science categories.

Dendrobium nobile, a species of orchid native to South-east Asia, has been revered in traditional medicine systems for centuries due to its medicinal properties and therapeutic benefits. With a rich history in Chinese medicine and other traditional healing practices, there is now much interest in the chemical constituents of this orchid and potential applications for various health conditions. The aim of this book is to bridge the gap between the traditional knowledge surrounding this remarkable plant and the cutting-edge scientific investigations that have shed light on its pharmacological activities.

Plant And Fungal Extracts And Metabolites In Neurotherapy Exploring Their Pharmacology And Potential Clinical Uses

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Author : Jian Hao
language : en
Publisher: Frontiers Media SA
Release Date : 2025-05-29

Plant And Fungal Extracts And Metabolites In Neurotherapy Exploring Their Pharmacology And Potential Clinical Uses written by Jian Hao and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-05-29 with Science categories.

Exploring phytochemistry and the treatment of neurological disorders, this research topic addresses CNS disorders like Alzheimer's and Parkinson's, which lack effective treatments. A key area of research in this context is plants used in traditional and local medical systems. The research topic merges ancient herbal traditions with modern science, aiming to develop groundbreaking treatments for debilitating CNS conditions. Plant and fungal metabolites known for their neuroprotective and anti-inflammatory properties, offer promising therapeutic strategies. Advances in understanding their molecular mechanisms could offer novel therapeutic options for treating such neurological disorders. Therefore this research topic explores the research themes linking ethnopharmacology and neuropharmacology. By integrating traditional knowledge with contemporary scientific techniques, studying plant and fungal extracts and individual metabolites could transform global treatment approaches for CNS disorders. We envision that these contributions will improve the treatment of central nervous system (CNS) disorders by harnessing the therapeutic potential of phytochemicals and that they will contribute to a better understanding of existing treatments using plant and fungal extracts. It addresses significant challenges posed by neurodegenerative diseases, traumatic injuries, and strokes, characterized by complex pathologies and limited effective treatments. By exploring the mechanisms, bioavailability, and safety profiles of such extracts and metabolites, along with potential synergies with existing therapies, this research seeks to bridge the gap between traditional and modern medical practices. Advances in analytical technologies, molecular biology, and clinical methodologies facilitate precise identification, isolation, and evaluation of these compounds. The initiative encourages collaborative research spanning molecular studies to clinical trials. This effort underscores the critical role of plant-derived compounds in neurotherapy and promotes their further exploration and application. The Research Topic encompasses exploring medicinal plants and fungi for the treatment of CNS disorders, conducting mechanistic studies on metabolites' interactions with the CNS, and clinical trials to evaluate the efficacy and safety of such preparations. These essential components aim to provide a comprehensive understanding of how plant-derived compounds can play a crucial role in Neurotherapy, paving the way for innovative treatments and improved outcomes for individuals grappling with CNS-related conditions. • Discovery of new metabolites or chemically well-characterised (special) extracts for treating CNS disorder. • Advances in drug delivery systems to enhance the bioavailability and therapeutic impact of chemically well-defined extracts and metabolites. • Exploration of the molecular mechanisms of such metabolites and extracts and their interactions with the CNS. • Clinical or pre-clinical studies on such preparations. Please note: All contributions to this Research Topic must follow the guidelines listed in this section: • Please self-assess your MS using the ConPhyMP tool, and follow the standards established in the ConPhyMP statement Front. Pharmacol. 13:953205.’ WITH ‘Please self-assess your MS using the ConPhyMP tool, and follow the standards established in the ConPhyMP statement Front. Pharmacol. 13:953205. • All the manuscripts need to fully comply with the Four Pillars of Best Practice in Ethnopharmacology (you can freely download the full version here). Importantly, please ascertain that the ethnopharmacological context is clearly described (pillar 3d) and that the material investigated is characterized in detail (pillars 2 a and b). Importantly note some specific points based on the above: • The introduction must include a description of the topic’s background within an ethnopharmacological context and provide bibliographical references that illustrate the preparation’s application in traditional medicine or general healthcare. • Research based solely on in silico approaches (e.g., network studies or docking experiments) does not fit with the scopes of this RT. • Small molecules exhibiting in silico or in vitro effects but without specific pharmacological targets do not fit with the scopes of this RT. • Chemical anti-oxidant assays like the DPPH or ABTS assay are of no pharmacological relevance, Therefore they can only be used as chemical-analytical assays without pharmacological claims.

Handbook Of Research On Advanced Phytochemicals And Plant Based Drug Discovery

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Author : Singh, Ajeet
language : en
Publisher: IGI Global
Release Date : 2022-06-24

Handbook Of Research On Advanced Phytochemicals And Plant Based Drug Discovery written by Singh, Ajeet and has been published by IGI Global this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-24 with Science categories.

A great deal of interest has been generated recently in the isolation, characterization, and biological activity of phytochemicals. Phytochemicals have the potential to enhance pharmaceuticals and drug discovery. As such, there is an urgent need for current research in the global scope of phytochemicals including the chemical and physical characteristics, analytical procedures, biological activity, safety, and industrial applications. The Handbook of Research on Advanced Phytochemicals and Plant-Based Drug Discovery examines the applications of bioactive molecules from a health perspective, examining the pharmacological aspects of medicinal plants, the phytochemical and biological activities of different natural products, and ethnobotany and medicinal properties. Moreover, it presents a novel dietary approach for human disease management. Covering topics such as computer-aided drug design, government regulation, and medicinal plant taxonomy, this major reference work is beneficial to pharmacists, medical practitioners, phytologists, hospital administrators, government officials, faculty and students of higher education, librarians, researchers, and academicians.

Phytochemicals As Lead Compounds For New Drug Discovery

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Author : Chukwuebuka Egbuna
language : en
Publisher: Elsevier
Release Date : 2019-09-07

Phytochemicals As Lead Compounds For New Drug Discovery written by Chukwuebuka Egbuna and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-07 with Science categories.

Phytochemicals as Lead Compounds for New Drug Discovery presents complete coverage of the recent advances in the discovery of phytochemicals from medicinal plants as models to the development of new drugs and chemical entities. Functional bioactive compounds of plant origin have been an invaluable source for many human therapeutic drugs and have played a major role in the treatment of diseases around the world. These compounds possess enormous structural and chemical diversity and have led to many important discoveries. This book presents fundament concepts and factors affecting the choice for plant-based products, as well as recent advances in computer-aided drug discovery and FDA drug candidacy acceptance criteria. It also details the various bioactive lead compounds and molecular targets for a range of life-threatening diseases including cancer, diabetes, and neurodegenerative diseases. Written by a global team of experts, Phytochemicals as Lead Compounds for New Drug Discovery is an ideal resource for drug developers, phytochemists, plant biochemists, food and medicinal chemists, nutritionists and toxicologists, chemical ecologists, taxonomists, analytical chemists, and other researchers in those fields. It will also be very valuable to professors, students, and researchers in this domain. - Presents fundamental concepts and factors affecting choice for plant-based products - Details the FDA drug candidacy acceptance criteria, including bottlenecks and way forward - Highlights recent advances in computational-based drug discovery - Focuses on the discovery of new drugs and potential druggable targets for the treatment of chronic diseases of world importance

Medicinal Plant Research In Africa

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Author : Victor Kuete
language : en
Publisher: Elsevier
Release Date : 2025-04-16

Medicinal Plant Research In Africa written by Victor Kuete and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-04-16 with Medical categories.

Medicinal Plant Research in Africa, second edition is an updated and complete reference on the pharmacology of most relevant African species and their phytochemical properties. Although pharmacopoeias of most African countries are available and contain an impressive number of medicinal plants used for various therapeutic purposes, however there was no global standard book on the nature and specificity of chemicals isolated in African medicinal plants. This book has set the standard when it first published in 2013 and now is updated with novel phytochemicals belonging to diverse classes of terpenoids, phenolics, and alkaloids. The first chapter cover monoterpenes and related phytochemicals and is followed by sesquiterpenes on chapter two. Chapter tri reviews diterpenoids and chapter four provides an overview of triterpenes and steroids. Essential oils, simple phenols, phenolic acids and related esters come next in chapters five and six, respectively. The following chapters cover coumarins, flavonoids, quinones, xanthones, lignans and stilbenes. Tannins, alkaloids, and ceramides. Chapters 15 to 20 focus on specific health conditions starting with antibiotic infection, antimalarial and other antiprotozoal diseases, cytotoxic and anticancer activity, anti-inflammatory and analgesic action, antidiabetic botanicals and the applications of African plant phytochemicals on reproductive, cardiovascular, and central nervous systems conditions. The final chapter covers the market and industry updates since the first edition published. "Medicinal Plant Research in Africa, 2 Ed." provides a complete overview of the main phytochemical principles present in the African flora and their pharmaceutical use. Pharmaceutical scientists, Ethnopharmacists, botanists, and medicinal chemists will benefit from the content organization and the inclusion of the most recent methods for structural identification of phytochemicals, pharmacological techniques, and data interpretation. - Covers novel chemical structures, and new pharmacological data - Highlights how phytochemicals can help overcome drug resistance - Provides updated methods for structural identification of phytochemicals, pharmacological techniques, and data interpretation

Phytopharmaceuticals

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Author : Kamal Shah
language : en
Publisher:
Release Date : 2021

Phytopharmaceuticals written by Kamal Shah and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with Phytochemicals categories.

"Medicinal plants contain a variety of bioactive compounds, (also referred to as phytochemicals). in the leaves, stems, flowers and fruits. This book covers these bioactive compounds, their available sources, how the bioactive molecules are isolated from the plants, the biochemistry, structural composition and potential biological activities. Also discussed are the pharmacological aspects of medicinal plants, phytochemistry and biological activities of different natural products, ethnobotany and medicinal properties, as well as a novel dietary approach for various disease management and therapeutic potential. The importance of phytopharmaceutical of plants and potential applications in the food and pharma industries is highlighted"--

Ethnopharmacology Of Medicinal Plants

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Author : Christophe Wiart
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-11-04

Ethnopharmacology Of Medicinal Plants written by Christophe Wiart and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-04 with Medical categories.

In 1860, Oliver Wendell Holmes pointedly expressed himself to the Massachusetts Medical Society: “I firmly believe that if the whole Material Medica, as now used, could be sunk to the bottom of the sea, it would be all the better for mankind, and all the worst for the fishes.” Should one think the same about the current approach in drug discovery from plants? Probably yes. Despite the spending of billions of US dollars, and three decades of efforts, high-throughput screenings have only allowed the discovery of a couple of drugs. One could have reasonably expected the discovery of an arsenal of drugs from the millions of plant extracts randomly tested, but “hits” can be inactive in vitro or too toxic, some molecules need to be metabolized first to be active, and false-positive and false-negative results are common. The bitter truth is that the robotic approach in discovering drugs from plants has proven, to date, its inability to excavate the hundreds of molecules that will contribute to the health progress of Man. However, one can reasonably see that the last patches of primary rainforest on earth hold still hundreds of spectacularly active drugs that await discovery.

Human Medicinal Agents From Plants

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Author : A. Douglas Kinghorn
language : en
Publisher:
Release Date : 1993

Human Medicinal Agents From Plants written by A. Douglas Kinghorn and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Health & Fitness categories.

From a symposium at the April 1992 meeting of the American Chemical Society in San Francisco, 22 papers explore the current role and importance of plant-derived natural products in the discovery and development of drugs, in anticancer and cancer chemopreventive agents, in anti-infective and antimicrobial chemotherapeutic agents, and in the potential for products with multiple biological activities. Annotation copyright by Book News, Inc., Portland, OR

Phytochemical Drug Discovery For Central Nervous System Disorders

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