Phytochemicals Targeting Tumor Microenvironment In Gastrointestinal Cancers
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Phytochemicals Targeting Tumor Microenvironment In Gastrointestinal Cancers
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Author : Ganji Purnachandra Nagaraju
language : en
Publisher: Springer Nature
Release Date : 2020-10-07
Phytochemicals Targeting Tumor Microenvironment In Gastrointestinal Cancers written by Ganji Purnachandra Nagaraju and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-07 with Medical categories.
Gastrointestinal (GI) malignancies account for a large portion of cancers worldwide. Although incidence of esophageal, gastric, and colorectal cancers has decreased in recent years, pancreatic and liver cancer have increased. The mainstay of GI cancer therapy is chemoradiation and surgery. Despite significant medical advancements, diagnosis and therapy for GI cancers remain challenging due to tumor cell resistance to chemoradiotherapy. The tumor’s increased cell signalling due to excessive transcription factor activation and increased stellate cell activity leads to collagen deposition formation of a dense stroma around the tumor, which prevents drugs from reaching the malignant cells. This leads to tumor chemoresistance. To circumvent these difficulties, drug therapy targeting the tumor’s specific microenvironment and the additive anticancer effect of phytochemicals can allow for more effective treatment. This volume will be the first on the market on the topic of phytochemicals and their effect on the tumor microenvironment (TME). TME is an emerging area of research and the book will be a welcome introductory addition to the field.
Recent Advances In Nanotechnology
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Author : Zishan Husain Khan
language : en
Publisher: Springer Nature
Release Date : 2023-09-07
Recent Advances In Nanotechnology written by Zishan Husain Khan and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-07 with Technology & Engineering categories.
This volume comprises the select peer-reviewed proceedings of the International Conference on Nanotechnology: Opportunities and Challenges (ICNOC22). It aims to provide a comprehensive and broad-spectrum picture of the state-of-the-art research and development in nanomaterials, nanocomposites, nanobiosensors, nanochemistry, renewable energy, nanochemistry in medicine, batteries and supercapacitors, targeted cellular therapies, among others. This volume will be useful for researchers and professionals working in nanotechnology and allied fields.
Advanced Molecular Targets In The Diagnosis And Treatment Of Gastrointestinal Cancers
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Author : Zsolt Kovacs
language : en
Publisher: Frontiers Media SA
Release Date : 2023-06-05
Advanced Molecular Targets In The Diagnosis And Treatment Of Gastrointestinal Cancers written by Zsolt Kovacs and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-05 with Medical categories.
Gastrointestinal cancers are among the most common cancer types, based on the Cancer Genome Atlas. GI cancers are within the most frequent malignancy, with almost 150.000 new cases in 2020. On one hand a big number of researches are focused on the diagnosis, new diagnostic approaches in upper and lower gastrointestinal tract cancers. On the other hand in the last 10 years several papers had been published about the possible therapeutic targets, pointing to precision and personalized medicine.
Medicinal Plants In Gastrointestinal Cancers And Tumor Microenvironments
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Author : Qingmin Sun
language : en
Publisher: Frontiers Media SA
Release Date : 2022-09-13
Medicinal Plants In Gastrointestinal Cancers And Tumor Microenvironments written by Qingmin Sun and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-13 with Science categories.
Therapeutic Targets For Inflammation And Cancer Novel Therapies For Digestive Diseases
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Author : Chi-hin Cho
language : en
Publisher: World Scientific
Release Date : 2017-04-20
Therapeutic Targets For Inflammation And Cancer Novel Therapies For Digestive Diseases written by Chi-hin Cho and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-04-20 with Medical categories.
This unique book deals with both inflammation and cancer in a single source of publication. They are seldom grouped together although it has been known that both diseases are closely associated, particularly in the gastrointestinal tract and liver. As the book touches on two such major areas of diseases in humans, it should be of interest to a wider audience of researchers and readers. It is noted that the book combines the effort of both basic scientists and clinicians from different countries with extensive experiences in molecular biology and clinical practice to unveil the most updated picture of the pathogenesis and therapeutic strategies in the treatment of inflammation and cancer in the digestive tract. In this regard, potential pathogenic modulators and also therapeutic options are widely discussed. These types of information would definitely broaden our knowledge in better understanding these diseases.
Handbook Of Oxidative Stress In Cancer Therapeutic Aspects
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Author : Sajal Chakraborti
language : en
Publisher: Springer Nature
Release Date : 2022-09-28
Handbook Of Oxidative Stress In Cancer Therapeutic Aspects written by Sajal Chakraborti and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-28 with Medical categories.
This reference book, which is the second volume of Targeting Oxidative Stress in Cancer, explores oxidative stress as the potential therapeutic target for cancer therapy. The initial chapters discuss the molecular mechanisms of oxidative stress and its effects on different signaling pathways. Subsequently, the sections examine the impact of redox signaling on tumor cell proliferation and consider the therapeutic potential of dietary phytochemicals and nutraceuticals in reactive oxygen species (ROS)-induced cancer. In turn, it examines the evidence supporting the use of Vitamin C in cancer management, before presenting various synthetic and natural compounds that have therapeutic implications for oxidative stress-induced cancer. It also explores the correlation between non-coding RNA and oxidative stress. Furthermore, the book summarizes the role of stem cells in ROS-induced cancer therapy and reviews the therapeutic applications of nanoparticles to alter redox haemostasis in cancer cells. Lastly, it explores heat-shock proteins, ubiquitin ligases, and probiotics as potential therapeutic agents in ROS-mediated cancer. This book is a useful resource for basic and translational scientists as well as clinicians interested in the field of oxidative stress and cancer therapy.
Identification Of Novel Biomarkers For Pancreatic And Hepatocellular Cancers
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Author : Brendan Jenkins
language : en
Publisher: Frontiers Media SA
Release Date : 2022-12-02
Identification Of Novel Biomarkers For Pancreatic And Hepatocellular Cancers written by Brendan Jenkins and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-02 with Medical categories.
Evolution Of Phytochemicals And Phytotherapies In The Treatment And Management Of Cancer Targeted Strategies In Cancer Precision Medicine
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Author : Mohd Adnan
language : en
Publisher: Frontiers Media SA
Release Date : 2023-11-24
Evolution Of Phytochemicals And Phytotherapies In The Treatment And Management Of Cancer Targeted Strategies In Cancer Precision Medicine written by Mohd Adnan and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-24 with Science categories.
There is a rising recurrence of cancers in humans and related complications of chemotherapeutic agents that reduce the clinical potency of numerous anticancer agents, including those which are currently in use. Hence, there is a consistent need for the development of alternative or synergistic anticancer drugs with lower side complications. One imperative approach to develop novel anticancer agents with potent efficiency is to discover natural resource-derived bioactive compounds. Diverse phytochemical constituents (like vincristine, vinblastine, taxol analogs etc.) derived from plants have been manifested as effective therapeutics in the treatment, prevention and management of cancer. Therefore, phytochemical constituents aid as prime source and candidates for the discovery of anticancer drugs, particularly when they are screened against their molecular targets via various approaches. Plants are predicted to have innumerable functional phytochemical constituents with potent features, which can be explored via in silico, in vitro as well as in vivo approaches for targeted cancer therapy and the most suitable cascade can be identified. Therefore, this research topic aims to cover the current trends and advancements in phytotherapies with an emphasis on targeted strategies in cancer precision medicine.
New Mechanisms For Anti Cancer Drugs
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Author : Ayaz Shahid
language : en
Publisher: Frontiers Media SA
Release Date : 2024-04-15
New Mechanisms For Anti Cancer Drugs written by Ayaz Shahid and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-04-15 with Science categories.
Cancer is the second leading cause of death. Every year, many anticancer drug candidates are discovered and synthesized, but the major challenge lies in identifying, characterizing and evaluating their efficacy. The aim of this Research Topic, "New Mechanisms for Anti-Cancer Drugs" is to collect a group of publications focused on novel chemical compounds exhibiting new modes of actions and/or new target proteins to fulfill their cytotoxic activity on cancer cells. In this context, we will also be pleased to consider studies on drug repurposing, including approved, discontinued, and shelved drugs, when anti-cancer activity results from an unexpected mode of action.
Phytochemicals
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Author : Iraj Rasooli
language : en
Publisher: BoD – Books on Demand
Release Date : 2011-12-22
Phytochemicals written by Iraj Rasooli and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-12-22 with Science categories.
Among the thousands of naturally occurring constituents so far identified in plants and exhibiting a long history of safe use, there are none that pose - or reasonably might be expected to pose - a significant risk to human health at current low levels of intake when used as flavoring substances. Due to their natural origin, environmental and genetic factors will influence the chemical composition of the plant essential oils. Factors such as species and subspecies, geographical location, harvest time, plant part used and method of isolation all affect chemical composition of the crude material separated from the plant. The screening of plant extracts and natural products for antioxidative and antimicrobial activity has revealed the potential of higher plants as a source of new agents, to serve the processing of natural products.