Pioneering Stem Cell Gene Therapy Trials
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Pioneering Stem Cell Gene Therapy Trials
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Author : Roger Bertolotti
language : en
Publisher: CRC Press
Release Date : 2003-10-15
Pioneering Stem Cell Gene Therapy Trials written by Roger Bertolotti and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-10-15 with Science categories.
The first unequivocal success for Gene Therapy was reported in April 2000 for X-SCID patients. Pioneering stem cell/gene therapy clinical trials are the focus of this book. Therapy successes such as the X-SCID trial and improved ADA-SCID ones are presented together with pioneering angio/vasculogenic clinical trials mediated either by transient gene
Autologous And Cancer Stem Cell Gene Therapy
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Author : Roger Bertolotti
language : en
Publisher: World Scientific
Release Date : 2008
Autologous And Cancer Stem Cell Gene Therapy written by Roger Bertolotti and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Medical categories.
Stem cells provide for life-long cell replacement in tissues and organs, and have inherent homing abilities that are critical in therapeutic applications. Stem cells are also the driving force of cancer where genetic/epigenetic alterations culminate in tumorigenesis either in tissue stem cells or in some of their derivatives. As a rare subset of the tumor, cancer stem cells are the only drive of tumor initiation/propagation. Autologous and cancer stem cells are thus the key targets of 1) long-term and transient-regenerative/epigenetic gene therapy and 2) of recurrence-free anticancer therapy, respectively. While cancer stem cell gene therapy still needs time to accomplish, autologous stem cells have been instrumental in the first unequivocal successes for gene therapy whereby ex vivo retrovirally corrected hematopoietic stem cells have been returned to the patients. This timely book presents 1) the aforementioned stem cell gene therapy achievements that rely on random-integration of therapeutic transgenes into host chromosomes and 2) emerging experimental approaches aimed at eliminating random-integration oncogenic hazards through site-specific integration or gene targeting. Breakthrough endonuclease-boosted gene targeting for gene correction (inherited diseases) or targeted integration of therapeutic transgenes (other disorders) culminating in an efficiency compatible with clinical trials is one of the highlights of the book. Highlights also include the pioneering transplantation of adult pluripotent stem cells as a substitute for tissue-specific stem cells, thereby pinpointing the invaluable potential for stem cell gene therapy applications of autologous cells able to contribute to all three germ layers. Stem cell gene therapy is thus discussed in terms of 1) magnifying stem cell therapeutic homing through transient regenerative gene therapy and 2) of tackling most pathologies (including mitochondrial DNA diseases and ageing disorders) through stem cell repopulation dynamics into appropriate niches (long-term engraftment) and tissues (cell turn-over). Regarding cancer stem cell gene therapy, focus is on both the increasing number of identified tissue-specific cancer stem cells as the ultimate therapeutic targets and on the development of armed stem cells as tumor-homing vectors for targeted anticancer therapy. Sample Chapter(s). Introduction: Toward a Universal Platform for Autologous Stem Cell Gene Therapy (335 KB). Chapter 1: Stem Cell Gene Therapy for ADA-Deficiency without Myelopreparative Conditioning (318 KB). Contents: Introduction: Toward a Universal Platform for Autologous Stem Cell Gene Therapy; Long-term Stem Cell Gene Therapy: From Current Clinical Random-Integration Achievements to Stem Cell Gene Targeting/Cybridization: From Pioneering Clinical Retroviral Gene Therapy to Experimental Site-Specific Integrative Gene Therapy; Stem Cell Gene Targeting/Cybridization: Toward Endonuclease-Boosted Gene Repair/Alteration, Custom Site-Specific Integrative Gene Therapy and Transmitochondrial Therapy/Rejuvenation; Adult Pluripotent Stem Cells: Emerging Stem Cell/Gene Therapy Breakthrough; Cancer Stem Cell Gene Therapy: Cancer Stem Cells as Breakthrough Targets of Cancer Gene Therapy; Armed Stem Cells as Tumor-Homing Vectors for Cancer Gene Therapy. Readership: Clinicians, scientists, physicians, veterinarians, dentists, pharmacists/chemists, interested in an ongoing medical/veterinarian breakthrough that is expected to revolutionize the practice of Medicine/Dentistry and that relies on cell biology, molecular biology/genetics, developmental biology, biochemistry, molecular pathology and animal science.
Stem Cell Therapy
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Author : Erik V. Greer
language : en
Publisher: Nova Publishers
Release Date : 2006
Stem Cell Therapy written by Erik V. Greer and has been published by Nova Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Biyomedikal araştorma categories.
Among the many applications of stem cell research are nervous system diseases, diabetes, heart disease, auto-immune diseases as well as Parkinson's disease, end-stage kidney disease, liver failure, cancer, spinal cord injury, multiple sclerosis, Parkinson's disease, and Alzheimer's disease. Stem cells are self-renewing, unspecialised cells that can give rise to multiple types all of specialised cells of the body. Stem cell research also involves complex ethical and legal considerations since they involve adult, foetal tissue and embryonic sources. This new book brings together leading research from throughout the world in this frontier field.
How Adult Stem Cell Therapies Can Save Your Life
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Author : Bernard van Zyl
language : en
Publisher: iUniverse
Release Date : 2009-03-20
How Adult Stem Cell Therapies Can Save Your Life written by Bernard van Zyl and has been published by iUniverse this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-03-20 with Biography & Autobiography categories.
Laced with hope and promise for sufferers of seemingly incurable illnesses, How Adult Stem Cell Therapies Can Save Your Life: Medicines Best Kept Secret Saved My Life reveals that non-controversial adult stem cell therapies are already available for those with serious diseases and injuries. This book is a practical guide to those seeking adult stem cell treatments with step-by-step instructions on how to use the Internet to locate suitable FDA approved clinical trials for almost all major infirmities Seven years ago, van Zyl suffered cardiac arrest; his heart literally stopped until doctors shocked his chest. Over the next ten months, after receiving bypass surgery, an angioplasty, and entering a cardiac rehabilitation program, van Zyls heart was still deteriorating. Turned down by two heart transplant centers, van Zyls only hope lay in the Food and Drug Administration (FDA), or more specifically, a new FDA-approved clinical trial for adult stem cell therapies. One of 24 patients selected with heart failure, van Zyl entered the aggressive treatment group in 2004, where adult stem cells were harvested from van Zyls own body and injected directly into his failing heart. The results were astonishing. Now 75, van Zyl lives a healthy, vigorous life. How Adult Stem Cell Therapies Can Save Your Life offers a plethora of information on the latest adult stem cell treatments for over a dozen diseases and conditions. While much has been made of the medical viability and ethical concerns of other types of stem cell therapies, van Zyl is living proof that adult stem cell therapies can save lives.
Exploring Novel Clinical Trial Designs For Gene Based Therapies
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Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher: National Academies Press
Release Date : 2020-08-27
Exploring Novel Clinical Trial Designs For Gene Based Therapies written by National Academies of Sciences, Engineering, and Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-27 with Medical categories.
Recognizing the potential design complexities and ethical issues associated with clinical trials for gene therapies, the Forum on Regenerative Medicine of the National Academies of Sciences, Engineering, and Medicine held a 1-day workshop in Washington, DC, on November 13, 2019. Speakers at the workshop discussed patient recruitment and selection for gene-based clinical trials, explored how the safety of new therapies is assessed, reviewed the challenges involving dose escalation, and spoke about ethical issues such as informed consent and the role of clinicians in recommending trials as options to their patients. The workshop also included discussions of topics related to gene therapies in the context of other available and potentially curative treatments, such as bone marrow transplantation for hemoglobinopathies. This publication summarizes the presentation and discussion of the workshop.
Revolutionary Therapies How The California Stem Cell Program Saved Lives Eased Suffering And Changed The Face Of Medicine Forever
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Author : Don C Reed
language : en
Publisher: World Scientific
Release Date : 2020-03-04
Revolutionary Therapies How The California Stem Cell Program Saved Lives Eased Suffering And Changed The Face Of Medicine Forever written by Don C Reed and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-04 with Science categories.
For author Don C Reed, father of a paralyzed son, the California Institute for Regenerative Medicine (CIRM) is the greatest medical advance since penicillin.REVOLUTIONARY THERAPIES is Reed's third book about the $3 billion stem cell program.Voted into law in November 2004, CIRM is now running out of money.Should its funding be renewed? Thereby hangs a tale, or rather several dozen of them, for each of the book's 71 short chapters is framed by a yarn or vignette.The factual background is accurate, vetted by the scientists, but Reed's goal is clearly both entertainment and education.A favorite example is a little girl named Evie, imprisoned in a plastic bubble: her body's immune system did not work, and she would die outside. She joined a CIRM clinical trial ... Imagine how Evie's parents felt — when she got well.Some stories are comical, like 'How Stem Cell Research Saved My Car'; others surprising, like the comparison between politics and the giant crocodile Gustave; others are tragic or inspiring: but all point to this: More than 100 million Americans suffer chronic disease, causing mountains of medical debt — and the only way to reduce that expense ($3 trillion last year) — is cure.Related Link(s)
Mesenchymal Stromal Cells
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Author : Hematti Peiman
language : en
Publisher: Academic Press
Release Date : 2016-08-11
Mesenchymal Stromal Cells written by Hematti Peiman and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-11 with Medical categories.
Mesenchymal Stromal Cells: Translational Pathways to Clinical Adoption provides the latest information on the necessary steps for successful production of stem cells for a clinical trial. Written by professionals with hands-on experience in bringing MSC therapies to the clinic, and building on the biology and mechanisms of action, this unique book covers the development and production of clinical-grade products that are suitable for use in humans. From design of a cell production facility, to obtaining regulatory approval and reimbursement issues, it is a useful guide for researchers and administrators across biomedical research. Provides methodologies for clinical MSC production, from designing a facility, to post-market approval Includes real-life examples of MSC production in academic centers and MSC production for biopharmaceutical clinical trials Offers a unique perspective on the clinical aspects of MSC studies Presents the principles of clinical trials that can be applied to the production of various cell therapies
Gene Therapy For Hiv
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Author : Gerhard Bauer
language : en
Publisher: Springer Science & Business Media
Release Date : 2014-02-07
Gene Therapy For Hiv written by Gerhard Bauer and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-02-07 with Medical categories.
This Brief describes the concept and realization of gene therapy for HIV from the unique historic perspective and insight of two pioneers of the clinical applications of stem cell gene therapy for HIV. Gerhard Bauer applied ribozyme-anti-HIV and other vectors to manufacture clinical grade, HIV-resistant hematopoietic stem cells for the first patients that received stem cell gene therapy for HIV, including the first child in the world and the first fully marrow-ablated HIV infected patient. Joseph Anderson developed the most recent and most potent combination anti-HIV lentiviral vectors and pluripotent stem cell applications for HIV gene therapy and tested these in the appropriate in vitro and vivo models, paving the way for novel HIV gene therapy approaches to possibly cure patients. In Gene Therapy for HIV, Bauer and Anderson discuss the unique aspects of this therapy, including its limitations and proper safety precautions and outline a path for a possible functional cure for HIV using stem cell gene therapy based on a cure already achieved with a bone marrow stem cell transplantation performed in Germany using donor stem cells with a naturally arising CCR5 mutation. In addition, the Brief provides a thorough and methodical explanation of the basics of gene therapy, gene therapy vector development, in vitro and in vivo models for HIV gene therapy and clinical applications of HIV gene therapy, including Good Manufacturing Practices.
Stem Cell And Gene Based Therapy
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Author : Alexander Battler
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-06-26
Stem Cell And Gene Based Therapy written by Alexander Battler and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-06-26 with Medical categories.
Regenerative medicine – stem cell and gene-based therapy – offers a new approach for restoring function of damaged organs and tissues. This is the first book to cover the major new aspects and field of regenerative medicine. This title is therefore a timely addition to the literature. It brings together the major approaches to regenerative medicine in one text, which ensures that techniques learnt in one discipline are disseminated across other areas of medicine.
Novel Perspectives Of Stem Cell Manufacturing And Therapies
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Author : Diana Kitala
language : en
Publisher: BoD – Books on Demand
Release Date : 2021-04-14
Novel Perspectives Of Stem Cell Manufacturing And Therapies written by Diana Kitala and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-04-14 with Technology & Engineering categories.
In the 1950s, Nobel Prize winner Dr. E. Donnall Thomas was the first to successfully transplant hematopoietic stem cells. Since then, studies on stem cells have evolved and expanded worldwide. There are more than 650,000 scientific publications on stem cells and more than 8000 stem cell clinical trials. This book summarizes types of stem cells, key studies, ongoing trials, and future perspectives. It also includes ethical, formal, and legal aspects to give the reader a comprehensive view of the field.