Plant Molecular Farming For The Production Of Next Generation Vaccines And Biologics Prospects And Challenges
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Plant Molecular Farming For The Production Of Next Generation Vaccines And Biologics Prospects And Challenges
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Author :
language : en
Publisher: Frontiers Media SA
Release Date : 2024-03-11
Plant Molecular Farming For The Production Of Next Generation Vaccines And Biologics Prospects And Challenges written by and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-11 with Science categories.
Infectious diseases are still a major threat to public health. The vaccine remains the most important and safer way of combating infectious diseases. Therefore, there is an urgent need to look for new ways of vaccine generation that can cut down production costs and processing time. The development of rDNA technology allows the expression and purification of proteins in unlimited quantity, thus opening an avenue for the development of protein-based vaccines as a prophylactic measure against infectious diseases. Recombinant therapeutic proteins derived from biological sources, including mammalian cells, microorganisms, suspension cultures, or genetically modified organisms by employing biotechnological processes, are widely used in clinical applications, especially for the treatment and prevention of human or veterinary infections. Since the development of human insulin by utilizing recombinant DNA technology in E. coli in the 1980s, the recombinant therapeutic protein production field has significantly grown and gained major attention. Plant molecular farming, the production of biologics in plant cells or transgenic plants, could offer a cost-effective adaptable strategy to produce biologics, particularly in low-resource settings. Molecular farming-based strategies could provide an alternative strategy to traditional biologics or vaccine production, enabling rapid development, effective deployment, and safe administration of vaccines. The concept of PMF was initially documented three decades back when recombinant growth hormone was produced in tobacco and sunflower plants. Even with such a long history of significant advantages and several proof-of-concept studies, very few plant-derived therapeutic products have been clinically translated. However, the recent progress around the approval of the plant-based biopharmaceutical ZMapp by the FDA, Medicago’s COVID-19 vaccine by Health Canada, and the safety of a few plant-derived vaccines in clinical trials have displayed the potential of a plant platform for biopharmaceutical production. Furthermore, constant efforts are being made with respect to the optimization of expression techniques, downstream processing, and defining standard guidelines for plant products to make an impact of plant-derived products on an array of applications.
Proceedings Of Ispmf 2018 Plant Molecular Farming
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Author : Anneli Ritala
language : en
Publisher: Frontiers Media SA
Release Date : 2020-06-16
Proceedings Of Ispmf 2018 Plant Molecular Farming written by Anneli Ritala and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-16 with categories.
Environmental Effects Of Transgenic Plants
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 2002-02-22
Environmental Effects Of Transgenic Plants written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-02-22 with Technology & Engineering categories.
Transgenic crops offer the promise of increased agricultural productivity and better quality foods. But they also raise the specter of harmful environmental effects. In this new book, a panel of experts examines: • Similarities and differences between crops developed by conventional and transgenic methods • Potential for commercialized transgenic crops to change both agricultural and nonagricultural landscapes • How well the U.S. government is regulating transgenic crops to avoid any negative effects. Environmental Effects of Transgenic Plants provides a wealth of information about transgenic processes, previous experience with the introduction of novel crops, principles of risk assessment and management, the science behind current regulatory schemes, issues in monitoring transgenic products already on the market, and more. The book discusses public involvementâ€"and public confidenceâ€"in biotechnology regulation. And it looks to the future, exploring the potential of genetic engineering and the prospects for environmental effects.
Molecular Pharming
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Author : Allison R. Kermode
language : en
Publisher: John Wiley & Sons
Release Date : 2018-03-12
Molecular Pharming written by Allison R. Kermode and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-03-12 with Science categories.
A single volume collection that surveys the exciting field of plant-made pharmaceuticals and industrial proteins This comprehensive book communicates the recent advances and exciting potential for the expanding area of plant biotechnology and is divided into six sections. The first three sections look at the current status of the field, and advances in plant platforms and strategies for improving yields, downstream processing, and controlling post-translational modifications of plant-made recombinant proteins. Section four reviews high-value industrial and pharmacological proteins that are successfully being produced in established and emerging plant platforms. The fifth section looks at regulatory challenges facing the expansion of the field. The final section turns its focus toward small molecule therapeutics, drug screening, plant specialized metabolites, and plants as model organisms to study human disease processes. Molecular Pharming: Applications, Challenges and Emerging Areas offers in-depth coverage of molecular biology of plant expression systems and manipulation of glycosylation processes in plants; plant platforms, subcellular targeting, recovery, and downstream processing; plant-derived protein pharmaceuticals and case studies; regulatory issues; and emerging areas. It is a valuable resource for researchers that are in the field of plant molecular pharming, as well as for those conducting basic research in gene expression, protein quality control, and other subjects relevant to molecular and cellular biology. Broad ranging coverage of a key area of plant biotechnology Describes efforts to produce pharmaceutical and industrial proteins in plants Provides reviews of recent advances and technology breakthroughs Assesses realities of regulatory and cost hurdles Forward looking with coverage of small molecule technologies and the use of plants as models of human disease processes Providing wide-ranging and unique coverage, Molecular Pharming: Applications, Challenges and Emerging Areas will be of great interest to the plant science, plant biotechnology, protein science, and pharmacological communities.
Sustainable Food Production
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Author : Paul Christou
language : en
Publisher: Springer
Release Date : 2012-12-05
Sustainable Food Production written by Paul Christou and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-05 with Technology & Engineering categories.
Gathering some 90 entries from the Encyclopedia of Sustainability Science and Technology, this book covers animal breeding and genetics for food, crop science and technology, ocean farming and sustainable aquaculture, transgenic livestock for food and more.
Basic And Applied Aspects Of Biotechnology
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Author : Varsha Gupta
language : en
Publisher: Springer
Release Date : 2016-10-22
Basic And Applied Aspects Of Biotechnology written by Varsha Gupta and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-22 with Technology & Engineering categories.
This book explores the journey of biotechnology, searching for new avenues and noting the impressive accomplishments to date. It has harmonious blend of facts, applications and new ideas. Fast-paced biotechnologies are broadly applied and are being continuously explored in areas like the environmental, industrial, agricultural and medical sciences. The sequencing of the human genome has opened new therapeutic opportunities and enriched the field of medical biotechnology while analysis of biomolecules using proteomics and microarray technologies along with the simultaneous discovery and development of new modes of detection are paving the way for ever-faster and more reliable diagnostic methods. Life-saving bio-pharmaceuticals are being churned out at an amazing rate, and the unraveling of biological processes has facilitated drug designing and discovery processes. Advances in regenerative medical technologies (stem cell therapy, tissue engineering, and gene therapy) look extremely promising, transcending the limitations of all existing fields and opening new dimensions for characterizing and combating diseases.
Livestock S Long Shadow
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Author : Henning Steinfeld
language : en
Publisher: Food & Agriculture Org.
Release Date : 2006
Livestock S Long Shadow written by Henning Steinfeld and has been published by Food & Agriculture Org. this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Business & Economics categories.
"The assessment builds on the work of the Livestock, Environment and Development (LEAD) Initiative"--Pref.
Pharming
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Author : Eckard Rehbinder
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-09-27
Pharming written by Eckard Rehbinder and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-09-27 with Medical categories.
A recently established technique termed pharming uses genetically modified plants and animals for the production of biopharmaceuticals. The present interdisciplinary study comprises an extended overview of the state of the art of pharming, as well as in depth analyses of the environmental risks and other ethical and legal issues of pharming. Public attitudes to pharming are investigated on the basis of an original survey in 15 countries worldwide. The study concludes with specific recommendations addressed towards science, industry and politics.
Viral Nanoparticles
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Author : Nicole F. Steinmetz
language : en
Publisher: CRC Press
Release Date : 2019-08-21
Viral Nanoparticles written by Nicole F. Steinmetz and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-21 with Technology & Engineering categories.
This book overviews the applications of viral nanoparticles (VNPs) in areas ranging from materials science to biomedicine. It summarizes the many different VNP building blocks and describes chemistries that allow one to attach, entrap, or display functionalities on VNPs. The book outlines the strategies for the construction of 1-, 2-, and 3-D arrays, highlights the achievements in utilizing VNPs as tools for novel biosensors and nanoelectronic devices, and describes efforts in designing VNPs for biomedical applications, including their use as gene delivery vectors, novel vaccines, imaging modalities, and applications in targeted therapeutics.
Plant Viral Vectors
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Author : Kenneth Palmer
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-12-06
Plant Viral Vectors written by Kenneth Palmer and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-06 with Medical categories.
In this volume, the authors provide an excellent overview of how far the plant viral vector field has come. The discipline is no longer exclusively in the domain of academics—there is a small, but growing number of small biotechnology companies that exploit plant viruses as the platform for commercial innovation in crop improvement, industrial product manufacturing, and human and veterinary health care.