Platinum Coordination Complexes In Cancer Chemotherapy
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Platinum Coordination Complexes In Cancer Chemotherapy
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Author : T.A. Connors
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Platinum Coordination Complexes In Cancer Chemotherapy written by T.A. Connors and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
It was a great pleasure and honour to have been invited to attend this Seminar and to present a final impression. The association in this field between the Chester Beatty Research Institute and Dr. Rosenberg's School at East Lansing is something which I specially value and many would doubtless like to know how it came about. In the course of its work in carcinogenesis and on chemotherapy over many years, the Chester Beatty Research Institute was frequently drawn to the importance of many metals - as for example lead, iron, metalloid arsenic and the metalloid quali ties of the carcinogenic hydrocarbons. Interest started in platinum many years ago, following the possibility, c1aimed by others, that various complexes between the metal and mercaptopurine might possess significant chemotherapeutic properties. Va rious attempts to confirm such findings ended, however, in complete failure. Interest in platinum was revived by the fresh observations of Dr. Rosenberg and his collea gues, and here the outcome was entirely different. Very soon it was possible to con firm the intense growth-inhibitory properties of cis-platinum (II) diamminedi chloride and related substances. After communicating these results to Dr. Rosenberg, it was a pleasure to welcome hirn in London where he gave a Seminar which greatly engaged the interest of many of the staff. Later, several of these were to enjoy Dr. Rosenberg's hospitality at an international conference on the subject to be held in East Lansing, where many rapidly developing aspects were open for discussion.
Platinum And Other Metal Coordination Compounds In Cancer Chemotherapy
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Author : Stephen B. Howell
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11
Platinum And Other Metal Coordination Compounds In Cancer Chemotherapy written by Stephen B. Howell and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Medical categories.
Taken together the data presented in this review, and work by many other investigators, support the notion that DNA excision repair is important in a tumor cell's resistance to platinum compounds. Inhibition of this repair system by combination chemotherapy with the excision repair inhibitors HU and Ara-C produces synergistic cell kills and increased levels and persistance of DNA interstrand crosslinks. The studies with cis-DDP and ~-DDP in combination with UV induced thymine dimers suggest that there may be competition for DNA repair enzymes between the dimer and the platinum lesion. Whether the competing lesion is an intrastrand crosslink, interstrand crosslink, or platinum monoadduct (or all of these lesions) cannot be determined. The similarity between an intrastrand crosslink and a cyclobutane dimer suggests that these lesions may compete for repair. However, the increased peak levels of interstrand crosslinks, and increased persistence of these lesions at later time points suggest that this lesion may also be a substrate for the repair system. These observations may be of clinical relevance. Recently Dr. Kathy Albain of our institution has completed a Phase III I study using a 12 hour pretreatment with HU and Ara-C in patients prior to their cis-DDP therapy. She observed a significant number of responders in this trial (54). She is currently completing a second Phase IIII study substituting IV HU for the oral formulation. We anticipate initiating other clinical trials based upon these observations.
Platinum Coordination Complexes In Cancer Chemotherapy
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Author : Miles P. Hacker
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Platinum Coordination Complexes In Cancer Chemotherapy written by Miles P. Hacker and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The idea for convening a Fourth International Symposium on Platinum Coordination Complexes in Cancer Chemotherapy was born in an assembly of researchers from the Vermont Regional Cancer Center and the Norris Cotton Cancer Center who shared a common interest in metal complexes. It was agreed by those assembled that sufficient time had passed since the Third International Symposium on Platinum Coor dination Complexes in Cancer Chemotherapy held in 1976 at the Wadley Institutes of Molecular Medicine in Dallas, Texas, during which several advances in the chemistry, biochemistry, pharmacology and clinical use of platinum complexes had occurred, to warrant a fourth symposium. Furthermore, intensive investigations in progress were bringing sophisticated methodologies to bear on the problems in the field, clinical trials were yielding interesting results, and unique approaches to cancer therapy were being designed. Therefore, an organizing committee was formed and planning culminated in the symposium which was held in Burlington, Vermont, June 22-24, 1983.
Platinum And Other Metal Coordination Compounds In Cancer Chemotherapy 2
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Author : Steef van de Velde
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11
Platinum And Other Metal Coordination Compounds In Cancer Chemotherapy 2 written by Steef van de Velde and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Medical categories.
The 7th International Symposium on Platinum and other metal coordination compounds in Cancer Chemotherapy, ISPCC '95, organized by the European Cancer Centre, was held in Amsterdam, the Netherlands, March 1-4, 1995. As with previous ISPCC meetings, the goal of ISPCC '95 was to bring together c1inicians, clinical investigators, scientists, and laboratory workers from many disciplines to promote further collaboration and cooperation in the development of new platinum and other metal coordination compounds as weil as in new ways to use 'c1assical' drugs as cisplatin and carboplatin in the treatment of cancer. Important aspects addressed by experts in the field inc1uded the synthesis and activity of new platinum compounds, the biochemistry and molecular pharrnacology as weil as the c1inical pharrnacology of this c1ass of antineoplastic agents, an overview of current c1inical studies, one special minisymposium on the mechanisms of cell kill of platinum, and one on resistance against platinum compounds. Finally, the current status of development of nonplatinum metal complexes was discussed. This volume contains the contributions of the various speakers at ISPCC '95 and provides an up-to-date and comprehensive overview of this important c1ass of anticancer agents, ranging from synthesis and molecular pharrnacology on one hand to c1inical pharrnacology and cIinical investigations on the other hand. The Organizing Corrunittee and Editors wish to express their gratitude to the contributors to this volume, to the various organizations and pharrnaceutical companies for their generous sponsoring of ISPCC '95, and to the Plenum Publishing Company for their help in producing this volume.
Ruthenium And Other Non Platinum Metal Complexes In Cancer Chemotherapy
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Author : Etienne Baulieu
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-07
Ruthenium And Other Non Platinum Metal Complexes In Cancer Chemotherapy written by Etienne Baulieu and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-07 with Medical categories.
With contributions by numerous experts
Platinum And Other Metal Coordination Compounds In Cancer Chemotherapy
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Author : Marino Nicolini
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Platinum And Other Metal Coordination Compounds In Cancer Chemotherapy written by Marino Nicolini and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Proceedings of the Fifth International Symposium, held in Abano Terme (Padova), italy, June 29-July 2, 1987
Platinum And Other Heavy Metal Compounds In Cancer Chemotherapy
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Author : Andrea Bonetti
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-01-09
Platinum And Other Heavy Metal Compounds In Cancer Chemotherapy written by Andrea Bonetti and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-01-09 with Medical categories.
Cisplatin, the first member of the family of platinum-containing chemotherapeutic agents, was discovered by Barnett Rosenberg in 1965 and approved by the FDA for marketing in 1978. After 30 years of use in the clinic, cisplatin remains a central element of many treatment regimens. Cisplatin is still an irreplaceable component of a regimen that produces high cure rates in even advanced nonseminomatous germ-cell cancers, and is widely used in the treatment of ovarian cancers and other gynecologic cancers, head and neck, and numerous other tumor types. The development of carboplatin has reduced some of the adverse events associated with cisplatin treatment, and the introduction of the DACH platinum compound oxaliplatin has broadened the spectrum of activity of the platinums to include gastro-intestinal cancers, especially colorectal cancer. The clinical importance of this family of drugs continues to drive investigation into how these drugs work and how to improve their efficacy and reduce their toxicity. The papers in this volume were presented in Verona, Italy, during the tenth International Symposium on Platinum Coordination Compounds in Cancer Chemotherapy. The symposium was jointly organized by the Department of Oncology of the Mater Salutis Hospital – Azienda Sanitaria Locale 21 of the Veneto Region – and by the Department of Medicine and Public Health, Section of Pharmacology, the University of Verona. They reflect the vitality of this field and the increasing use of new molecular and cell biologic, genetic, and biochemical tools to identify approaches to further improve their use.
Metal Complexes In Cancer Chemotherapy
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Author : Bernhard K. Keppler
language : en
Publisher: VCH Publishers
Release Date : 1993
Metal Complexes In Cancer Chemotherapy written by Bernhard K. Keppler and has been published by VCH Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Medical categories.
Cancer Chemotherapy Reports
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Author :
language : en
Publisher:
Release Date : 1975
Cancer Chemotherapy Reports written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1975 with Antineoplastic agents categories.
The Discovery Use And Impact Of Platinum Salts As Chemotherapy Agents For Cancer
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Author : Daphne A. Christie
language : en
Publisher: Qmul History C20medicine
Release Date : 2007
The Discovery Use And Impact Of Platinum Salts As Chemotherapy Agents For Cancer written by Daphne A. Christie and has been published by Qmul History C20medicine this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Medical categories.
Serendipity played a large part in the discovery of the biological actions of the simple platinum coordination complexes. In the mid-1960s, Professor Barnett Rosenberg and colleagues found that a simple platinum-based compound prevented bacteria from dividing normally. He tested the compound on cancer cells and showed that it was biologically active. Cisplatin has since emerged as one of the most widely prescribed anticancer agents. Cisplatin has been shown to be effective either alone or in combination for the treatment of a wide variety of solid cancers in man, including testicular and ovarian cancers. It is also palliative in the treatment of cancers of the head and neck, bladder, prostate, lung, cervix, and in some paediatric cancers. Toxic side effects of the drug include damage to the kidney and severe side effects include such nausea and vomiting that patients have been known to refuse treatment. In turn, the cisplatin-induced emesis provided a major stimulus for research into anti-emetics, which has provided several effective drugs for the relief of many kinds of nausea and vomiting, especially that associated with radio- and chemotherapy. The relief of such toxic side effects has been an important factor in encouraging patients to continue successfully otherwise unpleasant forms of cancer therapy. Participants who attended this Witness Seminar include representatives from several areas of work on the platinum compounds: chemists who worked with Rosenberg; oncologists who pioneered their use clinically; and pharmacologists who examined the emetic properties of these compounds, and devised, in particular, the 5HT3 receptor antagonists