Polycystic Kidney Disease
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Polycystic Kidney Disease
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Author : Christian Riella
language : en
Publisher: Biota Publishing
Release Date : 2017-01-24
Polycystic Kidney Disease written by Christian Riella and has been published by Biota Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-24 with Medical categories.
This book reviews important aspects of polycystic kidney diseases, the latest scientific understanding of the diseases and syndromes, along with the therapies being developed. Cystic kidney diseases comprise a spectrum of genetic syndromes defined by renal cyst formation and expansion with variable extrarenal manifestations. The most prevalent disorder is the autosomal dominant polycystic kidney disease (ADPKD). It is the most common monogenetic disorder in humans and accounts for 4.4% of end-stage renal disease (ESRD) cases in the U.S. Patients inevitably progress to ESRD and require renal replacement therapy in the form of dialysis or transplantation. Through advancements in genomics and proteomics approaches, novel genes responsible for cystic diseases have been identified, further expanding our understanding of basic mechanisms of disease pathogenesis. The hallmark among all cystic genetic syndromes is the formation and growth of fluid-filled cysts, which originate from tubular epithelia of nephron segments. Cysts are the disease, and treatment strategies are being developed to target prevention or delay of cyst formation and expansion at an early stage, however no such therapy is currently approved.
Polycystic Kidney Disease
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Author : Jinghua Hu
language : en
Publisher: CRC Press
Release Date : 2019-10-24
Polycystic Kidney Disease written by Jinghua Hu and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-24 with Medical categories.
This volume focuses on the investigatory methods applied to autosomal dominant polycystic kidney disease (ADPKD), one of the most common human genetic diseases. ADPKD is caused by mutations in PKD1 and TRPP2, two integral membrane proteins that function as receptor/ion channels in primary cilia of tubular epithelial cells. Thus, ADPKD belongs to ciliopathies, a group of disorders caused by abnormal cilia formation or function. This proposed book will cover the state-of-the-art methods ranging from molecular biology, biochemistry, electrophysiology, to tools in model animal studies. Key Features Explores the role of cilia in polycystic kidney disease Focuses on myriad state-of-the-art methods and techniques Reviews specific mutations integral to this autosomal genetic disease Includes discussions of model systems
Polycystic Kidney Disease Ecab
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Author : K V Dakshinamurty
language : en
Publisher: Elsevier Health Sciences
Release Date : 2012-06-15
Polycystic Kidney Disease Ecab written by K V Dakshinamurty and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-06-15 with Medical categories.
Renal cystic diseases include a large number of sporadic and genetically determined congenital, developmental, or acquired conditions. A cyst is a cavity lined by epithelium and filled with fluid. Cysts derive primarily from tubules (from Bowman’s capsule to the collecting duct). Cystic kidneys of different etiologies may appear morphologically similar, whereas the same etiologic entity may cause a wide spectrum of renal abnormalities. Simple renal cysts are acquired and are not associated with any disease. In contrast, polycystic kidney diseases can be complicated by renal failure or tumor development. Autosomal dominant polycystic kidney disease (ADPKD) is the most common potentially lethal single-gene disorder. Its prevalence at birth is between 1:400 and 1:1,000. It may progress to end stage renal disease by age 60 with 4.4% of patients requiring renal replacement therapy (dialysis or transplant) have ADPKD. The book is a comprehensive guide to diagnosis and management of the condition with special reference and experience around the same in India. The authors have put together the most relevant facts about the disease for an easy comprehension and understanding of the same by practitioners and students across the specialty.
Polycystic Kidney Disease
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Author : European Concerted Action Towards Prevention of Renal Failure Caused by Polycystic Kidney Disease (Committee). Int. Workshop
language : en
Publisher: S. Karger AG (Switzerland)
Release Date : 1992
Polycystic Kidney Disease written by European Concerted Action Towards Prevention of Renal Failure Caused by Polycystic Kidney Disease (Committee). Int. Workshop and has been published by S. Karger AG (Switzerland) this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Medical categories.
Problems In Diagnosis And Management Of Polycystic Kidney Disease
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Author : Jared J. Grantham
language : en
Publisher:
Release Date : 1985
Problems In Diagnosis And Management Of Polycystic Kidney Disease written by Jared J. Grantham and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1985 with Medical categories.
Medifocus Guidebook On
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Author : Medifocus.com, Inc. Staff
language : en
Publisher: Medifocus_com Inc
Release Date : 2011
Medifocus Guidebook On written by Medifocus.com, Inc. Staff and has been published by Medifocus_com Inc this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Health & Fitness categories.
The MediFocus Guidebook on Polycystic Kidney Disease is the most comprehensive, up-to-date source of information available. You will get answers to your questions, including risk factors of Polycystic Kidney Disease, standard and alternative treatment options, leading doctors, hospitals and medical centers that specialize in Polycystic Kidney Disease, results of the latest clinical trials, support groups and additional resources, and promising new treatments on the horizon. This one of a kind Guidebook offers answers to your critical health questions including the latest treatments, clinical trials, and expert research; high quality, professional level information you can trust and understand culled from the latest peer-reviewed journals; and a unique resource to find leading experts, institutions, and support organizations including contact information and hyperlinks. This Guidebook was updated on January 18, 2012.
Cystogenesis
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Author : Jong Hoon Park
language : en
Publisher: Springer
Release Date : 2016-10-12
Cystogenesis written by Jong Hoon Park and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-12 with Medical categories.
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a highly prevalent hereditary renal disorder in which fluid-filled cysts are appeared in both kidneys. Main causative genes of ADPKD are PKD1 and PKD2, encoding for polycystin-1 (PC1) and polycystin-2 (PC2) respectively. Those proteins are localized on primary cilia and function as mechanosensor in response to the fluid flow, translating mechanistic stimuli into calcium signaling. With mutations either of PKD1 or PKD2, hyper-activated renal tubular epithelial cell proliferation is observed, followed by disrupted calcium homeostasis and aberrant intracellular cyclic AMP (cAMP) accumulation. Increased cell proliferation with fluid secretion leads to the development of thousands of epithelial-lined, fluid-filled cysts in kidneys. It is also accompanied by interstitial inflammation, fibrosis, and finally reaching end-stage renal disease (ESRD). In human ADPKD, the age at which renal failure typically occurs is later in life, however no specific targeted medications are available to cure ADPKD. Recently, potential therapeutic targets or surrogate diagnostic biomarkers for ADPKD are proposed with the advances in the understanding of ADPKD pathogenesis, and some of them were attempted for clinical trials. Herein, we will summarize genetic and epi-genetic molecular mechanisms in ADPKD progression, and overview the currently available biomarkers or potential therapeutic reagents suggested.
Polycystic Kidney Disease
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Author : Leonard Watson
language : en
Publisher:
Release Date : 1996
Polycystic Kidney Disease written by Leonard Watson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Medical categories.
Many inherited diseases and non-hereditary disorders have in common the development of renal cystic disease. The most common, autosonal dominant polycystic kidney disease, is responsible for 5-10% of end-stage renal failure treated by dialysis or transplantation. Since the publication six years ago of the last book on polycystic kidney disease, a number of genes causing the disease have been identified, mapped, or sequenced; new experimental models and the application of molecular biology techniques have provided new insights into the pathogenesis R polycystic kidney disease; novel clinical studies have provided valuable information for the prevention, evaluation, and treatment of the complications of this disease. This book provides an updated, state-of-the-art review of the genetics, pathophysiology, evaluation, and management of these diseases and will be of interest to both basic researchers and clinicians in nephrology.
Polycystic Kidney Disease
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Author : Benjamin D. Cowley, Jr.
language : en
Publisher: Springer
Release Date : 2018-05-24
Polycystic Kidney Disease written by Benjamin D. Cowley, Jr. and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-24 with Medical categories.
This comprehensive guide to polycystic kidney disease captures the growing knowledge of this common, potentially-fatal and hereditary disease. The first two sections of the book provide an overview of PKD gene structures, mutations and pathophysiologic mechanisms. This is followed by chapters focused on PKD’s clinical features, including renal and extrarenal manifestations, and appropriate management of patients. The final section covers current clinical trials and emerging therapies in PKD. Authored by experts in the field, this book provides the clinician and researcher with critical information on basic and translational science and clinical approaches in one concise resource.
Autosomal Dominant Polycystic Kidney Disease
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Author : A. Sessa
language : en
Publisher: S. Karger AG (Switzerland)
Release Date : 1995
Autosomal Dominant Polycystic Kidney Disease written by A. Sessa and has been published by S. Karger AG (Switzerland) this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with Medical categories.
This volume contains over 40 informative contributions from leading specialists in the field focusing on the following inheritable diseases: - Polycystic kidney disease - Tuberous sclerosis complex - Von Hippel-Lindau disease - Alport syndrome - Primary hyperoxaluria - Cystinuria - Anderson-Fabry disease Recent scientific advances have changed our knowledge regarding several hereditary kidney diseases and the application of this knowledge will open a new era of molecular medicine in which the risk of disease can be accurately assessed by DNA-based diagnostic procedures. The appropriate use of preemptive medical care will benefit all patients and lower the social costs of certain diseases but ethical guidelines need to be clearly established. The goal of this volume is to bring together the latest findings of clinical nephrologists, geneticists and molecular biologists in order to further the clinical application of genetic diagnostic techniques for some of the most common inherited nephropathies. Throwing new light on a range of important topics and issues, the book is very valuable for all those interested in the field.