Polyester Drug Delivery Systems
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Handbook Of Polyester Drug Delivery Systems
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Author : M. N. V. Ravi Kumar
language : en
Publisher: CRC Press
Release Date : 2017-03-27
Handbook Of Polyester Drug Delivery Systems written by M. N. V. Ravi Kumar and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-27 with Medical categories.
In the quest for innovative drug delivery systems attempting to meet the unmet needs in pharmaceutical space, research has taken a much more complicated path that poses a significant challenge for translation. Despite the progress made with novel materials, polyesters still remain at the helm of drug delivery technologies. This book provides a single source of reference of polyester drug delivery systems that covers a broad spectrum of materials design, manufacturing techniques, and applications.
Polyester Drug Delivery Systems
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Author : Trystan Worrell
language : en
Publisher: Foster Academics
Release Date : 2023-09-26
Polyester Drug Delivery Systems written by Trystan Worrell and has been published by Foster Academics this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-26 with Medical categories.
Polyester refers to a category of synthetic polymers built up from several chemical repeating units connected together by ester (CO-O) groups. They include both naturally occurring chemicals like those found in insects and plants, and synthetic chemicals like polybutyrate. Polyesters exhibit a diverse range of properties and useful applications. They are used as building blocks in drug delivery vehicles due to their properties of biodegradability and biocompatibility. Poly(caprolactones) (PCL), poly(dioxanone)s (PDO), poly(valerolactone)s (PVL), poly(lactide)s (PLA), poly(lactide-co-glycolide) (PLGA), poly(butyrolactone)s (PBL) and poly(glycolide)s (PGA) are some common polyesters utilized in drug delivery applications. The usage of polyester drug delivery systems may enhance bioavailability and pharmacokinetic properties, enable local administration, and prevent medication deactivation. This book elucidates prospective developments with respect to polyester drug delivery systems. Scientists and students actively engaged in the study of these drug delivery systems will find it full of crucial and unexplored concepts.
Modifiable Hyperbranched Polyester Drug Delivery Systems
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Author : Dorothy Ogden
language : en
Publisher:
Release Date : 2011
Modifiable Hyperbranched Polyester Drug Delivery Systems written by Dorothy Ogden and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Polymerization categories.
This work encompassed synthesis and characterization of biocompatible hyperbranched polyester drug delivery systems prepared with fumaric acid, glycerol and polyethylene glycol. The polymers were manufactured in the melt utilizing A2 + CB2 polymerization. The ratio of A2:CB2 was modified and excess B was added to end-cap the polymers to avoid cross-linking. Fumaric acid was selected as the A2 monomer because the double bond provided a site for polymer backbone modification or covalent attachment of active pharmaceutical ingredients. Acetaminophen and Ondansetron Hydrochloride were added to evaluate feasibility of using the polyesters as drug delivery systems. The weight average molecular weight of the A2 + CB2 polymer systems with the end-capping agent ranged from 5100 to 8500 Da with PDI values between 1.3 and 1.7. The polymers containing Acetaminophen appeared to degrade while the polymers with Ondansetron were determined to be immediate-release dosage forms.
Aliphatic Polyester Nanoparticles For Drug Delivery Systems
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Author : Narumol Kreua-ongarjnukool
language : en
Publisher:
Release Date : 2019
Aliphatic Polyester Nanoparticles For Drug Delivery Systems written by Narumol Kreua-ongarjnukool and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Medical categories.
Drug delivery systems using aliphatic polyester nanoparticles are usually prepared via an emulsion process. These nanoparticles can control drug release and improve pharmacokinetics. Aliphatic polyesters are linear polymers containing ester linkages, showing sensitivity to hydrolytic degradation. The byproducts then promote autocatalytic degradation. These byproducts could enter the Krebs cycle and be eliminated from the body, resulting in the high biocompatibility of these nanoparticles. The properties of these polyesters are linked to the drug release rate due to biodegradation, i.e., polymer crystallinity, glass transition temperature, polymer hydrophobicity, and molecular weight (MW), all of which relatively influence hydrolysis. Mathematical equations have been used to study the factors and mechanisms that affect drug dissolution compared to experimental release data. The equations used as models for predicting the kinetics of drug release include the zero-order, first-order, Higuchi, Hixson-Crowell, and Korsmeyer-Peppas equations. Aliphatic polyester-based controlled drug delivery has surrounded much of the current activity in the estimation parameters of nanoparticles and stimulated additional research. Polymeric nanoparticles have potential in a wide range of applications, such as in biotechnology, vaccine systems, and the pharmaceutical industry. The main goal of this chapter is to discuss aliphatic polyester nanoparticles as drug carrier systems.
Encyclopedia Of Pharmaceutical Technology
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Author : James C. Boylan
language : en
Publisher: CRC Press
Release Date : 1989-10-11
Encyclopedia Of Pharmaceutical Technology written by James C. Boylan and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989-10-11 with Medical categories.
"The Encyclopedia of Pharmaceutical Technology presents up-to-date and interdisciplinary contributions by leading international authorities in all areas of drugs and drug delivery systems. Major components of the Encyclopedia cover drugs, including physicochemical properties, preformulation, incompatibilities, metabolism, pharmacokinetics, stability, and decomposition...drug delivery systems (and devices), encompassing development, routes of administration, formulation alternatives, dosage form selection, scale up, manufacturing, process validation, bioavailability, and computerization...post-production considerations, ranging from patient compliance and physicians' preferences to national and international agencies; and more."
Polymeric Delivery Systems
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Author : Magda A. El-Nokaly
language : en
Publisher: Wiley-VCH
Release Date : 1993-04-20
Polymeric Delivery Systems written by Magda A. El-Nokaly and has been published by Wiley-VCH this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-04-20 with Medical categories.
Presents recent advances in basic research and applications of polymeric delivery systems. Examines preparation and properties of biodegradable and other polymer delivery systems. Stimulates new ideas for the application of polymeric drug delivery technology to cosmetics, foods, pharmaceuticals, and pesticide systems.
Encyclopedia Of Pharmaceutical Technology Biodegradable Polyester Polymers As Drug Carriers To Clinical Pharmacokinetics And Pharmacodynamics
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Author :
language : en
Publisher:
Release Date : 1988
Encyclopedia Of Pharmaceutical Technology Biodegradable Polyester Polymers As Drug Carriers To Clinical Pharmacokinetics And Pharmacodynamics written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988 with Pharmaceutical technology categories.
Handbook Of Polyester Drug Delivery Systems
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Author : M. N. V. Ravi Kumar
language : en
Publisher: CRC Press
Release Date : 2017-03-27
Handbook Of Polyester Drug Delivery Systems written by M. N. V. Ravi Kumar and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-27 with Medical categories.
In the quest for innovative drug delivery systems attempting to meet the unmet needs in pharmaceutical space, research has taken a much more complicated path that poses a significant challenge for translation. Despite the progress made with novel materials, polyesters still remain at the helm of drug delivery technologies. This book provides a single source of reference of polyester drug delivery systems that covers a broad spectrum of materials design, manufacturing techniques, and applications.
Polymeric Drug Delivery Systems
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Author : Irina Muljajew
language : de
Publisher:
Release Date : 2022*
Polymeric Drug Delivery Systems written by Irina Muljajew and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022* with categories.
Hydrophobe Wirkstoffe weisen häufig eine schlechten Bioverfügbarkeit und Transporteffizienz auf. Diese Nachteile können durch ein optimiertes Nanoträgersystem kompensiert werden. Hierfür sind polymerbasierte Mizellen und Nanopartikel mit einem hydrophoben Kern besonders geeignet. Die Personalisierung des jeweiligen Polymergrundgerüsts sollte jedoch unter Beachtung der kausalen Zusammenhänge erfolgen. In diesem Zusammenhang wurden in der vorliegenden Dissertation ausgewählte Kandidaten der Polyester, Polyesteramide und Poly(2-ethyl-2-oxazolin)e untersucht. Neben ihrer Synthese, wurden diese Materialien hinsichtlich ihrer Anwendung als Nanocarrier und Struktur-Eigenschafts-Beziehungen bewertet. Die konstante hydrophile-hydrophobe-Balance wurde für wohldefinierte Poly(ɛ-caprolacton)-Analoga mit unterschiedlicher Mikroarchitektur validiert. Trotz unterschiedlicher thermischer Polymereigenschaften wurden vielversprechende Nanopartikel mit gleicher Größe und ausgezeichneter Langzeitstabilität erhalten. Eine Polyesteramid-Bibliothek wurde durch die Polyaddition von acht Dicarbonsäuren und 2,2`-Bis(2-oxazoline) erzeugt. Im Anschluss wurden die geeigneten Materialien in einer Kompatibilitätsstudie mit dem hydrophoben, antientzündlichen Wirkstoff Indomethacin untersucht. Formulierbarkeit des Polymers, aber auch die Kompatibilität der Kernkomponenten in Bulk hatten beide einen signifikanten Einfluss auf die Qualität der beladenen Nanoträger. Die Einführung einer hydrophilen Stealth-Schale erfolgte im Makromonomeransatz durch Kombination der kationischen Ringöffnungspolymerization und einer kontrollierten, radikalischen Polymerisation. Resultierende Kern-Schale-Mizellen basierend auf dem hydrophoben Poly(methylmethacrylat)-Rückgrat und hydrophilien Seitenketten aus Oligo(2-ethyl-2-oxazolin) wurden in Abhängigkeit der variierenden Rückgrat-Endgruppe untersucht. Mittels intravitaler Mikroskopie wurde ein Endgruppeneinfluss auf die Leberzellspezifität in Mausstudien festgestellt.
Biodegradable Polyesters
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Author : Stoyko Fakirov
language : en
Publisher: John Wiley & Sons
Release Date : 2015-04-06
Biodegradable Polyesters written by Stoyko Fakirov and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-04-06 with Technology & Engineering categories.
Collating otherwise hard-to-get and recently acquired knowledge in one work, this is a comprehensive reference on the synthesis, properties, characterization, and applications of this eco-friendly class of plastics. A group of internationally renowned researchers offer their first-hand experience and knowledge, dealing exclusively with those biodegradable polyesters that have become increasingly important over the past two decades due to environmental concerns on the one hand and newly-devised applications in the biomedical field on the other. The result is an unparalleled overview for the industrial chemist and materials scientist, as well as for developers and researchers in industry and academia alike.