Polysaccharides Peptides And Proteins
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Polysaccharides Peptides And Proteins
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Author : R. T. Coutts
language : en
Publisher: Elsevier
Release Date : 2014-05-12
Polysaccharides Peptides And Proteins written by R. T. Coutts and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-12 with Science categories.
Pharmaceutical Monographs, Volume 4: Polysaccharides Peptides and Proteins provides information pertinent to a wide variety of naturally-occurring macromolecules that are either peptide, protein, or polysaccharide in nature, which are important as medicinal and pharmaceutical agents. This monograph presents the basic physical and chemical properties of polysaccharides. Organized into four chapters, this volume begins with an overview of the pharmaceutical importance of the class of compounds known as polysaccharides. This text then provides data on the structure of the polysaccharides that is obtained by isolating and identifying the product formed on hydrolysis of the molecule itself. Other chapters consider plant gums and mucilages as important medicinal and pharmaceutical products. This monograph discusses as well the autohydrolysis of gum arabic. The final chapter deals with the clinical applications of various peptide-type antibiotics. This monograph is a valuable resource for undergraduate students of pharmacy and allied subjects.
Polysaccharides Peptides And Proteins
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Author : Ronald Thomson Coutts
language : en
Publisher: London : Heinemann Medical Books
Release Date : 1966
Polysaccharides Peptides And Proteins written by Ronald Thomson Coutts and has been published by London : Heinemann Medical Books this book supported file pdf, txt, epub, kindle and other format this book has been release on 1966 with Peptides categories.
Peptide And Protein Drug Delivery Using Polysaccharides
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Author : Aakanchha Jain
language : en
Publisher: Elsevier
Release Date : 2023-10-10
Peptide And Protein Drug Delivery Using Polysaccharides written by Aakanchha Jain and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-10 with Science categories.
Peptide and Protein Drug Delivery Using Polysaccharides offers an interdisciplinary discussion of polysaccharides applied in peptide and protein drug delivery. Chapters consider basic biology of different polysaccharides of current interest and their production at pilot and large-scale stages by various techniques including, but not limited to, cell and hairy root cultures. Other sections examine factors affecting polysaccharide absorption, metabolism, and excretion in nascent, encapsulated, or conjugated forms, with unique coverage of vaccine absorption, metabolism, and drug delivery. A final section considers analytical methods for detection in tissue fluids and homogenates. Accessible figures, tables, and graphical abstracts are included throughout to support understanding. Specific polysaccharides discussed for therapeutic purposes include cellulose, hyaluronic acid, heparin, carageenan, alginic acid, agar and myrrh, acacia, tragacanth, ghatti gum, chitin, chitosan, starch, glycogen and dextran. Adopts an interdisciplinary approach across biochemistry, molecular biology, pharmaceutical sciences and drug delivery, and biotechnological perspectives Features accessible figures, tables and graphical abstracts across all chapters to support understanding Examines various polysaccharides of current interest and aspects affecting their absorption, metabolism, excretion and detection
Bioinspired Matrices Assembled By Polysaccharide Protein Interactions
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Author : Le Zhang
language : en
Publisher: ProQuest
Release Date : 2008
Bioinspired Matrices Assembled By Polysaccharide Protein Interactions written by Le Zhang and has been published by ProQuest this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Colloids categories.
Bioinspired matrices assembled on the basis of noncovalent interactions between proteins and polysaccharides have been proved suitable to deliver therapeutically relevant proteins or DNAs. Our initial efforts were dedicated to the relationship between mechanical properties of hydrogels assembled based on specific interactions between low molecular weight heparin (LMWH) and heparin binding peptides (HBPs) such as HIP, ATIII, and PF4 ZIP peptides. The measured differences in affinity and kinetics for LMWH-HBP binding likely lead to observed differences in the phase separation behavior of the poly (ethylene glycol) (PEG)-LMWH/PEG-HIP hydrogels versus the PEG-LMWH/PEG-ATIII hydrogels. More attention has been given to the PF4 ZIP peptide employed for the noncovalent assembly of heparinized hydrogels. Multifunctional star PEG-PF4 ZIP bioconjugates complexed with star PEG-LMWH form hydrogels that exhibit increasing elastic moduli with increasing mole ratio of PEG-PF4 ZIP . The viscoelastic properties of the hydrogels can be controlled via alterations in the ratio between LMWH and PF4 ZIP peptide, and comparisons with other PEG-LMWH/PEG-HBP hydrogels suggest the importance of both LMWH/HBP binding kinetics and the binding capacity of LMWH in determining rheological properties in these hydrogels. Characterization of the PEG-LMWH/PEG-PF4 ZIP hydrogels suggests that useful moduli for soft tissue engineering applications are obtained at physiological temperatures and after applying high shear. Furthermore, in the basic fibroblast growth factor (bFGF) release, bFGF/vascular endothelial growth factor (VEGF) co-release, and hydrogel erosion results, the combination of growth factor (GF) release profiles and hydrogel erosion profiles suggests that GF delivery from the assembled hydrogels is mainly an erosion-controlled process that may permit co-release of GF with PEG-LMWH and may therefore also improve the bioactivity of GF delivered from these matrices. Hydrogels with such engineered mechanical properties and biological activities may find expanded use in controlled delivery of therapeutics and in other biological applications. In addition to the multivalent PEG-HBPs, a growth factor with two LMWH-binding sites, VEGF, was also employed to physically crosslink PEG-unfractionated LMWH based on protein-polysaccharide interactions, and the assembled networks can be selectively eroded in the presence of the growth factor receptors. The VEGF released from these hydrogels is bioactive and able to increase proliferation of VEGF-responsive cell lines. A receptor-mediated hydrogel erosion and protein delivery are suggested from the release of VEGF crosslinks in response to cell surface KDR. Employing similar approaches, other therapeutically important difunctional proteins or synthetic peptides can also act as crosslinks of environmentally-responsive systems and be delivered in a targeted manner. The multivalent PEG-HBPs are also capable of binding both heparin and plasmid DNA sufficiently well to make them valuable for serving as DNA delivery vectors. Transfection studies suggest the PEG-HBPs possess significant transfection efficiency. Apart from the highly toxic PEG-ATIII vector, increased heparin affinity of PEG-HBPs correlated well with increased cellular uptake and increased transfection efficiency. In general, cell surface binding and cellular uptake, mediated by heparan sulfate, play a key role in the transfection pathway. Given that the structures and components of PEG-HBPs can be accurately tuned, the multivalent PEG-HBPs may find broader applications in gene delivery.
Molecular Design And Modeling
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Author : John Joseph Langone
language : en
Publisher: Gulf Professional Publishing
Release Date : 1991
Molecular Design And Modeling written by John Joseph Langone and has been published by Gulf Professional Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Antigen-antibody reactions categories.
Computer-based design and modeling, computational approaches, and instrumental methods for elucidating molecular mechanisms of protein folding and ligand-acceptor interactions are included in Volumes 202 and 203, as are genetic and chemical methods for the production of functional molecules including antibodies and antigens, enzymes, receptors, nucleic acids and polysaccharides, and drugs.
Functional Properties Of Food Macromolecules
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Author : S.E. Hill
language : en
Publisher: Springer Science & Business Media
Release Date : 1998-08-31
Functional Properties Of Food Macromolecules written by S.E. Hill and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-08-31 with Science categories.
This edition updates the substantial progress that has occurred since 1988 in many aspects of understanding, measuring and utilizing functional macromolecules.
Food Biopolymers Structural Functional And Nutraceutical Properties
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Author : Adil Gani
language : en
Publisher: Springer Nature
Release Date : 2021-02-11
Food Biopolymers Structural Functional And Nutraceutical Properties written by Adil Gani and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-11 with Technology & Engineering categories.
Food biopolymers: Structural, functional and nutraceutical properties provides valuable coverage of all major food biopolymers from plant, animal and marine sources. The text focuses on the structural characteristics of biopolymers including starch, non-starch polysaccharides, proteins and fats. A full section is dedicated to the nutraceutical potential and applications of these polymers. Further sections provide comprehensive overviews of the development of functional food products and important data on biopolymer behavior and nutraceutical potential during processing. Researchers hoping to gain a basic understanding of the techno-functional, nutraceutical potential and applications of food biopolymers will find a singular source with this text. The first section of this work focuses on the the structure, functions, bioactivity and applications of starches. The next chapters cover non-starch polysaccharides. Further sections are dedicated to proteins, lipids and oils. A detailed overview is provided for each, followed by application procedures, specifics on individual types, proteins and enzymes, and nutraceutical properties. This work can be used as a singular source for all relevant information on food biopolymers and their structural and functional properties, including their potential to increase food quality, improve shelf life, and reduce pollution and waste in the food industry.
An Introduction To Polysaccharide Biotechnology
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Author : Stephen E. Harding
language : en
Publisher: CRC Press
Release Date : 2002-09-11
An Introduction To Polysaccharide Biotechnology written by Stephen E. Harding and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-09-11 with Medical categories.
Timely book gives account of the production and uses of polysaccharides. Focuses on the main developments. Also explains and illustrates how current work on polysaccharides may lead to major future developments in this field.
Advances In Biopolymers
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Author : American Chemical Society. Meeting
language : en
Publisher:
Release Date : 2006
Advances In Biopolymers written by American Chemical Society. Meeting and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Language Arts & Disciplines categories.
The necessity to better understand the functionality and nutrition of biopolymers in foods and to replace synthetic macromolecules with polymers derived from natural resources in order develop a sustainable economy has been an impetus for research on structure/function relationships and applications for these natural materials. Because of their ability to aggregate, associate, interact and form networks, systems containing biopolymers are extremely complex and elucidating structure/function relationships in these systems is difficult. This symposium series book covers selected recent research and developments involving elucidation of networks, protein-polysaccharide interactions; and isolation, characterization, modification and applications of biopolymers.
Molecular Design And Modeling Concepts And Applications Part A Proteins Peptides And Enzymes
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Author :
language : en
Publisher: Academic Press
Release Date : 1991-10-09
Molecular Design And Modeling Concepts And Applications Part A Proteins Peptides And Enzymes written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-10-09 with Science categories.
Computer-based design and modeling, computational approaches, and instrumental methods for elucidating molecular mechanisms of protein folding and ligand-acceptor interactions are included in Volumes 202 and 203, as are genetic and chemical methods for the production of functional molecules including antibodies and antigens, enzymes, receptors, nucleic acids and polysaccharides, and drugs.