Post Translational Modifications In Health And Disease
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Post Translational Modifications In Health And Disease
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Author : Cecilio J. Vidal
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-10-13
Post Translational Modifications In Health And Disease written by Cecilio J. Vidal and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-10-13 with Science categories.
Post-translational modifications serve many different purposes in several cellular processes such as gene expression, protein folding and transport to appropriate cell compartment, protein-lipid and protein-protein interactions, enzyme regulation, signal transduction, cell proliferation and differentiation, protein stability, recycling and degradation. Although several-hundred different modifications are known, the significance of many of them remains unknown. The enormous versatility of the modifications which frequently alter the physico-chemical properties of the respective proteins represents an extraordinary challenge in understanding their physiological role. Since essential cellular functions are regulated by protein modifications, an improvement of current understanding of their meaning might allow new avenues to prevent and/or alleviate human and animal diseases.
Post Translational Modifications In Health And Disease
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Author :
language : en
Publisher: Springer
Release Date : 2011-04-11
Post Translational Modifications In Health And Disease written by and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-11 with categories.
Protein Modificomics
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Author : Tanveer Ali Dar
language : en
Publisher: Academic Press
Release Date : 2019-05-21
Protein Modificomics written by Tanveer Ali Dar and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-21 with Science categories.
Protein Modificomics: From Modifications to Clinical Perspectives comprehensively deals with all of the most recent aspects of post-translational modification (PTM) of proteins, including discussions on diseases involving PTMs, such as Alzheimer's, Huntington's, X-linked spinal muscular atrophy-2, aneurysmal bone cyst, angelman syndrome and OFC10. The book also discusses the role PTMs play in plant physiology and the production of medicinally important primary and secondary metabolites. The understanding of PTMs in plants helps us enhance the production of these metabolites without greatly altering the genome, providing robust eukaryotic systems for the production and isolation of desired products without considerable downstream and isolation processes.
Protein Deimination In Human Health And Disease
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Author : Anthony P. Nicholas
language : en
Publisher: Springer
Release Date : 2017-09-20
Protein Deimination In Human Health And Disease written by Anthony P. Nicholas and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-20 with Medical categories.
Published in 2014, Protein Deimination in Human Health and Disease was the first book on this novel post-translational modification, in which selected positively-charged arginine amino acids are converted to neutral citrulline amino acids by the peptidyl-arginine deiminase (PAD) family of enzymes. This area of research continues to expand rapidly, necessitating the need for this second edition. Chronicling the latest inflammatory, epigenetic, neurodegenerative, and carcinogenic processes, Protein Deimination in Human Health and Disease, Second Edition, updates the latest advances in deimination research, including new information on PAD enzyme structure and activity, and how PAD knock-out animals are being used to study known and newly-discovered links to various human diseases. The first edition outlined what was known about citrullinated proteins in normal tissues such as skin and hair, as well as in maladies such as rheumatoid arthritis (RA), multiple sclerosis (MS), Alzheimer’s disease (AD), glaucoma, peripheral nerve injury, neonatal hypoxic brain damage, and breast cancer. This second edition addresses numerous additional disorders such as diabetes, asthma, traumatic brain injury, inflammatory bowel disease, lupus, bone disease, heart failure, fronto-temporal dementia, and prostate and colon cancer. It also provides updates on the deimination research covering the three seminal diseases first linked to this process (RA, MS and AD), and details how auto-antibodies against citrullinated proteins contribute to disease. In addition, new hypotheses on the possible pathologic mechanisms of citrullinated myelin basic protein and glial fibrillary acidic protein are also proposed. This second edition also outlines the latest developments in therapeutic strategies, including the use of new PAD antagonists and innovative techniques such as micro-vescicles and stem cells as possible mechanisms to treat these conditions.
Protein Phosphorylation In Health And Disease
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Author : Allegra Via
language : en
Publisher: Frontiers Media SA
Release Date : 2016-08-11
Protein Phosphorylation In Health And Disease written by Allegra Via and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-11 with Genetics categories.
Protein phosphorylation is one of the most abundant reversible post-translational modifications in eukaryotes. It is involved in virtually all cellular processes by regulating protein function, localization and stability and by mediating protein-protein interactions. Furthermore, aberrant protein phosphorylation is implicated in the onset and progression of human diseases such as cancer and neurodegenerative disorders. In the last years, tens of thousands of in vivo phosphorylation events have been identified by large-scale quantitative phospho-proteomics experiment suggesting that a large fraction of the proteome might be regulated by phosphorylation. This data explosion is increasingly enabling the development of computational approaches, often combined with experimental validation, aiming at prioritizing phosphosites and assessing their functional relevance. Some computational approaches also address the inference of specificity determinants of protein kinases/phosphatases and the identification of phosphoresidue recognition domains. In this context, several challenging issues are still open regarding phosphorylation, including a better understanding of the interplay between phosphorylation and allosteric regulation, agents and mechanisms disrupting or promoting abnormal phosphorylation in diseases, the identification and modulation of novel phosphorylation inhibitors, and so forth. Furthermore, the determinants of kinase and phosphatase recognition and binding specificity are still unknown in several cases, as well as the impact of disease mutations on phosphorylation-mediated signaling. The articles included in this Research Topic illustrate the very diverse aspects of phosphorylation, ranging from structural changes induced by phosphorylation to the peculiarities of phosphosite evolution. Some also provide a glimpse into the huge complexity of phosphorylation networks and pathways in health and disease, and underscore that a deeper knowledge of such processes is essential to identify disease biomarkers, on one hand, and design more effective therapeutic strategies, on the other.
Post Translational Modifications In Cellular Functions And Diseases
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Author : Shibo Ying
language : en
Publisher:
Release Date : 2021
Post Translational Modifications In Cellular Functions And Diseases written by Shibo Ying and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with Cell metabolism categories.
Post-Translational Modifications (PTMs) may occur at any stage following the translation process in the lifecycle of specific proteins. PTMs regulate several cellular processes including protein stability, subcellular localization, and protein-protein interactions. In recent years, more and more target proteins of PTMs have been proved to be related to epigenetic regulation and cell fate. Some enzymes that catalyze PTMs have also been found to be involved in human diseases. This book intends to provide the reader with an overview of the current state of the art in this research field, which focuses on the recent advances, new findings and perspectives in cellular functions, and their clinical significance in human diseases. We hope this book will help researchers in this area.
Cell Death Regulation In Health And Disease Part C
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Author :
language : en
Publisher: Academic Press
Release Date : 2020-05-14
Cell Death Regulation In Health And Disease Part C written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-14 with Science categories.
Cell Death Regulation in Health and Disease - Part C, Volume 353 in the International Review of Cell and Molecular Biology series, reviews and details current advances in cell and molecular biology. The IRCMB series maintains the highest standard by publishing timely topics authored by prominent cell and molecular biologists, with this release covering Developmental and seasonal regulation of neural cell death in birds, Post-translational modifications in cell death regulation, The role of cell death in tissue regeneration and fibrosis, Crosstalk between the apoptosis and autophagy signaling pathways, IP3 receptor signal integration in cell death and survival decisions, and more. Provides a comprehensive collection of front-of-the line research in the field of cell death regulation Authored by established and active cell and molecular biologists drawn from international sources Includes only invited review articles, covering selected topics in many different organisms and disease settings
Molecular Mechanisms And Physiology Of Disease
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Author : Nilanjana Maulik
language : en
Publisher: Springer
Release Date : 2014-05-31
Molecular Mechanisms And Physiology Of Disease written by Nilanjana Maulik and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-31 with Medical categories.
In a simplified form, epigenetics refers to heritable changes in phenotype that are not due to changes in the underlying DNA sequence. In this book, epigenetic mechanisms of regulation and dysregulation in health and disease are explored in great depth. Detailed chapters on epigenetic processes including DNA methylation and chromatin post-translational modifications including potential interventions with DNA methyltransferase inhibitors and histone deacetylase inhibitors are explored in initial chapters. These provide a detailed overview and important background to the entire field. The book is then focussed on epigenetic mechanisms involved in various diseases including anti-inflammatory and autoimmune conditions. Important accounts relating to the effects of epigenetics in metabolic syndrome, cardiovascular disease and asthma are the focus of subsequent chapters. The role of epigenetic dysregulation in malignancy is a current topic of interest and represents an intense field of research. A large component of this book is dedicated to the analysis of aberrant epigenetic processes in carcinogenesis and cancer progression. Further, chapters are focused on emerging cancer prevention using nutritional components and anti-cancer therapies particularly with histone deacetylase inhibitors, which have already been approved for the treatment of cutaneous T-cell lymphoma. The emerging role of nanoparticle preparations, especially in the context of delivering potential epigenetic therapies to target cells in various diseases, is also explored in this book. Overall, this book encompasses a wide range of topics related to epigenetic mechanisms in health and disease and would appeal to anyone with an interest in epigenetics, chromatin biology and emerging epigenetic interventions and therapies.
Transcription And Translation In Health And Disease
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Author : Manoj Garg
language : en
Publisher: Elsevier
Release Date : 2023-01-30
Transcription And Translation In Health And Disease written by Manoj Garg and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-30 with Science categories.
Transcription and Translation in Health and Disease provides a detailed overview of the regulators underlying transcription and translation in relation to a variety of human diseases and disorders. Beginning with an introduction into the current perspectives relating to these processes in human disease, the book expands to focus on specific mechanisms underlying conditions such as arthritis, cancer, neurological disorders, diabetes and cardiovascular disease. This book considers RNA processing and related mechanisms in eukaryotes including RNA splicing, RNA binding proteins, RNA interference, microRNAs, RNA editing, transcription factors, RNAi screening, CRISPR activation, CRISPR-Cas9 interference, and post-translational modifications. It provides a structured and detailed overview of the various regulators underlying molecular processes and their impact on health and disease, equipping readers with the necessary knowledge for further investigation in the areas of treatment and therapeutic intervention. Discusses the role played by transcription and translational regulation in various diseases, including cancer, diabetes, cardiovascular disease and neurological disease Considers a range of post-transcriptional regulators, including RNA-binding proteins, non-coding RNAs, epigenetic modifiers, alternative splicing and telomerase-binding proteins Covers the topic from fundamental knowledge to the latest developments in clinical application Includes a section dedicated to therapeutic applications
The Role Of Sarcomeric Proteins And Their Post Translational Modifications In Striated Muscle Health Disease And Aging
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Author : Zachery Robert Gregorich
language : en
Publisher:
Release Date : 2017
The Role Of Sarcomeric Proteins And Their Post Translational Modifications In Striated Muscle Health Disease And Aging written by Zachery Robert Gregorich and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.
Sarcomeric proteins, including both myofilament and Z-disc proteins, constitute the molecular machinery responsible for force production in a Ca2+-dependent manner. In addition to regulation by Ca2+, convincing evidence now indicates that the post-translational modification (PTM) of myofilament proteins is an essential mechanism enabling the Ca2+-independent modulation of striated muscle contractility. Moreover, the view of the Z-discs as passive structures, necessary only for force transmission between adjacent sarcomeres, has undergone a paradigm shift, with the results of recent studies implicating these structures in signaling, and even in the regulation of striated muscle contractile function. In the studies detailed in this thesis, top-down mass spectrometry-based proteomics was employed in combination with functional assays to gain insights into the role of sarcomeric proteins and their PTMs in the heart under basal conditions and in response to myocardial injury, as well as in skeletal muscle during natural aging. Collectively, the key findings presented herein shed new light on the roles of myofilament protein PTMs in cardiac and skeletal muscle contractile function under basal and pathological conditions. Also noteworthy was the identification of alterations in the phosphorylation of Z-disc proteins in cardiac and skeletal muscles in response to infarction and natural aging, respectively. These findings provide the first evidence that the Z-discs may be involved in the early events in the heart after injury and in aging skeletal muscles. Moreover, evidence that enigma homolog protein isoforms, which localize to the Z-discs in striated muscles, play a role in setting the kinetics of force redevelopment, at least in mouse myocardium, is also presented. Thus, these findings not only provide new information regarding the contributions made by myofilament protein PTMs to striated muscle contractility, but also open new avenues to explore the role of Z-disc proteins in striated muscle biology. Furthermore, these results add to a growing list of contributions made by top-down mass spectrometry to the advancement of our understanding of the functions of protein PTMs in health and disease.