Post Translational Modifications In Cellular Functions And Diseases
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Post Translational Modifications In Cellular Functions And Diseases
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Author : Shibo Ying
language : en
Publisher:
Release Date : 2021
Post Translational Modifications In Cellular Functions And Diseases written by Shibo Ying and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with Cell metabolism categories.
Post-Translational Modifications (PTMs) may occur at any stage following the translation process in the lifecycle of specific proteins. PTMs regulate several cellular processes including protein stability, subcellular localization, and protein-protein interactions. In recent years, more and more target proteins of PTMs have been proved to be related to epigenetic regulation and cell fate. Some enzymes that catalyze PTMs have also been found to be involved in human diseases. This book intends to provide the reader with an overview of the current state of the art in this research field, which focuses on the recent advances, new findings and perspectives in cellular functions, and their clinical significance in human diseases. We hope this book will help researchers in this area.
Post Translational Modifications In Health And Disease
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Author : Cecilio J. Vidal
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-10-13
Post Translational Modifications In Health And Disease written by Cecilio J. Vidal and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-10-13 with Science categories.
Post-translational modifications serve many different purposes in several cellular processes such as gene expression, protein folding and transport to appropriate cell compartment, protein-lipid and protein-protein interactions, enzyme regulation, signal transduction, cell proliferation and differentiation, protein stability, recycling and degradation. Although several-hundred different modifications are known, the significance of many of them remains unknown. The enormous versatility of the modifications which frequently alter the physico-chemical properties of the respective proteins represents an extraordinary challenge in understanding their physiological role. Since essential cellular functions are regulated by protein modifications, an improvement of current understanding of their meaning might allow new avenues to prevent and/or alleviate human and animal diseases.
Protein Modificomics
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Author : Tanveer Ali Dar
language : en
Publisher: Academic Press
Release Date : 2019-05-21
Protein Modificomics written by Tanveer Ali Dar and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-21 with Science categories.
Protein Modificomics: From Modifications to Clinical Perspectives comprehensively deals with all of the most recent aspects of post-translational modification (PTM) of proteins, including discussions on diseases involving PTMs, such as Alzheimer's, Huntington's, X-linked spinal muscular atrophy-2, aneurysmal bone cyst, angelman syndrome and OFC10. The book also discusses the role PTMs play in plant physiology and the production of medicinally important primary and secondary metabolites. The understanding of PTMs in plants helps us enhance the production of these metabolites without greatly altering the genome, providing robust eukaryotic systems for the production and isolation of desired products without considerable downstream and isolation processes.
Protein Modificomics
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Author : Tanveer Ali Dar
language : en
Publisher: Academic Press
Release Date : 2019-05-18
Protein Modificomics written by Tanveer Ali Dar and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-18 with Science categories.
Protein Modificomics: From Modifications to Clinical Perspectives comprehensively deals with all of the most recent aspects of post-translational modification (PTM) of proteins, including discussions on diseases involving PTMs, such as Alzheimer’s, Huntington’s, X-linked spinal muscular atrophy-2, aneurysmal bone cyst, angelman syndrome and OFC10. The book also discusses the role PTMs play in plant physiology and the production of medicinally important primary and secondary metabolites. The understanding of PTMs in plants helps us enhance the production of these metabolites without greatly altering the genome, providing robust eukaryotic systems for the production and isolation of desired products without considerable downstream and isolation processes. Provides thorough insights into the post translational modifications (PTMs) of proteins in both the plant and animal kingdom Presents diagrammatic representations of various protein modification and estimation mechanisms in four-color Includes coverage of diseases involving post translational modifications
Protein Modifications In Pathogenic Dysregulation Of Signaling
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Author : Jun-ichiro Inoue
language : en
Publisher: Springer
Release Date : 2015-09-02
Protein Modifications In Pathogenic Dysregulation Of Signaling written by Jun-ichiro Inoue and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-09-02 with Science categories.
This book is devoted to recent advances in analysis of the molecular basis and dynamics of post-translational modifications (PTMs) of proteins for a comprehensive understanding of their key roles in cell signaling networks and diverse biological processes, and their perturbation in a variety of life-threatening diseases such as cancer and inflammatory diseases. The book includes research regarding PTMs and methods of their investigation derived from interdisciplinary collaborations between leading scientists in the fields of molecular, medical, proteomic, structural, and mathematical biology. This book consists of four sections. The first part focuses on recent advances in procedures for analysis of PTMs and cell signaling. The second part is devoted to mathematical simulation of signal transduction pathways and of the formation of protein complexes in living cells. The third part deals with structural and functional analyses of proteins involved in the regulation of PTMs and cell signaling. The fourth part describes cutting-edge findings regarding critical signal transduction pathways and their dysregulation in human diseases. This book is aimed at both established scientists and students in various fields of biology including molecular, cellular, structural, proteomic, and mathematical biology. Readers can access cutting-edge research and methodologies in their own field as well as interdisciplinary research that impacts on their field. The book can function as a reference for pharmaceutical scientists, biomedical researchers, and clinicians for the development of molecular-targeted therapy of human diseases.
Sumo Regulation Of Cellular Processes
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Author : Victor Willson
language : en
Publisher: Springer
Release Date : 2009-12-22
Sumo Regulation Of Cellular Processes written by Victor Willson and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-12-22 with Medical categories.
Over a decade ago, a small cellular protein of 12 kDa, with 18% homology to the well-known ubiquitin protein, was co-discovered and termed Small Ubiquitin-like Modifier, or SUMO. Sumoylation is a post-translational modification that utilizes SUMO as the modifier group covalently attached to target substrates. This state-of-the art review on the sumoylation system deals with protein modification as it pertains to regulation of diverse cellular functions. Each chapter has been written by a leading researcher and covers the role of sumoylation in fundamental biochemical activities (transcription, RNA processing, chromatin remodelling, DNA repair, nucleocytoplasmic transport, ion channel regulation, and metabolic pathways). The text also examines the part sumoylation plays in critical cellular processes such as mitosis, meiosis, differentiation, senescence, and apoptosis. Lastly, the emerging role of sumoylation in specific diseases, including cancer and diabetes as well as neurodegenerative ones, is explored with an emphasis on defining molecular mechanisms that may provide new targets for treatment or prevention. While SUMO was discovered more than 10 years ago, this is still a relatively young field, and much remains to be discovered about the biochemical and biological properties of this modification system. In just the last few years, it has become clear that sumoylation modifies hundreds of cellular proteins, and there has been increased appreciation for the breadth of cellular functions that are impacted by this post-translational modification.
Post Translational Modifications That Modulate Enzyme Activity
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Author :
language : en
Publisher: Academic Press
Release Date : 2019-10-12
Post Translational Modifications That Modulate Enzyme Activity written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-12 with Science categories.
Post-translational Modifications That Modulate Enzyme Activity, Volume 626 in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Updated chapters include Crosstalk between cellular metabolism and histone acetylation, Isolation of protein complexes and modifications that regulate transcriptional machinery, High-throughput phosphoproteome mapping through multiplexed mass spectrometry, Differentiation of D and L epimerization in proteins, Biochemical analysis of protein arginylation, Site-specific Determination of lysine acetylation stoichiometries on the proteome-scale, Genomic and biochemical analysis of RNA post-transcriptional modifications, Isolation and characterization of glycosylated (neuro)peptides, and more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Enzymology series Includes the latest information on Post-translational Modifications that Modulate Enzyme Activity
The Role Of Protein Post Translational Modifications In Protein Rna Interactions And Rnp Assemblies
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Author : Roberto Giambruno
language : en
Publisher: Frontiers Media SA
Release Date : 2022-02-11
The Role Of Protein Post Translational Modifications In Protein Rna Interactions And Rnp Assemblies written by Roberto Giambruno and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-11 with Science categories.
Dr. Nicolas Lux Fawzi is a member of the Scientific Advisory Board of Dewpoint Therapeutics LLC. All other Topic Editors declare no competing interests with regards to the Research Topic.
Protein Modifications In Pathogenic Dysregulation Of Signaling
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Author : Jun-ichiro Inoue
language : en
Publisher:
Release Date : 2015
Protein Modifications In Pathogenic Dysregulation Of Signaling written by Jun-ichiro Inoue and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with categories.
This book is devoted to recent advances in analysis of the molecular basis and dynamics of post-translational modifications (PTMs) of proteins for a comprehensive understanding of their key roles in cell signaling networks and diverse biological processes, and their perturbation in a variety of life-threatening diseases such as cancer and inflammatory diseases. The book includes research regarding PTMs and methods of their investigation derived from interdisciplinary collaborations between leading scientists in the fields of molecular, medical, proteomic, structural, and mathematical biology. This book consists of four sections. The first part focuses on recent advances in procedures for analysis of PTMs and cell signaling. The second part is devoted to mathematical simulation of signal transduction pathways and of the formation of protein complexes in living cells. The third part deals with structural and functional analyses of proteins involved in the regulation of PTMs and cell signaling. The fourth part describes cutting-edge findings regarding critical signal transduction pathways and their dysregulation in human diseases. This book is aimed at both established scientists and students in various fields of biology including molecular, cellular, structural, proteomic, and mathematical biology. Readers can access cutting-edge research and methodologies in their own field as well as interdisciplinary research that impacts on their field. The book can function as a reference for pharmaceutical scientists, biomedical researchers, and clinicians for the development of molecular-targeted therapy of human diseases.
Post Translational Modifications And Compartmentalized Protein Quality Control In Cardiac Muscle And Disease
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Author : Huabo Su
language : en
Publisher: Frontiers Media SA
Release Date : 2021-10-18
Post Translational Modifications And Compartmentalized Protein Quality Control In Cardiac Muscle And Disease written by Huabo Su and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-18 with Science categories.
