Post Translational Modifications That Modulate Enzyme Activity
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Post Translational Modifications That Modulate Enzyme Activity
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Author :
language : en
Publisher: Academic Press
Release Date : 2019-10-12
Post Translational Modifications That Modulate Enzyme Activity written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-12 with Science categories.
Post-translational Modifications That Modulate Enzyme Activity, Volume 626 in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Updated chapters include Crosstalk between cellular metabolism and histone acetylation, Isolation of protein complexes and modifications that regulate transcriptional machinery, High-throughput phosphoproteome mapping through multiplexed mass spectrometry, Differentiation of D and L epimerization in proteins, Biochemical analysis of protein arginylation, Site-specific Determination of lysine acetylation stoichiometries on the proteome-scale, Genomic and biochemical analysis of RNA post-transcriptional modifications, Isolation and characterization of glycosylated (neuro)peptides, and more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Enzymology series Includes the latest information on Post-translational Modifications that Modulate Enzyme Activity
Post Translational Modifications In Health And Disease
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Author : Cecilio J. Vidal
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-10-13
Post Translational Modifications In Health And Disease written by Cecilio J. Vidal and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-10-13 with Science categories.
Post-translational modifications serve many different purposes in several cellular processes such as gene expression, protein folding and transport to appropriate cell compartment, protein-lipid and protein-protein interactions, enzyme regulation, signal transduction, cell proliferation and differentiation, protein stability, recycling and degradation. Although several-hundred different modifications are known, the significance of many of them remains unknown. The enormous versatility of the modifications which frequently alter the physico-chemical properties of the respective proteins represents an extraordinary challenge in understanding their physiological role. Since essential cellular functions are regulated by protein modifications, an improvement of current understanding of their meaning might allow new avenues to prevent and/or alleviate human and animal diseases.
Alteration And Modulation Of Protein Activity By Varying Post Translational Modification
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Author :
language : en
Publisher:
Release Date : 2015
Alteration And Modulation Of Protein Activity By Varying Post Translational Modification written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with categories.
Embodiments of the invention include methods of altering the enzymatic activity or solubility of an extremophilic enzyme or post-translationally modifying a protein of interest via using isolated or partially purified glycosyltransferases and/or post-translational modification proteins, extracts of cells comprising glycosyltransferases and/or post-translational modification proteins, and/or in cells comprising one or more glycosyltransferases and/or post-translational modification proteins.
Novel Cofactors
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Author : Judith P. Klinman
language : en
Publisher: Gulf Professional Publishing
Release Date : 2001-10-05
Novel Cofactors written by Judith P. Klinman and has been published by Gulf Professional Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-10-05 with Medical categories.
A cofactor is a component part of many enzymes and functions by uniting with another molecule in order to become active. The use of cofactors to supplement the native amino acids of a protein is essential to maintain the chemical capabilities necessary for organisms to survive. This volume focuses on the significant advances of the past decade in identifying and describing new cofactors--either small molecules or those derived posttranslationally.
Protein Modificomics
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Author : Tanveer Ali Dar
language : en
Publisher: Academic Press
Release Date : 2019-05-21
Protein Modificomics written by Tanveer Ali Dar and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-21 with Science categories.
Protein Modificomics: From Modifications to Clinical Perspectives comprehensively deals with all of the most recent aspects of post-translational modification (PTM) of proteins, including discussions on diseases involving PTMs, such as Alzheimer's, Huntington's, X-linked spinal muscular atrophy-2, aneurysmal bone cyst, angelman syndrome and OFC10. The book also discusses the role PTMs play in plant physiology and the production of medicinally important primary and secondary metabolites. The understanding of PTMs in plants helps us enhance the production of these metabolites without greatly altering the genome, providing robust eukaryotic systems for the production and isolation of desired products without considerable downstream and isolation processes.
Posttranslational Modification Of Proteins
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Author : Christopher Walsh
language : en
Publisher: Roberts and Company Publishers
Release Date : 2006
Posttranslational Modification Of Proteins written by Christopher Walsh and has been published by Roberts and Company Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Science categories.
Covering the major classes of posttranslational modifications, Posttranslational Modification of Proteins is the first comprehensive treatment of this burgeoning area of proteome diversification.
Chemical And Biochemical Studies Of Ubiquitin Conjugation Machinery
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Author : Renuka Kuchibhotla Pandya
language : en
Publisher:
Release Date : 2010
Chemical And Biochemical Studies Of Ubiquitin Conjugation Machinery written by Renuka Kuchibhotla Pandya and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.
The post-translational modification of proteins is a major mechanism employed in eukaryotic cells to expand the functional diversity of the proteome. Covalent modification of amino acid side chains confers new or altered functionality to the modified protein by creating new recognition surfaces on the protein for the interaction of nucleic acids or other proteins, modulating enzymatic activity, or altering cellular localization or half-life. The post-translational modification of proteins with ubiquitin (Ub) is an important mechanism of regulating protein function. Ub is a 76-residue protein that is primarily attached to lysine residues in target proteins through an enzymatic cascade catalyzed by E1, E2, and E3 enzymes. Ub conjugation is important for fundamental cellular processes, including transcription, DNA repair, endocytosis, apoptosis, and signal transduction. Ub conjugation is reversible. Proteases termed deubiquitinating enzymes (DUBs) function to remove Ub from target proteins. Genome sequencing efforts have uncovered the existence of many predicted enzymes with unknown function. Many enzymes have been assigned function based on sequence homology to proteins with known function without confirmation of enzymatic activity. A powerful chemical approach to determine enzyme function from a complex mixture of proteins is activity-based protein profiling. This method makes use of chemical probes that are active site-directed for the assignment of function to proteins. We describe here the design and generation of an expanded set of Ub-based chemical probes with which we identified and recovered E1, E2, and E3 Ub ligases from cell lysates. Furthermore, we describe the biochemical and structural characterization of the catalytic domain of one E3 Ub ligase we recovered, HUWE1, and the identification of a structural element within the catalytic domain of HUWE1 that modulates its activity. Finally, we discuss a protein engineering method that we are applying to the HUWE1 catalytic domain to understand how the conformational flexibility of this domain is important to its function.
Biosimilars Of Monoclonal Antibodies
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Author : Cheng Liu
language : en
Publisher: John Wiley & Sons
Release Date : 2016-12-09
Biosimilars Of Monoclonal Antibodies written by Cheng Liu and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-09 with Medical categories.
Addressing a significant need by describing the science and process involved to develop biosimilars of monoclonal antibody (mAb) drugs, this book covers all aspects of biosimilar development: preclinical, clinical, regulatory, manufacturing. • Guides readers through the complex landscape involved with developing biosimilar versions of monoclonal antibody (mAb) drugs • Features flow charts, tables, and figures that clearly illustrate processes and makes the book comprehensible and accessible • Includes a review of FDA-approved mAb drugs as a quick reference to facts and useful information • Examines new technologies and strategies for improving biosimilar mAbs
Sumoylation And Ubiquitination
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Author : Van G. Wilson
language : en
Publisher:
Release Date : 2019-09
Sumoylation And Ubiquitination written by Van G. Wilson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09 with Science categories.
Most proteins undergo post-translational modifications altering physical and chemical properties, folding, conformation distribution, stability, activity and function. Ubiquitin and SUMOs are related small proteins that are members of the large ubiquitin superfamily of post-translational modifiers. Written by highly respected leaders in their fields under the expert guidance of the editor, this volume covers the principles of ubiquitination and SUMOylation, presents detailed reviews of current and emerging concepts and highlights new advances in all areas of SUMOylation and ubiquitination. Topics of note include: the ubiquitin superfamily, the ubiquitin toolbox, onco viral exploitation of the SUMO system, small molecule modulators of desumoylation, mass spectrometry, global proteomic profiling of SUMO and ubiquitin, biotin-based approaches, genetic screening, SUMOylation networks in humans, targets for ubiquitin ligases, regulation of p53, protein homeostasis, miRNAs, DNA replication, DNA damage response, telomere biology, intracellular trafficking, regulation of angiogenesis, brain ischemia, autophagy, assembly and activity, antiviral defense, HIV infection, amyloid and amyloid-like proteins, plant immunity. This comprehensive and up-to-date book is the definitive reference volume on all aspects of SUMOylation and ubiquitination and is an essential acquisition for anyone involved in this area of biology.
Protein Conformation
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Author : Derek J. Chadwick
language : en
Publisher: John Wiley & Sons
Release Date : 2008-04-30
Protein Conformation written by Derek J. Chadwick and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-30 with Science categories.
How the amino acid sequence of a protein determines its three-dimensional structure is a major problem in biology and chemistry. Leading experts in the fields of NMR spectroscopy, X-ray crystallography, protein engineering and molecular modeling offer provocative insights into current views on the protein folding problem and various aspects for future progress.