Potential Biomarkers In Neurovascular Disorders Volume Ii
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Potential Biomarkers In Neurovascular Disorders Volume Ii
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Author : Wen-Jun Tu
language : en
Publisher: Frontiers Media SA
Release Date : 2023-10-31
Potential Biomarkers In Neurovascular Disorders Volume Ii written by Wen-Jun Tu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-31 with Medical categories.
Neurovascular disorders are a group of pathological conditions resulting from the neurovascular injury. Neurovascular disorders include cerebral ischemia, intracerebral hemorrhage, subarachnoid hemorrhage, venous sinus thrombosis, glioma, carotid disease, cerebral small vessel disease, and vascular dementia, among others. Although we have accumulated more understanding of both the genetic links and the basic mechanisms behind the pathophysiology of neurovascular diseases over the years, the exact mechanisms are still unclear. Therefore, there is an urgency to identify important therapeutic targets.
Potential Biomarkers In Neurovascular Disorders
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Author : John Zhang
language : en
Publisher: Frontiers Media SA
Release Date : 2023-05-05
Potential Biomarkers In Neurovascular Disorders written by John Zhang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-05 with Medical categories.
Novel Therapeutic Target And Drug Discovery For Neurological Diseases Volume Ii
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Author : Rui Liu
language : en
Publisher: Frontiers Media SA
Release Date : 2025-03-12
Novel Therapeutic Target And Drug Discovery For Neurological Diseases Volume Ii written by Rui Liu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-03-12 with Science categories.
This Research Topic is the second volume of the Research Topic " Novel Therapeutic Target and Drug Discovery for Neurological Diseases". Please see the first volume here. Neurological diseases represent heterogeneous disorders that involve complex pathological alterations with only a few effective treatments; therefore, there is a great need for the development of novel therapeutic targets and therapies. There are more than six hundred neurological disorders, including dementia, cerebrovascular diseases, mental illness, brain tumor, and infection-caused central diseases, all arising from disruption to the central nervous system. Researchers are attempting to identify promising targets and potential drug candidates from new biological techniques and pharmacological animal studies. Thus, novel target discovery and mechanism elucidation, as well as the development of small-molecule entities, natural compounds, and polypeptides for the treatment of neurological dysfunction, may offer exciting clues for novel therapeutic strategies to halt or mitigate the course of neurological diseases.
The Neurovascular Unit As A Potential Biomarker And Therapeutic Target In Cerebrovascular Disease
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Author : Shereen Nizari
language : en
Publisher: Frontiers Media SA
Release Date : 2022-05-26
The Neurovascular Unit As A Potential Biomarker And Therapeutic Target In Cerebrovascular Disease written by Shereen Nizari and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-26 with Science categories.
Neural Engineering Techniques For Autism Spectrum Disorder Volume 2
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Author : Jasjit Suri
language : en
Publisher: Academic Press
Release Date : 2022-10-17
Neural Engineering Techniques For Autism Spectrum Disorder Volume 2 written by Jasjit Suri and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-10-17 with Science categories.
Neural Engineering for Autism Spectrum Disorder, Volume Two: Diagnosis and Clinical Analysis presents the latest advances in neural engineering and biomedical engineering as applied to the clinical diagnosis and treatment of Autism Spectrum Disorder (ASD). Advances in the role of neuroimaging, magnetic resonance spectroscopy, MRI, fMRI, DTI, video analysis of sensory-motor and social behaviors, and suitable data analytics useful for clinical diagnosis and research applications for Autism Spectrum Disorder are covered, including relevant case studies. The application of brain signal evaluation, EEG analytics, fuzzy model and temporal fractal analysis of rest state BOLD signals and brain signals are also presented. A clinical guide for general practitioners is provided along with a variety of assessment techniques such as magnetic resonance spectroscopy. The book is presented in two volumes, including Volume One: Imaging and Signal Analysis Techniques comprised of two Parts: Autism and Medical Imaging, and Autism and Signal Analysis. Volume Two: Diagnosis and Treatment includes Autism and Clinical Analysis: Diagnosis, and Autism and Clinical Analysis: Treatment. - Presents applications of Neural Engineering techniques for diagnosis of Autism Spectrum Disorder (ASD) - Includes in-depth technical coverage of assessment techniques, such as the functional and structural networks underlying visuospatial vs. linguistic reasoning in autism - Covers treatment techniques for Autism Spectrum Disorder (ASD), including social skills intervention, behavioral treatment, evidence-based treatments, and technical tools such as Magnetic Resonance Spectroscopy for ASD - Written by engineers for engineers, computer scientists, researchers and clinicians who need to understand the technology and applications of Neural Engineering for the detection and diagnosis of Autism Spectrum Disorder (ASD)
Biomarkers In Neurology Volume Ii
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Author : Wael M. Y. Mohamed
language : en
Publisher: Frontiers Media SA
Release Date : 2023-08-01
Biomarkers In Neurology Volume Ii written by Wael M. Y. Mohamed and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-08-01 with Medical categories.
The Alzheimer S Disease Challenge Volume Ii
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Author : Mohammad Amjad Kamal
language : en
Publisher: Frontiers Media SA
Release Date : 2024-04-15
The Alzheimer S Disease Challenge Volume Ii written by Mohammad Amjad Kamal and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-04-15 with Science categories.
Given the success of Volume I of this Research Topic, we are pleased to announce the launch of Volume II: “The Alzheimer's Disease Challenge”. The repeated failure of clinical trials on the amyloid-based medications and the pessimistic calculations of Alzheimer's disease cost burden for the next few decades present a severe challenge to humankind with severe social implications. In recent years, several alternative diagnostic and treatment procedures have been presented to treat and manage Alzheimer’s disease as it has been nearly impossible to suggest a holistic solution. Several revelations in human biology have highlighted the multiparametric character of the disease. Besides the amyloid aggregation and neurofibrillary tangles that result in Aβ toxicity and tau phosphorylation, processes such as Gene Mutations, Proteins Misfolding, Brain Biochemical and Histopathological Changes, Behavioral Changes, Nutrition and Metabolism Alterations, and Autonomic Dysfunctions due to Central Nervous System dysregulations are common signs and probably early diagnostic biomarkers in most of the Alzheimer's classification categories.
Biomarkers Of Brain Injury And Neurological Disorders
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Author : Kevin K. W. Wang
language : en
Publisher: CRC Press
Release Date : 2014-10-28
Biomarkers Of Brain Injury And Neurological Disorders written by Kevin K. W. Wang and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-28 with Medical categories.
This book explores the recent advances in the techniques and platforms used in biomarker research that have revolutionized the way we study, diagnose, and treat brain injury conditions. The contributors describe different biomarker studies pertaining to brain injury and other neurological disorders and analyze the different models and technologies
Immunological Mechanisms Biomarkers And Immunotherapies Of Alzheimer S Disease
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Author : Yu-Hui Liu
language : en
Publisher: Frontiers Media SA
Release Date : 2021-09-24
Immunological Mechanisms Biomarkers And Immunotherapies Of Alzheimer S Disease written by Yu-Hui Liu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-24 with Science categories.
Ferroptosis In Stroke Neurotrauma And Neurodegeneration Volume Ii
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Author : Anwen Shao
language : en
Publisher: Frontiers Media SA
Release Date : 2023-07-31
Ferroptosis In Stroke Neurotrauma And Neurodegeneration Volume Ii written by Anwen Shao and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-31 with Science categories.
This Research Topic is part of the Ferroptosis in Stroke, Neurotrauma and Neurodegeneration series: Ferroptosis in Stroke, Neurotrauma and Neurodegeneration Ferroptosis is a recently defined iron-dependent non-apoptotic form of cell death. Diverse stressors can destabilize metabolic processes in the cell, leading to excessive intracellular accumulation of reactive oxygen species that culminate in the collapse and rupture of the membrane structure of cellular organelles, such as mitochondria, endoplasmic reticulum, and lysosome. Ferroptosis is a form of cell death characterized by the accumulation of intracellular iron and lipid ROS. The primary morphologic manifestations of ferroptosis include cell volume shrinkage and increased mitochondrial membrane density. These are different from apoptotic types of cell death such as necroptosis (early destruction of membrane integrity, cell and organelle swelling, cytoplasmic granulation and chromatin fragmentation, and cellular lysis), and pyroptosis (necrosis-like cell-membrane pore formation and rupture, cellular swelling, pro-inflammatory intracellular content release, as well as apoptosis-like nuclear condensation and DNA fragmentation). Emerging evidence shows that ferroptosis has significant implications in neurological diseases such as stroke, traumatic brain injury (TBI), Alzheimer's disease and Parkinson's disease. Additionally, ferroptosis inhibition has been shown to protect neurons and ameliorate cognitive impairment in various disease animal models. To date, several ferroptosis inhibitors have been found. As Ferroptosis is characterized by the accumulation of intracellular iron and lipid ROS, these inhibitors are primarily categorized as either antioxidants or iron chelators. For example in hemorrhagic stroke, it was found that the neuronal death and iron deposition, induced by hemoglobin in organotypic hippocampal slice cultures and primary cortical neurons, can be attenuated by administration of ferrostatin-1, or other ferroptosis inhibitors. In this Research Topic researchers are welcome to submit original research and review articles. We are interested in all topics associated with ferroptosis and neurological diseases, from underlying mechanisms to clinical transformation including potential targeting and treatment and others. We also welcome original articles analyzing similarities and differences among ferroptosis and other kinds of cell death, such as apoptosis and pyroptosis, in neurological diseases and hope to find key insights for future drug-development.