Power Analysis Of Trials With Multilevel Data
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Power Analysis Of Trials With Multilevel Data
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Author : Mirjam Moerbeek
language : en
Publisher: CRC Press
Release Date : 2015-07-01
Power Analysis Of Trials With Multilevel Data written by Mirjam Moerbeek and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-07-01 with Mathematics categories.
Power Analysis of Trials with Multilevel Data is a valuable reference for anyone who wants to perform power calculations on trials with hierarchical data. It provides a thorough overview of power analysis, familiarizing you with terminology and notation, outlining the key concepts of statistical power and power analysis, and covering all common hierarchical designs.
Design And Analysis Of Pragmatic Trials
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Author : Song Zhang
language : en
Publisher: CRC Press
Release Date : 2023-05-16
Design And Analysis Of Pragmatic Trials written by Song Zhang and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-16 with Mathematics categories.
This book begins with an introduction of pragmatic cluster randomized trials (PCTs) and reviews various pragmatic issues that need to be addressed by statisticians at the design stage. It discusses the advantages and disadvantages of each type of PCT, and provides sample size formulas, sensitivity analyses, and examples for sample size calculation. The generalized estimating equation (GEE) method will be employed to derive sample size formulas for various types of outcomes from the exponential family, including continuous, binary, and count variables. Experimental designs that have been frequently employed in PCTs will be discussed, including cluster randomized designs, matched-pair cluster randomized design, stratified cluster randomized design, stepped-wedge cluster randomized design, longitudinal cluster randomized design, and crossover cluster randomized design. It demonstrates that the GEE approach is flexible to accommodate pragmatic issues such as hierarchical correlation structures, different missing data patterns, randomly varying cluster sizes, etc. It has been reported that the GEE approach leads to under-estimated variance with limited numbers of clusters. The remedy for this limitation is investigated for the design of PCTs. This book can assist practitioners in the design of PCTs by providing a description of the advantages and disadvantages of various PCTs and sample size formulas that address various pragmatic issues, facilitating the proper implementation of PCTs to improve health care. It can also serve as a textbook for biostatistics students at the graduate level to enhance their knowledge or skill in clinical trial design. Key Features: Discuss the advantages and disadvantages of each type of PCTs, and provide sample size formulas, sensitivity analyses, and examples. Address an unmet need for guidance books on sample size calculations for PCTs; A wide variety of experimental designs adopted by PCTs are covered; The sample size solutions can be readily implemented due to the accommodation of common pragmatic issues encountered in real-world practice; Useful to both academic and industrial biostatisticians involved in clinical trial design; Can be used as a textbook for graduate students majoring in statistics and biostatistics.
Power And Sample Size In R
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Author : Catherine M. Crespi
language : en
Publisher: CRC Press
Release Date : 2025-02-06
Power And Sample Size In R written by Catherine M. Crespi and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-02-06 with Mathematics categories.
Power and Sample Size in R guides the reader through power and sample size calculations for a wide variety of study outcomes and designs and illustrates their implementation in R software. It is designed to be used as a learning tool for students as well as a resource for experienced statisticians and investigators. The book begins by explaining the process of power calculation step by step at an introductory level and then builds to increasingly complex and varied topics. For each type of study design, the information needed to perform a calculation and the factors that affect power are explained. Concepts are explained with statistical rigor but made accessible through intuition and examples. Practical advice for performing sample size and power calculations for real studies is given throughout. The book demonstrates calculations in R. It is integrated with the companion R package powertools and also draws on and summarizes the capabilities of other R packages. Only a basic proficiency in R is assumed. Topics include comparison of group means and proportions; ANOVA, including multiple comparisons; power for confidence intervals; multistage designs; linear, logistic and Poisson regression; crossover studies; multicenter, cluster randomized and stepped wedge designs; and time to event outcomes. Chapters are also devoted to designing noninferiority, superiority by a margin and equivalence studies and handling multiple primary endpoints. By emphasizing statistical thinking about the factors that influence power for different study designs and outcomes as well as providing R code, this book equips the reader with the knowledge and tools to perform their own calculations with confidence. Key Features: Explains power and sample size calculation for a wide variety of study designs and outcomes Suitable for both students and experienced researchers Highlights key factors influencing power and provides practical tips for designing real studies Includes extensive examples with R code
Optimization Of Behavioral Biobehavioral And Biomedical Interventions
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Author : Linda M. Collins
language : en
Publisher: Springer
Release Date : 2018-07-28
Optimization Of Behavioral Biobehavioral And Biomedical Interventions written by Linda M. Collins and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-07-28 with Social Science categories.
Behavioral, biobehavioral, and biomedical interventions are programs with the objective of improving and maintaining human health and well-being, broadly defined, in individuals, families, schools, organizations, or communities. These interventions may be aimed at, for example, preventing or treating disease, promoting physical and mental health, preventing violence, or improving academic achievement. This book provides additional information on a principled empirical framework for developing interventions that are more effective, efficient, economical, and scalable. This framework is introduced in the monograph, "Optimization of Behavioral, Biobehavioral, and Biomedical Interventions: The Multiphase Optimization Strategy (MOST)" by Linda M. Collins (Springer, 2018). The present book is focused on advanced topics related to MOST. The chapters, all written by experts, are devoted to topics ranging from experimental design and data analysis to development of a conceptual model and implementation of a complex experiment in the field. Intervention scientists who are preparing to apply MOST will find this book an important reference and guide for their research. Fields to which this work pertains include public health (medicine, nursing, health economics, implementation sciences), behavioral sciences (psychology, criminal justice), statistics, and education.
Multilevel Modeling Of Educational Data
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Author : Ann A. O'Connell
language : en
Publisher: IAP
Release Date : 2008-04-01
Multilevel Modeling Of Educational Data written by Ann A. O'Connell and has been published by IAP this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-01 with Education categories.
(sponsored by the Educational Statisticians, SIG) Multilevel Modeling of Educational Data, co-edited by Ann A. O’Connell, Ed.D., and D. Betsy McCoach, Ph.D., is the next volume in the series: Quantitative Methods in Education and the Behavioral Sciences: Issues, Research and Teaching (Information Age Publishing), sponsored by the Educational Statisticians' Special Interest Group (Ed-Stat SIG) of the American Educational Research Association. The use of multilevel analyses to examine effects of groups or contexts on individual outcomes has burgeoned over the past few decades. Multilevel modeling techniques allow educational researchers to more appropriately model data that occur within multiple hierarchies (i.e.- the classroom, the school, and/or the district). Examples of multilevel research problems involving schools include establishing trajectories of academic achievement for children within diverse classrooms or schools or studying school-level characteristics on the incidence of bullying. Multilevel models provide an improvement over traditional single-level approaches to working with clustered or hierarchical data; however, multilevel data present complex and interesting methodological challenges for the applied education research community. In keeping with the pedagogical focus for this book series, the papers this volume emphasize applications of multilevel models using educational data, with chapter topics ranging from basic to advanced. This book represents a comprehensive and instructional resource text on multilevel modeling for quantitative researchers who plan to use multilevel techniques in their work, as well as for professors and students of quantitative methods courses focusing on multilevel analysis. Through the contributions of experienced researchers and teachers of multilevel modeling, this volume provides an accessible and practical treatment of methods appropriate for use in a first and/or second course in multilevel analysis. A supporting website links chapter examples to actual data, creating an opportunity for readers to reinforce their knowledge through hands-on data analysis. This book serves as a guide for designing multilevel studies and applying multilevel modeling techniques in educational and behavioral research, thus contributing to a better understanding of and solution for the challenges posed by multilevel systems and data.
Textbook Of Clinical Trials In Oncology
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Author : Susan Halabi
language : en
Publisher: CRC Press
Release Date : 2019-04-24
Textbook Of Clinical Trials In Oncology written by Susan Halabi and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-04-24 with Medical categories.
There is an increasing need for educational resources for statisticians and investigators. Reflecting this, the goal of this book is to provide readers with a sound foundation in the statistical design, conduct, and analysis of clinical trials. Furthermore, it is intended as a guide for statisticians and investigators with minimal clinical trial experience who are interested in pursuing a career in this area. The advancement in genetic and molecular technologies have revolutionized drug development. In recent years, clinical trials have become increasingly sophisticated as they incorporate genomic studies, and efficient designs (such as basket and umbrella trials) have permeated the field. This book offers the requisite background and expert guidance for the innovative statistical design and analysis of clinical trials in oncology. Key Features: Cutting-edge topics with appropriate technical background Built around case studies which give the work a "hands-on" approach Real examples of flaws in previously reported clinical trials and how to avoid them Access to statistical code on the book’s website Chapters written by internationally recognized statisticians from academia and pharmaceutical companies Carefully edited to ensure consistency in style, level, and approach Topics covered include innovating phase I and II designs, trials in immune-oncology and rare diseases, among many others
Introduction To Power Analysis
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Author : E. C. Hedberg
language : en
Publisher: SAGE Publications
Release Date : 2017-12-05
Introduction To Power Analysis written by E. C. Hedberg and has been published by SAGE Publications this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-12-05 with Social Science categories.
Introduction to Power Analysis: Two-Group Studies provides readers with the background, examples, and explanation they need to read technical papers and materials that include complex power analyses. This clear and accessible guide explains the components of test statistics and their sampling distributions, and author Eric Hedberg walks the reader through the simple and complex considerations of this research question. Filled with graphics and examples, the reader is taken on a tour of power analyses from covariates to clusters, seeing how the complicated task of comparing two groups, and the power analysis, can be made easy.
Model Based Geostatistics For Global Public Health
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Author : Peter J. Diggle
language : en
Publisher: CRC Press
Release Date : 2019-03-04
Model Based Geostatistics For Global Public Health written by Peter J. Diggle and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-03-04 with Mathematics categories.
Model-based Geostatistics for Global Public Health: Methods and Applications provides an introductory account of model-based geostatistics, its implementation in open-source software and its application in public health research. In the public health problems that are the focus of this book, the authors describe and explain the pattern of spatial variation in a health outcome or exposure measurement of interest. Model-based geostatistics uses explicit probability models and established principles of statistical inference to address questions of this kind. Features: Presents state-of-the-art methods in model-based geostatistics. Discusses the application these methods some of the most challenging global public health problems including disease mapping, exposure mapping and environmental epidemiology. Describes exploratory methods for analysing geostatistical data, including: diagnostic checking of residuals standard linear and generalized linear models; variogram analysis; Gaussian process models and geostatistical design issues. Includes a range of more complex geostatistical problems where research is ongoing. All of the results in the book are reproducible using publicly available R code and data-sets, as well as a dedicated R package. This book has been written to be accessible not only to statisticians but also to students and researchers in the public health sciences. The Authors Peter Diggle is Distinguished University Professor of Statistics in the Faculty of Health and Medicine, Lancaster University. He also holds honorary positions at the Johns Hopkins University School of Public Health, Columbia University International Research Institute for Climate and Society, and Yale University School of Public Health. His research involves the development of statistical methods for analyzing spatial and longitudinal data and their applications in the biomedical and health sciences. Dr Emanuele Giorgi is a Lecturer in Biostatistics and member of the CHICAS research group at Lancaster University, where he formerly obtained a PhD in Statistics and Epidemiology in 2015. His research interests involve the development of novel geostatistical methods for disease mapping, with a special focus on malaria and other tropical diseases. In 2018, Dr Giorgi was awarded the Royal Statistical Society Research Prize "for outstanding published contribution at the interface of statistics and epidemiology." He is also the lead developer of PrevMap, an R package where all the methodology found in this book has been implemented.
Statistical Analysis Of Questionnaires
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Author : Francesco Bartolucci
language : en
Publisher: CRC Press
Release Date : 2015-07-23
Statistical Analysis Of Questionnaires written by Francesco Bartolucci and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-07-23 with Mathematics categories.
Statistical Analysis of Questionnaires: A Unified Approach Based on R and Stata presents special statistical methods for analyzing data collected by questionnaires. The book takes an applied approach to testing and measurement tasks, mirroring the growing use of statistical methods and software in education, psychology, sociology, and other fields.
Linear Mixed Models
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Author : Brady T. West
language : en
Publisher: CRC Press
Release Date : 2022-06-24
Linear Mixed Models written by Brady T. West and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-24 with Mathematics categories.
Highly recommended by JASA, Technometrics, and other leading statistical journals, the first two editions of this bestseller showed how to easily perform complex linear mixed model (LMM) analyses via a variety of software programs. Linear Mixed Models: A Practical Guide Using Statistical Software, Third Edition continues to lead readers step-by-step through the process of fitting LMMs. The third edition provides a comprehensive update of the available tools for fitting linear mixed-effects models in the newest versions of SAS, SPSS, R, Stata, and HLM. All examples have been updated, with a focus on new tools for visualization of results and interpretation. New conceptual and theoretical developments in mixed-effects modeling have been included, and there is a new chapter on power analysis for mixed-effects models. Features: •Dedicates an entire chapter to the key theories underlying LMMs for clustered, longitudinal, and repeated measures data •Provides descriptions, explanations, and examples of software code necessary to fit LMMs in SAS, SPSS, R, Stata, and HLM •Contains detailed tables of estimates and results, allowing for easy comparisons across software procedures •Presents step-by-step analyses of real-world data sets that arise from a variety of research settings and study designs, including hypothesis testing, interpretation of results, and model diagnostics •Integrates software code in each chapter to compare the relative advantages and disadvantages of each package •Supplemented by a website with software code, datasets, additional documents, and updates Ideal for anyone who uses software for statistical modeling, this book eliminates the need to read multiple software-specific texts by covering the most popular software programs for fitting LMMs in one handy guide. The authors illustrate the models and methods through real-world examples that enable comparisons of model-fitting options and results across the software procedures.