Practical Applications Of Quantitative Structure Activity Relationships Qsar In Environmental Chemistry And Toxicology
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Practical Applications Of Quantitative Structure Activity Relationships Qsar In Environmental Chemistry And Toxicology
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Author : W. Karcher
language : en
Publisher: Springer Science & Business Media
Release Date : 1990-05-31
Practical Applications Of Quantitative Structure Activity Relationships Qsar In Environmental Chemistry And Toxicology written by W. Karcher and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990-05-31 with Science categories.
Based on the Lectures given during the Eurocourse on `Practical Applications of Quantitative Structure-Activity (QSAR) in Environmental Chemistry and Toxicology' held at the Joint Research Centre Ispra, Italy, June 11--15, 1990
Quantitative Structure Activity Relationship Qsar Models Of Mutagens And Carcinogens
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Author : Romualdo Benigni
language : en
Publisher: CRC Press
Release Date : 2003-02-26
Quantitative Structure Activity Relationship Qsar Models Of Mutagens And Carcinogens written by Romualdo Benigni and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-02-26 with Medical categories.
Applied with success in a number of areas, QSAR studies have become particularly popular in the rational design of drugs and pesticides. Much has been published on the principles of QSAR in this area, but not on their application s to toxic chemicals. This book provides the first comprehensive, interdisciplinary presentation of QSAR studies on
Quantitative Structure Activity Relationships In Drug Design Predictive Toxicology And Risk Assessment
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Author : Roy, Kunal
language : en
Publisher: IGI Global
Release Date : 2015-02-28
Quantitative Structure Activity Relationships In Drug Design Predictive Toxicology And Risk Assessment written by Roy, Kunal and has been published by IGI Global this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-02-28 with Technology & Engineering categories.
Quantitative structure-activity relationships (QSARs) represent predictive models derived from the application of statistical tools correlating biological activity or other properties of chemicals with descriptors representative of molecular structure and/or property. Quantitative Structure-Activity Relationships in Drug Design, Predictive Toxicology, and Risk Assessment discusses recent advancements in the field of QSARs with special reference to their application in drug development, predictive toxicology, and chemical risk analysis. Focusing on emerging research in the field, this book is an ideal reference source for industry professionals, students, and academicians in the fields of medicinal chemistry and toxicology.
Chemical And Environmental Science Series Volume 1 Practical Applications Of Quantitative Structure Activity Relationships Qsar In Environmental Chemistry And Toxicology
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Author : W. Karcher
language : en
Publisher:
Release Date : 1990
Chemical And Environmental Science Series Volume 1 Practical Applications Of Quantitative Structure Activity Relationships Qsar In Environmental Chemistry And Toxicology written by W. Karcher and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with categories.
Structure Activity Relationships In Environmental Sciences
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Author : M. Nendza
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Structure Activity Relationships In Environmental Sciences written by M. Nendza and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Structure-Activity Relationships in Environmental Science is the first book of its kind that brings together information from a variety of sources into one document. It provides a comprehensive overview of the entire field of quantitative structure-activity relationships (QSARs) as well as being a reference for SAR experts. The book comprises three parts. Part One covers the theoretical background of structure-activity studies and Part Two deals with the practical applications of such methods in the environmental sciences. Part Three critically discusses SAR models with respect to their reliability and their aptness in environmental hazard and risk assessment. Recommendations are made as to which model to use and the case is presented for using QSARs in hazard assessment. The use of QSARs is becoming increasingly important since there is little experimental data available on environmentally relevant chemicals. Structure-Activity Relationships in Environmental Sciences will thus serve as an invaluable guide to both postgraduate and research scientists as well as professional ecologists.
Applied Multivariate Analysis In Sar And Environmental Studies
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Author : J. Devillers
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-07
Applied Multivariate Analysis In Sar And Environmental Studies written by J. Devillers and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-07 with Science categories.
Based on the Lectures given during the Eurocourse on `Applied Multivariate Analysis in SAR and Environmental Studies' held at the Joint Research Centre, Ispra, Italy, June 24-28, 1991
Topological Indices And Related Descriptors In Qsar And Qspar
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Author : James Devillers
language : en
Publisher: CRC Press
Release Date : 2000-03-09
Topological Indices And Related Descriptors In Qsar And Qspar written by James Devillers and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-03-09 with Mathematics categories.
Topological Indices and Related Descriptors in QSAR and QSPAR reviews the state of the art in this field and highlights the important advances in the generation of descriptors calculated directly from the structure of molecules. This long-awaited comprehensive book provides all the necessary information to calculate and use these descriptors for deriving structure-activity and structure-property relationships. Written by leading experts in the field, this book discusses the physicochemical significance, strengths, and weaknesses of these indices and presents numerous examples of applications. This book will be a valuable reference for anyone involved in the use of QSAR and QSPAR in the pharmaceutical, applied chemical, and environmental sciences. It is also suitable for use as a supplementary textbook on related graduate level courses.
Comparative Qsar
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Author : James Devillers
language : en
Publisher: CRC Press
Release Date : 1998-03-03
Comparative Qsar written by James Devillers and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-03-03 with Science categories.
As the 21st century approaches, there is little doubt that the tools and resources are available to unlock all the secrets of Quantitative Structure-Activity Relationships (QSAR) in order to design more efficient drugs and safer chemicals. The comparison QSAR models provide are a key to reach a deep understanding of the foundation and a better optimisation of the use of these statistical tools. Seeking out the similarities and differences among QSAR Models allows the user to estimate their simulation performances, find chemo-taxonomical links, and uncover In vivo/In Vitro relationships. The purpose of this book is to highlight the multifaceted aspect of the term "comparative QSAR" by bringing together QSAR experts of various origins and allowing them to offer their views on this diverse subject.
Computational Toxicology
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Author : Sean Ekins
language : en
Publisher: John Wiley & Sons
Release Date : 2007-06-30
Computational Toxicology written by Sean Ekins and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-06-30 with Science categories.
A comprehensive analysis of state-of-the-art molecular modeling approaches and strategies applied to risk assessment for pharmaceutical and environmental chemicals This unique volume describes how the interaction of molecules with toxicologically relevant targets can be predicted using computer-based tools utilizing X-ray crystal structures or homology, receptor, pharmacophore, and quantitative structure activity relationship (QSAR) models of human proteins. It covers the in vitro models used, newer technologies, and regulatory aspects. The book offers a complete systems perspective to risk assessment prediction, discussing experimental and computational approaches in detail, with: * An introduction to toxicology methods and an explanation of computational methods * In-depth reviews of QSAR methods applied to enzymes, transporters, nuclear receptors, and ion channels * Sections on applying computers to toxicology assessment in the pharmaceutical industry and in the environmental arena * Chapters written by leading international experts * Figures that illustrate computational models and references for further information This is a key resource for toxicologists and scientists in the pharmaceutical industry and environmental sciences as well as researchers involved in ADMET, drug discovery, and technology and software development.
Application Of Modern Toxicology Approaches For Predicting Acute Toxicity For Chemical Defense
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Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher: National Academies Press
Release Date : 2015-09-01
Application Of Modern Toxicology Approaches For Predicting Acute Toxicity For Chemical Defense written by National Academies of Sciences, Engineering, and Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-09-01 with Nature categories.
The US Department of Defense (DOD) is faced with an overwhelming task in evaluating chemicals that could potentially pose a threat to its deployed personnel. There are over 84,000 registered chemicals, and testing them with traditional toxicity-testing methods is not feasible in terms of time or money. In recent years, there has been a concerted effort to develop new approaches to toxicity testing that incorporate advances in systems biology, toxicogenomics, bioinformatics, and computational toxicology. Given the advances, DOD asked the National Research Council to determine how DOD could use modern approaches for predicting chemical toxicity in its efforts to prevent debilitating, acute exposures to deployed personnel. This report provides an overall conceptual approach that DOD could use to develop a predictive toxicology system. Application of Modern Toxicology Approaches for Predicting Acute Toxicity for Chemical Defense reviews the current state of computational and high-throughput approaches for predicting acute toxicity and suggests methods for integrating data and predictions. This report concludes with lessons learned from current high-throughput screening programs and suggests some initial steps for DOD investment.