Precision Molecular Pathology Of Lung Cancer
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Precision Molecular Pathology Of Lung Cancer
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Author : Philip T. Cagle
language : en
Publisher: Springer
Release Date : 2017-11-10
Precision Molecular Pathology Of Lung Cancer written by Philip T. Cagle and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-10 with Medical categories.
This new edition provides the latest information and insights into the molecular basis for lung cancer. Since the publication of the previous edition of this volume, dramatic changes have occurred with the classification of lung cancer, biomarker testing, and molecular therapy. The book covers these changes, providing updates and new insights on the background of lung cancer, testing methods, and the molecular pathology of specific cell types, including adenocarcinoma, squamous cell carcinoma, small cell carcinoma, and precursor and preinvasive lesions. Authored by experts in the field, Precision Molecular Pathology of Lung Cancer, Second Edition remains one of the few books that comprehensively covers the new molecular pathology of lung cancer and is a valuable resource for pathologists, medical oncologists, radiation oncologists, thoracic surgeons, and thoracic radiologists.
Molecular Pathology Of Lung Cancer
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Author : Philip T. Cagle
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-06-14
Molecular Pathology Of Lung Cancer written by Philip T. Cagle and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-06-14 with Medical categories.
As with other books in the Molecular Pathology Library Series, Molecular Pathology of Lung Cancer bridges the gap between the molecular specialist and the clinical practitioner, including the surgical pathologist who now has a key role in decisions regarding molecular targeted therapy for lung cancer. Molecular Pathology of Lung Cancer provides the latest information and current insights into the molecular basis for lung cancer, including precursor and preinvasive lesions, molecular diagnosis, molecular targeted therapy, molecular prognosis, molecular radiology and related fields for lung cancer generally and for the specific cell types. As many fundamental concepts about lung cancer have undergone revision in only the past few years, this book will likely be the first to comprehensively cover the new molecular pathology of lung cancer. It provides a foundation in this field for pathologists, medical oncologists, radiation oncologists, thoracic surgeons, thoracic radiologists and their trainees, physician assistants, and nursing staff.
Lung Cancer
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Author : Barbara Driscoll
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-01-18
Lung Cancer written by Barbara Driscoll and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-01-18 with Medical categories.
The Methods in Molecular Medicine series is intended as a resource for both novice and experienced investigators attempting to diversify their tech- logical base in research. Lung Cancer: Volume 1: Molecular Pathology Me- ods and Reviews presents an overview of the current status of assays employed to detect and characterize the multitude of pathologies that contribute to the development of this deadly disease. As with all volumes in the Methods in Molecular Medicine series, the reader should find that each methods-based chapter provides clear instructions for the performance of various protocols, supplemented by additional technical notes that provide valuable insight. These notes are designed to enable the reader to acquire the techniques described with a proficiency not easily achieved by re- ing standard method formats. No volume can exhaustively cover every aspect of biological research and there will be gaps in this endeavor that one or another research group will id- tify. Each section herein could readily be expanded into a book in its own right. However, I have sought to include a spectrum of techniques that should allow for the acquisition of key skills in each area covered.
Precision Molecular Pathology Of Prostate Cancer
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Author : Brian D. Robinson
language : en
Publisher: Springer
Release Date : 2018-02-13
Precision Molecular Pathology Of Prostate Cancer written by Brian D. Robinson and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-02-13 with Medical categories.
This volume focuses on our current understanding of the molecular underpinnings of prostate cancer and their potential application for precision medicine approaches. The emergence and applications of new technologies has allowed for a rapid expansion of our understanding of the molecular basis of prostate cancer and has revealed a remarkable genetic heterogeneity that may underlie the clinically variable behavior of the disease. The book consists of five sections which provide insight about the following: (1) General principles; (2) Molecular signatures of primary prostate cancer; (3) Molecular signatures of advanced prostate cancer; (4) Key molecular pathways in prostate cancer development and progression; (5) and Precision medicine approach: Diagnosis, treatment, prognosis. Precision Molecular Pathology of Prostate Cancer is an important resource for the practicing oncologist, urologist, and pathologist, and will also be useful for researchers in the prostate cancer community.
Practical Oncologic Molecular Pathology
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Author : Yi Ding
language : en
Publisher: Springer Nature
Release Date : 2021-07-10
Practical Oncologic Molecular Pathology written by Yi Ding and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-10 with Medical categories.
This book is a review and high-yield reference on the clinical molecular diagnostics of malignant neoplasms. It aims to address the practical questions frequently encountered in the molecular oncology practice, as well as key points and pitfalls in the clinical interpretation of molecular tests in guiding precision cancer management. The text uses a Q&A format and case presentations, with emphasis on understanding the molecular test methods, diagnosis, classification, risk assessment and clinical correlation. Starting with an update on the molecular biology of cancer, the book focuses on the topics related to molecular diagnostics and genetics-based precision oncology. Separate chapters are dedicated to discussion of the bioinformatics for the analysis of genetic/genomic data generated from molecular assays, and quality control (QC)/quality assurance (QA) programs in the clinical laboratories; both are critical in producing high quality results for clinical care of cancer patients. These are followed by organ system-based reviews and discussions on the molecular genetic abnormalities and related tests covering diverse types of common to rare malignant neoplasms. This book also provides up-to-date knowledge related to malignant neoplasms, discusses the established as well as evolving requirements for pathologic diagnosis of these malignancies. It also discusses the cost effective utilization of molecular tests in clinical oncology. Written by experts in the field, Practical Oncologic Molecular Pathology serves as a valuable reference for practicing pathologists, fellows, residents and other health care professionals.
Molecular Pathology Of Lung Diseases
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Author : Dani S. Zander
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-05-26
Molecular Pathology Of Lung Diseases written by Dani S. Zander and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-05-26 with Medical categories.
This major work, complete with 150 illustrations, many of them in color, bridges the gap between clinical pulmonary pathology and basic molecular science. Through a highly visual approach that features an abundance of tables and diagrams, the book offers a practical disease-based overview. The first two sections of the volume provide the reader with general concepts, terminology and procedures in molecular pathology. The remainder of the volume is subdivided into neoplastic and non-neoplastic lung diseases with detailed chapters covering the current molecular pathology of specific diseases. The book will be essential reading for pathologists, pulmonologists, thoracic surgeons and other health care providers interested in lung disease.
Lung Cancer
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Author : Barbara Driscoll
language : en
Publisher: Humana
Release Date : 2002-10-15
Lung Cancer written by Barbara Driscoll and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-10-15 with Medical categories.
The Methods in Molecular Medicine series is intended as a resource for both novice and experienced investigators attempting to diversify their tech- logical base in research. Lung Cancer: Volume 1: Molecular Pathology Me- ods and Reviews presents an overview of the current status of assays employed to detect and characterize the multitude of pathologies that contribute to the development of this deadly disease. As with all volumes in the Methods in Molecular Medicine series, the reader should find that each methods-based chapter provides clear instructions for the performance of various protocols, supplemented by additional technical notes that provide valuable insight. These notes are designed to enable the reader to acquire the techniques described with a proficiency not easily achieved by re- ing standard method formats. No volume can exhaustively cover every aspect of biological research and there will be gaps in this endeavor that one or another research group will id- tify. Each section herein could readily be expanded into a book in its own right. However, I have sought to include a spectrum of techniques that should allow for the acquisition of key skills in each area covered.
Molecular Diagnostics Of Cancer
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Author : Pier Paolo Piccaluga
language : en
Publisher: BoD – Books on Demand
Release Date : 2024-04-10
Molecular Diagnostics Of Cancer written by Pier Paolo Piccaluga and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-04-10 with Science categories.
Precision medicine, also known as personalized medicine, is an innovative approach to medical treatment and diagnosis that takes into account individual variability in genes, environment, and lifestyle for each person. In the context of cancer, precision medicine aims to tailor medical care to the specific genetic and molecular characteristics of each patient's tumor. This allows for more targeted and effective treatments, minimizing side effects and improving outcomes. The first step in precision medicine, especially in oncology, is represented by an accurate diagnosis, including molecular and genetic data. A comprehensive assessment in molecular pathology includes conventional and more innovative techniques, including polymerase chain reaction (PCR)-based approaches, Sanger sequencing, and next-generation sequencing for genomic profiling. Precision medicine relies on the analysis of the patient's genomic information, including the DNA mutations present in their tumor. Genomic profiling helps identify specific genetic alterations that are driving the growth of cancer cells. This information is crucial for selecting targeted therapies that directly interfere with these specific molecular abnormalities. In addition, molecular diagnostics provide: • biomarker identification • tumor heterogeneity assessment In turn, this translates into direct treatment decision support. The information obtained through molecular tests guides oncologists in making more informed decisions about the most appropriate treatments for individual patients. This can include targeted therapies, immunotherapies, or other interventions based on the specific molecular profile of the tumor. Prognostication becomes treatment-specific (prediction) and predictive models can be developed by integrating genetic and molecular data with clinical information, to estimate the likelihood of treatment response, recurrence, and overall prognosis. Overall, molecular pathology has significantly advanced cancer diagnostics and treatment, leading to improved outcomes and a shift toward more personalized and effective care. The integration of molecular diagnostics and genomic information has transformed how cancer is understood and managed, offering new hope for patients and providing oncologists with powerful tools to combat the complexity of the disease.
Diagnostic Molecular Pathology
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Author : William B. Coleman
language : en
Publisher: Academic Press
Release Date : 2023-10-27
Diagnostic Molecular Pathology written by William B. Coleman and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-27 with Science categories.
Diagnostic Molecular Pathology: A Guide to Applied Molecular Testing, Second Edition assembles a group of experts to discuss the molecular basis and mechanisms of major human diseases and disease processes and how the molecular features of disease can be harnessed to develop practical molecular tests for disease detection, diagnosis and prognosis. The book explains how molecular tests are utilized in the treatment of patients in personalized medicine, highlights new technologies and approaches of applied molecular pathology, and discusses how this discovery-based research yields new and useful biomarkers and tests. As it is essential to stay up-to-date on new molecular diagnostics in this changing field, this book covers critically important areas in the practice of personalized medicine and reflects our understanding of the pathology, pathogenesis and pathophysiology of human disease. Includes new material on mass spectrometry for infectious diseases, microbiome, homology-directed repair for PARPi, whole genome sequencing for constitutional testing, and much more Provides insights on the value of the molecular test in comparison to traditional methods, which include speed, precision, sensitivity and clinical impacts for the patient Focuses on the menu of molecular diagnostic tests available in modern molecular pathology or clinical laboratories that can be applied to disease detection, diagnosis and classification in the clinical workup of a patient Explains how molecular tests are utilized to guide the treatment of patients in personalized medicine (guided therapies) and for the prognostication of disease
Precision Cancer Medicine
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Author : Sameek Roychowdhury
language : en
Publisher: Springer Nature
Release Date : 2020-01-02
Precision Cancer Medicine written by Sameek Roychowdhury and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-02 with Medical categories.
Genomic sequencing technologies have augmented the classification of cancer beyond tissue of origin and towards a molecular taxonomy of cancer. This has created opportunities to guide treatment decisions for individual patients with cancer based on their cancer’s unique molecular characteristics, also known as precision cancer medicine. The purpose of this text will be to describe the contribution and need for multiple disciplines working together to deliver precision cancer medicine. This entails a multi-disciplinary approach across fields including molecular pathology, computational biology, clinical oncology, cancer biology, drug development, genetics, immunology, and bioethics. Thus, we have outlined a current text on each of these fields as they work together to overcome various challenges and create opportunities to deliver precision cancer medicine. As trainees and junior faculty enter their respective fields, this text will provide a framework for understanding the role and responsibility for each specialist to contribute to this team science approach.