Predictive Methods In Percutaneous Absorption
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Predictive Methods In Percutaneous Absorption
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Author : Gary P. Moss
language : en
Publisher: Springer
Release Date : 2015-07-01
Predictive Methods In Percutaneous Absorption written by Gary P. Moss and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-07-01 with Medical categories.
This book sheds new light on the development and use of quantitative models to describe the process of skin permeation. It critically reviews the development of quantitative predictive models of skin absorption and discusses key recommendations for model development. Topics presented include an introduction to skin physiology; the underlying theories of skin absorption; the physical laboratory-based processes used to generate skin absorption data, which is in turn used to construct mathematical models describing the skin permeation process; algorithms of skin permeability including quantitative structure-activity (or permeability) relationships (QSARs or QSPRs); relationships between permeability and molecular properties; the development of formulation-focused approaches to models of skin permeability prediction; the use of artificial membranes, e.g. polydimethylsiloxane as alternatives to mammalian skin; and lastly, the use of novel Machine Learning methods in developing the next generation of predictive skin permeability models. The book will be of interest to all researchers in academia and industry working in pharmaceutical discovery and development, as well as readers from the field of occupational exposure and risk assessment, especially those whose work involves agrochemicals, bulk chemicals and cosmetics.
Prediction Of Percutaneous Penetration
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Author : R. C. Scott
language : en
Publisher:
Release Date : 1991
Prediction Of Percutaneous Penetration written by R. C. Scott and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Chemotherapy categories.
Percutaneous Absorption
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Author : Robert L. Bronaugh
language : en
Publisher: CRC Press
Release Date : 1999-05-28
Percutaneous Absorption written by Robert L. Bronaugh and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-05-28 with Science categories.
Since publication of the Second Edition in 1989, numerous innovations have occurred that affect the way scientists look at issues in the field of percutaneous absorption. Focusing on recent advances as well as updating and expanding the scope of topics covered in the previous edition, Percutaneous Absorption, Third Edition provides thorough coverage of the skin's role as an important portal of entry for chemicals into the body. Assembles the work of nearly 80 experts-30 more than the Second Edition-into a unified, comprehensive volume that contains the latest ideas and research! Complete with nearly 600 drawings, photographs, equations, and tables and more than 1600 bibliographic citations of pertinent literature, Percutaneous Absorption, Third Edition details the applied biology of percutaneous penetration factors that affect skin permeation, such as age, vehicles, metabolism, hydration of skin, and chemical structure in vivo and in vitro techniques for measuring absorption, examining factors influencing methodology such as animal models, volatility of test compound, multiple dosage, and artificial membranes procedures for use in transdermal delivery, exploring topics such as effects of penetration enhancers on absorption, optimizing absorption, and the topical delivery of drugs to muscle tissue And presents new chapters on mathematical models cutaneous metabolism prediction of percutaneous absorption in vitro absorption methodology dermal decontamination concentration of chemicals in skin transdermal drug delivery mechanisms of absorption safety evaluation of cosmetics absorption of drugs and cosmetic ingredients nail penetration Emphasizes human applications-particularly useful for pharmacists, pharmacologists, dermatologists, cosmetic scientists, biochemists, toxicologists, public health officials, manufacturers of cosmetic and toiletry products, and graduate students in these disciplines! An invaluable reference source for readers who need to keep up with the latest developments in the field, Percutaneous Absorption, Third Edition is also an excellent experimental guide for laboratory personnel.
In Vitro Percutaneous Absorption
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Author : Robert L. Bronaugh
language : en
Publisher: CRC Press
Release Date : 2023-06-14
In Vitro Percutaneous Absorption written by Robert L. Bronaugh and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-14 with Medical categories.
This book covers all major areas of interest in the rapidly expanding field of in vitro methods for percutaneous absorption studies. Specific areas discussed include diffusion cell design, receptor fluid, preparation of skin, and temperature. The book covers experimental methodology, as well as the underlying principles and fundamentals that help professionals and students gain an understanding of the basis for currently used methodology.
Percutaneous Absorption
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Author : Nina Dragićević
language : en
Publisher: CRC Press
Release Date : 2021-07-30
Percutaneous Absorption written by Nina Dragićević and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-30 with Medical categories.
Updating and expanding the scope of topics covered in the previous edition, Percutaneous Absorption: Drugs, Cosmetics, Mechanisms, Methods, Fifth Edition supplies new chapters on topics currently impacting the field including cutaneous metabolism, skin contamination, exposure to protein allergens, in vitro absorption methodology and the percutaneous absorption of chemical mixtures. Complete with studies on the role of the skin as a key portal of entry for chemicals into the body, this book serves as a detailed reference source for recent advances in the field, as well as an experimental guide for laboratory personnel. Key Features: Details in vivo and in vitro methods for measuring absorption, dermal decontamination, mechanisms of transdermal delivery, and the relationship of transepidermal water loss to percutaneous absorption Considers a range of mathematical models, the safety evaluation of cosmetic ingredients, the absorption of hair dyes, nanoparticles for drug delivery, and other novel methods of drug delivery Discusses topics including skin metabolism, the skin reservoir, and the effects of desquamation on absorption
Dermal Absorption
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Author : J. Kielhorn
language : en
Publisher: World Health Organization
Release Date : 2006
Dermal Absorption written by J. Kielhorn and has been published by World Health Organization this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Medical categories.
Introduction and definitions -- Skin structure and function -- Skin transport mechanisms and theoretical concepts -- Metabolism in the skin -- In vitro tests for dermal absorption -- In vivo tests for dermal absorption -- Comparative studies -- Data collections -- Estimation/prediction of dermal penetration -- Use of dermal penetration studies in risk assessment -- Controversial topics in the assessment of dermal absorption -- Conclusions and recommendations.
Dermal Absorption Models In Toxicology And Pharmacology
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Author : Jim E. Riviere
language : en
Publisher: CRC Press
Release Date : 2005-08-24
Dermal Absorption Models In Toxicology And Pharmacology written by Jim E. Riviere and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-08-24 with Medical categories.
Many experimental methods and mathematical modeling approaches rooted in disciplines outside of toxicology can be effectively applied to estimating dermal absorption. Dermal Absorption Models in Toxicology and Pharmacology explores current approaches and techniques that can be used to quantify dermal absorption with endpoints useful in both toxicology and pharmacology. The book begins with a review of basic principles and the in vitro and in vivo experimental approaches available for assessing dermal absorption of drugs and chemicals. This is followed by coverage of mathematical or in silico models for quantitating percutaneous absorption and the applications of these techniques to the risk assessment process. The remainder of the book explores scenarios where the unique properties of the chemicals being studied or the matrix in which they are exposed must be considered and then wraps up with a comparative analysis of chemical permeability in human and animal skin. Many of the books covering this subject are just too comprehensive and serve primarily as reference works. This book takes a different approach. Jim Riviere's editorial guidance ensures that the information is readable, accessible, authoritative, and concise, making it the perfect resource for familiarizing new researchers and students to the field and updating established scientists.
Methods For Skin Absorption
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Author : Barbara W. Kemppainen
language : en
Publisher: CRC Press
Release Date : 1990-06-13
Methods For Skin Absorption written by Barbara W. Kemppainen and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990-06-13 with Medical categories.
This up-to-date volume describes the wide variety of available methods concerning percutaneous absorption of drugs and toxins. It discusses in detail the advantages and disadvantages of each method. This unique publication provides a clear, systematic presentation of each aspect which must be considered when designing and performing skin penetration experiments and when interpreting results. It includes specific information regarding necessary supplies and equipment, along with commercial sources for these items. This state-of-the-art book is an ideal instructional manual for investigators uninitiated in performing percutaneous absorption and metabolism studies. Those involved with investigative dermatology, dermatological research, toxicology, and pharmacology will find this reference interesting and indispensable.
Handbook Of Cosmetic Science And Technology
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Author : André O. Barel
language : en
Publisher: CRC Press
Release Date : 2009-03-03
Handbook Of Cosmetic Science And Technology written by André O. Barel and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-03-03 with Medical categories.
Edited by a team of experienced and internationally renowned contributors, the updated Third Edition is the standard reference for cosmetic chemists and dermatologists seeking the latest innovations and technology for the formulation, design, testing, use, and production of cosmetic products for skin, hair, and nails.New features in the Third Editi
Toxicology Of The Skin
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Author : Nancy A. Monteiro-Riviere
language : en
Publisher: CRC Press
Release Date : 2010-02-17
Toxicology Of The Skin written by Nancy A. Monteiro-Riviere and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-02-17 with Medical categories.
This key volume of the Target Organ Toxicology Series provides a fresh and modern approach to the subject of skin toxicology from the perspective of how the skin forms a barrier that protects the body from the external environment and how chemicals and drugs interact with the barrier properties of the skin. Any defects or perturbations to this barr