Dermal Absorption Models In Toxicology And Pharmacology
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Dermal Absorption Models In Toxicology And Pharmacology
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Author : Jim E. Riviere
language : en
Publisher: CRC Press
Release Date : 2005-08-24
Dermal Absorption Models In Toxicology And Pharmacology written by Jim E. Riviere and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-08-24 with Medical categories.
Many experimental methods and mathematical modeling approaches rooted in disciplines outside of toxicology can be effectively applied to estimating dermal absorption. Dermal Absorption Models in Toxicology and Pharmacology explores current approaches and techniques that can be used to quantify dermal absorption with endpoints useful in both toxicology and pharmacology. The book begins with a review of basic principles and the in vitro and in vivo experimental approaches available for assessing dermal absorption of drugs and chemicals. This is followed by coverage of mathematical or in silico models for quantitating percutaneous absorption and the applications of these techniques to the risk assessment process. The remainder of the book explores scenarios where the unique properties of the chemicals being studied or the matrix in which they are exposed must be considered and then wraps up with a comparative analysis of chemical permeability in human and animal skin. Many of the books covering this subject are just too comprehensive and serve primarily as reference works. This book takes a different approach. Jim Riviere's editorial guidance ensures that the information is readable, accessible, authoritative, and concise, making it the perfect resource for familiarizing new researchers and students to the field and updating established scientists.
Health Risk Assessment Dermal And Inhalation Exposure And Absorption Of Toxicants
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Author : Rhoda G.M. Wang
language : en
Publisher: CRC Press
Release Date : 2017-11-22
Health Risk Assessment Dermal And Inhalation Exposure And Absorption Of Toxicants written by Rhoda G.M. Wang and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-22 with Medical categories.
Health Risk Assessment is a comprehensive reference focusing on dermal absorption, cholinesterase inhibition, adverse reproductive effects, and carcinogenicity. The book features contributions from over 40 top scientists and covers topics such as PBPK modeling, cytochrome P-450 metabolism in skin, percutaneous absorption, adverse effects, new skin models, and the role of epidemiology in assessing the hazards of toxicants. Health Risk Assessment is essential for toxicologists, environmental chemists, pharmacologists, risk assessors, and managers working in industrial, pesticide, and pharmaceutical development. The book will also benefit individuals in environmental, regulatory, and registration affairs, as well as academicians and students.
Principles And Practice Of Skin Toxicology
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Author : Robert Chilcott
language : en
Publisher: John Wiley & Sons
Release Date : 2008-07-31
Principles And Practice Of Skin Toxicology written by Robert Chilcott and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-07-31 with Science categories.
Written by authorities in the field, this book provides a “bottom up” approach to studying skin toxicology. Principles and Practice of Skin Toxicology clearly outlines basic concepts, cites historical and modern references and contains a dictionary for easy reference. The inclusion of global legislation and regulatory aspects on the topic makes this a comprehensive review for every practitioner, clinical researcher in industry and academia, and MSc and PhD student of toxicology. Different sections cover skin structure and function, principles and measurement of skin absorption, clinical aspects of dermal toxicity and in vitro alternatives. A section on regulatory and legislative aspects includes case studies from the UK that fulfill European Union and US FDA requirements. A glossary provides definitions of technical terms, and the chapters contain an introduction, learning boxes and summary section for ease of use. Includes a chapter on drug delivery through the skin. Addresses risk assessment: a key area for the interpretation of skin absorption data that is rarely covered.
Dermal Absorption And Toxicity Assessment Second Edition
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Author : Michael S. Roberts
language : en
Publisher: CRC Press
Release Date : 2008
Dermal Absorption And Toxicity Assessment Second Edition written by Michael S. Roberts and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Health & Fitness categories.
The source Dermal Absorption and Toxicity Assessment supplies a state-of-the-art overview of the dermal absorption process, and is divided into six well organized sections. Written by internationally recognized experts in the field, this Second Edition is a complete revised and updated text, covering the wide range of methods used to assess skin absorption and the various governmental and industrial programs concerned with skin permeation and toxicity. These include alternative in silico, in vitro, and in vivo strategies to conduct studies for regulatory requirements. To make room for this new expanded content, the editors are publishing a concurrent text entitled: Dermatological and Cosmetic Development with a concentration on subjects concerned with dermatological and cosmetic therapies
Predictive Methods In Percutaneous Absorption
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Author : Gary P. Moss
language : en
Publisher: Springer
Release Date : 2015-07-01
Predictive Methods In Percutaneous Absorption written by Gary P. Moss and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-07-01 with Medical categories.
This book sheds new light on the development and use of quantitative models to describe the process of skin permeation. It critically reviews the development of quantitative predictive models of skin absorption and discusses key recommendations for model development. Topics presented include an introduction to skin physiology; the underlying theories of skin absorption; the physical laboratory-based processes used to generate skin absorption data, which is in turn used to construct mathematical models describing the skin permeation process; algorithms of skin permeability including quantitative structure-activity (or permeability) relationships (QSARs or QSPRs); relationships between permeability and molecular properties; the development of formulation-focused approaches to models of skin permeability prediction; the use of artificial membranes, e.g. polydimethylsiloxane as alternatives to mammalian skin; and lastly, the use of novel Machine Learning methods in developing the next generation of predictive skin permeability models. The book will be of interest to all researchers in academia and industry working in pharmaceutical discovery and development, as well as readers from the field of occupational exposure and risk assessment, especially those whose work involves agrochemicals, bulk chemicals and cosmetics.
Dermal Absorption
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Author : J. Kielhorn
language : en
Publisher: World Health Organization
Release Date : 2006
Dermal Absorption written by J. Kielhorn and has been published by World Health Organization this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Medical categories.
Introduction and definitions -- Skin structure and function -- Skin transport mechanisms and theoretical concepts -- Metabolism in the skin -- In vitro tests for dermal absorption -- In vivo tests for dermal absorption -- Comparative studies -- Data collections -- Estimation/prediction of dermal penetration -- Use of dermal penetration studies in risk assessment -- Controversial topics in the assessment of dermal absorption -- Conclusions and recommendations.
Methods For Skin Absorption
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Author : Barbara W. Kemppainen
language : en
Publisher: CRC Press
Release Date : 1990-06-13
Methods For Skin Absorption written by Barbara W. Kemppainen and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990-06-13 with Medical categories.
This up-to-date volume describes the wide variety of available methods concerning percutaneous absorption of drugs and toxins. It discusses in detail the advantages and disadvantages of each method. This unique publication provides a clear, systematic presentation of each aspect which must be considered when designing and performing skin penetration experiments and when interpreting results. It includes specific information regarding necessary supplies and equipment, along with commercial sources for these items. This state-of-the-art book is an ideal instructional manual for investigators uninitiated in performing percutaneous absorption and metabolism studies. Those involved with investigative dermatology, dermatological research, toxicology, and pharmacology will find this reference interesting and indispensable.
Health Risk Assessment
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Author : Rhoda G. M. Wang
language : en
Publisher: CRC PressI Llc
Release Date : 1993-01-01
Health Risk Assessment written by Rhoda G. M. Wang and has been published by CRC PressI Llc this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-01-01 with Health & Fitness categories.
1. Pharmacokinetcs, metabolism, and percutaneous penetration of the skin; 2. Route of exposure and toxicological response; 3. Dose, toxicity, and risk assessment; 4. New models in skin research.
Models For Assessing Drug Absorption And Metabolism
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Author : Ronald T. Borchardt
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Models For Assessing Drug Absorption And Metabolism written by Ronald T. Borchardt and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Medical categories.
Pharmaceutical scientists in industry and academia will appreciate this single reference for its detailed experimental procedures for conducting biopharmaceutical studies. This well-illustrated guide allows them to establish, validate, and implement commonly used in situ and in vitro model systems. Chapters provide ready access to these methodologies for studies of the intestinal, buccal, nasal and respiratory, vaginal, ocular, and dermal epithelium as well as the endothelial and elimination barriers.
Percutaneous Absorption
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Author : Robert L. Bronaugh
language : en
Publisher: CRC Press
Release Date : 1999-05-28
Percutaneous Absorption written by Robert L. Bronaugh and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-05-28 with Science categories.
Since publication of the Second Edition in 1989, numerous innovations have occurred that affect the way scientists look at issues in the field of percutaneous absorption. Focusing on recent advances as well as updating and expanding the scope of topics covered in the previous edition, Percutaneous Absorption, Third Edition provides thorough coverage of the skin's role as an important portal of entry for chemicals into the body. Assembles the work of nearly 80 experts-30 more than the Second Edition-into a unified, comprehensive volume that contains the latest ideas and research! Complete with nearly 600 drawings, photographs, equations, and tables and more than 1600 bibliographic citations of pertinent literature, Percutaneous Absorption, Third Edition details the applied biology of percutaneous penetration factors that affect skin permeation, such as age, vehicles, metabolism, hydration of skin, and chemical structure in vivo and in vitro techniques for measuring absorption, examining factors influencing methodology such as animal models, volatility of test compound, multiple dosage, and artificial membranes procedures for use in transdermal delivery, exploring topics such as effects of penetration enhancers on absorption, optimizing absorption, and the topical delivery of drugs to muscle tissue And presents new chapters on mathematical models cutaneous metabolism prediction of percutaneous absorption in vitro absorption methodology dermal decontamination concentration of chemicals in skin transdermal drug delivery mechanisms of absorption safety evaluation of cosmetics absorption of drugs and cosmetic ingredients nail penetration Emphasizes human applications-particularly useful for pharmacists, pharmacologists, dermatologists, cosmetic scientists, biochemists, toxicologists, public health officials, manufacturers of cosmetic and toiletry products, and graduate students in these disciplines! An invaluable reference source for readers who need to keep up with the latest developments in the field, Percutaneous Absorption, Third Edition is also an excellent experimental guide for laboratory personnel.