Preparation And Analysis Of Protein Crystals
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Preparation And Analysis Of Protein Crystals
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Author : Alexander McPherson
language : en
Publisher:
Release Date : 1989
Preparation And Analysis Of Protein Crystals written by Alexander McPherson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with Proteins categories.
Preparation And Analysis Of Protein Crystals
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Author :
language : en
Publisher:
Release Date : 1982
Preparation And Analysis Of Protein Crystals written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1982 with categories.
Preparation And Analysis Of Protein Crystals
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Author : Alexander McPherson
language : en
Publisher:
Release Date : 1989
Preparation And Analysis Of Protein Crystals written by Alexander McPherson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with Science categories.
Reprint. Originally published in 1982 by Wiley. McPherson (biochemistry, U. of Calif. Riverside) provides an interface between the techniques and practices common to most biochemists and the procedures familiar to x-ray diffractionists. Acidic paper. Annotation copyright Book News, Inc. Portland, Or
Crystallization Of Membrane Proteins
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Author : Hartmut Michel
language : en
Publisher: CRC Press
Release Date : 2018-01-18
Crystallization Of Membrane Proteins written by Hartmut Michel and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-18 with Medical categories.
The precise knowledge of the structure of biological macromolecules forms the basis of understanding their function and their mechanism of action. It also lays the foundation for rational protein and drug design. The only method to obtain this knowledge is still crystallography. At present, the structures of about 400 proteins are known at or nearly at atomic proteins. However, only two of them are membrane proteins or complexes of the membrane proteins. The reasons for the difference is not the crystals of membrane proteins resists forming special problems when being analysed. The reason is that the membrane proteins resist into forming into well-ordered crystals. The intention of this book is to help to produce well-ordered crystals proteins and to provide guidelines, it is aimed at both biochemists and protein crystallographer‘s.
Preparation And Analysis Of Protein Crystals
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Author : Alexander McPherson
language : en
Publisher: John Wiley & Sons
Release Date : 1982-05-04
Preparation And Analysis Of Protein Crystals written by Alexander McPherson and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 1982-05-04 with Science categories.
A complete guide to techniques and procedures for the preparation of proteins for crystallographic studies. Describes methods for protein crystallization; formation of isomorphous heavy atoms; x-ray diffraction and analysis; and photographic and computerbased data collection methods and instrumentation.
Data Analytics For Protein Crystallization
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Author : Marc L. Pusey
language : en
Publisher: Springer
Release Date : 2017-11-27
Data Analytics For Protein Crystallization written by Marc L. Pusey and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-27 with Computers categories.
This unique text/reference presents an overview of the computational aspects of protein crystallization, describing how to build robotic high-throughput and crystallization analysis systems. The coverage encompasses the complete data analysis cycle, including the set-up of screens by analyzing prior crystallization trials, the classification of crystallization trial images by effective feature extraction, the analysis of crystal growth in time series images, the segmentation of crystal regions in images, the application of focal stacking methods for crystallization images, and the visualization of trials. Topics and features: describes the fundamentals of protein crystallization, and the scoring and categorization of crystallization image trials; introduces a selection of computational methods for protein crystallization screening, and the hardware and software architecture for a basic high-throughput system; presents an overview of the image features used in protein crystallization classification, and a spatio-temporal analysis of protein crystal growth; examines focal stacking techniques to avoid blurred crystallization images, and different thresholding methods for binarization or segmentation; discusses visualization methods and software for protein crystallization analysis, and reviews alternative methods to X-ray diffraction for obtaining structural information; provides an overview of the current challenges and potential future trends in protein crystallization. This interdisciplinary work serves as an essential reference on the computational and data analytics components of protein crystallization for the structural biology community, in addition to computer scientists wishing to enter the field of protein crystallization.
Protein Crystallization
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Author : Terese M. Bergfors
language : en
Publisher: Internat'l University Line
Release Date : 2009
Protein Crystallization written by Terese M. Bergfors and has been published by Internat'l University Line this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Medical categories.
Crystals X Rays And Proteins
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Author : Dennis Sherwood
language : en
Publisher: OUP Oxford
Release Date : 2010-11-05
Crystals X Rays And Proteins written by Dennis Sherwood and has been published by OUP Oxford this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-05 with Science categories.
A complete account of the theory of the diffraction of X-rays by crystals, with particular reference to the processes of determining the structures of protein molecules. This book is aimed primarily at structural biologists and biochemists but will also be valuable to those entering the field with a background in physical sciences or chemistry. It may be used at any post-school level, and develops from first principles all relevant mathematics, diffraction and wave theory, assuming no mathematical knowledge beyond integral calculus. The book covers a host of important topics in the area, including: - The practical aspects of sample preparation and X-ray data collection, using both laboratory and synchrotron sources - Data analysis at both theoretical and practical levels - The important role played by the Patterson function in structure analysis, by both molecular replacement and experimental phasing approaches - Methods for improving the resulting electron density map - The theoretical basis of methods used in refinement of protein crystal structures - In-depth explanation of the crucial task of defining the binding sites of ligands and drug molecules - The complementary roles of other diffraction methods: these reveal further detail of great functional importance in a crystal structure.
Protein Structure Analysis
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Author : Roza Maria Kamp
language : en
Publisher: Springer Science & Business Media
Release Date : 1997
Protein Structure Analysis written by Roza Maria Kamp and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Science categories.
"Protein Structure Analysis - Preparation and Characterization" is a compilation of practical approaches to the structural analysis of proteins and peptides. Here, about 20 authors describe and comment on techniques for sensitive protein purification and analysis. These methods are used worldwide in biochemical and biotechnical research currently being carried out in pharmaceu tical and biomedical laboratories or protein sequencing facilities. The chapters have been written by scientists with extensive ex perience in these fields, and the practical parts are well documen ted so that the reader should be able to easily reproduce the described techniques. The methods compiled in this book were demonstrated in student courses and in the EMBO Practical Course on "Microsequence Analysis of Proteins" held in Berlin September 10-15, 1995. The topics also derived from a FEBS Workshop, held in Halkidiki, Thessaloniki, Greece, in April, 1995. Most of the authors participated in these courses as lecturers and tutors and made these courses extremely lively and successful. Since polypeptides greatly vary depending on their specific structure and function, strategies for their structural analysis must for the most part be adapted to each individual protein. Therefore, advantages and limitations of the experimen tal approaches are discussed here critically, so that the reader becomes familiar with problems that might be encountered.
The Next Generation In Membrane Protein Structure Determination
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Author : Isabel Moraes
language : en
Publisher: Springer
Release Date : 2016-08-23
The Next Generation In Membrane Protein Structure Determination written by Isabel Moraes and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-23 with Science categories.
This book reviews current techniques used in membrane protein structural biology, with a strong focus on practical issues. The study of membrane protein structures not only provides a basic understanding of life at the molecular level but also helps in the rational and targeted design of new drugs with reduced side effects. Today, about 60% of the commercially available drugs target membrane proteins and it is estimated that nearly 30% of proteins encoded in the human genome are membrane proteins. In recent years much effort has been put towards innovative developments to overcome the numerous obstacles associated with the structure determination of membrane proteins. This book reviews a variety of recent techniques that are essential to any modern researcher in the field of membrane protein structural biology. The topics that are discussed are not commonly found in textbooks. The scope of this book includes: Expression screening using fluorescent proteins The use of detergents in membrane protein research The use of NMR Synchrotron developments in membrane protein structural biology Visualisation and X-ray data collection of microcrystals X-ray diffraction data analysis from multiple crystals Serial millisecond crystallography Serial femtosecond crystallography Membrane protein structures in drug discovery The information provided in this book should be of interest to anyone working in the area of structural biology. Students will find carefully prepared overviews of basic ideas and advanced protein scientists will find the level of detail required to apply the material directly to their day to day work. Chapters 4, 5, 6, 8 and 9 of this book are published open access under a CC BY 4.0 license at link.springer.com.
