Data Analytics For Protein Crystallization
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Data Analytics For Protein Crystallization
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Author : Marc L. Pusey
language : en
Publisher: Springer
Release Date : 2017-11-27
Data Analytics For Protein Crystallization written by Marc L. Pusey and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-27 with Computers categories.
This unique text/reference presents an overview of the computational aspects of protein crystallization, describing how to build robotic high-throughput and crystallization analysis systems. The coverage encompasses the complete data analysis cycle, including the set-up of screens by analyzing prior crystallization trials, the classification of crystallization trial images by effective feature extraction, the analysis of crystal growth in time series images, the segmentation of crystal regions in images, the application of focal stacking methods for crystallization images, and the visualization of trials. Topics and features: describes the fundamentals of protein crystallization, and the scoring and categorization of crystallization image trials; introduces a selection of computational methods for protein crystallization screening, and the hardware and software architecture for a basic high-throughput system; presents an overview of the image features used in protein crystallization classification, and a spatio-temporal analysis of protein crystal growth; examines focal stacking techniques to avoid blurred crystallization images, and different thresholding methods for binarization or segmentation; discusses visualization methods and software for protein crystallization analysis, and reviews alternative methods to X-ray diffraction for obtaining structural information; provides an overview of the current challenges and potential future trends in protein crystallization. This interdisciplinary work serves as an essential reference on the computational and data analytics components of protein crystallization for the structural biology community, in addition to computer scientists wishing to enter the field of protein crystallization.
Protein Crystallography
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Author : Alexander Wlodawer
language : en
Publisher: Humana Press
Release Date : 2017-06-02
Protein Crystallography written by Alexander Wlodawer and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-02 with Science categories.
This volume provides methods for modern macromolecular crystallography, including all steps leading to crystal structure determination and analysis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Protein Crystallography aims to ensure successful results in the further study of this vital field.
Practical Protein Crystallography
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Author : Duncan E. McRee
language : en
Publisher: Academic Press
Release Date : 2012-12-02
Practical Protein Crystallography written by Duncan E. McRee and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Science categories.
Designed for easy use by both new and experienced protein crystallographers, this much-needed book is for anyone interested in solving protein structures by the method of crystallography. It contains many examples ofactual experiments and data, including electron density maps. Computer methods and computer code samples are presented. Practical Protein Crystallography is loaded with new information on area detectors, synchrotron radiation techniques, and the latest computer methods, and features the XtalView software system. Graduate students and teachers in physical biochemistry and pharmaceutical researchers will find this text a timely and convenient aid.
The Next Generation In Membrane Protein Structure Determination
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Author : Isabel Moraes
language : en
Publisher: Springer
Release Date : 2016-08-23
The Next Generation In Membrane Protein Structure Determination written by Isabel Moraes and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-23 with Science categories.
This book reviews current techniques used in membrane protein structural biology, with a strong focus on practical issues. The study of membrane protein structures not only provides a basic understanding of life at the molecular level but also helps in the rational and targeted design of new drugs with reduced side effects. Today, about 60% of the commercially available drugs target membrane proteins and it is estimated that nearly 30% of proteins encoded in the human genome are membrane proteins. In recent years much effort has been put towards innovative developments to overcome the numerous obstacles associated with the structure determination of membrane proteins. This book reviews a variety of recent techniques that are essential to any modern researcher in the field of membrane protein structural biology. The topics that are discussed are not commonly found in textbooks. The scope of this book includes: Expression screening using fluorescent proteins The use of detergents in membrane protein research The use of NMR Synchrotron developments in membrane protein structural biology Visualisation and X-ray data collection of microcrystals X-ray diffraction data analysis from multiple crystals Serial millisecond crystallography Serial femtosecond crystallography Membrane protein structures in drug discovery The information provided in this book should be of interest to anyone working in the area of structural biology. Students will find carefully prepared overviews of basic ideas and advanced protein scientists will find the level of detail required to apply the material directly to their day to day work. Chapters 4, 5, 6, 8 and 9 of this book are published open access under a CC BY 4.0 license at link.springer.com.
Protein Crystallization
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Author : Terese M. Bergfors
language : en
Publisher: Internat'l University Line
Release Date : 2009
Protein Crystallization written by Terese M. Bergfors and has been published by Internat'l University Line this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Medical categories.
Applying Big Data Analytics In Bioinformatics And Medicine
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Author : Lytras, Miltiadis D.
language : en
Publisher: IGI Global
Release Date : 2017-06-16
Applying Big Data Analytics In Bioinformatics And Medicine written by Lytras, Miltiadis D. and has been published by IGI Global this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-16 with Computers categories.
Many aspects of modern life have become personalized, yet healthcare practices have been lagging behind in this trend. It is now becoming more common to use big data analysis to improve current healthcare and medicinal systems, and offer better health services to all citizens. Applying Big Data Analytics in Bioinformatics and Medicine is a comprehensive reference source that overviews the current state of medical treatments and systems and offers emerging solutions for a more personalized approach to the healthcare field. Featuring coverage on relevant topics that include smart data, proteomics, medical data storage, and drug design, this publication is an ideal resource for medical professionals, healthcare practitioners, academicians, and researchers interested in the latest trends and techniques in personalized medicine.
Advanced Topics On Crystal Growth
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Author : Sukarno Olavo Ferreira
language : en
Publisher:
Release Date : 2013
Advanced Topics On Crystal Growth written by Sukarno Olavo Ferreira and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with categories.
Crystal growth is the key step of a great number of very important applications. The development of new devices and products, from the traditional microelectronic industry to pharmaceutical industry and many others, depends on crystallization processes. The objective of this book is not to cover all areas of crystal growth but just present, as specified in the title, important selected topics, as applied to organic and inorganic systems. All authors have been selected for being key researchers in their field of specialization, working in important universities and research labs around the world. The first section is mainly devoted to biological systems and covers topics like proteins, bone and ice crystallization. The second section brings some applications to inorganic systems and describes more general growth techniques like chemical vapor crystallization and electrodeposition. This book is mostly recommended for students working in the field of crystal growth and for scientists and engineers in the fields of crystalline materials, crystal engineering and the industrial applications of crystallization processes.
Preparation And Analysis Of Protein Crystals
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Author : Alexander McPherson
language : en
Publisher:
Release Date : 1989
Preparation And Analysis Of Protein Crystals written by Alexander McPherson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with Science categories.
Reprint. Originally published in 1982 by Wiley. McPherson (biochemistry, U. of Calif. Riverside) provides an interface between the techniques and practices common to most biochemists and the procedures familiar to x-ray diffractionists. Acidic paper. Annotation copyright Book News, Inc. Portland, Or
Protein Crystallography
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Author : Eaton E. Lattman
language : en
Publisher: JHU Press
Release Date : 2008-04-28
Protein Crystallography written by Eaton E. Lattman and has been published by JHU Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-28 with Science categories.
The proteome remains a mysterious realm. Researchers have determined the structures of only a small fraction of the proteins encoded by the human genome. Crystallography continues to be the primary method used to determine the structures of the remaining unknown proteins. This imaging technique uses the diffraction of X-rays to determine a protein’s three-dimensional molecular structure. Drawing on years of research and teaching experience, Eaton E. Lattman and Patrick J. Loll use clear examples and abundant illustrations to provide a concise and accessible primer on protein crystallography. Discussing the basics of diffraction, the behavior of two- and three-dimensional crystals, phase determination (including MIR and MAD phasing and molecular replacement), the Patterson function, and refinement, Lattman and Loll provide a complete overview of this important technique, illuminated by physical insights. The crisp writing style and simple illustrations will provide beginner crystallographers with a guide to the process of unraveling protein structure.
Crystallization Of Biological Macromolecules
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Author : Alexander McPherson
language : en
Publisher: CSHL Press
Release Date : 1999
Crystallization Of Biological Macromolecules written by Alexander McPherson and has been published by CSHL Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Biopolymers categories.
This extensively illustrated book by Alexander McPherson, a master practitioner, accomplishes several important goals: it presents the underlying physical and chemical principles of crystallization in an approachable way; it provides the reader with a biochemical context in which to understand and pursue successful crystal growth; it instructs the reader in practical aspects of the technologies required; and it lays out effective strategies for success that investigators can readily apply to their own experimental questions. This readable volume has been created for every investigator in biomedicine whose studies may require a shift in focus from gene to protein product, as well as chemists and physicists interested in the functions of biologically active macromolecules.