Data Analytics For Protein Crystallization
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Data Analytics For Protein Crystallization
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Author : Marc L. Pusey
language : en
Publisher: Springer
Release Date : 2017-11-27
Data Analytics For Protein Crystallization written by Marc L. Pusey and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-27 with Computers categories.
This unique text/reference presents an overview of the computational aspects of protein crystallization, describing how to build robotic high-throughput and crystallization analysis systems. The coverage encompasses the complete data analysis cycle, including the set-up of screens by analyzing prior crystallization trials, the classification of crystallization trial images by effective feature extraction, the analysis of crystal growth in time series images, the segmentation of crystal regions in images, the application of focal stacking methods for crystallization images, and the visualization of trials. Topics and features: describes the fundamentals of protein crystallization, and the scoring and categorization of crystallization image trials; introduces a selection of computational methods for protein crystallization screening, and the hardware and software architecture for a basic high-throughput system; presents an overview of the image features used in protein crystallization classification, and a spatio-temporal analysis of protein crystal growth; examines focal stacking techniques to avoid blurred crystallization images, and different thresholding methods for binarization or segmentation; discusses visualization methods and software for protein crystallization analysis, and reviews alternative methods to X-ray diffraction for obtaining structural information; provides an overview of the current challenges and potential future trends in protein crystallization. This interdisciplinary work serves as an essential reference on the computational and data analytics components of protein crystallization for the structural biology community, in addition to computer scientists wishing to enter the field of protein crystallization.
Protein Crystallization Strategies For Structural Genomics
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Author : Naomi E. Chayen
language : en
Publisher: Internat'l University Line
Release Date : 2007
Protein Crystallization Strategies For Structural Genomics written by Naomi E. Chayen and has been published by Internat'l University Line this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Science categories.
Protein Crystallization
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Author : Terese M. Bergfors
language : en
Publisher: Internat'l University Line
Release Date : 2009
Protein Crystallization written by Terese M. Bergfors and has been published by Internat'l University Line this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Medical categories.
Preparation And Analysis Of Protein Crystals
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Author : Alexander McPherson
language : en
Publisher: John Wiley & Sons
Release Date : 1982-05-04
Preparation And Analysis Of Protein Crystals written by Alexander McPherson and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 1982-05-04 with Science categories.
A complete guide to techniques and procedures for the preparation of proteins for crystallographic studies. Describes methods for protein crystallization; formation of isomorphous heavy atoms; x-ray diffraction and analysis; and photographic and computerbased data collection methods and instrumentation.
The Next Generation In Membrane Protein Structure Determination
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Author : Isabel Moraes
language : en
Publisher: Springer
Release Date : 2016-08-23
The Next Generation In Membrane Protein Structure Determination written by Isabel Moraes and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-23 with Science categories.
This book reviews current techniques used in membrane protein structural biology, with a strong focus on practical issues. The study of membrane protein structures not only provides a basic understanding of life at the molecular level but also helps in the rational and targeted design of new drugs with reduced side effects. Today, about 60% of the commercially available drugs target membrane proteins and it is estimated that nearly 30% of proteins encoded in the human genome are membrane proteins. In recent years much effort has been put towards innovative developments to overcome the numerous obstacles associated with the structure determination of membrane proteins. This book reviews a variety of recent techniques that are essential to any modern researcher in the field of membrane protein structural biology. The topics that are discussed are not commonly found in textbooks. The scope of this book includes: Expression screening using fluorescent proteins The use of detergents in membrane protein research The use of NMR Synchrotron developments in membrane protein structural biology Visualisation and X-ray data collection of microcrystals X-ray diffraction data analysis from multiple crystals Serial millisecond crystallography Serial femtosecond crystallography Membrane protein structures in drug discovery The information provided in this book should be of interest to anyone working in the area of structural biology. Students will find carefully prepared overviews of basic ideas and advanced protein scientists will find the level of detail required to apply the material directly to their day to day work. Chapters 4, 5, 6, 8 and 9 of this book are published open access under a CC BY 4.0 license at link.springer.com.
Knowledge Discovery In Proteomics
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Author : Igor Jurisica
language : en
Publisher: CRC Press
Release Date : 2005-09-02
Knowledge Discovery In Proteomics written by Igor Jurisica and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-09-02 with Computers categories.
Multi-modal representations, the lack of complete and consistent domain theories, rapid evolution of domain knowledge, high dimensionality, and large amounts of missing information - these are challenges inherent in modern proteomics. As our understanding of protein structure and function becomes ever more complicated, we have reached a point where
Protein Crystallography
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Author : Gwyndaf Evans
language : en
Publisher: Royal Society of Chemistry
Release Date : 2018-06-21
Protein Crystallography written by Gwyndaf Evans and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-21 with Science categories.
Protein crystallography has become vital to further understanding the structure and function of many complex biological systems. In recent years, structure determination has progressed tremendously however the quality of crystals and data sets can prevent the best results from being obtained. With contributions from world leading researchers whose software are used worldwide, this book provides a coherent approach on how to handle difficult crystallographic data and how to assess its quality. The chapters will cover all key aspects of protein crystallography, from instrumentation and data processing through to model building. This book also addresses challenges that protein crystallographers will face such as dealing with data from microcrystals and multi protein complexes. This book is ideal for both academics and researchers in industry looking for a comprehensive guide to protein crystallography.
Protein Crystallography
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Author : Alexander Wlodawer
language : en
Publisher: Humana Press
Release Date : 2017-06-02
Protein Crystallography written by Alexander Wlodawer and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-02 with Science categories.
This volume provides methods for modern macromolecular crystallography, including all steps leading to crystal structure determination and analysis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Protein Crystallography aims to ensure successful results in the further study of this vital field.
Preparation And Analysis Of Protein Crystals
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Author : Alexander McPherson
language : en
Publisher:
Release Date : 1989
Preparation And Analysis Of Protein Crystals written by Alexander McPherson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with Proteins categories.
Membrane Protein Crystallization
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Author :
language : en
Publisher: Academic Press
Release Date : 2009-05-29
Membrane Protein Crystallization written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-05-29 with Science categories.
This volume of Current Topics in Membranes focuses on Membrane Protein Crystallization, beginning with a review of past successes and general trends, then further discussing challenges of mebranes protein crystallization, cell free production of membrane proteins and novel lipids for membrane protein crystallization. This publication also includes tools to enchance membrane protein crystallization, technique advancements, and crystallization strategies used for photosystem I and its complexes, establishing Membrane Protein Crystallization as a needed, practical reference for researchers.