Protein Crystallography


Protein Crystallography
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Protein Crystallography


Protein Crystallography
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Author : T. L. Blundell
language : en
Publisher: Academic Press
Release Date : 1976-01-28

Protein Crystallography written by T. L. Blundell and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1976-01-28 with Science categories.




Protein Crystallography


Protein Crystallography
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Author : Eaton E. Lattman
language : en
Publisher: JHU Press
Release Date : 2008-04-28

Protein Crystallography written by Eaton E. Lattman and has been published by JHU Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-28 with Science categories.


The proteome remains a mysterious realm. Researchers have determined the structures of only a small fraction of the proteins encoded by the human genome. Crystallography continues to be the primary method used to determine the structures of the remaining unknown proteins. This imaging technique uses the diffraction of X-rays to determine a protein’s three-dimensional molecular structure. Drawing on years of research and teaching experience, Eaton E. Lattman and Patrick J. Loll use clear examples and abundant illustrations to provide a concise and accessible primer on protein crystallography. Discussing the basics of diffraction, the behavior of two- and three-dimensional crystals, phase determination (including MIR and MAD phasing and molecular replacement), the Patterson function, and refinement, Lattman and Loll provide a complete overview of this important technique, illuminated by physical insights. The crisp writing style and simple illustrations will provide beginner crystallographers with a guide to the process of unraveling protein structure.



Principles Of Protein X Ray Crystallography


Principles Of Protein X Ray Crystallography
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Author : Jan Drenth
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-09

Principles Of Protein X Ray Crystallography written by Jan Drenth and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Science categories.


New textbooks at all levels of chemistry appear with great regularity. Some fields such as basic biochemistry, organic reaction mechanisms, and chemical thermodynamics are well represented by many excellent texts, and new or revised editions are published sufficiently often to keep up with progress in research. However, some areas of chemistry, especially many of those taught at the graduate level, suffer from a real lack of up to-date textbooks. The most serious needs occur in fields that are rapidly changing. Textbooks in these subjects usually have to be written by scientists actually involved in the research that is advancing the field. It is not often easy to persuade such individuals to set time aside to help spread the knowledge they have accumulated. Our goal, in this series, is to pinpoint areas of chemistry where recent progress has outpaced what is covered in any available textbooks, and then seek out and persuade experts in these fields to produce relatively concise but instructive intro ductions to their fields. These should serve the needs of one-semester or one-quarter graduate courses in chemistry and biochemistry. In some cases, the availability of texts in active research areas should help stimulate the creation of new courses. Charles R. Cantor v Preface to the Second Edition Since the publication of the previous edition in 1994, X-ray crystallography of proteins has advanced by improvements in existing techniques and by addition of new techniques.



Practical Protein Crystallography


Practical Protein Crystallography
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Author : Duncan E. McRee
language : en
Publisher: Academic Press
Release Date : 2012-12-02

Practical Protein Crystallography written by Duncan E. McRee and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Science categories.


Designed for easy use by both new and experienced protein crystallographers, this much-needed book is for anyone interested in solving protein structures by the method of crystallography. It contains many examples ofactual experiments and data, including electron density maps. Computer methods and computer code samples are presented. Practical Protein Crystallography is loaded with new information on area detectors, synchrotron radiation techniques, and the latest computer methods, and features the XtalView software system. Graduate students and teachers in physical biochemistry and pharmaceutical researchers will find this text a timely and convenient aid.



Crystals X Rays And Proteins


Crystals X Rays And Proteins
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Author : Dennis Sherwood
language : en
Publisher: Oxford University Press
Release Date : 2011

Crystals X Rays And Proteins written by Dennis Sherwood and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Language Arts & Disciplines categories.


Information derived from X-ray crystal structures of biological molecules allows us to explain their functions in living organisms in extraordinary detail, and to develop drugs to treat disease. This book describes the principles and practice of X-ray diffraction as a key technique at the forefront of new discoveries in biology and medicine.



Protein Crystallography


Protein Crystallography
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Author : Konstantinos Beis
language : en
Publisher: Royal Society of Chemistry
Release Date : 2018-06-19

Protein Crystallography written by Konstantinos Beis and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-19 with Science categories.


Protein crystallography has become vital to further understanding the structure and function of many complex biological systems. In recent years, structure determination has progressed tremendously however the quality of crystals and data sets can prevent the best results from being obtained. With contributions from world leading researchers whose software are used worldwide, this book provides a coherent approach on how to handle difficult crystallographic data and how to assess its quality. The chapters will cover all key aspects of protein crystallography, from instrumentation and data processing through to model building. This book also addresses challenges that protein crystallographers will face such as dealing with data from microcrystals and multi protein complexes. This book is ideal for both academics and researchers in industry looking for a comprehensive guide to protein crystallography.



Neutron Protein Crystallography


Neutron Protein Crystallography
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Author : Nobuo Niimura
language : en
Publisher: Oxford University Press
Release Date : 2011-02-17

Neutron Protein Crystallography written by Nobuo Niimura and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-02-17 with Science categories.


One of the first books dedicated to the emerging field of neutron protein crystallography (NPC). It covers all of the practical aspects of NPC and demonstrates how NPC can explore protein features such as hydrogen bonds, protonation and deprotonation of amino acid residues, and hydration structures.



Protein Crystallography


Protein Crystallography
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Author : Alexander Wlodawer
language : en
Publisher: Humana
Release Date : 2018-06-09

Protein Crystallography written by Alexander Wlodawer and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-09 with Science categories.


This volume provides methods for modern macromolecular crystallography, including all steps leading to crystal structure determination and analysis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Protein Crystallography aims to ensure successful results in the further study of this vital field.



Protein Crystallography In Drug Discovery


Protein Crystallography In Drug Discovery
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Author : Robert E. Babine
language : en
Publisher: John Wiley & Sons
Release Date : 2008-07-15

Protein Crystallography In Drug Discovery written by Robert E. Babine and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-07-15 with Science categories.


The rational, structure-based approach has become standard in present-day drug design. As a consequence, the availability of high-resolution structures of target proteins is more often than not the basis for an entire drug development program. Protein structures suited for rational drug design are almost exclusively derived from crystallographic studies, and drug developers are relying heavily on the power of this method. Here, researchers from leading pharmaceutical companies present valuable first-hand information, much of it published for the first time. They discuss strategies to derive high-resolution structures for such important target protein classes as kinases or proteases, as well as selected examples of successful protein crystallographic studies. A special section on recent methodological developments, such as for high-throughput crystallography and microcrystallization, is also included. A valuable companion for crystallographers involved in protein structure determination as well as drug developers pursuing the structure-based approach for use in their daily work.



Protein Crystallization Strategies For Structural Genomics


Protein Crystallization Strategies For Structural Genomics
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Author : Naomi E. Chayen
language : en
Publisher: Internat'l University Line
Release Date : 2007

Protein Crystallization Strategies For Structural Genomics written by Naomi E. Chayen and has been published by Internat'l University Line this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Science categories.